Best TWAS P = 2.91e-11 · Best GWAS P= 1.87e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Mlh1 | alternative polyA | NM_031053.2 | 0.02 | 1 | 0.01 | 9.2e-03 | 5.77 | 7.96e-09 | 0.1 | FALSE |
| Adipose | Mlh1 | alternative polyA | XM_063266207.1 | 0.02 | 1 | 0.01 | 8.7e-03 | -5.77 | 7.96e-09 | 0.1 | FALSE |
| Adipose | Mlh1 | alternative polyA | NM_031053.2 | 0.02 | 1 | 0.01 | 1.1e-02 | 5.77 | 7.96e-09 | 0.1 | FALSE |
| Adipose | Mlh1 | alternative polyA | XM_063266207.1 | 0.02 | 1 | 0.01 | 9.9e-03 | -5.77 | 7.96e-09 | 0.1 | FALSE |
| Adipose | Ccrl2 | gene expression | Ccrl2 | 0.03 | 1 | 0.01 | 8.4e-03 | -5.39 | 7.01e-08 | 0.03 | FALSE |
| Adipose | Mlh1 | gene expression | Mlh1 | 0.72 | 443 | 0.66 | 7.7e-99 | 5.42 | 6.05e-08 | 0.36 | FALSE |
| Adipose | Trank1 | gene expression | Trank1 | 0.58 | 907 | 0.5 | 5.9e-64 | -5.51 | 3.51e-08 | 0.27 | FALSE |
| Adipose | Mlh1 | isoform ratio | XM_063266207.1 | 0.03 | 1 | 0.01 | 9.7e-03 | -5.7 | 1.19e-08 | 0.08 | FALSE |
| Adipose | Mlh1 | isoform ratio | XR_005487930.2 | 0.04 | 1 | 0.03 | 1.6e-04 | 5.54 | 3.10e-08 | 0.42 | FALSE |
| Adipose | Trank1 | isoform ratio | XM_039081617.2 | 0.03 | 1 | 0.03 | 6.7e-04 | 5.46 | 4.70e-08 | 0.08 | FALSE |
| Adipose | Setd2 | mRNA stability | Setd2 | 0.19 | 36 | 0.25 | 1.5e-27 | -5.26 | 1.48e-07 | 0.12 | FALSE |
| BLA | Epm2aip1 | gene expression | Epm2aip1 | 0.12 | 2357 | 0.12 | 6.0e-07 | -5.56 | 2.71e-08 | 0.24 | FALSE |
| BLA | LOC102552504 | gene expression | LOC102552504 | 0.08 | 2373 | 0.09 | 2.8e-05 | -5.35 | 8.63e-08 | 0.33 | FALSE |
| BLA | Lrrfip2 | gene expression | Lrrfip2 | 0.07 | 1 | 0.07 | 2.0e-04 | -5.82 | 5.73e-09 | 0.26 | FALSE |
| BLA | Mlh1 | gene expression | Mlh1 | 0.47 | 2356 | 0.52 | 5.6e-32 | 5.46 | 4.85e-08 | 0.27 | FALSE |
| BLA | Prss50 | gene expression | Prss50 | 0.17 | 70 | 0.17 | 4.0e-09 | 5.36 | 8.43e-08 | 0.24 | FALSE |
| BLA | Lrrfip2 | isoform ratio | XM_063265288.1 | 0.12 | 1 | 0.04 | 5.1e-03 | 5.48 | 4.26e-08 | 0.04 | FALSE |
| Brain | Pth1r | alternative TSS | XM_006244002.4 | 0.08 | 163 | 0.05 | 4.0e-05 | -5.49 | 4.10e-08 | 0.38 | FALSE |
| Brain | Ccdc12 | intron excision ratio | chr8_119514247_119546989 | 0.04 | 8 | 0.04 | 9.9e-05 | 5.46 | 4.65e-08 | 0.22 | FALSE |
