Hub : Traits : dissection: UMAP 3 of all traits : ← →

chr10:79,659,766-83,433,454

Best TWAS P=1.281845e-10 · Best GWAS P=1.086055e-10 conditioned to 0.5285978

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Phospho1	alternative polyA	ENSRNOT00000007352	0.13	0.02	top1	1	0.01	6.9e-03	5.2	-5.2	2.5e-07	-0.50	0.05	0.04	FALSE
2	Adipose	Phospho1	alternative polyA	ENSRNOT00000104900	0.12	0.01	top1	1	0.01	1.1e-02	5.2	5.2	2.5e-07	0.50	0.05	0.04	FALSE
3	Adipose	Phospho1	alternative polyA	ENSRNOT00000007352	0.28	0.07	enet	71	0.08	8.8e-09	5.2	-6.3	3.1e-10	-0.56	0.81	0.19	FALSE
4	Adipose	Phospho1	alternative polyA	ENSRNOT00000104900	0.27	0.07	enet	72	0.07	1.3e-08	5.2	6.4	2.1e-10	0.56	0.81	0.19	FALSE
5	Adipose	Mrpl45	alternative polyA	ENSRNOT00000014752	0.05	0.01	enet	15	0.02	3.3e-03	6.4	-6.3	3.3e-10	-0.85	0.19	0.78	FALSE
6	Adipose	Mrpl45	alternative polyA	ENSRNOT00000110256	0.05	0.02	top1	1	0.02	4.0e-03	6.4	6.4	1.7e-10	0.82	0.04	0.19	FALSE
7	Adipose	Npepps	alternative polyA	ENSRNOT00000031045	0.02	0.01	enet	76	0.01	7.0e-03	6.4	-6.1	8.6e-10	-0.93	0.19	0.57	FALSE
8	Adipose	Npepps	alternative polyA	ENSRNOT00000115585	0.02	0.01	enet	42	0.01	7.6e-03	6.4	6.0	1.6e-09	0.91	0.20	0.55	FALSE
9	Adipose	Phospho1	gene expression	ENSRNOG00000005569	0.34	0.31	top1	1	0.31	3.4e-35	5.2	-5.2	2.5e-07	-0.50	0.60	0.40	FALSE
10	Adipose	Mrpl45	gene expression	ENSRNOG00000010540	0.59	0.42	enet	54	0.43	1.4e-51	6.3	6.3	3.5e-10	0.98	0.13	0.87	FALSE
11	Adipose	Pip4k2b	gene expression	ENSRNOG00000013030	0.15	0.02	top1	1	0.02	1.1e-03	6.3	6.3	3.9e-10	0.58	0.05	0.24	FALSE
12	Adipose	Phospho1	isoform ratio	ENSRNOT00000115688	0.02	0.02	top1	1	0.01	7.4e-03	5.2	-5.2	2.0e-07	-0.52	0.05	0.03	FALSE
13	Adipose	Osbpl7	intron excision ratio	chr10:82036178:82037412	0.04	0.03	blup	888	0.04	2.5e-05	4.7	5.2	2.1e-07	0.81	0.83	0.16	FALSE
14	Adipose	Npepps	mRNA stability	ENSRNOG00000023095	0.24	0.07	top1	1	0.07	2.8e-08	6.4	6.4	1.9e-10	0.89	0.11	0.89	FALSE
15	BLA	Cbx1	gene expression	ENSRNOG00000008689	0.09	0.07	blup	1022	0.10	8.0e-06	4.5	-5.1	3.2e-07	-0.73	0.96	0.03	FALSE
16	BLA	Kpnb1	gene expression	ENSRNOG00000009275	0.13	0.06	top1	1	0.06	6.3e-04	6.3	6.3	3.6e-10	0.91	0.05	0.10	FALSE
17	BLA	Mrpl45	gene expression	ENSRNOG00000010540	0.78	0.59	enet	155	0.63	6.0e-43	6.2	6.3	2.5e-10	0.99	0.14	0.86	FALSE
