chr1:80,926,895-89,701,879

Trait: Right kidney weight

Best TWAS P = 1.22e-10 · Best GWAS P= 3.54e-09 conditioned to 1.00e+00

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
Adipose Zfp111 isoform ratio NM_133323.1 0.05 95 0.05 4.2e-06 5.33 9.83e-08 0.54 FALSE
Adipose Fkrp mRNA stability Fkrp 0.03 18 0.02 2.4e-03 -5.27 1.38e-07 0.37 FALSE
BLA Ccdc61 gene expression Ccdc61 0.1 94 0.07 1.8e-04 -5.43 5.55e-08 0.33 FALSE
BLA Lig1 gene expression Lig1 0.33 1 0.18 9.7e-10 5.34 9.32e-08 0.6 FALSE
Brain Arhgap35 isoform ratio NM_001271132.1 0.03 100 0.02 3.2e-03 -5.23 1.72e-07 0.45 FALSE
Brain Lig1 intron excision ratio chr1_83279770_83281290 0.16 5 0.16 7.8e-15 5.55 2.81e-08 0.66 FALSE
Brain Lig1 intron excision ratio chr1_83280733_83281290 0.08 12 0.07 7.7e-07 -5.69 1.28e-08 0.66 FALSE
Brain Ccdc61 mRNA stability Ccdc61 0.02 19 0.02 4.1e-03 -5.41 6.17e-08 0.32 FALSE
Brain Lig1 mRNA stability Lig1 0.21 38 0.19 6.9e-18 5.87 4.33e-09 0.66 FALSE
Brain Zswim9 mRNA stability Zswim9 0.04 1 0.04 8.4e-05 5.33 9.99e-08 0.08 FALSE
Eye Gemin7 alternative TSS XM_006228461.5 0.39 102 0.14 3.3e-03 5.29 1.20e-07 0.3 TRUE
Eye Lig1 gene expression Lig1 0.34 1 0.15 2.6e-03 5.36 8.31e-08 0.06 FALSE
Eye Pnma8b isoform ratio NM_001107481.1 0.5 111 0.24 1.6e-04 5.26 1.48e-07 0.33 FALSE
IL LOC108349062 isoform ratio XR_001835682.3 0.14 223 0.1 1.9e-03 -5.41 6.30e-08 0.31 TRUE
IL Ppp1r13l isoform ratio NM_001427130.1 0.2 17 0.15 1.9e-04 5.28 1.32e-07 0.44 FALSE
LHb Lig1 gene expression Lig1 0.19 1659 0.09 4.9e-03 5.28 1.28e-07 0.51 FALSE
LHb Lig1 mRNA stability Lig1 0.35 555 0.22 7.5e-06 5.36 8.41e-08 0.63 FALSE
Liver Sult2a1 alternative polyA NM_131903.1 0.09 2 0.09 8.5e-10 -5.48 4.29e-08 0.97 FALSE
Liver Sult2a1 alternative polyA XM_063281068.1 0.1 2 0.09 7.6e-10 5.38 7.60e-08 0.97 FALSE
Liver Zfp446 alternative TSS XM_017589934.3 0.08 96 0.01 2.9e-02 6.09 1.16e-09 0.21 FALSE
Liver Zfp446 alternative TSS XM_017589934.3 0.11 96 0.02 4.6e-03 5.35 8.60e-08 0.41 FALSE
Liver Apoc2 gene expression Apoc2 0.49 211 0.33 5.2e-37 5.33 1.01e-07 0.54 FALSE
Liver Selenow gene expression Selenow 0.63 949 0.24 1.3e-26 5.46 4.81e-08 0.85 FALSE
Liver Sult2a1 gene expression Sult2a1 0.18 2 0.26 3.3e-28 5.54 3.06e-08 0.98 TRUE
Liver Gemin7 isoform ratio XM_006228461.5 0.03 68 0.02 1.9e-03 5.27 1.36e-07 0.47 FALSE
Liver LOC120099768 intron excision ratio chr1_85186709_85200351 0.8 33 0.39 1.9e-45 -5.22 1.82e-07 0.82 FALSE
Liver LOC120099768 intron excision ratio chr1_85200528_85204893 0.82 31 0.41 2.2e-49 5.23 1.72e-07 0.82 FALSE