| Brain | Ccdc12 | intron excision ratio | chr8_119547056_119561689 | 0.05 | 18 | 0.05 | 1.1e-05 | -5.52 | 3.46e-08 | 0.23 | TRUE |
| Brain | Lrrfip2 | intron excision ratio | chr8_119970179_119989208 | 0.21 | 39 | 0.18 | 1.7e-16 | 5.24 | 1.56e-07 | 0.4 | FALSE |
| Brain | Mlh1 | intron excision ratio | chr8_120095325_120096995 | 0.02 | 1 | 0.03 | 8.1e-04 | 5.91 | 3.38e-09 | 0.13 | FALSE |
| Brain | Trank1 | intron excision ratio | chr8_120219593_120222781 | 0.06 | 1 | 0.06 | 1.4e-06 | -5.41 | 6.16e-08 | 0.3 | FALSE |
| Brain | Ccdc12 | mRNA stability | Ccdc12 | 0.17 | 11 | 0.16 | 8.4e-15 | 5.26 | 1.44e-07 | 0.43 | FALSE |
| IC | Kif9 | alternative polyA | NM_001192000.2 | 0.47 | 1 | 0.17 | 8.2e-08 | -5.25 | 1.54e-07 | 0.49 | FALSE |
| IC | Kif9 | alternative polyA | XM_006243994.5 | 0.52 | 1 | 0.18 | 5.7e-08 | 5.25 | 1.54e-07 | 0.5 | FALSE |
| IC | Map4 | alternative TSS | NM_001419954.1 | 0.16 | 1172 | 0.13 | 5.2e-06 | -5.22 | 1.77e-07 | 0.55 | FALSE |
| IC | Epm2aip1 | gene expression | Epm2aip1 | 0.13 | 39 | 0.15 | 1.1e-06 | -5.34 | 9.53e-08 | 0.3 | FALSE |
| IC | Kif9 | gene expression | Kif9 | 0.47 | 235 | 0.43 | 1.1e-19 | -5.28 | 1.32e-07 | 0.3 | FALSE |
| IC | Mlh1 | gene expression | Mlh1 | 0.48 | 27 | 0.51 | 1.8e-24 | 5.37 | 7.71e-08 | 0.2 | FALSE |
| IC | LOC102552504 | intron excision ratio | chr8_119958714_119959796 | 0.08 | 2339 | 0.02 | 4.7e-02 | 5.41 | 6.34e-08 | 0.2 | FALSE |
| IC | Lrrfip2 | intron excision ratio | chr8_119970179_119989208 | 0.32 | 2354 | 0.16 | 4.8e-07 | 5.24 | 1.57e-07 | 0.17 | FALSE |
| IC | Map4 | intron excision ratio | chr8_118901076_118922481 | 0.27 | 1172 | 0.16 | 2.0e-07 | -5.34 | 9.25e-08 | 0.52 | FALSE |
| IC | Map4 | intron excision ratio | chr8_118914903_118922481 | 0.28 | 1172 | 0.14 | 1.2e-06 | 5.37 | 7.68e-08 | 0.53 | FALSE |
| IL | Dclk3 | gene expression | Dclk3 | 0.29 | 81 | 0.17 | 8.7e-05 | -6.04 | 1.58e-09 | 0.4 | FALSE |
| IL | Mlh1 | gene expression | Mlh1 | 0.55 | 678 | 0.44 | 8.5e-12 | 5.62 | 1.91e-08 | 0.38 | FALSE |
| IL | Mlh1 | mRNA stability | Mlh1 | 0.24 | 1 | 0.1 | 2.1e-03 | 5.77 | 7.96e-09 | 0.06 | FALSE |
| LHb | Ccdc12 | gene expression | Ccdc12 | 0.49 | 2646 | 0.16 | 1.1e-04 | -5.8 | 6.65e-09 | 0.31 | FALSE |
| LHb | Mlh1 | gene expression | Mlh1 | 0.68 | 1 | 0.36 | 2.4e-09 | 5.56 | 2.63e-08 | 0.49 | FALSE |
