Best TWAS P=5.883374e-08 · Best GWAS P=4.469985e-08 conditioned to 1.52291e-89
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | NA | gene expression | ENSRNOG00000068595 | 0.24 | 0.12 | top1 | 1 | 0.12 | 6.2e-13 | -5.3 | 5.3 | 1.1e-07 | -0.93 | 0.22 | 0.78 | FALSE |
| 2 | BLA | Pnpla8 | gene expression | ENSRNOG00000039091 | 0.06 | 0.06 | top1 | 1 | 0.06 | 3.3e-04 | -5.2 | 5.2 | 2.3e-07 | -0.84 | 0.10 | 0.05 | FALSE |
| 3 | OFC | Pnpla8 | gene expression | ENSRNOG00000039091 | 0.21 | 0.18 | top1 | 1 | 0.18 | 5.2e-05 | -5.4 | 5.4 | 5.9e-08 | -0.86 | 0.13 | 0.14 | TRUE |
| 4 | PL2 | Pnpla8 | gene expression | ENSRNOG00000039091 | 0.19 | 0.07 | top1 | 1 | 0.06 | 2.0e-04 | -5.1 | 5.1 | 2.7e-07 | -0.82 | 0.18 | 0.21 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.