Best TWAS P=8.248932e-26 · Best GWAS P=0.2400947 conditioned to 8.140493e-62
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Liver | Stk40 | intron excision ratio | chr5:138406745:138409651 | 0.11 | 0.00 | blup | 1102 | 0.01 | 3.7e-02 | -1.09 | 5.5 | 3.2e-08 | 0.01 | 0.00 | 0.00 | TRUE |
| 2 | Liver | Stk40 | mRNA stability | ENSRNOG00000025679 | 0.26 | 0.04 | blup | 1102 | 0.13 | 2.0e-14 | -0.25 | -10.5 | 8.2e-26 | -0.87 | 0.03 | 0.02 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.