Hub : Traits

Delay discounting water rate 0 sec

Delay discounting using a sequential patch depletion procedure, water consumption rate during the last two sessions with an experimenter-imposed delay of 0 sec

Project: p50_david_dietz

410 significantly associated models · 46 unique genes

Significant Loci

#	chr	p0	p1	# assoc genes	# joint models	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	6	129200996	132888501	46	7	6.5e-10	3.1e-09	1	100	Cinp Mark3 Klc1 Xrcc3 Brf1 Inf2 Cep170b

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
dissection: UMAP 3 of all traits	8.2	42	20	286	-0.98	8.2e-246	Crip2 Tmem121 Cinp Cdc42bpb Tnfaip2 NEWGENE_619861 Mark3 Ckb Trmt61a Coa8 Klc1 Xrcc3 Zfyve21 Ppp1r13b Aspg NA Tmem179 Kif26a Clba1 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Pld4 Siva1 Inf2 Cep170b Rd3l Lbhd2 Adssl1 Tdrd9 AABR07065593.1 Bag5 AABR07065590.1 NA NA NA Diras3 Tedc1
dissection: PC 2 of all traits	8.2	40	14	200	0.99	4.7e-229	Crip2 Tmem121 Cdc42bpb Tnfaip2 NEWGENE_619861 Mark3 Ckb Trmt61a Coa8 Klc1 Xrcc3 Zfyve21 Ppp1r13b Aspg NA Tmem179 Kif26a Clba1 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Pld4 Siva1 Inf2 Cep170b Rd3l Lbhd2 Adssl1 Tdrd9 AABR07065593.1 Bag5 AABR07065590.1 NA NA NA Tedc1
EDL weight in grams	7.3	46	31	443	0.99	0.0e+00	Crip2 Tmem121 Cinp Traf3 Amn Cdc42bpb Exoc3l4 Tnfaip2 NEWGENE_619861 Mark3 Ckb Trmt61a Coa8 Klc1 Xrcc3 Zfyve21 Ppp1r13b Aspg NA Tmem179 Kif26a Clba1 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Tecpr2 Pld4 Siva1 Inf2 Cep170b Rd3l Lbhd2 Adssl1 Tdrd9 AABR07065593.1 Bag5 AABR07065590.1 NA NA NA Diras3 Tedc1

chisq ratio: Average Chi² statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes⁺: Shared significant genes at Bonferroni correction. # genes⁺⁺: Shared significant genes at transcriptome-wide significance. % genes⁺⁺: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue	modality	# hits	% hits/tests	avg chisq
Adipose	alternative polyA	2	0.094	1.5
Adipose	alternative TSS	0	0.000	1.5
Adipose	gene expression	18	0.217	1.6
Adipose	isoform ratio	4	0.141	1.5
Adipose	intron excision ratio	13	0.446	1.6
Adipose	mRNA stability	9	0.261	1.6
BLA	alternative polyA	5	0.417	1.8
BLA	alternative TSS	0	0.000	1.4
BLA	gene expression	12	0.198	1.6
BLA	isoform ratio	7	0.398	1.6
BLA	intron excision ratio	15	0.502	1.7
BLA	mRNA stability	9	0.445	1.7
Brain	alternative polyA	5	0.249	1.6
Brain	alternative TSS	3	0.175	1.4
Brain	gene expression	22	0.243	1.6
Brain	isoform ratio	12	0.380	1.5
Brain	intron excision ratio	28	0.518	1.6
Brain	mRNA stability	7	0.160	1.5
Eye	alternative polyA	1	0.559	1.4
Eye	alternative TSS	0	0.000	1.3
Eye	gene expression	1	0.089	1.5
Eye	isoform ratio	1	0.282	1.3
Eye	intron excision ratio	4	0.653	1.6
Eye	mRNA stability	2	0.862	1.9
IL	alternative polyA	3	0.493	1.6
IL	alternative TSS	0	0.000	1.6
IL	gene expression	10	0.274	1.6
IL	isoform ratio	2	0.253	1.6
IL	intron excision ratio	4	0.415	1.6
IL	mRNA stability	5	0.450	1.7
LHb	alternative polyA	0	0.000	1.5
LHb	alternative TSS	0	0.000	1.5
LHb	gene expression	6	0.187	1.6
LHb	isoform ratio	2	0.266	1.6
LHb	intron excision ratio	7	0.680	1.6
LHb	mRNA stability	2	0.193	1.6
Liver	alternative polyA	6	0.399	1.7
Liver	alternative TSS	0	0.000	1.5
Liver	gene expression	15	0.209	1.6
Liver	isoform ratio	5	0.209	1.6
Liver	intron excision ratio	13	0.297	1.6
Liver	mRNA stability	5	0.204	1.5
NAcc	alternative polyA	3	0.576	1.9
NAcc	alternative TSS	1	0.292	1.3
NAcc	gene expression	7	0.213	1.6
NAcc	isoform ratio	3	0.404	1.6
NAcc	intron excision ratio	7	0.734	1.6
NAcc	mRNA stability	4	0.369	1.7
NAcc2	alternative polyA	6	0.542	1.7
NAcc2	alternative TSS	0	0.000	1.4
NAcc2	gene expression	8	0.150	1.6
NAcc2	isoform ratio	6	0.389	1.6
NAcc2	intron excision ratio	8	0.302	1.6
NAcc2	mRNA stability	6	0.336	1.7
OFC	alternative polyA	1	0.171	1.4
OFC	alternative TSS	0	0.000	1.2
OFC	gene expression	5	0.135	1.6
OFC	isoform ratio	3	0.367	1.6
OFC	intron excision ratio	3	0.299	1.6
OFC	mRNA stability	3	0.278	1.7
PL	alternative polyA	4	0.668	1.9
PL	alternative TSS	0	0.000	1.4
PL	gene expression	8	0.215	1.6
PL	isoform ratio	2	0.230	1.5
PL	intron excision ratio	8	0.768	1.7
PL	mRNA stability	6	0.522	1.8
PL2	alternative polyA	8	0.637	2.0
PL2	alternative TSS	0	0.000	1.5
PL2	gene expression	14	0.219	1.6
PL2	isoform ratio	5	0.271	1.6
PL2	intron excision ratio	9	0.286	1.6
PL2	mRNA stability	7	0.287	1.6

avg chisq: Average Chi² (squared Z-score) across all models in this panel for this trait.