Hub : Traits : Left kidney weight : ← →

chr1:257,860,954-260,518,987

Trait: Left kidney weight

Best TWAS P=2.672628e-14 · Best GWAS P=1.966853e-13 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Dennd10	gene expression	ENSRNOG00000010230	0.03	0.03	top1	1	0.03	2.5e-04	-5.3	-5.3	9.1e-08	0.63	0.24	0.02	FALSE
2	Adipose	Prdx3	gene expression	ENSRNOG00000010958	0.19	0.22	lasso	34	0.22	1.6e-23	-5.6	-5.8	5.5e-09	0.77	1.00	0.00	TRUE
3	Adipose	Grk5	gene expression	ENSRNOG00000011439	0.17	0.20	lasso	24	0.22	8.6e-24	-5.1	5.8	6.4e-09	-0.64	1.00	0.00	FALSE
4	BLA	Rab11fip2	gene expression	ENSRNOG00000009523	0.11	0.05	top1	1	0.05	1.1e-03	-5.7	-5.7	1.5e-08	0.62	0.12	0.04	FALSE
5	BLA	Ces2c	gene expression	ENSRNOG00000036571	0.26	0.19	lasso	16	0.20	1.1e-10	-5.2	5.3	1.3e-07	-0.50	0.99	0.01	FALSE
6	BLA	Sfxn4	gene expression	ENSRNOG00000036572	0.07	0.02	top1	1	0.02	2.1e-02	-7.2	7.2	7.3e-13	-0.63	0.05	0.17	FALSE
7	BLA	Cacul1	isoform ratio	ENSRNOT00000084760	0.07	0.00	top1	1	0.00	2.4e-01	-5.1	-5.1	2.8e-07	0.35	0.07	0.04	FALSE
8	Brain	Rab11fip2	gene expression	ENSRNOG00000009523	0.09	0.05	lasso	2	0.06	3.6e-06	-7.0	-5.9	2.8e-09	-0.50	0.18	0.81	TRUE
9	Brain	Nanos1	gene expression	ENSRNOG00000025060	0.03	0.01	enet	58	0.01	2.2e-02	-5.4	-6.3	2.9e-10	0.66	0.49	0.37	FALSE
10	Brain	Ces2c	gene expression	ENSRNOG00000036571	0.20	0.28	blup	597	0.29	3.4e-27	-5.4	5.5	2.9e-08	-0.56	1.00	0.00	FALSE
11	Brain	Cacul1	isoform ratio	ENSRNOT00000050617	0.14	0.11	top1	1	0.11	3.3e-10	-6.9	6.9	4.6e-12	-0.51	0.23	0.77	FALSE
12	Brain	Zfp950	isoform ratio	ENSRNOT00000047883	0.04	0.03	blup	954	0.05	9.3e-06	-5.2	5.6	1.9e-08	-0.64	0.98	0.02	FALSE
13	Eye	NA	gene expression	ENSRNOG00000065260	0.45	0.18	top1	1	0.18	9.5e-04	-6.7	-6.7	2.3e-11	0.42	0.10	0.06	FALSE
14	IL	Ces2c	gene expression	ENSRNOG00000036571	0.35	0.35	top1	1	0.35	2.3e-09	-5.2	5.2	2.3e-07	-0.49	0.50	0.03	FALSE
15	IL	Sfxn4	gene expression	ENSRNOG00000036572	0.19	0.13	top1	1	0.13	5.3e-04	-5.2	5.2	2.0e-07	-0.49	0.08	0.05	FALSE
16	LHb	Ces2c	gene expression	ENSRNOG00000036571	0.25	0.12	blup	594	0.19	2.3e-05	-5.2	6.0	2.4e-09	-0.67	0.74	0.12	FALSE
17	Liver	Rab11fip2	gene expression	ENSRNOG00000009523	0.03	0.00	blup	2371	0.01	1.3e-02	-5.9	-7.0	3.0e-12	0.77	0.32	0.39	TRUE