| Liver | Pth1r | alternative polyA | NM_020073.2 | 0.05 | 8 | 0.05 | 1.7e-06 | 5.43 | 5.64e-08 | 0.29 | FALSE |
| Liver | Pth1r | alternative polyA | XM_039082024.2 | 0.06 | 31 | 0.05 | 2.4e-06 | -5.52 | 3.42e-08 | 0.33 | FALSE |
| Liver | Pth1r | alternative polyA | NM_020073.2 | 0.05 | 10 | 0.05 | 1.3e-06 | 5.42 | 6.05e-08 | 0.28 | FALSE |
| Liver | Pth1r | alternative polyA | XM_006243999.4 | 0.06 | 25 | 0.05 | 1.7e-06 | -5.46 | 4.87e-08 | 0.33 | FALSE |
| Liver | Rtp3 | alternative TSS | NM_001108190.1 | 0.22 | 17 | 0.11 | 6.4e-12 | 5.37 | 8.01e-08 | 0.09 | TRUE |
| Liver | Rtp3 | alternative TSS | XM_006243965.5 | 0.2 | 15 | 0.11 | 4.2e-12 | -5.3 | 1.14e-07 | 0.1 | FALSE |
| Liver | Mlh1 | gene expression | Mlh1 | 0.55 | 930 | 0.6 | 2.0e-84 | 5.59 | 2.24e-08 | 0.38 | FALSE |
| Liver | Trank1 | gene expression | Trank1 | 0.35 | 678 | 0.34 | 1.8e-39 | -5.29 | 1.22e-07 | 0.28 | FALSE |
| Liver | Mst1 | isoform ratio | NM_024352.1 | 0.07 | 224 | 0.06 | 1.2e-07 | -6.65 | 2.91e-11 | 0 | TRUE |
| Liver | Pth1r | isoform ratio | NM_020073.2 | 0.07 | 12 | 0.07 | 3.9e-08 | 5.43 | 5.57e-08 | 0.36 | FALSE |
| Liver | Mlh1 | mRNA stability | Mlh1 | 0.02 | 7 | 0.02 | 1.7e-03 | 5.67 | 1.40e-08 | 0.36 | FALSE |
| Liver | Pth1r | mRNA stability | Pth1r | 0.05 | 1 | 0.03 | 6.2e-04 | 5.39 | 7.01e-08 | 0.12 | FALSE |
| Liver | Rtp3 | mRNA stability | Rtp3 | 0.03 | 1 | 0.02 | 5.4e-03 | -5.78 | 7.29e-09 | 0.07 | FALSE |
| NAcc | LOC108351782 | gene expression | LOC108351782 | 0.04 | 2429 | 0.04 | 3.1e-07 | -5.25 | 1.48e-07 | 0.51 | FALSE |
| NAcc | Lrrfip2 | gene expression | Lrrfip2 | 0.09 | 92 | 0.14 | 7.2e-21 | -5.63 | 1.81e-08 | 0.67 | FALSE |
| NAcc | Trank1 | gene expression | Trank1 | 0.02 | 1 | 0.03 | 1.1e-05 | 5.41 | 6.32e-08 | 0.22 | FALSE |
| NAcc | Ccdc12 | intron excision ratio | chr8_119513818_119513907 | 0.04 | 17 | 0.03 | 1.5e-05 | 5.46 | 4.83e-08 | 0.29 | FALSE |
| NAcc | Kif9 | intron excision ratio | chr8_119353287_119354658 | 0.02 | 13 | 0.01 | 2.8e-03 | -5.44 | 5.25e-08 | 0.27 | FALSE |
| NAcc | Lrrfip2 | intron excision ratio | chr8_119970179_119989208 | 0.04 | 9 | 0.05 | 3.8e-08 | 5.34 | 9.06e-08 | 0.26 | FALSE |
| NAcc | Trank1 | intron excision ratio | chr8_120219593_120221549 | 0.02 | 1 | 0.02 | 2.3e-04 | 5.43 | 5.50e-08 | 0.22 | FALSE |
