Best TWAS P = 1.22e-10 · Best GWAS P= 3.54e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Zfp111 | isoform ratio | NM_133323.1 | 0.05 | 95 | 0.05 | 4.2e-06 | 5.33 | 9.83e-08 | 0.54 | FALSE |
| Adipose | Fkrp | mRNA stability | Fkrp | 0.03 | 18 | 0.02 | 2.4e-03 | -5.27 | 1.38e-07 | 0.37 | FALSE |
| BLA | Ccdc61 | gene expression | Ccdc61 | 0.1 | 94 | 0.07 | 1.8e-04 | -5.43 | 5.55e-08 | 0.33 | FALSE |
| BLA | Lig1 | gene expression | Lig1 | 0.33 | 1 | 0.18 | 9.7e-10 | 5.34 | 9.32e-08 | 0.6 | FALSE |
| Brain | Arhgap35 | isoform ratio | NM_001271132.1 | 0.03 | 100 | 0.02 | 3.2e-03 | -5.23 | 1.72e-07 | 0.45 | FALSE |
| Brain | Lig1 | intron excision ratio | chr1_83279770_83281290 | 0.16 | 5 | 0.16 | 7.8e-15 | 5.55 | 2.81e-08 | 0.66 | FALSE |
| Brain | Lig1 | intron excision ratio | chr1_83280733_83281290 | 0.08 | 12 | 0.07 | 7.7e-07 | -5.69 | 1.28e-08 | 0.66 | FALSE |
| Brain | Ccdc61 | mRNA stability | Ccdc61 | 0.02 | 19 | 0.02 | 4.1e-03 | -5.41 | 6.17e-08 | 0.32 | FALSE |
| Brain | Lig1 | mRNA stability | Lig1 | 0.21 | 38 | 0.19 | 6.9e-18 | 5.87 | 4.33e-09 | 0.66 | FALSE |
| Brain | Zswim9 | mRNA stability | Zswim9 | 0.04 | 1 | 0.04 | 8.4e-05 | 5.33 | 9.99e-08 | 0.08 | FALSE |
| Eye | Gemin7 | alternative TSS | XM_006228461.5 | 0.39 | 102 | 0.14 | 3.3e-03 | 5.29 | 1.20e-07 | 0.3 | TRUE |
| Eye | Lig1 | gene expression | Lig1 | 0.34 | 1 | 0.15 | 2.6e-03 | 5.36 | 8.31e-08 | 0.06 | FALSE |
| Eye | Pnma8b | isoform ratio | NM_001107481.1 | 0.5 | 111 | 0.24 | 1.6e-04 | 5.26 | 1.48e-07 | 0.33 | FALSE |
| IL | LOC108349062 | isoform ratio | XR_001835682.3 | 0.14 | 223 | 0.1 | 1.9e-03 | -5.41 | 6.30e-08 | 0.31 | TRUE |
| IL | Ppp1r13l | isoform ratio | NM_001427130.1 | 0.2 | 17 | 0.15 | 1.9e-04 | 5.28 | 1.32e-07 | 0.44 | FALSE |
| LHb | Lig1 | gene expression | Lig1 | 0.19 | 1659 | 0.09 | 4.9e-03 | 5.28 | 1.28e-07 | 0.51 | FALSE |
| LHb | Lig1 | mRNA stability | Lig1 | 0.35 | 555 | 0.22 | 7.5e-06 | 5.36 | 8.41e-08 | 0.63 | FALSE |
| Liver | Sult2a1 | alternative polyA | NM_131903.1 | 0.09 | 2 | 0.09 | 8.5e-10 | -5.48 | 4.29e-08 | 0.97 | FALSE |
| Liver | Sult2a1 | alternative polyA | XM_063281068.1 | 0.1 | 2 | 0.09 | 7.6e-10 | 5.38 | 7.60e-08 | 0.97 | FALSE |
| Liver | Zfp446 | alternative TSS | XM_017589934.3 | 0.08 | 96 | 0.01 | 2.9e-02 | 6.09 | 1.16e-09 | 0.21 | FALSE |
| Liver | Zfp446 | alternative TSS | XM_017589934.3 | 0.11 | 96 | 0.02 | 4.6e-03 | 5.35 | 8.60e-08 | 0.41 | FALSE |
| Liver | Apoc2 | gene expression | Apoc2 | 0.49 | 211 | 0.33 | 5.2e-37 | 5.33 | 1.01e-07 | 0.54 | FALSE |
| Liver | Selenow | gene expression | Selenow | 0.63 | 949 | 0.24 | 1.3e-26 | 5.46 | 4.81e-08 | 0.85 | FALSE |
| Liver | Sult2a1 | gene expression | Sult2a1 | 0.18 | 2 | 0.26 | 3.3e-28 | 5.54 | 3.06e-08 | 0.98 | TRUE |
| Liver | Gemin7 | isoform ratio | XM_006228461.5 | 0.03 | 68 | 0.02 | 1.9e-03 | 5.27 | 1.36e-07 | 0.47 | FALSE |
| Liver | LOC120099768 | intron excision ratio | chr1_85186709_85200351 | 0.8 | 33 | 0.39 | 1.9e-45 | -5.22 | 1.82e-07 | 0.82 | FALSE |
| Liver | LOC120099768 | intron excision ratio | chr1_85200528_85204893 | 0.82 | 31 | 0.41 | 2.2e-49 | 5.23 | 1.72e-07 | 0.82 | FALSE |
| Liver | Sult2a1 | intron excision ratio | chr1_84600558_84629968 | 0.08 | 1 | 0.06 | 2.7e-07 | -5.27 | 1.39e-07 | 0.97 | TRUE |
