Best TWAS P=1.37e-10 · Best GWAS P=3.55e-09 conditioned to 1e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint | 
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLA | Ctsc | gene expression | Ctsc | 0.1 | 1 | 0.08 | 7.2e-05 | -5.88 | 4.12e-09 | 0.42 | FALSE | 
| BLA | Ctsc | isoform ratio | XM_008759637.3 | 0.05 | 1 | 0.03 | 1.2e-02 | -5.77 | 7.85e-09 | 0.05 | FALSE | 
| BLA | Grm5 | isoform ratio | XM_017588780.2 | 0.06 | 2702 | 0.01 | 6.6e-02 | -6.18 | 6.29e-10 | 0.49 | FALSE | 
| Brain | Ctsc | alternative polyA | NM_017097.2 | 0.06 | 1 | 0.07 | 5.1e-07 | 5.77 | 7.85e-09 | 0.78 | FALSE | 
| Brain | Ctsc | alternative polyA | XM_008759637.3 | 0.06 | 1 | 0.07 | 2.3e-07 | -5.74 | 9.66e-09 | 0.75 | FALSE | 
| Brain | Grm5 | gene expression | Grm5 | 0.55 | 26 | 0.32 | 1.9e-30 | 6.42 | 1.37e-10 | 0.7 | TRUE | 
| Brain | Ctsc | isoform ratio | NM_017097.2 | 0.06 | 1 | 0.06 | 4.1e-06 | 5.58 | 2.34e-08 | 0.51 | FALSE | 
| Brain | Ctsc | isoform ratio | XM_008759637.3 | 0.06 | 1 | 0.06 | 1.2e-06 | -5.58 | 2.34e-08 | 0.54 | FALSE | 
| Brain | Grm5 | mRNA stability | Grm5 | 0.11 | 1 | 0.09 | 4.7e-09 | 5.73 | 1.00e-08 | 0.83 | FALSE | 
| Eye | Ctsc | gene expression | Ctsc | 0.37 | 2521 | 0.14 | 3.3e-03 | 5.89 | 3.96e-09 | 0.33 | FALSE | 
| Liver | LOC102554680 | gene expression | LOC102554680 | 0.04 | 2516 | 0.03 | 5.3e-04 | 5.44 | 5.37e-08 | 0.63 | TRUE | 
| NAcc | Grm5 | gene expression | Grm5 | 0.05 | 1 | 0.05 | 1.4e-06 | 5.44 | 5.42e-08 | 0.43 | FALSE | 
| NAcc | Ctsc | isoform ratio | NM_017097.2 | 0.03 | 1 | 0.04 | 2.3e-05 | 5.65 | 1.61e-08 | 0.22 | FALSE | 
| NAcc | Ctsc | isoform ratio | XM_008759637.3 | 0.03 | 1 | 0.04 | 5.3e-05 | -5.65 | 1.61e-08 | 0.15 | FALSE | 
| NAcc | Grm5 | isoform ratio | XM_017588779.2 | 0.05 | 2702 | 0.05 | 4.8e-06 | 6.1 | 1.09e-09 | 0.58 | FALSE | 
| PL | Grm5 | gene expression | Grm5 | 0.03 | 23 | 0.03 | 1.2e-04 | -5.26 | 1.40e-07 | 0.24 | TRUE | 
| PL | Grm5 | isoform ratio | XM_006229659.4 | 0.02 | 2702 | 0.01 | 5.9e-02 | 5.26 | 1.40e-07 | 0.21 | FALSE | 
| RMTg | Grm5 | mRNA stability | Grm5 | 0.21 | 2702 | 0.11 | 6.1e-04 | -5.86 | 4.70e-09 | 0.11 | FALSE |