Best TWAS P=7.66e-09 · Best GWAS P=4.47e-08 conditioned to 1.36e-123
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | LOC103692619 | alternative polyA | XR_005505908.1 | 0.05 | 1 | 0.03 | 4.5e-04 | -5.45 | 4.95e-08 | 0.28 | FALSE |
| Adipose | LOC103692619 | alternative polyA | XR_005505909.1 | 0.04 | 1 | 0.02 | 6.2e-03 | 5.45 | 4.95e-08 | 0.07 | FALSE |
| Adipose | LOC103692619 | alternative polyA | XR_005505908.1 | 0.05 | 1 | 0.03 | 4.5e-04 | -5.45 | 4.95e-08 | 0.28 | FALSE |
| Adipose | LOC103692619 | alternative polyA | XR_005505909.1 | 0.05 | 1 | 0.03 | 4.2e-04 | 5.45 | 4.95e-08 | 0.3 | FALSE |
| Adipose | LOC120103526 | gene expression | LOC120103526 | 0.09 | 1 | 0.06 | 2.1e-07 | -5.47 | 4.47e-08 | 0.88 | FALSE |
| Adipose | LOC120103526 | isoform ratio | XR_005505903.1 | 0.1 | 1 | 0.08 | 7.8e-09 | 5.36 | 8.42e-08 | 0.82 | FALSE |
| Adipose | LOC120103526 | isoform ratio | XR_005505905.1 | 0.15 | 12 | 0.08 | 8.7e-09 | -5.36 | 8.42e-08 | 0.81 | FALSE |
| Adipose | LOC120103526 | isoform ratio | XR_005505906.1 | 0.04 | 1 | 0.03 | 1.0e-04 | -5.24 | 1.59e-07 | 0.12 | FALSE |
| NAcc | LOC120103526 | alternative TSS | XR_005505902.1 | 0.05 | 1 | 0.04 | 2.3e-05 | 5.31 | 1.11e-07 | 0.76 | FALSE |
| NAcc | LOC120103526 | alternative TSS | XR_005505904.1 | 0.08 | 1 | 0.07 | 3.6e-08 | -5.31 | 1.11e-07 | 0.78 | FALSE |
| NAcc | LOC120103526 | gene expression | LOC120103526 | 0.14 | 1 | 0.08 | 3.3e-09 | -5.36 | 8.35e-08 | 0.83 | FALSE |
| NAcc | Pnpla8 | gene expression | Pnpla8 | 0.11 | 1 | 0.06 | 8.2e-08 | -5.38 | 7.43e-08 | 0.84 | FALSE |
| PL | LOC120103526 | alternative polyA | XR_005505904.1 | 0.06 | 1 | 0.05 | 8.6e-06 | 5.21 | 1.85e-07 | 0.6 | FALSE |
| PL | LOC120103526 | alternative polyA | XR_005505905.1 | 0.06 | 1 | 0.04 | 1.0e-05 | -5.21 | 1.85e-07 | 0.54 | FALSE |
| PL | LOC120103526 | alternative polyA | XR_005505901.1 | 0.07 | 1 | 0.05 | 5.9e-06 | -5.21 | 1.85e-07 | 0.59 | FALSE |
| PL | LOC120103526 | alternative polyA | XR_005505904.1 | 0.08 | 1 | 0.05 | 4.6e-06 | 5.21 | 1.85e-07 | 0.63 | FALSE |
| PL | LOC120103526 | gene expression | LOC120103526 | 0.09 | 1 | 0.04 | 1.6e-05 | -5.36 | 8.20e-08 | 0.8 | FALSE |
| PL | Pnpla8 | gene expression | Pnpla8 | 0.24 | 29 | 0.06 | 4.0e-07 | -5.78 | 7.66e-09 | 0.81 | TRUE |
| pVTA | LOC120103526 | alternative polyA | XR_005505901.1 | 0.13 | 2 | 0.06 | 1.4e-03 | 5.52 | 3.39e-08 | 0.71 | FALSE |
| pVTA | LOC120103526 | alternative polyA | XR_005505904.1 | 0.13 | 2 | 0.05 | 3.2e-03 | -5.51 | 3.51e-08 | 0.7 | FALSE |