Best TWAS P=3.572267e-08 · Best GWAS P=1.126712e-08 conditioned to 0.0658306
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Pmfbp1 | gene expression | ENSRNOG00000014505 | 0.15 | 0.08 | top1 | 1 | 0.08 | 8.8e-09 | 5.4 | 5.4 | 5.9e-08 | 0.78 | 0.25 | 0.75 | FALSE |
| 2 | Brain | NA | alternative TSS | ENSRNOT00000059225 | 0.06 | 0.04 | top1 | 1 | 0.04 | 2.5e-04 | 5.4 | -5.4 | 7.0e-08 | -0.71 | 0.17 | 0.38 | FALSE |
| 3 | Brain | NA | alternative TSS | ENSRNOT00000097735 | 0.07 | 0.04 | top1 | 1 | 0.04 | 2.2e-04 | 5.4 | 5.4 | 7.0e-08 | 0.71 | 0.18 | 0.41 | FALSE |
| 4 | Brain | Pmfbp1 | gene expression | ENSRNOG00000014505 | 0.21 | 0.16 | lasso | 10 | 0.19 | 1.5e-17 | 5.5 | 5.4 | 5.7e-08 | 0.92 | 0.16 | 0.84 | FALSE |
| 5 | Brain | NA | gene expression | ENSRNOG00000038766 | 0.08 | 0.04 | lasso | 15 | 0.06 | 5.4e-06 | 2.8 | -5.1 | 2.9e-07 | -0.81 | 0.22 | 0.77 | FALSE |
| 6 | Brain | Ist1 | intron excision ratio | chr19:37652320:37654806 | 0.09 | 0.04 | lasso | 4 | 0.05 | 2.4e-05 | 3.8 | 5.4 | 6.9e-08 | 0.73 | 0.33 | 0.60 | FALSE |
| 7 | LHb | Pmfbp1 | gene expression | ENSRNOG00000014505 | 0.46 | 0.29 | top1 | 1 | 0.29 | 1.1e-07 | 5.5 | 5.5 | 3.6e-08 | 0.87 | 0.15 | 0.62 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.