Best TWAS P=7.021123e-08 · Best GWAS P=4.289951e-08 conditioned to 0.09089581
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Afap1l2 | gene expression | ENSRNOG00000017164 | 0.04 | 0.03 | top1 | 1 | 0.03 | 2.3e-04 | 5.3 | 5.3 | 1.1e-07 | 0.80 | 0.06 | 0.61 | FALSE |
| 2 | Adipose | Fhip2a | mRNA stability | ENSRNOG00000017225 | 0.09 | 0.07 | top1 | 1 | 0.07 | 6.1e-08 | 5.3 | -5.3 | 1.5e-07 | -0.69 | 0.06 | 0.94 | FALSE |
| 3 | NAcc | NA | gene expression | ENSRNOG00000068699 | 0.43 | 0.21 | top1 | 1 | 0.21 | 1.8e-05 | 5.2 | 5.2 | 2.1e-07 | 0.75 | 0.11 | 0.37 | FALSE |
| 4 | PL | Casp7 | gene expression | ENSRNOG00000056216 | 0.13 | 0.04 | enet | 23 | 0.06 | 1.3e-02 | 4.6 | 5.4 | 7.0e-08 | 0.85 | 0.45 | 0.29 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.