18	BLA	Npepps	gene expression	ENSRNOG00000023095	0.42	0.16	lasso	3	0.16	3.8e-09	6.1	6.1	1.0e-09	1.00	0.14	0.86	FALSE
19	BLA	Skap1	gene expression	ENSRNOG00000023881	0.20	0.22	lasso	10	0.22	3.0e-12	5.1	5.2	2.5e-07	0.66	0.76	0.24	FALSE
20	BLA	Prr15l	gene expression	ENSRNOG00000049162	0.13	0.14	top1	1	0.14	5.3e-08	5.2	5.2	1.7e-07	0.74	0.84	0.02	FALSE
21	BLA	Phospho1	isoform ratio	ENSRNOT00000094757	0.05	0.04	top1	1	0.04	3.7e-03	5.5	5.5	3.5e-08	0.50	0.06	0.05	FALSE
22	BLA	Osbpl7	intron excision ratio	chr10:82036178:82036809	0.16	0.19	blup	888	0.22	9.0e-12	4.5	-5.2	2.2e-07	-0.79	1.00	0.00	FALSE
23	BLA	Snf8	mRNA stability	ENSRNOG00000006500	0.10	0.02	blup	1457	0.04	3.2e-03	5.0	-5.4	7.0e-08	-0.62	0.47	0.48	FALSE
24	BLA	Osbpl7	mRNA stability	ENSRNOG00000009473	0.05	0.06	top1	1	0.06	3.0e-04	5.1	5.1	2.8e-07	0.79	0.07	0.04	FALSE
25	BLA	Lrrc46	mRNA stability	ENSRNOG00000009902	0.06	0.03	blup	888	0.05	1.4e-03	4.5	5.3	1.3e-07	0.81	0.58	0.23	FALSE
26	BLA	Mrpl45	mRNA stability	ENSRNOG00000010540	0.30	0.12	enet	8	0.13	1.8e-07	6.1	6.2	7.5e-10	0.99	0.14	0.86	FALSE
27	Brain	Zfp652	alternative TSS	ENSRNOT00000022811	0.02	0.02	top1	1	0.02	1.2e-02	5.2	5.2	2.0e-07	0.47	0.05	0.04	FALSE
28	Brain	Zfp652	alternative TSS	ENSRNOT00000109486	0.02	0.02	top1	1	0.02	1.1e-02	5.2	-5.2	2.0e-07	-0.47	0.05	0.04	FALSE
29	Brain	Cisd3	alternative TSS	ENSRNOT00000116237	0.04	0.01	enet	18	0.02	2.3e-03	6.3	5.2	2.0e-07	0.89	0.30	0.48	FALSE
30	Brain	Kpnb1	gene expression	ENSRNOG00000009275	0.11	0.04	top1	1	0.04	8.3e-05	6.4	6.4	1.3e-10	0.91	0.06	0.52	FALSE
31	Brain	Tbkbp1	gene expression	ENSRNOG00000009370	0.23	0.09	blup	862	0.09	1.4e-08	6.4	-6.3	3.8e-10	-0.98	0.13	0.87	FALSE
32	Brain	Mrpl45	gene expression	ENSRNOG00000010540	0.82	0.64	enet	60	0.65	3.1e-78	6.4	6.3	2.4e-10	1.00	0.12	0.88	FALSE
33	Brain	Npepps	gene expression	ENSRNOG00000023095	0.38	0.21	lasso	14	0.23	6.8e-21	6.4	6.4	1.5e-10	0.98	0.13	0.87	FALSE
34	Brain	Skap1	gene expression	ENSRNOG00000023881	0.07	0.06	blup	1165	0.07	3.9e-07	5.6	5.3	1.4e-07	0.62	0.34	0.66	FALSE
35	Brain	Osbpl7	intron excision ratio	chr10:82036922:82037412	0.17	0.16	blup	888	0.19	2.3e-17	4.4	-5.2	2.4e-07	-0.83	1.00	0.00	FALSE
