Best TWAS P = 5.17e-11 · Best GWAS P= 1.22e-09 conditioned to 1e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLA | Ctsc | gene expression | Ctsc | 0.15 | 281 | 0.12 | 7.5e-07 | -5.81 | 6.29e-09 | 0.55 | FALSE |
| BLA | Ctsc | isoform ratio | NM_017097.2 | 0.06 | 1 | 0.03 | 1.8e-02 | 5.7 | 1.23e-08 | 0.04 | FALSE |
| BLA | Ctsc | isoform ratio | XM_008759637.4 | 0.06 | 1 | 0.02 | 1.8e-02 | -5.7 | 1.23e-08 | 0.04 | FALSE |
| Brain | Ctsc | alternative polyA | NM_017097.2 | 0.06 | 24 | 0.07 | 6.8e-07 | 5.94 | 2.89e-09 | 0.62 | FALSE |
| Brain | Ctsc | alternative polyA | XM_008759637.4 | 0.06 | 24 | 0.07 | 7.0e-07 | -5.95 | 2.75e-09 | 0.62 | FALSE |
| Brain | Grm5 | gene expression | Grm5 | 0.46 | 13 | 0.3 | 2.7e-28 | -6.57 | 5.17e-11 | 0.62 | TRUE |
| Brain | Ctsc | isoform ratio | NM_017097.2 | 0.06 | 1 | 0.05 | 2.1e-05 | 5.75 | 9.09e-09 | 0.53 | FALSE |
| Brain | Ctsc | isoform ratio | XM_008759637.4 | 0.06 | 1 | 0.05 | 2.6e-05 | -5.75 | 9.09e-09 | 0.52 | FALSE |
| Brain | Grm5 | mRNA stability | Grm5 | 0.1 | 1 | 0.09 | 4.9e-09 | 5.84 | 5.37e-09 | 0.64 | FALSE |
| Eye | Ctsc | gene expression | Ctsc | 0.34 | 13 | 0.16 | 1.8e-03 | 5.66 | 1.51e-08 | 0.36 | TRUE |
| IC | Ctsc | alternative polyA | NM_017097.2 | 0.09 | 1 | 0.06 | 1.6e-03 | 5.36 | 8.14e-08 | 0.04 | FALSE |
| IC | Ctsc | alternative polyA | XM_008759637.4 | 0.08 | 1 | 0.05 | 2.6e-03 | -5.36 | 8.14e-08 | 0.04 | FALSE |
| IC | Grm5 | gene expression | Grm5 | 0.3 | 44 | 0.24 | 1.4e-10 | -6.22 | 4.82e-10 | 0.21 | FALSE |
| IC | Grm5 | isoform ratio | XM_006229659.5 | 0.06 | 52 | 0.03 | 2.4e-02 | -6.47 | 9.58e-11 | 0.27 | FALSE |
| IL | Ctsc | gene expression | Ctsc | 0.44 | 18 | 0.11 | 1.6e-03 | 5.98 | 2.20e-09 | 0.52 | FALSE |
| Liver | LOC102554680 | gene expression | LOC102554680 | 0.05 | 13 | 0.04 | 7.2e-05 | -5.71 | 1.13e-08 | 0.64 | FALSE |
| NAcc | Ctsc | alternative polyA | NM_017097.2 | 0.04 | 1 | 0.04 | 2.0e-06 | 5.64 | 1.75e-08 | 0.39 | FALSE |
| NAcc | Ctsc | alternative polyA | XM_008759637.4 | 0.04 | 27 | 0.04 | 1.0e-06 | -6.14 | 8.46e-10 | 0.6 | TRUE |
| NAcc | Grm5 | gene expression | Grm5 | 0.08 | 1 | 0.08 | 7.3e-12 | 5.64 | 1.71e-08 | 0.38 | FALSE |
| NAcc | Ctsc | isoform ratio | NM_017097.2 | 0.05 | 1 | 0.05 | 2.9e-08 | 5.64 | 1.75e-08 | 0.42 | FALSE |
| NAcc | Ctsc | isoform ratio | XM_008759637.4 | 0.05 | 1 | 0.05 | 1.5e-07 | -5.64 | 1.75e-08 | 0.43 | FALSE |
| NAcc | Ctsc | intron excision ratio | chr1_151443766_151448822 | 0.02 | 1 | 0.01 | 1.7e-03 | -5.64 | 1.75e-08 | 0.04 | FALSE |
| NAcc | Ctsc | intron excision ratio | chr1_151443766_151458158 | 0.02 | 4 | 0.01 | 8.6e-03 | 5.9 | 3.67e-09 | 0.52 | TRUE |
| NAcc | Grm5 | mRNA stability | Grm5 | 0.03 | 1 | 0.03 | 3.3e-05 | 5.64 | 1.71e-08 | 0.17 | FALSE |
| PL | Grm5 | gene expression | Grm5 | 0.03 | 2746 | 0.02 | 2.8e-03 | -5.99 | 2.14e-09 | 0.35 | FALSE |
| PL | Grm5 | intron excision ratio | chr1_150723078_150733678 | 0.03 | 2746 | 0.02 | 1.7e-03 | -5.4 | 6.65e-08 | 0.14 | FALSE |
| pVTA | Grm5 | mRNA stability | Grm5 | 0.06 | 2746 | 0.03 | 3.6e-03 | -6.16 | 7.47e-10 | 0.49 | TRUE |