Best TWAS P=4.58e-10 · Best GWAS P=1.20e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Brca2 | alternative polyA | XM_039089544.1 | 0.03 | 1 | 0.02 | 2.4e-03 | -5.3 | 1.13e-07 | 0.09 | FALSE |
| Adipose | Elavl1 | alternative TSS | XM_039089620.1 | 0.24 | 2417 | 0.11 | 7.3e-12 | -5.26 | 1.46e-07 | 0.72 | FALSE |
| Adipose | Elavl1 | alternative TSS | XM_039089620.1 | 0.17 | 2417 | 0.07 | 1.7e-08 | -5.21 | 1.92e-07 | 0.72 | FALSE |
| Adipose | Elavl1 | alternative TSS | XM_039089621.1 | 0.15 | 2417 | 0.07 | 7.6e-08 | 5.18 | 2.24e-07 | 0.72 | FALSE |
| Adipose | Fry | alternative TSS | XM_039089331.1 | 0.05 | 36 | 0.04 | 1.5e-05 | -5.22 | 1.79e-07 | 0.07 | TRUE |
| Adipose | Stard13 | alternative TSS | XM_039089673.1 | 0.03 | 1441 | 0.02 | 6.6e-03 | -5.3 | 1.14e-07 | 0.44 | FALSE |
| Adipose | Stard13 | alternative TSS | XM_039089673.1 | 0.04 | 1441 | 0.02 | 1.6e-03 | -5.19 | 2.09e-07 | 0.54 | FALSE |
| Adipose | Hsph1 | gene expression | Hsph1 | 0.44 | 46 | 0.21 | 4.2e-23 | 5.31 | 1.09e-07 | 0.48 | FALSE |
| Adipose | LOC102549089 | gene expression | LOC102549089 | 0.12 | 19 | 0.05 | 1.9e-06 | -5.4 | 6.62e-08 | 0.82 | FALSE |
| Adipose | LOC102549494 | gene expression | LOC102549494 | 0.69 | 255 | 0.49 | 1.0e-61 | -5.63 | 1.78e-08 | 0.36 | FALSE |
| Adipose | LOC102553253 | gene expression | LOC102553253 | 0.02 | 1 | 0.01 | 4.4e-02 | -5.22 | 1.82e-07 | 0.03 | FALSE |
| Adipose | LOC120095830 | gene expression | LOC120095830 | 0.05 | 2744 | 0 | 2.5e-01 | 6.16 | 7.33e-10 | 0.33 | FALSE |
| Adipose | N4bp2l1 | gene expression | N4bp2l1 | 0.36 | 19 | 0.28 | 1.1e-31 | 5.45 | 4.94e-08 | 0.95 | FALSE |
| Adipose | Xab2 | gene expression | Xab2 | 0.13 | 35 | 0.05 | 5.7e-06 | 5.43 | 5.59e-08 | 0.61 | FALSE |
| Adipose | LOC102549494 | isoform ratio | XR_005491684.1 | 0.18 | 312 | 0.07 | 8.4e-08 | 5.63 | 1.82e-08 | 0.36 | FALSE |
| Adipose | LOC102549494 | isoform ratio | XR_595225.2 | 0.11 | 1 | 0.03 | 2.2e-04 | -5.21 | 1.92e-07 | 0.25 | FALSE |
| Adipose | Medag | isoform ratio | NM_001398809.1 | 0.03 | 2342 | 0.01 | 2.0e-02 | 5.37 | 8.01e-08 | 0.39 | FALSE |
| Adipose | LOC102549494 | intron excision ratio | chr12_4999737_4999823 | 0.04 | 3323 | 0 | 1.4e-01 | 6.12 | 9.38e-10 | 0.3 | FALSE |
| Adipose | Fry | mRNA stability | Fry | 0.1 | 3289 | 0.06 | 1.0e-07 | -5.43 | 5.51e-08 | 0.04 | FALSE |
