Best TWAS P = 3.71e-10 · Best GWAS P= 1.88e-10 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Ifih1 | alternative polyA | XM_063284355.1 | 0.07 | 1648 | 0.04 | 6.4e-05 | 5.23 | 1.68e-07 | 0.54 | FALSE |
| Adipose | Fign | alternative TSS | XM_063283273.1 | 0.04 | 2493 | 0.02 | 2.7e-03 | 6.08 | 1.20e-09 | 0.48 | FALSE |
| Adipose | Tank | alternative TSS | XM_006234273.5 | 0.04 | 1 | 0.02 | 2.8e-03 | -5.56 | 2.65e-08 | 0.17 | FALSE |
| Adipose | Tank | alternative TSS | XM_006234273.5 | 0.04 | 1 | 0.02 | 3.6e-03 | -5.57 | 2.52e-08 | 0.15 | FALSE |
| Adipose | Fign | gene expression | Fign | 0.11 | 1 | 0.09 | 2.0e-10 | -6.27 | 3.71e-10 | 0.87 | TRUE |
| Adipose | Grb14 | gene expression | Grb14 | 0.33 | 35 | 0.23 | 1.1e-24 | -5.44 | 5.34e-08 | 0.18 | FALSE |
| Adipose | Tank | gene expression | Tank | 0.21 | 1462 | 0.13 | 5.5e-14 | -5.32 | 1.02e-07 | 0.83 | FALSE |
| Adipose | Ifih1 | isoform ratio | XM_039105671.2 | 0.06 | 90 | 0.06 | 2.4e-07 | 5.35 | 8.94e-08 | 0.42 | FALSE |
| Adipose | Tank | isoform ratio | XM_006234274.4 | 0.08 | 1 | 0.03 | 2.9e-04 | 5.56 | 2.65e-08 | 0.68 | FALSE |
| Adipose | Ifih1 | mRNA stability | Ifih1 | 0.13 | 1648 | 0.14 | 4.3e-15 | -5.22 | 1.79e-07 | 0.38 | FALSE |
| BLA | Cobll1 | gene expression | Cobll1 | 0.08 | 41 | 0.05 | 1.3e-03 | 5.6 | 2.10e-08 | 0.53 | FALSE |
| BLA | Gca | isoform ratio | NM_001106483.4 | 0.38 | 1622 | 0.37 | 6.5e-21 | 5.36 | 8.42e-08 | 0.5 | FALSE |
| BLA | Gca | isoform ratio | XM_039104486.2 | 0.46 | 1622 | 0.44 | 1.4e-25 | -5.32 | 1.02e-07 | 0.43 | FALSE |
| BLA | Gca | intron excision ratio | chr3_67734856_67736020 | 0.3 | 1 | 0.21 | 1.6e-11 | 5.35 | 8.76e-08 | 0.72 | FALSE |
| BLA | Gca | intron excision ratio | chr3_67734856_67736716 | 0.34 | 1 | 0.28 | 3.6e-15 | -5.35 | 8.76e-08 | 0.72 | FALSE |
| BLA | Grb14 | mRNA stability | Grb14 | 0.37 | 38 | 0.38 | 1.5e-21 | 5.5 | 3.90e-08 | 0.24 | FALSE |
| Brain | Ifih1 | alternative TSS | XM_039105671.2 | 0.06 | 1 | 0.06 | 4.6e-06 | 5.3 | 1.16e-07 | 0.56 | FALSE |
| Brain | Cobll1 | gene expression | Cobll1 | 0.05 | 2442 | 0.05 | 1.6e-05 | 5.69 | 1.29e-08 | 0.78 | FALSE |
| Brain | Grb14 | gene expression | Grb14 | 0.62 | 390 | 0.6 | 4.9e-70 | -5.73 | 9.93e-09 | 0.24 | FALSE |
| Brain | Ifih1 | gene expression | Ifih1 | 0.14 | 5 | 0.22 | 9.6e-21 | -5.29 | 1.21e-07 | 0.37 | TRUE |
| Brain | LOC108350383 | gene expression | LOC108350383 | 0.04 | 1 | 0.05 | 2.7e-05 | -5.23 | 1.72e-07 | 0.05 | FALSE |
