Best TWAS P = 1.19e-08 · Best GWAS P= 9.41e-09 conditioned to 1.72e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | LOC134485167 | gene expression | LOC134485167 | 0.06 | 2244 | 0 | 9.8e-02 | 5.51 | 3.62e-08 | 0.36 | FALSE |
| Adipose | Plekha7 | gene expression | Plekha7 | 0.34 | 1041 | 0.06 | 8.0e-07 | 5.29 | 1.24e-07 | 0.47 | FALSE |
| BLA | Rps15a | gene expression | Rps15a | 0.14 | 2737 | 0.1 | 6.7e-06 | -5.49 | 4.08e-08 | 0.46 | FALSE |
| Brain | Plekha7 | alternative TSS | XM_063279498.1 | 0.03 | 1 | 0.01 | 1.6e-02 | 5.3 | 1.18e-07 | 0.04 | FALSE |
| Brain | LOC120099912 | gene expression | LOC120099912 | 0.14 | 1 | 0.13 | 6.8e-12 | 5.3 | 1.18e-07 | 0.76 | FALSE |
| Brain | Smg1 | intron excision ratio | chr1_181954419_181977476 | 0.05 | 1 | 0.01 | 2.2e-02 | -5.26 | 1.45e-07 | 0.04 | FALSE |
| IC | Rps15a | gene expression | Rps15a | 0.14 | 7 | 0.06 | 1.8e-03 | -5.51 | 3.56e-08 | 0.15 | FALSE |
| IL | Rps15a | gene expression | Rps15a | 0.16 | 2737 | 0 | 2.8e-01 | -5.7 | 1.19e-08 | 0.28 | TRUE |
| NAcc | Tmc7 | intron excision ratio | chr1_182317521_182320753 | 0.05 | 14 | 0.05 | 9.6e-08 | 5.32 | 1.06e-07 | 0.57 | FALSE |
| OFC | Xylt1 | gene expression | Xylt1 | 0.23 | 35 | 0.06 | 1.3e-02 | 5.44 | 5.19e-08 | 0.21 | FALSE |
| pVTA | Tmc7 | gene expression | Tmc7 | 0.22 | 31 | 0.23 | 1.3e-18 | 5.3 | 1.17e-07 | 0.57 | FALSE |
| pVTA | Syt17 | isoform ratio | XM_017588770.3 | 0.04 | 1 | 0.03 | 1.1e-03 | -5.54 | 3.10e-08 | 0.14 | FALSE |
| pVTA | Rps15a | intron excision ratio | chr1_181860280_181861108 | 0.1 | 15 | 0.08 | 5.1e-07 | 5.32 | 1.04e-07 | 0.62 | FALSE |
| pVTA | Syt17 | intron excision ratio | chr1_182191400_182195689 | 0.05 | 2706 | 0.02 | 4.5e-03 | -5.37 | 7.82e-08 | 0.44 | FALSE |
| pVTA | Syt17 | intron excision ratio | chr1_182191405_182195689 | 0.05 | 2706 | 0.04 | 7.5e-04 | 5.3 | 1.14e-07 | 0.53 | FALSE |