| Adipose | LOC102549494 | mRNA stability | LOC102549494 | 0.07 | 43 | 0.04 | 7.4e-05 | -5.78 | 7.50e-09 | 0.35 | TRUE |
| BLA | Insr | gene expression | Insr | 0.7 | 10 | 0.55 | 2.7e-34 | 5.48 | 4.25e-08 | 0.8 | FALSE |
| BLA | LOC102549494 | gene expression | LOC102549494 | 0.3 | 3325 | 0.28 | 2.6e-15 | 6.23 | 4.58e-10 | 0.43 | TRUE |
| BLA | N4bp2l2 | gene expression | N4bp2l2 | 0.08 | 1 | 0.05 | 1.6e-03 | -5.53 | 3.17e-08 | 0.13 | FALSE |
| BLA | Snapc2 | gene expression | Snapc2 | 0.16 | 15 | 0.06 | 3.7e-04 | 5.4 | 6.51e-08 | 0.68 | TRUE |
| BLA | N4bp2l2 | isoform ratio | XM_039089150.1 | 0.06 | 702 | 0.05 | 9.4e-04 | 5.26 | 1.44e-07 | 0.71 | FALSE |
| BLA | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.34 | 21 | 0.2 | 3.9e-11 | -5.38 | 7.52e-08 | 0.86 | FALSE |
| BLA | Pet100 | intron excision ratio | chr12_1680995_1681508 | 0.33 | 1836 | 0.2 | 1.0e-10 | 5.34 | 9.48e-08 | 0.85 | FALSE |
| BLA | Slc7a1 | intron excision ratio | chr12_6628367_6680427 | 0.47 | 2764 | 0.02 | 3.3e-02 | -5.36 | 8.18e-08 | 0.23 | TRUE |
| BLA | Snapc2 | mRNA stability | Snapc2 | 0.54 | 35 | 0.27 | 8.6e-15 | -5.29 | 1.24e-07 | 0.87 | FALSE |
| Brain | N4bp2l2 | alternative polyA | XM_039089151.1 | 0.03 | 1 | 0.02 | 7.3e-03 | -5.19 | 2.05e-07 | 0.05 | FALSE |
| Brain | Insr | alternative TSS | XM_039089098.1 | 0.34 | 48 | 0.2 | 2.4e-18 | -5.44 | 5.30e-08 | 0.88 | FALSE |
| Brain | Insr | alternative TSS | XM_039089098.1 | 0.34 | 48 | 0.2 | 3.5e-18 | -5.43 | 5.57e-08 | 0.88 | FALSE |
| Brain | LOC102548389 | alternative TSS | XM_039089917.1 | 0.04 | 1983 | 0.03 | 5.9e-04 | -5.41 | 6.14e-08 | 0.46 | FALSE |
| Brain | LOC102549494 | gene expression | LOC102549494 | 0.37 | 4 | 0.32 | 4.9e-30 | 5.93 | 2.97e-09 | 0.47 | FALSE |
| Brain | N4bp2l1 | gene expression | N4bp2l1 | 0.11 | 601 | 0.07 | 8.7e-07 | -5.41 | 6.33e-08 | 0.94 | FALSE |
| Brain | Rxfp2 | gene expression | Rxfp2 | 0.16 | 28 | 0.17 | 2.4e-15 | 5.84 | 5.29e-09 | 0.44 | FALSE |
| Brain | Insr | isoform ratio | XM_039089096.1 | 0.23 | 1 | 0.16 | 1.5e-14 | 5.51 | 3.55e-08 | 0.88 | FALSE |
| Brain | Insr | isoform ratio | XM_039089097.1 | 0.09 | 1555 | 0.06 | 1.8e-06 | 5.23 | 1.67e-07 | 0.5 | FALSE |
| Brain | LOC108352411 | isoform ratio | XR_005491694.1 | 0.04 | 13 | 0.01 | 1.8e-02 | 5.37 | 7.94e-08 | 0.39 | FALSE |
