Best TWAS P=2.350227e-07 · Best GWAS P=1.294945e-07 conditioned to 2.171896e-81
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | NA | gene expression | ENSRNOG00000068595 | 0.24 | 0.12 | top1 | 1 | 0.12 | 6.2e-13 | -5.1 | 5.1 | 3.3e-07 | -0.91 | 0.20 | 0.80 | FALSE |
| 2 | OFC | Pnpla8 | gene expression | ENSRNOG00000039091 | 0.21 | 0.18 | top1 | 1 | 0.18 | 5.2e-05 | -5.2 | 5.2 | 2.4e-07 | -0.86 | 0.13 | 0.13 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.