Hub : Traits : Delay discounting water rate 18 sec :

chr1:140,614,300-142,727,457

Trait: Delay discounting water rate 18 sec

Best TWAS P=1.947021e-10 · Best GWAS P=3.548998e-09 conditioned to 0.3564941

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	BLA	Ctsc	alternative polyA	ENSRNOT00000022342	0.07	0.00	blup	2518	0.01	5.1e-02	5.4	-6.4	2.1e-10	-0.73	0.44	0.22	FALSE
2	BLA	Ctsc	alternative polyA	ENSRNOT00000097085	0.07	0.00	blup	2518	0.02	3.2e-02	-4.6	6.3	3.5e-10	0.69	0.45	0.19	FALSE
3	BLA	Ctsc	gene expression	ENSRNOG00000016496	0.12	0.10	top1	1	0.10	5.0e-06	5.6	5.6	1.8e-08	0.94	0.23	0.35	FALSE
4	BLA	Ctsc	mRNA stability	ENSRNOG00000016496	0.05	0.03	top1	1	0.03	1.5e-02	5.6	-5.6	1.9e-08	-0.89	0.10	0.04	FALSE
5	Brain	Grm5	gene expression	ENSRNOG00000016429	0.16	0.10	lasso	6	0.15	5.3e-14	5.7	-6.4	1.9e-10	-0.85	0.30	0.70	TRUE
6	Brain	Ctsc	isoform ratio	ENSRNOT00000022342	0.03	0.04	top1	1	0.04	1.7e-04	5.9	-5.9	3.5e-09	-0.89	0.09	0.32	FALSE
7	Eye	Ctsc	gene expression	ENSRNOG00000016496	0.29	0.15	top1	1	0.15	2.9e-03	5.6	5.6	2.5e-08	0.92	0.14	0.06	FALSE
8	IL	Ctsc	gene expression	ENSRNOG00000016496	0.30	0.16	top1	1	0.16	1.0e-04	5.6	5.6	2.3e-08	0.92	0.13	0.07	FALSE
9	PL	Grm5	mRNA stability	ENSRNOG00000016429	0.04	0.03	top1	1	0.03	1.3e-03	5.6	5.6	1.6e-08	0.92	0.09	0.06	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.