| Brain | LOC102549494 | intron excision ratio | chr12_5001884_5002075 | 0.03 | 1 | 0.04 | 1.9e-04 | 5.22 | 1.82e-07 | 0.1 | FALSE |
| Brain | Brca2 | mRNA stability | Brca2 | 0.5 | 10 | 0.37 | 6.8e-36 | 5.23 | 1.70e-07 | 0.87 | FALSE |
| Brain | Katnal1 | mRNA stability | Katnal1 | 0.29 | 30 | 0.28 | 4.6e-26 | -5.37 | 7.77e-08 | 0.81 | FALSE |
| Eye | Elavl1 | intron excision ratio | chr12_2667464_2684652 | 0.69 | 8 | 0.37 | 1.3e-06 | 5.6 | 2.12e-08 | 0.72 | FALSE |
| Eye | Insr | mRNA stability | Insr | 0.82 | 1 | 0.26 | 6.5e-05 | -5.56 | 2.70e-08 | 0.09 | TRUE |
| IL | Hmgb1 | alternative polyA | XM_039089112.1 | 0.61 | 2381 | 0.17 | 8.8e-05 | -5.96 | 2.54e-09 | 0.56 | FALSE |
| IL | Katnal1 | gene expression | Katnal1 | 0.37 | 2316 | 0.14 | 3.3e-04 | 5.69 | 1.27e-08 | 0.17 | FALSE |
| IL | LOC102553253 | gene expression | LOC102553253 | 0.21 | 1 | 0.18 | 4.9e-05 | -5.31 | 1.10e-07 | 0.12 | FALSE |
| IL | Hmgb1 | isoform ratio | NM_012963.3 | 0.49 | 1 | 0.19 | 2.0e-05 | -5.45 | 5.06e-08 | 0.12 | FALSE |
| IL | Hmgb1 | isoform ratio | XM_039089112.1 | 0.44 | 1 | 0.21 | 1.1e-05 | 5.35 | 8.76e-08 | 0.12 | FALSE |
| IL | Insr | intron excision ratio | chr12_1257822_1307450 | 0.78 | 225 | 0.53 | 4.8e-15 | -5.25 | 1.54e-07 | 0.88 | FALSE |
| LHb | Cers4 | gene expression | Cers4 | 0.3 | 12 | 0.11 | 1.3e-03 | 5.28 | 1.26e-07 | 0.46 | FALSE |
| LHb | Insr | intron excision ratio | chr12_1257822_1307450 | 0.71 | 407 | 0.34 | 5.1e-09 | -5.47 | 4.58e-08 | 0.74 | FALSE |
| LHb | Brca2 | mRNA stability | Brca2 | 0.29 | 435 | 0.12 | 7.5e-04 | 5.6 | 2.16e-08 | 0.8 | FALSE |
| Liver | Brca2 | gene expression | Brca2 | 0.04 | 1 | 0.03 | 4.3e-04 | -5.3 | 1.13e-07 | 0.24 | FALSE |
| Liver | Hmgb1 | gene expression | Hmgb1 | 0.17 | 1 | 0.11 | 1.4e-12 | 5.44 | 5.42e-08 | 0.84 | FALSE |
| Liver | LOC102549494 | gene expression | LOC102549494 | 0.02 | 3323 | 0.01 | 7.0e-03 | 6.12 | 9.16e-10 | 0.17 | FALSE |
| Liver | Mcoln1 | gene expression | Mcoln1 | 0.07 | 1 | 0.03 | 1.2e-04 | -5.52 | 3.34e-08 | 0.47 | TRUE |
| Liver | N4bp2l1 | gene expression | N4bp2l1 | 0.2 | 88 | 0.16 | 4.6e-17 | 5.33 | 9.78e-08 | 0.86 | FALSE |
| Liver | Insr | intron excision ratio | chr12_1257822_1307450 | 0.4 | 1 | 0.19 | 6.8e-21 | -5.51 | 3.51e-08 | 0.88 | FALSE |
| Liver | LOC120095871 | intron excision ratio | chr12_3871255_3873703 | 0.15 | 1117 | 0.09 | 2.7e-10 | 5.31 | 1.09e-07 | 0.74 | FALSE |
