Best TWAS P = 1.16e-07 · Best GWAS P= 2.18e-07 conditioned to 2.59e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Znf431l4 | alternative polyA | XM_006240824.5 | 0.09 | 3 | 0.07 | 2.0e-08 | -5.24 | 1.62e-07 | 0.48 | FALSE |
| Adipose | Apc2 | alternative TSS | XM_039078652.2 | 0.06 | 1534 | 0.04 | 1.1e-05 | 5.21 | 1.87e-07 | 0.42 | FALSE |
| Adipose | Apc2 | alternative TSS | XM_063263171.1 | 0.02 | 1534 | 0.01 | 1.4e-02 | -5.22 | 1.81e-07 | 0.33 | FALSE |
| Adipose | Apc2 | alternative TSS | XM_039078652.2 | 0.06 | 1534 | 0.04 | 8.5e-06 | 5.21 | 1.89e-07 | 0.42 | FALSE |
| Adipose | Plk5 | alternative TSS | XM_063263420.1 | 0.03 | 1417 | 0.02 | 2.5e-03 | -5.22 | 1.83e-07 | 0.42 | FALSE |
| Adipose | Znf431l4 | gene expression | Znf431l4 | 0.1 | 14 | 0.08 | 8.7e-09 | -5.28 | 1.27e-07 | 0.47 | FALSE |
| Adipose | Ndufs7 | isoform ratio | XM_006240972.5 | 0.03 | 1527 | 0.02 | 3.5e-03 | -5.22 | 1.75e-07 | 0.4 | FALSE |
| Adipose | Arhgap45 | intron excision ratio | chr7_10339856_10340526 | 0.02 | 99 | 0.01 | 1.0e-02 | 5.26 | 1.43e-07 | 0.36 | FALSE |
| Adipose | Arhgap45 | intron excision ratio | chr7_10339856_10340711 | 0.02 | 67 | 0.01 | 1.1e-02 | -5.28 | 1.31e-07 | 0.36 | FALSE |
| Adipose | Zfp709l3 | intron excision ratio | chr7_8270159_8281158 | 0.12 | 194 | 0.12 | 5.8e-13 | -5.25 | 1.55e-07 | 0.44 | FALSE |
| Adipose | Apc2 | mRNA stability | Apc2 | 0.04 | 1534 | 0.02 | 1.1e-03 | 5.21 | 1.86e-07 | 0.42 | FALSE |
| Adipose | Csnk1g2 | mRNA stability | Csnk1g2 | 0.03 | 1494 | 0.02 | 5.1e-03 | 5.22 | 1.76e-07 | 0.35 | FALSE |
| Adipose | Gpx4 | mRNA stability | Gpx4 | 0.06 | 1399 | 0.05 | 1.2e-06 | 5.21 | 1.85e-07 | 0.46 | FALSE |
| BLA | Zfp347 | alternative TSS | XM_063262945.1 | 0.27 | 46 | 0.29 | 5.8e-16 | 5.25 | 1.54e-07 | 0.46 | FALSE |
| BLA | Prtn3 | gene expression | Prtn3 | 0.05 | 1656 | 0.04 | 2.3e-03 | -5.22 | 1.80e-07 | 0.38 | FALSE |
| BLA | Pwwp3a | gene expression | Pwwp3a | 0.27 | 1525 | 0.34 | 1.2e-18 | 5.25 | 1.56e-07 | 0.47 | FALSE |
| BLA | Cbarp | isoform ratio | NM_001388507.1 | 0.06 | 1417 | 0.06 | 2.5e-04 | -5.21 | 1.92e-07 | 0.47 | FALSE |
| BLA | Cbarp | intron excision ratio | chr7_10217596_10219275 | 0.06 | 1417 | 0.06 | 4.8e-04 | -5.23 | 1.72e-07 | 0.47 | FALSE |
| BLA | Izumo4 | intron excision ratio | chr7_9658924_9659145 | 0.04 | 1484 | 0.03 | 1.6e-02 | -5.22 | 1.80e-07 | 0.32 | FALSE |
| Brain | Plk5 | alternative polyA | XM_006240922.5 | 0.06 | 1417 | 0.04 | 1.1e-04 | 5.23 | 1.68e-07 | 0.46 | FALSE |
| Brain | Csnk1g2 | gene expression | Csnk1g2 | 0.03 | 1494 | 0.02 | 3.7e-03 | 5.21 | 1.86e-07 | 0.39 | FALSE |