36	Brain	Mrpl45	intron excision ratio	chr10:82310718:82313694	0.23	0.08	top1	1	0.08	5.4e-08	6.4	6.4	1.9e-10	0.89	0.12	0.88	FALSE
37	Brain	Tbkbp1	mRNA stability	ENSRNOG00000009370	0.14	0.05	top1	1	0.05	2.0e-05	6.4	-6.4	1.9e-10	-0.87	0.09	0.66	FALSE
38	Eye	Gip	gene expression	ENSRNOG00000006306	0.78	0.11	enet	498	0.15	2.9e-03	5.1	6.2	4.1e-10	0.55	0.30	0.11	FALSE
39	Eye	Nfe2l1	gene expression	ENSRNOG00000008830	0.75	0.10	lasso	21	0.11	9.6e-03	4.7	-5.3	1.5e-07	-0.64	0.43	0.07	FALSE
40	Eye	Spop	intron excision ratio	chr10:80401845:80416909	0.47	0.09	top1	1	0.09	1.9e-02	5.1	-5.1	3.0e-07	-0.46	0.09	0.06	FALSE
41	IL	Nfe2l1	gene expression	ENSRNOG00000008830	0.73	0.42	enet	8	0.45	4.0e-12	4.5	-5.2	1.6e-07	-0.66	0.96	0.04	FALSE
42	IL	Mrpl10	gene expression	ENSRNOG00000009567	0.45	0.14	lasso	5	0.21	7.1e-06	6.1	5.8	8.5e-09	0.91	0.40	0.58	FALSE
43	IL	Mrpl45	gene expression	ENSRNOG00000010540	0.87	0.42	lasso	7	0.42	3.2e-11	6.4	6.0	1.7e-09	0.97	0.13	0.87	FALSE
44	IL	NA	gene expression	ENSRNOG00000069592	0.46	0.26	blup	1422	0.31	3.5e-08	4.9	-5.3	1.2e-07	-0.57	0.46	0.54	FALSE
45	IL	Mrpl45	intron excision ratio	chr10:82310718:82313694	0.31	0.13	top1	1	0.13	5.0e-04	6.4	6.4	1.7e-10	0.81	0.05	0.09	FALSE
46	IL	Mrpl45	intron excision ratio	chr10:82310797:82313694	0.32	0.13	top1	1	0.13	4.4e-04	6.4	-6.4	1.3e-10	-0.81	0.05	0.10	TRUE
47	IL	Cdk5rap3	mRNA stability	ENSRNOG00000048747	0.26	0.07	blup	938	0.10	2.3e-03	4.5	5.3	1.2e-07	0.82	0.45	0.23	FALSE
48	LHb	Mrpl45	gene expression	ENSRNOG00000010540	0.87	0.44	enet	11	0.48	6.7e-13	6.3	6.3	3.3e-10	0.98	0.13	0.87	FALSE
49	LHb	NA	gene expression	ENSRNOG00000069592	0.31	0.18	blup	1421	0.21	1.1e-05	5.0	-5.2	1.8e-07	-0.55	0.51	0.47	FALSE
50	Liver	Ube2z	gene expression	ENSRNOG00000006868	0.04	0.03	top1	1	0.03	2.6e-04	5.4	5.4	5.8e-08	0.58	0.13	0.24	FALSE
51	Liver	Atp5mc1	gene expression	ENSRNOG00000007235	0.08	0.07	top1	1	0.07	2.0e-08	5.5	5.5	3.7e-08	0.58	0.23	0.77	FALSE
52	Liver	Kpnb1	gene expression	ENSRNOG00000009275	0.06	0.05	blup	867	0.06	8.0e-07	6.2	5.9	4.5e-09	0.90	0.19	0.81	FALSE
53	Liver	Sp2	gene expression	ENSRNOG00000010492	0.05	0.07	blup	881	0.07	5.7e-08	4.6	5.2	1.9e-07	0.78	0.92	0.08	FALSE
54	Liver	Mrpl45	gene expression	ENSRNOG00000010540	0.66	0.54	lasso	25	0.56	2.6e-74	6.4	6.2	4.1e-10	0.96	0.14	0.86	FALSE