| NAcc | Trank1 | intron excision ratio | chr8_120219593_120222781 | 0.05 | 1 | 0.07 | 1.7e-10 | -5.5 | 3.74e-08 | 0.5 | FALSE |
| NAcc | Dclk3 | mRNA stability | Dclk3 | 0.02 | 1 | 0.03 | 2.8e-05 | 5.58 | 2.46e-08 | 0.32 | FALSE |
| NAcc | Lrrfip2 | mRNA stability | Lrrfip2 | 0.02 | 2389 | 0.01 | 5.9e-03 | 5.39 | 6.90e-08 | 0.25 | FALSE |
| OFC | Epm2aip1 | gene expression | Epm2aip1 | 0.24 | 8 | 0.14 | 4.1e-04 | -5.87 | 4.23e-09 | 0.38 | FALSE |
| OFC | LOC102552504 | gene expression | LOC102552504 | 0.6 | 1 | 0.19 | 2.8e-05 | -5.56 | 2.63e-08 | 0.08 | FALSE |
| OFC | Mlh1 | gene expression | Mlh1 | 0.65 | 1 | 0.31 | 3.4e-08 | 5.41 | 6.38e-08 | 0.31 | FALSE |
| OFC | Map4 | mRNA stability | Map4 | 0.51 | 1172 | 0.37 | 7.7e-10 | 5.2 | 1.94e-07 | 0.53 | FALSE |
| PL | Fam240a | gene expression | Fam240a | 0.07 | 3 | 0.05 | 3.3e-06 | 5.22 | 1.78e-07 | 0.28 | TRUE |
| PL | LOC108351782 | gene expression | LOC108351782 | 0.03 | 1 | 0.01 | 1.7e-02 | -5.41 | 6.38e-08 | 0.03 | FALSE |
| PL | Lrrfip2 | gene expression | Lrrfip2 | 0.08 | 2389 | 0.1 | 2.9e-11 | -5.41 | 6.45e-08 | 0.16 | FALSE |
| PL | Mlh1 | gene expression | Mlh1 | 0.57 | 160 | 0.59 | 2.0e-79 | 5.33 | 9.76e-08 | 0.34 | FALSE |
| PL | Mlh1 | isoform ratio | XR_005487930.2 | 0.04 | 1 | 0.05 | 3.1e-06 | 5.41 | 6.32e-08 | 0.29 | FALSE |
| PL | LOC102552504 | intron excision ratio | chr8_119957747_119958158 | 0.05 | 1 | 0.01 | 7.7e-03 | 5.6 | 2.11e-08 | 0.08 | FALSE |
| PL | LOC102552504 | intron excision ratio | chr8_119957747_119958652 | 0.04 | 1 | 0.01 | 1.2e-02 | -5.6 | 2.11e-08 | 0.05 | FALSE |
| PL | LOC102552504 | mRNA stability | LOC102552504 | 0.02 | 2373 | 0.02 | 2.9e-03 | 5.28 | 1.28e-07 | 0.24 | FALSE |
| pVTA | Map4 | alternative TSS | NM_001419954.1 | 0.48 | 81 | 0.12 | 1.6e-09 | 5.42 | 5.86e-08 | 0.61 | FALSE |
| pVTA | Dclk3 | gene expression | Dclk3 | 0.49 | 47 | 0.22 | 2.7e-17 | 5.46 | 4.73e-08 | 0.53 | FALSE |
| pVTA | LOC102552504 | intron excision ratio | chr8_119957747_119958158 | 0.03 | 1 | 0.03 | 1.1e-03 | 5.62 | 1.90e-08 | 0.05 | FALSE |
| pVTA | LOC102552504 | intron excision ratio | chr8_119957747_119958652 | 0.03 | 3 | 0.02 | 7.8e-03 | -5.62 | 1.91e-08 | 0.34 | FALSE |
| RMTg | Mlh1 | gene expression | Mlh1 | 0.33 | 1 | 0.29 | 2.5e-08 | 5.25 | 1.49e-07 | 0.1 | FALSE |