| Liver | Zfp324 | intron excision ratio | chr1_82674660_82675044 | 0.25 | 751 | 0.12 | 7.4e-13 | 5.21 | 1.86e-07 | 0.58 | FALSE |
| Liver | Zfp446 | intron excision ratio | chr1_82674660_82675044 | 0.25 | 749 | 0.12 | 7.4e-13 | 5.23 | 1.69e-07 | 0.55 | FALSE |
| Liver | Lig1 | mRNA stability | Lig1 | 0.04 | 1659 | 0.01 | 7.4e-03 | 5.23 | 1.66e-07 | 0.49 | FALSE |
| NAcc | Gemin7 | alternative TSS | XM_006228461.5 | 0.13 | 29 | 0.16 | 1.1e-23 | 5.27 | 1.38e-07 | 0.52 | FALSE |
| NAcc | Bcam | gene expression | Bcam | 0.15 | 74 | 0.19 | 1.0e-27 | 5.24 | 1.61e-07 | 0.51 | FALSE |
| NAcc | Fkrp | gene expression | Fkrp | 0.16 | 1080 | 0.11 | 4.3e-16 | 5.28 | 1.27e-07 | 0.49 | FALSE |
| NAcc | Lig1 | intron excision ratio | chr1_83280733_83281290 | 0.02 | 5 | 0.02 | 6.2e-04 | -5.33 | 9.56e-08 | 0.39 | TRUE |
| NAcc | Zbtb45 | intron excision ratio | chr1_82710277_82711694 | 0.09 | 1 | 0.04 | 1.1e-06 | -5.49 | 3.97e-08 | 0.99 | FALSE |
| OFC | Znf8 | alternative polyA | NM_001402794.1 | 0.69 | 735 | 0.02 | 1.3e-01 | -5.22 | 1.78e-07 | 0.32 | TRUE |
| OFC | Zbtb45 | alternative TSS | XM_006228115.5 | 0.36 | 776 | 0.04 | 3.8e-02 | 5.88 | 4.20e-09 | 0.51 | FALSE |
| OFC | LOC108348449 | gene expression | LOC108348449 | 0.34 | 14 | 0.06 | 1.2e-02 | -6.44 | 1.22e-10 | 0.53 | TRUE |
| OFC | Fosb | mRNA stability | Fosb | 0.16 | 11 | 0.12 | 7.3e-04 | 5.26 | 1.45e-07 | 0.38 | FALSE |
| OFC | Lig1 | mRNA stability | Lig1 | 0.22 | 1659 | 0.05 | 2.1e-02 | 5.33 | 9.58e-08 | 0.45 | FALSE |
| OFC | Nova2 | mRNA stability | Nova2 | 0.19 | 299 | 0.13 | 6.2e-04 | -5.4 | 6.82e-08 | 0.34 | FALSE |
| PL | Mzf1 | alternative TSS | XM_006228116.5 | 0.04 | 36 | 0.02 | 6.8e-03 | 5.47 | 4.50e-08 | 0.62 | FALSE |
| PL | Zswim9 | alternative TSS | XM_039100810.2 | 0.03 | 1660 | 0.02 | 3.3e-03 | 5.31 | 1.09e-07 | 0.54 | FALSE |
| PL | Zswim9 | gene expression | Zswim9 | 0.03 | 28 | 0.02 | 1.8e-03 | 5.92 | 3.26e-09 | 0.53 | FALSE |
| PL | Lig1 | intron excision ratio | chr1_83279770_83281290 | 0.07 | 58 | 0.05 | 1.3e-06 | 5.88 | 4.13e-09 | 0.66 | FALSE |
| PL | Lig1 | intron excision ratio | chr1_83280733_83281290 | 0.05 | 41 | 0.04 | 2.7e-05 | -5.63 | 1.79e-08 | 0.65 | FALSE |
| PL | Zbtb45 | intron excision ratio | chr1_82710277_82711694 | 0.04 | 34 | 0.02 | 1.1e-03 | -5.55 | 2.89e-08 | 0.54 | FALSE |
| PL | Ercc2 | mRNA stability | Ercc2 | 0.03 | 8 | 0.03 | 1.2e-04 | -5.23 | 1.66e-07 | 0.53 | FALSE |
| PL | Lig1 | mRNA stability | Lig1 | 0.16 | 25 | 0.11 | 1.7e-12 | 5.67 | 1.44e-08 | 0.66 | FALSE |
| pVTA | Fbxo46 | intron excision ratio | chr1_87898229_87911724 | 0.79 | 10 | 0.09 | 1.2e-07 | 5.37 | 7.78e-08 | 0.32 | FALSE |
| pVTA | Lig1 | mRNA stability | Lig1 | 0.09 | 1659 | 0.02 | 4.9e-03 | 5.4 | 6.60e-08 | 0.51 | FALSE |
| RMTg | Vom1r47 | alternative TSS | XM_063270359.1 | 0.3 | 177 | 0.11 | 8.0e-04 | -5.66 | 1.50e-08 | 0.42 | TRUE |
| RMTg | Vom1r47 | alternative TSS | XM_063270367.1 | 0.28 | 166 | 0.09 | 1.9e-03 | 5.52 | 3.31e-08 | 0.32 | FALSE |
| RMTg | Vom1r47 | isoform ratio | XM_063270359.1 | 0.29 | 143 | 0.15 | 1.1e-04 | -5.5 | 3.77e-08 | 0.53 | FALSE |
| RMTg | Zfp94 | mRNA stability | Zfp94 | 0.13 | 36 | 0.05 | 1.7e-02 | -5.21 | 1.85e-07 | 0.35 | FALSE |