55	Liver	Prr15l	gene expression	ENSRNOG00000049162	0.05	0.04	blup	943	0.06	5.2e-07	4.7	5.4	6.1e-08	0.82	0.61	0.39	FALSE
56	Liver	Psmb3	gene expression	ENSRNOG00000052730	0.15	0.02	top1	1	0.02	3.4e-03	6.3	6.3	3.8e-10	0.84	0.04	0.08	FALSE
57	Liver	Phospho1	isoform ratio	ENSRNOT00000115688	0.02	0.01	blup	1424	0.02	2.2e-03	4.9	-5.5	4.3e-08	-0.56	0.50	0.23	FALSE
58	Liver	Ube2z	mRNA stability	ENSRNOG00000006868	0.03	0.03	enet	65	0.03	1.4e-04	4.9	5.3	1.4e-07	0.55	0.60	0.39	FALSE
59	Liver	Sp2	mRNA stability	ENSRNOG00000010492	0.02	0.02	blup	881	0.02	9.0e-04	6.3	5.6	2.3e-08	0.85	0.27	0.62	FALSE
60	NAcc	Tbkbp1	gene expression	ENSRNOG00000009370	0.88	0.27	top1	1	0.27	1.2e-06	6.4	-6.4	1.3e-10	-0.91	0.07	0.55	FALSE
61	NAcc	Mrpl45	gene expression	ENSRNOG00000010540	0.87	0.25	blup	858	0.29	2.6e-07	6.2	6.4	1.8e-10	0.99	0.14	0.86	FALSE
62	NAcc	Mrpl45	intron excision ratio	chr10:82310797:82313694	0.29	0.03	lasso	3	0.04	4.3e-02	6.4	-5.3	8.9e-08	-0.88	0.14	0.30	FALSE
63	NAcc2	Cbx1	gene expression	ENSRNOG00000008689	0.29	0.11	top1	1	0.11	1.5e-06	5.2	-5.2	2.2e-07	-0.71	0.78	0.02	FALSE
64	NAcc2	Tbkbp1	gene expression	ENSRNOG00000009370	0.27	0.16	enet	85	0.18	5.1e-10	6.1	-5.6	1.8e-08	-0.88	0.13	0.87	FALSE
65	NAcc2	Mrpl45	gene expression	ENSRNOG00000010540	0.75	0.59	lasso	21	0.61	8.1e-41	6.2	6.2	5.0e-10	0.98	0.13	0.87	FALSE
66	NAcc2	Npepps	gene expression	ENSRNOG00000023095	0.10	0.04	blup	860	0.05	7.3e-04	4.6	5.6	2.8e-08	0.88	0.37	0.53	FALSE
67	OFC	Nfe2l1	alternative TSS	ENSRNOT00000067542	0.24	0.07	enet	8	0.10	2.0e-03	4.5	5.7	1.4e-08	0.76	0.25	0.44	FALSE
68	OFC	Mrpl45	gene expression	ENSRNOG00000010540	0.88	0.48	top1	1	0.48	3.6e-13	6.4	6.4	2.0e-10	0.90	0.12	0.88	FALSE
69	OFC	Npepps	gene expression	ENSRNOG00000023095	0.40	0.14	top1	1	0.14	4.3e-04	6.1	6.1	1.1e-09	0.88	0.06	0.07	FALSE
70	OFC	Skap1	gene expression	ENSRNOG00000023881	0.21	0.14	top1	1	0.14	3.6e-04	5.2	5.2	2.2e-07	0.66	0.07	0.06	FALSE
71	OFC	Snx11	isoform ratio	ENSRNOT00000011474	0.25	0.07	top1	1	0.07	8.1e-03	6.4	6.4	1.9e-10	0.74	0.06	0.08	FALSE
72	OFC	Snx11	isoform ratio	ENSRNOT00000089146	0.15	0.04	blup	1021	0.05	3.0e-02	6.4	-5.5	3.0e-08	-0.80	0.24	0.41	FALSE
73	OFC	Mrpl45	intron excision ratio	chr10:82310718:82313694	0.30	0.11	top1	1	0.11	1.5e-03	6.3	6.3	3.5e-10	0.89	0.05	0.08	FALSE