Liver Sult2a1 intron excision ratio chr1_84600558_84629968 0.08 1 0.06 2.7e-07 -5.27 1.39e-07 0.97 TRUE
Liver Zfp324 intron excision ratio chr1_82674660_82675044 0.25 751 0.12 7.4e-13 5.21 1.86e-07 0.58 FALSE
Liver Zfp446 intron excision ratio chr1_82674660_82675044 0.25 749 0.12 7.4e-13 5.23 1.69e-07 0.55 FALSE
Liver Lig1 mRNA stability Lig1 0.04 1659 0.01 7.4e-03 5.23 1.66e-07 0.49 FALSE
NAcc Gemin7 alternative TSS XM_006228461.5 0.13 29 0.16 1.1e-23 5.27 1.38e-07 0.52 FALSE
NAcc Bcam gene expression Bcam 0.15 74 0.19 1.0e-27 5.24 1.61e-07 0.51 FALSE
NAcc Fkrp gene expression Fkrp 0.16 1080 0.11 4.3e-16 5.28 1.27e-07 0.49 FALSE
NAcc Lig1 intron excision ratio chr1_83280733_83281290 0.02 5 0.02 6.2e-04 -5.33 9.56e-08 0.39 TRUE
NAcc Zbtb45 intron excision ratio chr1_82710277_82711694 0.09 1 0.04 1.1e-06 -5.49 3.97e-08 0.99 FALSE
OFC Znf8 alternative polyA NM_001402794.1 0.69 735 0.02 1.3e-01 -5.22 1.78e-07 0.32 TRUE
OFC Zbtb45 alternative TSS XM_006228115.5 0.36 776 0.04 3.8e-02 5.88 4.20e-09 0.51 FALSE
OFC LOC108348449 gene expression LOC108348449 0.34 14 0.06 1.2e-02 -6.44 1.22e-10 0.53 TRUE
OFC Fosb mRNA stability Fosb 0.16 11 0.12 7.3e-04 5.26 1.45e-07 0.38 FALSE
OFC Lig1 mRNA stability Lig1 0.22 1659 0.05 2.1e-02 5.33 9.58e-08 0.45 FALSE
OFC Nova2 mRNA stability Nova2 0.19 299 0.13 6.2e-04 -5.4 6.82e-08 0.34 FALSE
PL Mzf1 alternative TSS XM_006228116.5 0.04 36 0.02 6.8e-03 5.47 4.50e-08 0.62 FALSE
PL Zswim9 alternative TSS XM_039100810.2 0.03 1660 0.02 3.3e-03 5.31 1.09e-07 0.54 FALSE
PL Zswim9 gene expression Zswim9 0.03 28 0.02 1.8e-03 5.92 3.26e-09 0.53 FALSE
PL Lig1 intron excision ratio chr1_83279770_83281290 0.07 58 0.05 1.3e-06 5.88 4.13e-09 0.66 FALSE
PL Lig1 intron excision ratio chr1_83280733_83281290 0.05 41 0.04 2.7e-05 -5.63 1.79e-08 0.65 FALSE
PL Zbtb45 intron excision ratio chr1_82710277_82711694 0.04 34 0.02 1.1e-03 -5.55 2.89e-08 0.54 FALSE
PL Ercc2 mRNA stability Ercc2 0.03 8 0.03 1.2e-04 -5.23 1.66e-07 0.53 FALSE
PL Lig1 mRNA stability Lig1 0.16 25 0.11 1.7e-12 5.67 1.44e-08 0.66 FALSE
pVTA Fbxo46 intron excision ratio chr1_87898229_87911724 0.79 10 0.09 1.2e-07 5.37 7.78e-08 0.32 FALSE
pVTA Lig1 mRNA stability Lig1 0.09 1659 0.02 4.9e-03 5.4 6.60e-08 0.51 FALSE
RMTg Vom1r47 alternative TSS XM_063270359.1 0.3 177 0.11 8.0e-04 -5.66 1.50e-08 0.42 TRUE
RMTg Vom1r47 alternative TSS XM_063270367.1 0.28 166 0.09 1.9e-03 5.52 3.31e-08 0.32 FALSE
RMTg Vom1r47 isoform ratio XM_063270359.1 0.29 143 0.15 1.1e-04 -5.5 3.77e-08 0.53 FALSE
RMTg Zfp94 mRNA stability Zfp94 0.13 36 0.05 1.7e-02 -5.21 1.85e-07 0.35 FALSE