18	Liver	Nanos1	gene expression	ENSRNOG00000025060	0.03	0.02	top1	1	0.02	1.2e-03	-5.6	-5.6	1.9e-08	0.71	0.07	0.03	FALSE
19	Liver	Zfp950	gene expression	ENSRNOG00000032668	0.03	0.01	top1	1	0.01	7.7e-03	-6.7	-6.7	1.7e-11	0.61	0.03	0.04	FALSE
20	Liver	Cacul1	isoform ratio	ENSRNOT00000050617	0.03	0.02	top1	1	0.02	1.3e-03	-6.0	6.0	1.8e-09	-0.61	0.07	0.03	TRUE
21	Liver	Cacul1	mRNA stability	ENSRNOG00000009954	0.03	0.01	top1	1	0.01	1.4e-02	-6.6	6.6	5.2e-11	-0.59	0.05	0.03	FALSE
22	NAcc	Prlhr	gene expression	ENSRNOG00000009922	0.14	0.09	blup	1904	0.11	2.3e-08	-6.6	5.6	1.6e-08	-0.51	0.40	0.60	FALSE
23	NAcc	Zfp950	gene expression	ENSRNOG00000032668	0.05	0.01	lasso	15	0.02	7.3e-03	-7.4	7.6	2.7e-14	-0.98	0.18	0.68	TRUE
24	NAcc	Ces2c	gene expression	ENSRNOG00000036571	0.22	0.17	blup	597	0.22	5.3e-16	-5.2	6.0	2.7e-09	-0.68	0.99	0.01	FALSE
25	NAcc	Sfxn4	gene expression	ENSRNOG00000036572	0.07	0.04	top1	1	0.04	3.8e-04	-6.9	6.9	5.2e-12	-0.46	0.06	0.08	FALSE
26	NAcc	Cacul1	isoform ratio	ENSRNOT00000050617	0.05	0.05	blup	1781	0.05	9.6e-05	-7.2	5.8	5.2e-09	-0.51	0.34	0.61	FALSE
27	NAcc	Cacul1	isoform ratio	ENSRNOT00000084760	0.05	0.05	blup	1781	0.05	1.6e-04	-7.2	-5.9	4.4e-09	0.52	0.34	0.61	FALSE
28	OFC	Rab11fip2	gene expression	ENSRNOG00000009523	0.30	0.23	lasso	17	0.27	5.1e-07	-6.3	-6.2	5.9e-10	0.64	0.78	0.21	FALSE
29	OFC	Ces2c	gene expression	ENSRNOG00000036571	0.38	0.42	top1	1	0.42	3.6e-11	-5.2	5.2	1.6e-07	-0.53	0.92	0.01	FALSE
30	OFC	Sfxn4	gene expression	ENSRNOG00000036572	0.41	0.18	enet	17	0.26	7.0e-07	-5.2	5.2	2.0e-07	-0.53	0.93	0.06	FALSE
31	OFC	Rab11fip2	mRNA stability	ENSRNOG00000009523	0.16	0.19	top1	1	0.19	2.9e-05	-6.3	-6.3	2.3e-10	0.37	0.12	0.05	FALSE
32	PL	Rab11fip2	gene expression	ENSRNOG00000009523	0.06	0.04	enet	76	0.05	1.5e-04	-6.1	-6.4	1.6e-10	0.67	0.67	0.32	FALSE
33	PL	Ces2c	gene expression	ENSRNOG00000036571	0.39	0.38	top1	1	0.38	3.4e-30	-5.4	5.4	5.7e-08	-0.57	1.00	0.00	FALSE
34	PL	NA	gene expression	ENSRNOG00000068145	0.06	0.03	lasso	13	0.04	6.9e-04	4.7	-5.1	2.8e-07	0.49	0.73	0.06	TRUE
35	PL	Cacul1	isoform ratio	ENSRNOT00000050617	0.03	0.02	top1	1	0.02	1.8e-02	-7.2	7.2	4.9e-13	-0.57	0.06	0.18	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.