Hub : Traits : BMI without tail : ← →

chr1:258,394,596-260,518,987

Trait: BMI without tail

Best TWAS P=7.867199e-16 · Best GWAS P=1.446359e-15 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Dennd10	gene expression	ENSRNOG00000010230	0.03	0.03	top1	1	0.03	2.5e-04	-6.7	-6.7	2.5e-11	0.72	0.24	0.02	FALSE
2	Adipose	Prdx3	gene expression	ENSRNOG00000010958	0.19	0.22	lasso	34	0.22	1.6e-23	-5.4	-5.6	2.8e-08	0.55	1.00	0.00	FALSE
3	Adipose	Grk5	gene expression	ENSRNOG00000011439	0.17	0.20	lasso	24	0.22	8.6e-24	-7.2	7.0	2.2e-12	-0.75	0.98	0.02	FALSE
4	BLA	Rab11fip2	gene expression	ENSRNOG00000009523	0.11	0.05	top1	1	0.05	1.1e-03	-5.7	-5.7	1.5e-08	0.70	0.12	0.04	TRUE
5	BLA	Ces2c	gene expression	ENSRNOG00000036571	0.26	0.19	lasso	16	0.20	1.1e-10	-6.9	6.9	6.8e-12	-0.77	0.28	0.72	FALSE
6	BLA	Sfxn4	gene expression	ENSRNOG00000036572	0.07	0.02	top1	1	0.02	2.1e-02	-8.1	8.1	7.9e-16	-0.86	0.04	0.35	TRUE
7	BLA	Cacul1	isoform ratio	ENSRNOT00000084760	0.07	0.00	top1	1	0.00	2.4e-01	-7.2	-7.2	4.9e-13	0.71	0.07	0.04	FALSE
8	Brain	Rab11fip2	gene expression	ENSRNOG00000009523	0.09	0.05	lasso	2	0.06	3.6e-06	-5.6	-5.8	7.6e-09	-0.42	0.96	0.04	FALSE
9	Brain	Prlhr	gene expression	ENSRNOG00000009922	0.03	0.01	blup	1906	0.01	1.4e-02	-2.9	5.4	5.6e-08	-0.76	0.42	0.29	FALSE
10	Brain	Nanos1	gene expression	ENSRNOG00000025060	0.03	0.01	enet	58	0.01	2.2e-02	-6.6	-7.4	1.2e-13	0.91	0.41	0.48	FALSE
11	Brain	Ces2c	gene expression	ENSRNOG00000036571	0.20	0.28	blup	597	0.29	3.4e-27	-6.6	6.7	2.0e-11	-0.75	0.28	0.72	FALSE
12	Brain	Sfxn4	gene expression	ENSRNOG00000036572	0.09	0.08	lasso	36	0.09	2.2e-08	-3.9	5.5	3.1e-08	-0.61	0.99	0.01	FALSE
13	Brain	Cacul1	isoform ratio	ENSRNOT00000050617	0.14	0.11	top1	1	0.11	3.3e-10	-7.7	7.7	1.7e-14	-0.95	0.23	0.77	FALSE
14	Brain	Cacul1	isoform ratio	ENSRNOT00000084760	0.12	0.10	enet	5	0.11	5.6e-10	-7.7	-6.9	6.3e-12	-0.44	0.16	0.84	TRUE
15	Brain	Zfp950	isoform ratio	ENSRNOT00000047883	0.04	0.03	blup	954	0.05	9.3e-06	-7.1	6.2	6.1e-10	-0.66	0.94	0.05	FALSE
16	Brain	Cacul1	intron excision ratio	chr1:259677583:259686255	0.12	0.08	enet	36	0.10	1.6e-09	-7.9	7.3	3.2e-13	-0.28	0.14	0.86	TRUE
17	Eye	NA	gene expression	ENSRNOG00000065260	0.45	0.18	top1	1	0.18	9.5e-04	-7.6	-7.6	2.5e-14	0.91	0.10	0.06	FALSE
18	IL	Ces2c	gene expression	ENSRNOG00000036571	0.35	0.35	top1	1	0.35	2.3e-09	-6.9	6.9	6.0e-12	-0.77	0.15	0.70	FALSE
19	IL	Sfxn4	gene expression	ENSRNOG00000036572	0.19	0.13	top1	1	0.13	5.3e-04	-6.9	6.9	6.0e-12	-0.83	0.08	0.05	FALSE
20	LHb	Ces2c	gene expression	ENSRNOG00000036571	0.25	0.12	blup	594	0.19	2.3e-05	-6.8	6.3	2.4e-10	-0.70	0.30	0.65	FALSE
21	Liver	Rab11fip2	gene expression	ENSRNOG00000009523	0.03	0.00	blup	2371	0.01	1.3e-02	-2.3	-5.2	2.2e-07	0.75	0.39	0.24	TRUE