| Brain | LOC134479620 | gene expression | LOC134479620 | 0.03 | 1495 | 0.02 | 5.0e-03 | -5.22 | 1.81e-07 | 0.36 | FALSE |
| Brain | Plk5 | gene expression | Plk5 | 0.35 | 1417 | 0.35 | 3.1e-34 | 5.21 | 1.89e-07 | 0.47 | FALSE |
| Brain | Pwwp3a | gene expression | Pwwp3a | 0.32 | 203 | 0.32 | 1.9e-30 | -5.24 | 1.61e-07 | 0.48 | FALSE |
| Brain | Reep6 | gene expression | Reep6 | 0.1 | 5 | 0.07 | 5.6e-07 | 5.26 | 1.48e-07 | 0.46 | FALSE |
| Brain | Rexo1 | isoform ratio | XM_063263421.1 | 0.05 | 1457 | 0.04 | 2.0e-04 | 5.24 | 1.57e-07 | 0.44 | FALSE |
| Eye | Midn | alternative TSS | XM_008765097.4 | 0.26 | 1417 | 0.15 | 2.3e-03 | -5.23 | 1.66e-07 | 0.32 | FALSE |
| IC | Grin3b | gene expression | Grin3b | 0.13 | 1400 | 0.06 | 2.2e-03 | -5.21 | 1.93e-07 | 0.44 | FALSE |
| IC | Pwwp3a | gene expression | Pwwp3a | 0.22 | 54 | 0.11 | 2.4e-05 | -5.25 | 1.54e-07 | 0.44 | FALSE |
| IC | Scamp4 | mRNA stability | Scamp4 | 0.14 | 1509 | 0.07 | 4.6e-04 | 5.22 | 1.77e-07 | 0.4 | FALSE |
| IL | LOC134479811 | gene expression | LOC134479811 | 0.16 | 1423 | 0.05 | 2.0e-02 | -5.23 | 1.66e-07 | 0.28 | FALSE |
| IL | Znf431l4 | gene expression | Znf431l4 | 0.25 | 13 | 0.1 | 2.0e-03 | 5.28 | 1.29e-07 | 0.34 | FALSE |
| LHb | Ndufs7 | intron excision ratio | chr7_10106899_10107410 | 0.18 | 1527 | 0.12 | 1.1e-03 | -5.23 | 1.74e-07 | 0.4 | FALSE |
| LHb | Ndufs7 | intron excision ratio | chr7_10106899_10107529 | 0.13 | 1527 | 0.09 | 4.7e-03 | 5.23 | 1.74e-07 | 0.33 | FALSE |
| Liver | Zfp77 | alternative polyA | XM_063264477.1 | 0.37 | 356 | 0.3 | 3.8e-34 | 5.28 | 1.29e-07 | 0.48 | FALSE |
| Liver | Zfp77 | alternative polyA | XM_063264477.1 | 0.36 | 357 | 0.3 | 7.4e-34 | 5.26 | 1.43e-07 | 0.47 | FALSE |
| Liver | Rps15 | alternative TSS | XM_063263114.1 | 0.03 | 1540 | 0.02 | 4.4e-03 | 5.21 | 1.84e-07 | 0.39 | FALSE |
| Liver | Rps15 | alternative TSS | XM_063263114.1 | 0.03 | 1540 | 0.02 | 1.7e-03 | 5.21 | 1.88e-07 | 0.42 | FALSE |
| Liver | Rps15 | alternative TSS | XM_063263115.1 | 0.03 | 1540 | 0.02 | 1.1e-03 | -5.22 | 1.80e-07 | 0.42 | FALSE |
| Liver | LOC108351405 | gene expression | LOC108351405 | 0.15 | 1444 | 0.15 | 2.4e-16 | 5.23 | 1.73e-07 | 0.47 | FALSE |
| Liver | Scamp4 | gene expression | Scamp4 | 0.07 | 301 | 0.06 | 2.0e-07 | -5.3 | 1.16e-07 | 0.44 | TRUE |
| Liver | Pcsk4 | mRNA stability | Pcsk4 | 0.07 | 1445 | 0.06 | 3.8e-07 | -5.23 | 1.72e-07 | 0.46 | FALSE |
| NAcc | Arhgap45 | alternative TSS | XM_039078979.2 | 0.04 | 1379 | 0.05 | 1.5e-07 | -5.22 | 1.76e-07 | 0.49 | FALSE |
| NAcc | Arhgap45 | alternative TSS | XM_039078979.2 | 0.03 | 1379 | 0.04 | 4.1e-06 | -5.23 | 1.66e-07 | 0.47 | FALSE |