| Brain | Gca | isoform ratio | NM_001106483.4 | 0.19 | 11 | 0.32 | 1.5e-30 | 5.4 | 6.81e-08 | 0.38 | FALSE |
| Brain | Grb14 | isoform ratio | NM_031623.2 | 0.06 | 2786 | 0.05 | 2.9e-05 | 5.33 | 9.62e-08 | 0.62 | TRUE |
| Brain | Grb14 | intron excision ratio | chr3_69997205_70000169 | 0.02 | 2786 | 0.01 | 2.1e-02 | 5.65 | 1.64e-08 | 0.44 | FALSE |
| Brain | LOC108350383 | intron excision ratio | chr3_68231297_68231717 | 0.08 | 1304 | 0.08 | 6.6e-08 | -5.56 | 2.72e-08 | 0.39 | FALSE |
| Brain | LOC108350383 | intron excision ratio | chr3_68231369_68231717 | 0.04 | 1304 | 0.03 | 1.2e-03 | 5.48 | 4.24e-08 | 0.37 | FALSE |
| Brain | Gca | mRNA stability | Gca | 0.12 | 1 | 0.15 | 4.2e-14 | -5.23 | 1.72e-07 | 0.57 | FALSE |
| IC | Grb14 | alternative TSS | XM_039105749.2 | 0.1 | 2786 | 0.02 | 3.5e-02 | -5.52 | 3.39e-08 | 0.48 | FALSE |
| IC | Cobll1 | gene expression | Cobll1 | 0.09 | 2442 | 0.01 | 8.1e-02 | 5.22 | 1.81e-07 | 0.48 | FALSE |
| IC | Kcnh7 | gene expression | Kcnh7 | 0.12 | 1304 | 0.1 | 5.3e-05 | 5.23 | 1.66e-07 | 0.16 | FALSE |
| IC | Tank | gene expression | Tank | 0.15 | 1 | 0.06 | 2.2e-03 | 5.36 | 8.34e-08 | 0.07 | FALSE |
| IC | Grb14 | isoform ratio | XM_039105749.2 | 0.08 | 2786 | 0.01 | 1.1e-01 | -5.53 | 3.26e-08 | 0.39 | FALSE |
| IC | LOC108350383 | intron excision ratio | chr3_68231297_68231717 | 0.13 | 1 | 0.08 | 2.6e-04 | -5.46 | 4.90e-08 | 0.1 | FALSE |
| IC | Kcnh7 | mRNA stability | Kcnh7 | 0.1 | 1304 | 0.04 | 7.4e-03 | 5.28 | 1.30e-07 | 0.33 | TRUE |
| IL | Fign | alternative TSS | XM_063283273.1 | 0.2 | 1 | 0.11 | 1.4e-03 | 5.21 | 1.93e-07 | 0.05 | FALSE |
| IL | Fign | gene expression | Fign | 0.18 | 2493 | 0.07 | 8.6e-03 | -5.97 | 2.31e-09 | 0.31 | FALSE |
| IL | Gca | isoform ratio | XM_039104486.2 | 0.35 | 1622 | 0.19 | 2.6e-05 | -5.26 | 1.46e-07 | 0.44 | FALSE |
| IL | Gca | intron excision ratio | chr3_67734856_67736020 | 0.29 | 1622 | 0.09 | 3.5e-03 | 5.22 | 1.75e-07 | 0.42 | FALSE |
| IL | Gca | intron excision ratio | chr3_67734856_67736716 | 0.29 | 1622 | 0.09 | 3.3e-03 | -5.22 | 1.82e-07 | 0.41 | FALSE |
| IL | Gca | mRNA stability | Gca | 0.26 | 1 | 0.13 | 5.3e-04 | -5.26 | 1.43e-07 | 0.06 | FALSE |
| IL | Grb14 | mRNA stability | Grb14 | 0.73 | 26 | 0.43 | 1.2e-11 | 5.44 | 5.34e-08 | 0.25 | FALSE |
| IL | Tank | mRNA stability | Tank | 0.3 | 1462 | 0.06 | 1.4e-02 | 5.32 | 1.03e-07 | 0.46 | TRUE |
| LHb | Grb14 | gene expression | Grb14 | 0.34 | 1 | 0.22 | 5.3e-06 | -5.75 | 8.76e-09 | 0.1 | FALSE |
| LHb | Cobll1 | mRNA stability | Cobll1 | 0.22 | 1 | 0.04 | 3.2e-02 | -5.48 | 4.18e-08 | 0.05 | FALSE |