22	Liver	Nanos1	gene expression	ENSRNOG00000025060	0.03	0.02	top1	1	0.02	1.2e-03	-5.4	-5.4	6.7e-08	0.72	0.07	0.03	FALSE
23	Liver	Zfp950	gene expression	ENSRNOG00000032668	0.03	0.01	top1	1	0.01	7.7e-03	-7.6	-7.6	4.3e-14	0.80	0.03	0.04	FALSE
24	Liver	Cacul1	isoform ratio	ENSRNOT00000050617	0.03	0.02	top1	1	0.02	1.3e-03	-7.2	7.2	6.3e-13	-0.94	0.07	0.03	FALSE
25	Liver	Cacul1	isoform ratio	ENSRNOT00000084760	0.03	0.01	blup	1780	0.02	4.5e-03	-7.2	-6.8	9.4e-12	0.84	0.31	0.42	FALSE
26	Liver	Cacul1	mRNA stability	ENSRNOG00000009954	0.03	0.01	top1	1	0.01	1.4e-02	-7.5	7.5	8.2e-14	-0.92	0.05	0.03	FALSE
27	NAcc	Prlhr	gene expression	ENSRNOG00000009922	0.14	0.09	blup	1904	0.11	2.3e-08	-7.5	6.9	4.2e-12	-0.92	0.22	0.78	FALSE
28	NAcc	Zfp950	gene expression	ENSRNOG00000032668	0.05	0.01	lasso	15	0.02	7.3e-03	-5.2	6.2	6.4e-10	-0.80	0.36	0.36	FALSE
29	NAcc	Ces2c	gene expression	ENSRNOG00000036571	0.22	0.17	blup	597	0.22	5.3e-16	-6.9	6.2	4.2e-10	-0.69	0.29	0.71	FALSE
30	NAcc	Sfxn4	gene expression	ENSRNOG00000036572	0.07	0.04	top1	1	0.04	3.8e-04	-7.5	7.5	4.6e-14	-0.89	0.06	0.05	FALSE
31	NAcc	Cacul1	isoform ratio	ENSRNOT00000050617	0.05	0.05	blup	1781	0.05	9.6e-05	-8.1	7.8	8.3e-15	-0.95	0.18	0.80	FALSE
32	NAcc	Cacul1	isoform ratio	ENSRNOT00000084760	0.05	0.05	blup	1781	0.05	1.6e-04	-8.0	-7.8	7.3e-15	0.95	0.19	0.79	FALSE
33	OFC	Rab11fip2	gene expression	ENSRNOG00000009523	0.30	0.23	lasso	17	0.27	5.1e-07	-7.1	-7.1	8.7e-13	0.94	0.44	0.55	TRUE
34	OFC	Cacul1	gene expression	ENSRNOG00000009954	0.45	0.24	blup	1782	0.41	9.5e-11	-3.5	5.7	1.2e-08	-0.77	0.50	0.50	FALSE
35	OFC	Ces2c	gene expression	ENSRNOG00000036571	0.38	0.42	top1	1	0.42	3.6e-11	-6.8	6.8	8.3e-12	-0.76	0.22	0.76	FALSE
36	OFC	Sfxn4	gene expression	ENSRNOG00000036572	0.41	0.18	enet	17	0.26	7.0e-07	-6.8	7.2	8.6e-13	-0.84	0.89	0.09	FALSE
37	OFC	Rab11fip2	mRNA stability	ENSRNOG00000009523	0.16	0.19	top1	1	0.19	2.9e-05	-7.1	-7.1	1.6e-12	0.86	0.12	0.05	FALSE
38	PL	Rab11fip2	gene expression	ENSRNOG00000009523	0.06	0.04	enet	76	0.05	1.5e-04	-6.9	-7.3	2.1e-13	0.88	0.36	0.63	FALSE
39	PL	Cacul1	gene expression	ENSRNOG00000009954	0.24	0.16	enet	45	0.18	2.4e-13	-4.2	5.3	1.4e-07	-0.78	1.00	0.00	FALSE
40	PL	Ces2c	gene expression	ENSRNOG00000036571	0.39	0.38	top1	1	0.38	3.4e-30	-6.6	6.6	3.2e-11	-0.76	0.52	0.48	FALSE
41	PL	Sfxn4	gene expression	ENSRNOG00000036572	0.17	0.05	enet	158	0.10	9.5e-08	-6.9	6.2	4.9e-10	-0.70	0.89	0.11	FALSE
42	PL	Cacul1	isoform ratio	ENSRNOT00000050617	0.03	0.02	top1	1	0.02	1.8e-02	-8.0	8.0	1.1e-15	-0.91	0.05	0.23	FALSE
43	PL	Zfp950	intron excision ratio	chr1:260237329:260247276	0.03	0.01	blup	954	0.02	1.2e-02	-7.9	7.2	5.9e-13	-0.83	0.24	0.50	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.