Best TWAS P = 3.81e-08 · Best GWAS P= 6.60e-07 conditioned to 2.05e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Prmt1 | alternative TSS | XM_006229144.5 | 0.62 | 29 | 0.09 | 2.4e-10 | 5.2 | 1.94e-07 | 0.58 | FALSE |
| BLA | Bcl2l12 | alternative TSS | XM_017589363.3 | 0.07 | 15 | 0.05 | 1.4e-03 | 5.26 | 1.42e-07 | 0.43 | FALSE |
| Brain | Cpt1c | isoform ratio | NM_001034925.2 | 0.06 | 5 | 0.05 | 2.7e-05 | 5.22 | 1.77e-07 | 0.57 | FALSE |
| Brain | Ctu1 | intron excision ratio | chr1_103252043_103254866 | 0.05 | 3350 | 0.02 | 8.0e-03 | 5.23 | 1.73e-07 | 0.59 | FALSE |
| Brain | Scaf1 | intron excision ratio | chr1_104633240_104634999 | 0.04 | 100 | 0.05 | 4.0e-05 | 5.23 | 1.67e-07 | 0.55 | FALSE |
| IC | Syt3 | intron excision ratio | chr1_104017429_104017749 | 0.06 | 2380 | 0.03 | 2.2e-02 | 5.23 | 1.70e-07 | 0.36 | FALSE |
| IC | Shank1 | mRNA stability | Shank1 | 0.16 | 14 | 0.14 | 2.2e-06 | 5.33 | 9.65e-08 | 0.45 | FALSE |
| IL | Josd2 | mRNA stability | Josd2 | 0.16 | 2173 | 0.04 | 3.7e-02 | 5.35 | 8.62e-08 | 0.3 | FALSE |
| LHb | Fuz | alternative polyA | XM_006229060.5 | 0.25 | 114 | 0.2 | 2.1e-05 | 5.37 | 7.86e-08 | 0.52 | FALSE |
| LHb | Med25 | intron excision ratio | chr1_104505814_104510610 | 0.18 | 48 | 0.09 | 4.6e-03 | -5.21 | 1.85e-07 | 0.38 | FALSE |
| Liver | Bcl2l12 | mRNA stability | Bcl2l12 | 0.07 | 73 | 0.03 | 3.5e-04 | 5.31 | 1.09e-07 | 0.6 | FALSE |
| NAcc | C1h19orf81 | intron excision ratio | chr1_103994174_103994823 | 0.03 | 19 | 0.02 | 5.7e-04 | 5.34 | 9.23e-08 | 0.45 | FALSE |
| NAcc | Fcgrt | mRNA stability | Fcgrt | 0.02 | 14 | 0.02 | 2.7e-04 | -5.21 | 1.85e-07 | 0.46 | FALSE |
| NAcc | Lrrc4b | mRNA stability | Lrrc4b | 0.06 | 2313 | 0.07 | 1.3e-10 | -5.28 | 1.30e-07 | 0.45 | FALSE |
| OFC | Fuz | alternative polyA | NM_001399381.1 | 0.33 | 112 | 0.21 | 1.1e-05 | -5.21 | 1.86e-07 | 0.52 | FALSE |
| PL | Tsks | gene expression | Tsks | 0.04 | 15 | 0.04 | 9.4e-05 | 5.29 | 1.22e-07 | 0.55 | FALSE |
| PL | Fuz | isoform ratio | NM_001399381.1 | 0.03 | 16 | 0.02 | 6.0e-03 | -5.27 | 1.38e-07 | 0.4 | FALSE |
| pVTA | Cpt1c | alternative TSS | NM_001034925.2 | 0.16 | 14 | 0.19 | 1.8e-15 | 5.21 | 1.88e-07 | 0.57 | FALSE |
| pVTA | Cpt1c | alternative TSS | NM_001034925.2 | 0.2 | 46 | 0.23 | 2.8e-18 | 5.28 | 1.31e-07 | 0.58 | FALSE |
| pVTA | Cpt1c | alternative TSS | XM_063262004.1 | 0.22 | 5 | 0.13 | 2.4e-10 | -5.24 | 1.63e-07 | 0.58 | FALSE |
| pVTA | Scaf1 | isoform ratio | XM_063272028.1 | 0.06 | 112 | 0.05 | 3.6e-05 | -5.5 | 3.81e-08 | 0.59 | TRUE |
| pVTA | Cpt1c | mRNA stability | Cpt1c | 0.03 | 7 | 0.02 | 4.5e-03 | -5.29 | 1.24e-07 | 0.43 | FALSE |
| pVTA | Lrrc4b | mRNA stability | Lrrc4b | 0.06 | 37 | 0.07 | 1.7e-06 | -5.31 | 1.10e-07 | 0.45 | FALSE |