| Liver | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.2 | 76 | 0.1 | 4.0e-11 | 5.34 | 9.10e-08 | 0.52 | FALSE |
| Liver | Brca2 | mRNA stability | Brca2 | 0.18 | 431 | 0.13 | 2.3e-14 | 5.61 | 1.98e-08 | 0.95 | FALSE |
| Liver | Pet100 | mRNA stability | Pet100 | 0.5 | 1831 | 0.31 | 3.8e-35 | 5.52 | 3.40e-08 | 0.85 | FALSE |
| NAcc | N4bp2l2 | alternative polyA | XM_039089150.1 | 0.03 | 1 | 0.02 | 1.4e-03 | -5.35 | 8.65e-08 | 0.1 | FALSE |
| NAcc | Elavl1 | alternative TSS | NM_001108848.1 | 0.04 | 1 | 0.02 | 7.4e-04 | -5.43 | 5.77e-08 | 0.23 | TRUE |
| NAcc | Hmgb1 | gene expression | Hmgb1 | 0.06 | 1 | 0.04 | 5.6e-06 | 5.34 | 9.31e-08 | 0.65 | FALSE |
| NAcc | Katnal1 | gene expression | Katnal1 | 0.14 | 2316 | 0.11 | 1.3e-12 | 5.51 | 3.65e-08 | 0.66 | FALSE |
| NAcc | Rxfp2 | gene expression | Rxfp2 | 0.07 | 3326 | 0.06 | 5.6e-08 | -6.01 | 1.82e-09 | 0.12 | FALSE |
| NAcc | Snapc2 | gene expression | Snapc2 | 0.15 | 1 | 0.07 | 1.1e-08 | 5.61 | 2.04e-08 | 0.98 | FALSE |
| NAcc | Stxbp2 | gene expression | Stxbp2 | 0.1 | 1833 | 0.05 | 7.4e-07 | -5.43 | 5.63e-08 | 0.74 | FALSE |
| NAcc | Brca2 | isoform ratio | XM_017598372.2 | 0.06 | 1 | 0.04 | 8.0e-06 | -5.29 | 1.23e-07 | 0.89 | FALSE |
| NAcc | LOC120095871 | isoform ratio | XM_039089913.1 | 0.07 | 1121 | 0.06 | 1.7e-07 | 5.27 | 1.38e-07 | 0.73 | FALSE |
| NAcc | LOC120095871 | isoform ratio | XM_039089914.1 | 0.07 | 1121 | 0.06 | 2.3e-07 | -5.26 | 1.42e-07 | 0.73 | FALSE |
| NAcc | Medag | isoform ratio | XM_039089922.1 | 0.03 | 1 | 0.01 | 2.5e-02 | -5.3 | 1.13e-07 | 0.05 | FALSE |
| NAcc | Stard13 | isoform ratio | XM_039089671.1 | 0.05 | 1 | 0.02 | 1.1e-03 | 5.36 | 8.32e-08 | 0.3 | FALSE |
| NAcc | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.1 | 6 | 0.05 | 1.2e-06 | -5.24 | 1.65e-07 | 0.51 | FALSE |
| NAcc | Brca2 | mRNA stability | Brca2 | 0.23 | 24 | 0.16 | 2.9e-18 | -5.26 | 1.42e-07 | 0.87 | FALSE |
| OFC | Insr | alternative TSS | XM_039089098.1 | 0.53 | 1 | 0.17 | 8.9e-05 | -5.48 | 4.30e-08 | 0.15 | FALSE |
| OFC | Insr | alternative TSS | XM_039089098.1 | 0.53 | 1 | 0.17 | 8.9e-05 | -5.48 | 4.30e-08 | 0.15 | FALSE |
| OFC | LOC102549494 | gene expression | LOC102549494 | 0.69 | 508 | 0.52 | 2.3e-14 | -5.8 | 6.66e-09 | 0.38 | FALSE |
| OFC | Stxbp2 | gene expression | Stxbp2 | 0.35 | 1 | 0.1 | 2.7e-03 | 5.56 | 2.70e-08 | 0.07 | FALSE |