| LHb | Grb14 | mRNA stability | Grb14 | 0.4 | 1 | 0.25 | 9.7e-07 | 5.32 | 1.06e-07 | 0.06 | FALSE |
| Liver | LOC134486366 | alternative TSS | XR_010065195.1 | 0.05 | 1 | 0.04 | 1.7e-05 | -5.4 | 6.55e-08 | 0.03 | FALSE |
| Liver | LOC134486366 | alternative TSS | XR_010065197.1 | 0.05 | 1 | 0.04 | 2.9e-05 | 5.4 | 6.55e-08 | 0.03 | FALSE |
| Liver | Fign | gene expression | Fign | 0.06 | 1 | 0.05 | 3.9e-06 | -6.11 | 9.72e-10 | 0.59 | FALSE |
| Liver | Slc38a11 | gene expression | Slc38a11 | 0.07 | 1 | 0.03 | 9.8e-05 | 5.82 | 5.94e-09 | 0.24 | FALSE |
| Liver | Grb14 | mRNA stability | Grb14 | 0.39 | 12 | 0.4 | 2.1e-47 | 5.33 | 9.88e-08 | 0.19 | FALSE |
| NAcc | Tank | alternative polyA | XM_006234273.5 | 0.05 | 10 | 0.02 | 4.5e-04 | 5.43 | 5.60e-08 | 0.78 | FALSE |
| NAcc | Tank | alternative polyA | XM_039104358.2 | 0.12 | 1 | 0.06 | 2.1e-09 | -5.39 | 7.23e-08 | 0.8 | FALSE |
| NAcc | Fign | alternative TSS | XM_008761889.4 | 0.01 | 1 | 0.02 | 5.7e-04 | -5.55 | 2.85e-08 | 0.03 | FALSE |
| NAcc | Grb14 | alternative TSS | NM_031623.2 | 0.06 | 2786 | 0.06 | 3.7e-09 | 5.61 | 2.01e-08 | 0.76 | FALSE |
| NAcc | Cobll1 | gene expression | Cobll1 | 0.03 | 5 | 0.05 | 2.4e-08 | 6.09 | 1.14e-09 | 0.82 | TRUE |
| NAcc | Fign | gene expression | Fign | 0.04 | 26 | 0.05 | 4.5e-08 | 6.24 | 4.43e-10 | 0.56 | FALSE |
| NAcc | LOC134486367 | gene expression | LOC134486367 | 0.12 | 18 | 0.14 | 2.5e-20 | 5.91 | 3.50e-09 | 0.69 | FALSE |
| NAcc | Cobll1 | isoform ratio | XM_039106332.2 | 0.02 | 1 | 0.02 | 1.3e-03 | -5.95 | 2.75e-09 | 0.21 | FALSE |
| NAcc | Grb14 | isoform ratio | NM_031623.2 | 0.08 | 2786 | 0.06 | 3.5e-10 | 5.42 | 6.00e-08 | 0.78 | FALSE |
| NAcc | LOC134486367 | isoform ratio | XR_010065198.1 | 0.07 | 2343 | 0.06 | 6.1e-10 | 5.3 | 1.18e-07 | 0.51 | FALSE |
| NAcc | Tank | isoform ratio | XM_039104358.2 | 0.1 | 19 | 0.06 | 2.8e-09 | -5.31 | 1.08e-07 | 0.82 | FALSE |
| NAcc | Grb14 | intron excision ratio | chr3_70017203_70090309 | 0.04 | 2786 | 0.03 | 8.2e-06 | 5.43 | 5.54e-08 | 0.72 | FALSE |
| NAcc | Tank | intron excision ratio | chr3_66571619_66573417 | 0.04 | 1 | 0.03 | 3.8e-05 | -5.51 | 3.57e-08 | 0.83 | FALSE |
| NAcc | Tank | intron excision ratio | chr3_66573535_66574956 | 0.05 | 5 | 0.03 | 5.2e-05 | -5.44 | 5.24e-08 | 0.81 | FALSE |
| NAcc | Slc4a10 | mRNA stability | Slc4a10 | 0.02 | 1 | 0.03 | 8.7e-05 | -5.26 | 1.45e-07 | 0.16 | FALSE |
| OFC | Fap | gene expression | Fap | 0.14 | 1732 | 0.11 | 1.7e-03 | 5.27 | 1.39e-07 | 0.34 | FALSE |
