Best TWAS P=1.676286e-07 · Best GWAS P=4.147343e-08 conditioned to 1
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | Cep63 | intron excision ratio | chr8:103163124:103164803 | 0.06 | 0.01 | lasso | 1 | 0.01 | 2.2e-02 | 5.2 | -5.2 | 2.2e-07 | -0.77 | 0.27 | 0.41 | FALSE |
2 | BLA | Rab6b | mRNA stability | ENSRNOG00000009198 | 0.07 | 0.04 | top1 | 1 | 0.04 | 3.6e-03 | 5.1 | -5.1 | 3.1e-07 | -0.56 | 0.08 | 0.09 | FALSE |
3 | LHb | Cep63 | alternative polyA | ENSRNOT00000031313 | 0.30 | 0.10 | top1 | 1 | 0.10 | 2.4e-03 | 5.2 | 5.2 | 2.5e-07 | 0.94 | 0.09 | 0.06 | FALSE |
4 | LHb | Cep63 | alternative polyA | ENSRNOT00000031313 | 0.30 | 0.13 | top1 | 1 | 0.13 | 6.3e-04 | 5.2 | 5.2 | 2.5e-07 | 0.94 | 0.09 | 0.07 | FALSE |
5 | LHb | Cep63 | alternative polyA | ENSRNOT00000084413 | 0.31 | 0.10 | top1 | 1 | 0.10 | 1.9e-03 | 5.2 | -5.2 | 2.5e-07 | -0.95 | 0.09 | 0.06 | FALSE |
6 | LHb | Amotl2 | gene expression | ENSRNOG00000008487 | 0.39 | 0.19 | lasso | 4 | 0.21 | 9.3e-06 | 5.1 | 5.2 | 1.7e-07 | 0.96 | 0.28 | 0.72 | TRUE |
7 | Liver | Slco2a1 | intron excision ratio | chr8:103637317:103654517 | 0.09 | 0.04 | top1 | 1 | 0.04 | 1.2e-05 | 5.2 | -5.2 | 2.2e-07 | -0.70 | 0.10 | 0.52 | FALSE |
8 | Liver | Slco2a1 | intron excision ratio | chr8:103641675:103654517 | 0.08 | 0.03 | top1 | 1 | 0.03 | 7.2e-04 | 5.2 | 5.2 | 2.2e-07 | 0.81 | 0.05 | 0.07 | FALSE |
9 | NAcc2 | Amotl2 | gene expression | ENSRNOG00000008487 | 0.31 | 0.24 | enet | 25 | 0.29 | 8.4e-16 | 5.0 | 5.2 | 1.8e-07 | 0.71 | 0.34 | 0.66 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.