Hub : Traits : dissection: UMAP 3 of all traits : ← →

chr7:27,898,185-30,904,027

Best TWAS P=8.86207e-12 · Best GWAS P=3.359549e-13 conditioned to 0

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	BLA	Nudt4	gene expression	ENSRNOG00000009094	0.46	0.35	lasso	64	0.38	1.9e-21	-4.7	-5.2	1.5e-07	-0.30	1.00	0.00	TRUE
2	BLA	Plxnc1	mRNA stability	ENSRNOG00000007970	0.11	0.11	top1	1	0.11	3.0e-06	6.2	-6.2	6.5e-10	-0.61	0.32	0.15	FALSE
3	Brain	Socs2	gene expression	ENSRNOG00000008965	0.22	0.09	enet	118	0.11	5.0e-10	6.2	-5.6	2.2e-08	-0.51	0.07	0.93	TRUE
4	Brain	Nudt4	gene expression	ENSRNOG00000009094	0.86	0.63	lasso	57	0.74	8.6e-100	-4.4	-5.1	2.9e-07	0.00	1.00	0.00	TRUE
5	LHb	Plxnc1	gene expression	ENSRNOG00000007970	0.41	0.09	blup	3118	0.22	7.2e-06	4.5	5.5	3.9e-08	0.58	0.77	0.19	FALSE
6	LHb	Vezt	mRNA stability	ENSRNOG00000006514	0.40	0.20	enet	84	0.21	1.1e-05	4.7	-5.1	2.9e-07	-0.71	0.38	0.62	FALSE
7	Liver	Socs2	mRNA stability	ENSRNOG00000008965	0.04	0.02	blup	3463	0.02	5.8e-03	-5.5	5.4	5.3e-08	0.43	0.82	0.03	TRUE
8	NAcc	Nudt4	gene expression	ENSRNOG00000009094	0.44	0.08	enet	7	0.12	1.4e-03	4.5	-5.2	1.5e-07	-0.40	0.73	0.05	FALSE
9	OFC	Socs2	isoform ratio	ENSRNOT00000103867	0.33	0.15	top1	1	0.15	2.3e-04	-5.2	5.2	1.7e-07	0.03	0.15	0.05	TRUE
10	PL2	Socs2	gene expression	ENSRNOG00000008965	0.09	0.04	top1	1	0.04	3.6e-03	6.7	-6.7	2.8e-11	-0.71	0.13	0.06	TRUE
11	PL2	Nudt4	gene expression	ENSRNOG00000009094	0.67	0.55	enet	88	0.56	5.9e-36	4.6	-5.2	2.1e-07	-0.35	1.00	0.00	TRUE
12	PL2	Socs2	intron excision ratio	chr7:29987686:30043188	0.06	0.01	enet	66	0.01	5.2e-02	4.3	6.8	8.9e-12	0.66	0.49	0.29	TRUE
13	PL2	Socs2	intron excision ratio	chr7:30015321:30041048	0.06	0.00	blup	3386	0.03	8.8e-03	4.2	5.8	7.6e-09	0.58	0.51	0.18	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.