| OFC | Fign | gene expression | Fign | 0.33 | 2493 | 0.18 | 3.9e-05 | -6.08 | 1.21e-09 | 0.38 | FALSE |
| OFC | Grb14 | gene expression | Grb14 | 0.33 | 55 | 0.2 | 1.7e-05 | -5.57 | 2.59e-08 | 0.57 | FALSE |
| OFC | Gca | isoform ratio | NM_001106483.4 | 0.55 | 1622 | 0.38 | 5.3e-10 | 5.28 | 1.26e-07 | 0.42 | FALSE |
| OFC | Gca | isoform ratio | XM_039104486.2 | 0.54 | 1622 | 0.37 | 7.6e-10 | -5.29 | 1.21e-07 | 0.42 | TRUE |
| OFC | Gca | intron excision ratio | chr3_67734856_67736020 | 0.41 | 1 | 0.38 | 4.7e-10 | 5.26 | 1.43e-07 | 0.52 | FALSE |
| OFC | Gca | intron excision ratio | chr3_67734856_67736716 | 0.46 | 1 | 0.41 | 8.5e-11 | -5.26 | 1.43e-07 | 0.56 | FALSE |
| OFC | Gca | mRNA stability | Gca | 0.2 | 1 | 0.17 | 6.7e-05 | -5.46 | 4.80e-08 | 0.13 | FALSE |
| PL | Fap | gene expression | Fap | 0.05 | 1732 | 0.05 | 3.3e-06 | 5.26 | 1.41e-07 | 0.45 | FALSE |
| PL | Gca | gene expression | Gca | 0.08 | 22 | 0.1 | 1.1e-10 | -5.44 | 5.43e-08 | 0.45 | FALSE |
| PL | LOC108350383 | gene expression | LOC108350383 | 0.03 | 1304 | 0.03 | 8.5e-04 | -5.22 | 1.76e-07 | 0.18 | FALSE |
| PL | Tank | gene expression | Tank | 0.04 | 1 | 0.03 | 3.1e-04 | 5.46 | 4.80e-08 | 0.2 | FALSE |
| PL | Gca | isoform ratio | XM_063283272.1 | 0.03 | 1622 | 0.03 | 2.2e-04 | 5.24 | 1.59e-07 | 0.43 | FALSE |
| PL | Slc4a10 | intron excision ratio | chr3_67354934_67357618 | 0.05 | 1 | 0.05 | 6.9e-06 | -5.32 | 1.03e-07 | 0.52 | FALSE |
| PL | Slc4a10 | intron excision ratio | chr3_67357734_67358508 | 0.03 | 1 | 0.03 | 8.5e-04 | 5.25 | 1.55e-07 | 0.06 | FALSE |
| pVTA | Cobll1 | gene expression | Cobll1 | 0.08 | 1 | 0.07 | 1.2e-06 | 5.57 | 2.62e-08 | 0.5 | FALSE |
| pVTA | Grb14 | gene expression | Grb14 | 0.6 | 117 | 0.39 | 1.8e-33 | -5.34 | 9.34e-08 | 0.8 | TRUE |
| pVTA | Gca | isoform ratio | NM_001106483.4 | 0.04 | 1622 | 0.01 | 1.9e-02 | 5.29 | 1.19e-07 | 0.42 | FALSE |
| pVTA | Gca | isoform ratio | XM_039104486.2 | 0.07 | 1622 | 0.07 | 2.2e-06 | -5.22 | 1.81e-07 | 0.41 | FALSE |
| pVTA | Gca | intron excision ratio | chr3_67734856_67736020 | 0.05 | 1622 | 0.04 | 4.9e-04 | 5.22 | 1.79e-07 | 0.42 | FALSE |
| pVTA | Gca | intron excision ratio | chr3_67734856_67736716 | 0.09 | 1622 | 0.09 | 5.6e-08 | -5.22 | 1.82e-07 | 0.4 | FALSE |
| pVTA | LOC108350383 | intron excision ratio | chr3_68231369_68231717 | 0.03 | 1304 | 0.02 | 6.5e-03 | 5.55 | 2.92e-08 | 0.41 | FALSE |
| pVTA | Grb14 | mRNA stability | Grb14 | 0.19 | 2786 | 0.23 | 1.3e-18 | 5.38 | 7.44e-08 | 0.22 | FALSE |