| OFC | Hmgb1 | isoform ratio | NM_012963.3 | 0.23 | 2381 | 0.12 | 1.1e-03 | 5.59 | 2.31e-08 | 0.6 | FALSE |
| PL | N4bp2l2 | alternative polyA | XM_039089150.1 | 0.04 | 1 | 0.03 | 6.6e-04 | -5.25 | 1.55e-07 | 0.09 | FALSE |
| PL | N4bp2l1 | alternative TSS | NM_001035222.2 | 0.05 | 1 | 0.04 | 1.4e-05 | 5.52 | 3.39e-08 | 0.85 | FALSE |
| PL | N4bp2l1 | alternative TSS | XM_039089675.1 | 0.05 | 1 | 0.04 | 1.4e-05 | -5.53 | 3.17e-08 | 0.88 | FALSE |
| PL | Hmgb1 | gene expression | Hmgb1 | 0.19 | 2381 | 0.07 | 5.8e-08 | -5.28 | 1.33e-07 | 0.71 | FALSE |
| PL | Katnal1 | gene expression | Katnal1 | 0.21 | 8 | 0.16 | 1.5e-17 | 5.52 | 3.49e-08 | 0.08 | TRUE |
| PL | LOC102549494 | gene expression | LOC102549494 | 0.3 | 39 | 0.27 | 2.8e-29 | 5.6 | 2.17e-08 | 0.47 | FALSE |
| PL | N4bp2l1 | gene expression | N4bp2l1 | 0.05 | 1 | 0.04 | 3.5e-05 | 5.32 | 1.05e-07 | 0.8 | FALSE |
| PL | LOC120095871 | intron excision ratio | chr12_3870992_3873703 | 0.19 | 1121 | 0.16 | 5.5e-17 | -5.2 | 1.96e-07 | 0.74 | FALSE |
| PL | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.29 | 1836 | 0.16 | 7.5e-17 | -5.34 | 9.08e-08 | 0.56 | FALSE |
| PL | Snapc2 | mRNA stability | Snapc2 | 0.52 | 68 | 0.31 | 2.8e-35 | 5.26 | 1.42e-07 | 0.97 | FALSE |
| pVTA | LOC102549494 | gene expression | LOC102549494 | 0.15 | 3325 | 0.08 | 2.3e-04 | 6.03 | 1.66e-09 | 0.33 | FALSE |
| pVTA | Insr | isoform ratio | XM_039089096.1 | 0.22 | 1 | 0.11 | 1.8e-05 | 5.56 | 2.70e-08 | 0.61 | FALSE |
| RMTg | Brca2 | gene expression | Brca2 | 0.26 | 2 | 0.11 | 5.8e-04 | 5.18 | 2.19e-07 | 0.71 | FALSE |
| RMTg | Cers4 | gene expression | Cers4 | 0.29 | 2124 | 0.09 | 2.4e-03 | 5.41 | 6.39e-08 | 0.62 | FALSE |
| RMTg | Insr | intron excision ratio | chr12_1257822_1307450 | 0.46 | 1 | 0.3 | 1.2e-08 | -5.56 | 2.70e-08 | 0.79 | FALSE |
| RMTg | Insr | intron excision ratio | chr12_1264110_1307450 | 0.37 | 1 | 0.21 | 3.1e-06 | 5.56 | 2.70e-08 | 0.32 | FALSE |
| RMTg | Insr | intron excision ratio | chr12_1264114_1307450 | 0.31 | 1 | 0.18 | 1.4e-05 | 5.56 | 2.70e-08 | 0.22 | FALSE |
| RMTg | LOC120095871 | intron excision ratio | chr12_3870992_3873703 | 0.2 | 30 | 0.14 | 1.3e-04 | 5.3 | 1.18e-07 | 0.59 | FALSE |
| RMTg | N4bp2l2 | intron excision ratio | chr12_141578_178994 | 0.23 | 1 | 0.12 | 5.1e-04 | 5.28 | 1.28e-07 | 0.1 | FALSE |