| NAcc | C7h19orf25 | gene expression | C7h19orf25 | 0.09 | 28 | 0.07 | 1.8e-11 | -5.3 | 1.17e-07 | 0.47 | FALSE |
| NAcc | Pwwp3a | gene expression | Pwwp3a | 0.15 | 1525 | 0.17 | 3.0e-25 | 5.23 | 1.70e-07 | 0.41 | FALSE |
| NAcc | Reep6 | gene expression | Reep6 | 0.04 | 1443 | 0.04 | 7.6e-07 | 5.21 | 1.87e-07 | 0.45 | FALSE |
| NAcc | Arhgap45 | isoform ratio | XM_039078978.2 | 0.02 | 1379 | 0.02 | 4.0e-04 | -5.23 | 1.68e-07 | 0.47 | FALSE |
| NAcc | Cbarp | isoform ratio | NM_001388507.1 | 0.04 | 1417 | 0.04 | 4.0e-06 | -5.24 | 1.63e-07 | 0.49 | FALSE |
| NAcc | Midn | isoform ratio | XM_006240912.5 | 0.02 | 1417 | 0.03 | 9.4e-05 | 5.22 | 1.80e-07 | 0.47 | FALSE |
| NAcc | Plk5 | isoform ratio | XR_355240.5 | 0.11 | 1417 | 0.14 | 1.3e-20 | 5.22 | 1.82e-07 | 0.46 | FALSE |
| NAcc | Scamp4 | mRNA stability | Scamp4 | 0.02 | 1509 | 0.01 | 2.0e-03 | 5.23 | 1.73e-07 | 0.43 | FALSE |
| NAcc | Sf3a2 | mRNA stability | Sf3a2 | 0.06 | 1484 | 0.05 | 1.4e-08 | 5.22 | 1.76e-07 | 0.46 | FALSE |
| OFC | Gamt | gene expression | Gamt | 0.15 | 1531 | 0.07 | 1.1e-02 | -5.21 | 1.86e-07 | 0.37 | FALSE |
| OFC | Spmap2 | gene expression | Spmap2 | 0.46 | 474 | 0.36 | 1.8e-09 | 5.23 | 1.66e-07 | 0.33 | FALSE |
| OFC | Mier2 | isoform ratio | XR_010053000.1 | 0.31 | 437 | 0.3 | 7.4e-08 | 5.23 | 1.68e-07 | 0.34 | FALSE |
| OFC | Plk5 | isoform ratio | XR_355240.5 | 0.13 | 1417 | 0.11 | 1.5e-03 | 5.22 | 1.78e-07 | 0.37 | FALSE |
| OFC | Izumo4 | mRNA stability | Izumo4 | 0.16 | 1484 | 0.15 | 2.6e-04 | -5.22 | 1.81e-07 | 0.39 | FALSE |
| PL | Atp5f1d | alternative TSS | XM_063262989.1 | 0.03 | 1417 | 0.03 | 2.2e-04 | -5.23 | 1.70e-07 | 0.47 | FALSE |
| PL | Plk5 | alternative TSS | XM_039079005.2 | 0.08 | 1417 | 0.09 | 5.1e-10 | -5.22 | 1.77e-07 | 0.46 | FALSE |
| PL | Zfp347 | isoform ratio | XM_039078333.2 | 0.06 | 17 | 0.04 | 7.3e-05 | -5.29 | 1.23e-07 | 0.28 | FALSE |
| PL | Pcsk4 | mRNA stability | Pcsk4 | 0.02 | 1445 | 0.01 | 1.3e-02 | -5.22 | 1.79e-07 | 0.38 | FALSE |
| pVTA | Apc2 | alternative TSS | XM_063263171.1 | 0.03 | 1534 | 0.02 | 6.9e-03 | -5.22 | 1.80e-07 | 0.35 | FALSE |
| pVTA | Apc2 | alternative TSS | XM_063263171.1 | 0.02 | 1534 | 0.02 | 1.3e-02 | -5.21 | 1.86e-07 | 0.34 | FALSE |
| pVTA | Apc2 | gene expression | Apc2 | 0.21 | 1534 | 0.25 | 1.0e-19 | 5.21 | 1.87e-07 | 0.47 | FALSE |
| pVTA | Fgf22 | gene expression | Fgf22 | 0.06 | 75 | 0.04 | 1.6e-04 | -5.23 | 1.73e-07 | 0.38 | FALSE |
| pVTA | Pwwp3a | gene expression | Pwwp3a | 0.15 | 1525 | 0.16 | 9.1e-13 | 5.24 | 1.63e-07 | 0.47 | FALSE |
| pVTA | LOC120093775 | intron excision ratio | chr7_9802860_9804622 | 0.03 | 1457 | 0.02 | 9.7e-03 | 5.23 | 1.69e-07 | 0.34 | FALSE |