Best TWAS P = 1.22e-08 · Best GWAS P= 2.40e-07 conditioned to 7.94e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Prmt1 | alternative TSS | XM_006229144.5 | 0.62 | 29 | 0.09 | 2.4e-10 | 5.31 | 1.11e-07 | 0.63 | FALSE |
| Adipose | Prmt1 | intron excision ratio | chr1_104602489_104604508 | 0.08 | 33 | 0.04 | 3.5e-05 | 5.29 | 1.22e-07 | 0.6 | FALSE |
| Adipose | Rcn3 | mRNA stability | Rcn3 | 0.26 | 21 | 0.13 | 2.0e-14 | -5.42 | 5.98e-08 | 0.63 | FALSE |
| Adipose | Scaf1 | mRNA stability | Scaf1 | 0.05 | 431 | 0.03 | 5.7e-04 | -5.28 | 1.32e-07 | 0.56 | FALSE |
| BLA | Syt3 | alternative TSS | XM_039102277.1 | 0.12 | 125 | 0.06 | 6.4e-04 | 5.29 | 1.24e-07 | 0.55 | FALSE |
| BLA | Syt3 | alternative TSS | XM_063282307.1 | 0.12 | 120 | 0.05 | 9.2e-04 | -5.32 | 1.03e-07 | 0.56 | FALSE |
| Brain | Cpt1c | alternative TSS | XM_017589139.2 | 0.08 | 23 | 0.05 | 1.4e-05 | -5.44 | 5.33e-08 | 0.68 | FALSE |
| Brain | Med25 | gene expression | Med25 | 0.46 | 12 | 0.25 | 1.0e-22 | 5.25 | 1.49e-07 | 0.73 | FALSE |
| Brain | Cpt1c | isoform ratio | NM_001034925.2 | 0.06 | 5 | 0.05 | 2.7e-05 | 5.21 | 1.93e-07 | 0.43 | FALSE |
| Brain | Ctu1 | intron excision ratio | chr1_103252043_103254866 | 0.05 | 3350 | 0.02 | 8.0e-03 | 5.25 | 1.55e-07 | 0.6 | FALSE |
| IL | Josd2 | mRNA stability | Josd2 | 0.16 | 2173 | 0.04 | 3.7e-02 | 5.24 | 1.62e-07 | 0.26 | FALSE |
| LHb | Fuz | alternative polyA | XM_006229060.5 | 0.25 | 114 | 0.2 | 2.1e-05 | 5.4 | 6.72e-08 | 0.44 | FALSE |
| LHb | Med25 | intron excision ratio | chr1_104505814_104510610 | 0.18 | 48 | 0.09 | 4.6e-03 | -5.39 | 6.93e-08 | 0.39 | FALSE |
| NAcc | C1h19orf81 | intron excision ratio | chr1_103994174_103994823 | 0.03 | 19 | 0.02 | 5.7e-04 | 5.7 | 1.22e-08 | 0.58 | TRUE |
| NAcc | Fcgrt | mRNA stability | Fcgrt | 0.02 | 14 | 0.02 | 2.7e-04 | -5.24 | 1.57e-07 | 0.51 | FALSE |
| OFC | Fuz | alternative polyA | NM_001399381.1 | 0.33 | 112 | 0.21 | 1.1e-05 | -5.44 | 5.35e-08 | 0.56 | FALSE |
| PL | Med25 | alternative TSS | XM_063284073.1 | 0.03 | 5 | 0.01 | 3.7e-02 | 5.21 | 1.93e-07 | 0.43 | FALSE |
| PL | Med25 | alternative TSS | XM_063284073.1 | 0.03 | 5 | 0.01 | 5.9e-02 | 5.22 | 1.81e-07 | 0.39 | FALSE |
| PL | Tsks | gene expression | Tsks | 0.04 | 15 | 0.04 | 9.4e-05 | 5.24 | 1.63e-07 | 0.5 | FALSE |
| PL | Fuz | isoform ratio | NM_001399381.1 | 0.03 | 16 | 0.02 | 6.0e-03 | -5.22 | 1.82e-07 | 0.38 | FALSE |
| pVTA | Cpt1c | alternative TSS | NM_001034925.2 | 0.16 | 14 | 0.19 | 1.8e-15 | 5.46 | 4.73e-08 | 0.69 | FALSE |
| pVTA | Cpt1c | alternative TSS | XM_063262004.1 | 0.15 | 5 | 0.11 | 3.0e-09 | -5.32 | 1.03e-07 | 0.69 | FALSE |
| pVTA | Cpt1c | alternative TSS | NM_001034925.2 | 0.2 | 46 | 0.23 | 2.8e-18 | 5.45 | 4.92e-08 | 0.69 | FALSE |
| pVTA | Cpt1c | alternative TSS | XM_063262004.1 | 0.22 | 5 | 0.13 | 2.4e-10 | -5.46 | 4.84e-08 | 0.7 | FALSE |
| pVTA | Cpt1c | mRNA stability | Cpt1c | 0.03 | 7 | 0.02 | 4.5e-03 | -5.48 | 4.16e-08 | 0.46 | FALSE |