Hub : Traits : Right kidney weight : ← →

chr1:257,860,954-260,518,987

Trait: Right kidney weight

Best TWAS P=3.213563e-14 · Best GWAS P=7.815477e-14 conditioned to 0

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Dennd10	gene expression	ENSRNOG00000010230	0.03	0.03	top1	1	0.03	2.5e-04	-5.3	-5.3	1.3e-07	0.59	0.24	0.02	FALSE
2	Adipose	Prdx3	gene expression	ENSRNOG00000010958	0.19	0.22	lasso	34	0.22	1.6e-23	-5.5	-5.8	8.2e-09	0.71	1.00	0.00	FALSE
3	Adipose	Grk5	gene expression	ENSRNOG00000011439	0.17	0.20	lasso	24	0.22	8.6e-24	-4.7	5.6	2.4e-08	-0.65	1.00	0.00	FALSE
4	BLA	Rab11fip2	gene expression	ENSRNOG00000009523	0.11	0.05	top1	1	0.05	1.1e-03	-5.6	-5.6	2.2e-08	0.67	0.12	0.04	FALSE
5	BLA	Ces2c	gene expression	ENSRNOG00000036571	0.26	0.19	lasso	16	0.20	1.1e-10	-5.1	5.1	2.8e-07	-0.45	1.00	0.00	FALSE
6	BLA	Sfxn4	gene expression	ENSRNOG00000036572	0.07	0.02	top1	1	0.02	2.1e-02	-6.8	6.8	8.8e-12	-0.61	0.06	0.05	FALSE
7	Brain	Rab11fip2	gene expression	ENSRNOG00000009523	0.09	0.05	lasso	2	0.06	3.6e-06	-6.7	-5.9	3.2e-09	-0.56	0.21	0.79	TRUE
8	Brain	Nanos1	gene expression	ENSRNOG00000025060	0.03	0.01	enet	58	0.01	2.2e-02	-5.2	-6.1	9.1e-10	0.61	0.65	0.17	FALSE
9	Brain	Ces2c	gene expression	ENSRNOG00000036571	0.20	0.28	blup	597	0.29	3.4e-27	-5.2	5.4	5.4e-08	-0.50	1.00	0.00	FALSE
10	Brain	Cacul1	isoform ratio	ENSRNOT00000050617	0.14	0.11	top1	1	0.11	3.3e-10	-6.9	6.9	3.9e-12	-0.57	0.30	0.70	FALSE
11	Brain	Zfp950	isoform ratio	ENSRNOT00000047883	0.04	0.03	blup	954	0.05	9.3e-06	-5.0	5.6	2.5e-08	-0.56	0.98	0.02	FALSE
12	Eye	NA	gene expression	ENSRNOG00000065260	0.45	0.18	top1	1	0.18	9.5e-04	-6.5	-6.5	9.2e-11	0.47	0.10	0.06	FALSE
13	LHb	Ces2c	gene expression	ENSRNOG00000036571	0.25	0.12	blup	594	0.19	2.3e-05	-5.1	5.9	2.9e-09	-0.58	0.75	0.11	FALSE
14	Liver	Rab11fip2	gene expression	ENSRNOG00000009523	0.03	0.00	blup	2371	0.01	1.3e-02	-5.6	-6.9	5.0e-12	0.86	0.34	0.34	TRUE
15	Liver	Nanos1	gene expression	ENSRNOG00000025060	0.03	0.02	top1	1	0.02	1.2e-03	-5.5	-5.5	4.8e-08	0.68	0.07	0.03	TRUE
16	Liver	Zfp950	gene expression	ENSRNOG00000032668	0.03	0.01	top1	1	0.01	7.7e-03	-6.5	-6.5	7.7e-11	0.55	0.03	0.03	FALSE
17	Liver	Cacul1	isoform ratio	ENSRNOT00000050617	0.03	0.02	top1	1	0.02	1.3e-03	-6.1	6.1	8.4e-10	-0.64	0.07	0.03	TRUE
18	Liver	Cacul1	mRNA stability	ENSRNOG00000009954	0.03	0.01	top1	1	0.01	1.4e-02	-6.8	6.8	1.0e-11	-0.65	0.05	0.03	FALSE
19	NAcc	Prlhr	gene expression	ENSRNOG00000009922	0.14	0.09	blup	1904	0.11	2.3e-08	-6.8	5.7	1.4e-08	-0.56	0.48	0.52	FALSE
20	NAcc	Zfp950	gene expression	ENSRNOG00000032668	0.05	0.01	lasso	15	0.02	7.3e-03	-7.4	7.6	3.2e-14	-0.91	0.13	0.76	TRUE
21	NAcc	Ces2c	gene expression	ENSRNOG00000036571	0.22	0.17	blup	597	0.22	5.3e-16	-5.0	5.9	3.0e-09	-0.59	0.99	0.01	FALSE
22	NAcc	Sfxn4	gene expression	ENSRNOG00000036572	0.07	0.04	top1	1	0.04	3.8e-04	-6.7	6.7	2.2e-11	-0.47	0.06	0.04	FALSE
23	NAcc	Cacul1	isoform ratio	ENSRNOT00000050617	0.05	0.05	blup	1781	0.05	9.6e-05	-6.8	5.7	1.2e-08	-0.56	0.58	0.33	FALSE
24	NAcc	Cacul1	isoform ratio	ENSRNOT00000084760	0.05	0.05	blup	1781	0.05	1.6e-04	-7.0	-5.7	9.7e-09	0.56	0.58	0.33	FALSE
25	OFC	Rab11fip2	gene expression	ENSRNOG00000009523	0.30	0.23	lasso	17	0.27	5.1e-07	-6.4	-6.2	4.2e-10	0.72	0.76	0.22	FALSE
26	OFC	Ces2c	gene expression	ENSRNOG00000036571	0.38	0.42	top1	1	0.42	3.6e-11	-5.1	5.1	3.5e-07	-0.47	0.92	0.00	FALSE
27	OFC	Sfxn4	gene expression	ENSRNOG00000036572	0.41	0.18	enet	17	0.26	7.0e-07	-5.1	5.2	2.6e-07	-0.51	0.97	0.01	FALSE
28	OFC	Rab11fip2	mRNA stability	ENSRNOG00000009523	0.16	0.19	top1	1	0.19	2.9e-05	-6.4	-6.4	1.3e-10	0.44	0.12	0.05	FALSE
29	PL	Rab11fip2	gene expression	ENSRNOG00000009523	0.06	0.04	enet	76	0.05	1.5e-04	-6.1	-6.5	1.1e-10	0.74	0.64	0.35	FALSE
30	PL	Ces2c	gene expression	ENSRNOG00000036571	0.39	0.38	top1	1	0.38	3.4e-30	-5.3	5.3	1.2e-07	-0.50	1.00	0.00	FALSE
31	PL	NA	gene expression	ENSRNOG00000068145	0.06	0.03	lasso	13	0.04	6.9e-04	4.8	-5.3	1.0e-07	0.56	0.64	0.17	TRUE
32	PL	Cacul1	isoform ratio	ENSRNOT00000050617	0.03	0.02	top1	1	0.02	1.8e-02	-7.0	7.0	2.9e-12	-0.60	0.06	0.05	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.