74	OFC	Mrpl45	intron excision ratio	chr10:82310797:82313694	0.33	0.12	top1	1	0.12	7.4e-04	6.3	-6.3	3.5e-10	-0.89	0.05	0.09	FALSE
75	PL	Nfe2l1	gene expression	ENSRNOG00000008830	0.72	0.44	blup	1031	0.46	2.8e-12	4.5	-5.2	1.8e-07	-0.76	0.99	0.01	FALSE
76	PL	Mrpl10	gene expression	ENSRNOG00000009567	0.35	0.12	blup	883	0.18	4.2e-05	6.2	5.6	2.2e-08	0.87	0.47	0.51	FALSE
77	PL	Mrpl45	gene expression	ENSRNOG00000010540	0.92	0.54	top1	1	0.54	4.6e-15	6.2	6.2	4.7e-10	0.88	0.23	0.76	FALSE
78	PL	Npepps	gene expression	ENSRNOG00000023095	0.50	0.05	lasso	3	0.07	8.0e-03	6.2	6.0	2.7e-09	0.99	0.13	0.69	FALSE
79	PL	Skap1	gene expression	ENSRNOG00000023881	0.19	0.12	lasso	2	0.13	7.0e-04	4.5	5.3	1.1e-07	0.17	0.46	0.36	TRUE
80	PL	Mrpl45	intron excision ratio	chr10:82310718:82313694	0.50	0.15	top1	1	0.15	2.1e-04	6.4	6.4	1.3e-10	0.92	0.05	0.16	FALSE
81	PL	Mrpl45	intron excision ratio	chr10:82310797:82313694	0.52	0.16	top1	1	0.16	1.0e-04	6.4	-6.4	1.3e-10	-0.92	0.05	0.19	FALSE
82	PL2	Psmb3	alternative TSS	ENSRNOT00000105409	0.17	0.03	enet	14	0.05	1.2e-03	6.1	5.3	1.5e-07	0.87	0.21	0.65	FALSE
83	PL2	Ttll6	gene expression	ENSRNOG00000004939	0.10	0.06	blup	1486	0.06	2.4e-04	4.8	-5.1	2.6e-07	-0.61	0.61	0.39	FALSE
84	PL2	Mrpl45	gene expression	ENSRNOG00000010540	0.81	0.56	lasso	24	0.57	2.3e-37	6.1	6.2	6.5e-10	0.99	0.13	0.87	FALSE
85	PL2	Npepps	gene expression	ENSRNOG00000023095	0.29	0.12	top1	1	0.12	2.9e-07	6.4	6.4	1.8e-10	0.92	0.10	0.81	FALSE
86	PL2	Skap1	gene expression	ENSRNOG00000023881	0.27	0.17	lasso	3	0.18	2.6e-10	5.3	5.2	1.6e-07	0.65	0.40	0.60	FALSE
87	PL2	Prr15l	gene expression	ENSRNOG00000049162	0.06	0.03	top1	1	0.03	1.4e-02	6.4	6.4	1.8e-10	0.78	0.04	0.07	FALSE
88	PL2	B4galnt2	gene expression	ENSRNOG00000067203	0.07	0.06	blup	1405	0.06	2.2e-04	4.9	-5.1	2.8e-07	-0.56	0.58	0.40	FALSE
89	PL2	Psmb3	isoform ratio	ENSRNOT00000112080	0.09	0.03	top1	1	0.03	1.2e-02	6.3	-6.3	3.9e-10	-0.58	0.04	0.05	FALSE
90	PL2	Mrpl45	intron excision ratio	chr10:82310718:82313694	0.11	0.02	top1	1	0.02	1.9e-02	6.2	6.2	4.5e-10	0.90	0.04	0.06	FALSE
91	PL2	Mrpl45	mRNA stability	ENSRNOG00000010540	0.31	0.13	top1	1	0.13	2.0e-07	6.3	6.3	3.6e-10	0.85	0.18	0.76	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.