Best TWAS P=3.095094e-24 · Best GWAS P=0.0008112136 conditioned to 0.02738253
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | Stk40 | intron excision ratio | chr5:138406745:138409651 | 0.20 | 0.03 | blup | 1102 | 0.06 | 2.2e-07 | 2.0 | -5.7 | 1.5e-08 | -0.40 | 0.31 | 0.17 | FALSE |
2 | Adipose | Stk40 | intron excision ratio | chr5:138406745:138412128 | 0.20 | 0.03 | blup | 1102 | 0.06 | 5.9e-07 | 2.0 | 5.4 | 6.1e-08 | 0.33 | 0.26 | 0.16 | TRUE |
3 | Liver | Map7d1 | gene expression | ENSRNOG00000010237 | 0.44 | 0.18 | blup | 855 | 0.29 | 1.3e-32 | 1.8 | 5.8 | 6.8e-09 | 0.93 | 0.40 | 0.17 | FALSE |
4 | Liver | Stk40 | mRNA stability | ENSRNOG00000025679 | 0.26 | 0.04 | blup | 1102 | 0.13 | 2.0e-14 | 2.2 | 10.2 | 3.1e-24 | 0.51 | 0.39 | 0.29 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.