Best TWAS P=1.180352e-08 · Best GWAS P=7.827832e-10 conditioned to 8.42336e-12
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | BLA | Arhgap28 | gene expression | ENSRNOG00000017065 | 0.18 | 0.09 | enet | 45 | 0.10 | 8.1e-06 | 5.0 | 5.5 | 5.0e-08 | -0.89 | 0.39 | 0.61 | TRUE |
| 2 | Brain | Arhgap28 | gene expression | ENSRNOG00000017065 | 0.10 | 0.10 | top1 | 1 | 0.10 | 6.6e-10 | 5.1 | 5.1 | 3.5e-07 | -0.77 | 0.92 | 0.07 | FALSE |
| 3 | IL | Lama1 | gene expression | ENSRNOG00000017237 | 0.26 | 0.20 | top1 | 1 | 0.20 | 1.6e-05 | 5.1 | 5.1 | 3.1e-07 | -0.70 | 0.12 | 0.12 | FALSE |
| 4 | LHb | Arhgap28 | gene expression | ENSRNOG00000017065 | 0.20 | 0.19 | top1 | 1 | 0.19 | 3.6e-05 | 5.7 | 5.7 | 1.2e-08 | -0.75 | 0.09 | 0.07 | TRUE |
| 5 | PL | AABR07068728.1 | gene expression | ENSRNOG00000025273 | 0.12 | 0.15 | lasso | 12 | 0.15 | 1.9e-11 | 2.6 | -5.5 | 4.9e-08 | -0.22 | 0.99 | 0.01 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.