Best TWAS P=5.75e-10 · Best GWAS P=4.32e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Pet100 | alternative TSS | ENSRNOT00000071928 | 0.22 | 116 | 0.13 | 3.4e-14 | 5.35 | 8.78e-08 | 0.72 | FALSE |
| Adipose | Pet100 | alternative TSS | ENSRNOT00000107172 | 0.22 | 122 | 0.13 | 2.6e-14 | -5.34 | 9.54e-08 | 0.71 | FALSE |
| Adipose | Xab2 | gene expression | ENSRNOG00000000988 | 0.14 | 1 | 0.05 | 2.2e-06 | -5.17 | 2.34e-07 | 0.7 | FALSE |
| Adipose | Trappc5 | gene expression | ENSRNOG00000001003 | 0.09 | 1 | 0.03 | 9.9e-05 | -5.21 | 1.85e-07 | 0.24 | FALSE |
| Adipose | Evi5l | gene expression | ENSRNOG00000001034 | 0.09 | 1 | -0 | 4.2e-01 | 5.36 | 8.26e-08 | 0.04 | FALSE |
| Adipose | Insr | gene expression | ENSRNOG00000029986 | 0.13 | 1 | 0.02 | 4.3e-03 | 5.23 | 1.66e-07 | 0.04 | FALSE |
| Adipose | Pet100 | isoform ratio | ENSRNOT00000071928 | 0.23 | 64 | 0.13 | 1.8e-14 | 5.43 | 5.73e-08 | 0.74 | FALSE |
| Adipose | Pet100 | isoform ratio | ENSRNOT00000107172 | 0.23 | 66 | 0.13 | 2.6e-14 | -5.43 | 5.49e-08 | 0.75 | FALSE |
| Adipose | Zfp958 | isoform ratio | ENSRNOT00000102786 | 0.03 | 169 | 0.01 | 6.9e-03 | 5.22 | 1.78e-07 | 0.46 | FALSE |
| Adipose | Zfp958 | intron excision ratio | chr12:3971128:3971331 | 0.03 | 1113 | 0.01 | 2.8e-02 | 5.48 | 4.20e-08 | 0.39 | FALSE |
| Adipose | Snapc2 | mRNA stability | ENSRNOG00000001056 | 0.11 | 19 | 0.01 | 5.0e-02 | -5.09 | 3.55e-07 | 0.06 | FALSE |
| Adipose | Elavl1 | mRNA stability | ENSRNOG00000001069 | 0.16 | 2406 | 0.07 | 9.4e-09 | 5.6 | 2.11e-08 | 0.75 | TRUE |
| BLA | Pet100 | alternative TSS | ENSRNOT00000110166 | 0.11 | 1 | 0.05 | 7.7e-04 | -5.27 | 1.35e-07 | 0.06 | FALSE |
| BLA | Stard13 | gene expression | ENSRNOG00000001090 | 0.17 | 1 | 0.13 | 2.4e-07 | 5.63 | 1.81e-08 | 0.85 | FALSE |
| BLA | Insr | gene expression | ENSRNOG00000029986 | 0.59 | 1546 | 0.39 | 5.5e-22 | 5.1 | 3.32e-07 | 0.72 | FALSE |
| BLA | Camsap3 | isoform ratio | ENSRNOT00000096347 | 0.13 | 20 | 0.03 | 9.2e-03 | -5.18 | 2.27e-07 | 0.71 | FALSE |
| BLA | Camsap3 | isoform ratio | ENSRNOT00000101379 | 0.13 | 1 | 0.06 | 4.4e-04 | 5.27 | 1.35e-07 | 0.08 | TRUE |
| BLA | Pet100 | intron excision ratio | chr12:1680794:1680963 | 0.36 | 13 | 0.19 | 1.7e-10 | -5.7 | 1.21e-08 | 0.76 | FALSE |
| BLA | Pet100 | intron excision ratio | chr12:1680995:1681508 | 0.35 | 11 | 0.2 | 9.8e-11 | 5.63 | 1.78e-08 | 0.75 | FALSE |
| BLA | ENSRNOG00000068541 | intron excision ratio | chr12:3870992:3873703 | 0.08 | 1116 | 0.04 | 3.3e-03 | -5.15 | 2.57e-07 | 0.63 | FALSE |
| BLA | Cers4 | mRNA stability | ENSRNOG00000001072 | 0.16 | 2109 | 0.08 | 5.0e-05 | 5.26 | 1.44e-07 | 0.66 | FALSE |
| BLA | Stard13 | mRNA stability | ENSRNOG00000001090 | 0.08 | 1438 | 0.05 | 1.3e-03 | 5.5 | 3.88e-08 | 0.45 | FALSE |
| Brain | ENSRNOG00000068541 | alternative TSS | ENSRNOT00000115928 | 0.08 | 60 | 0.05 | 1.4e-05 | 5.1 | 3.48e-07 | 0.23 | FALSE |
| Brain | Pcp2 | gene expression | ENSRNOG00000000993 | 0.12 | 1 | 0.1 | 1.8e-09 | 5.1 | 3.47e-07 | 0.67 | FALSE |
| Brain | Elavl1 | gene expression | ENSRNOG00000001069 | 0.07 | 2406 | 0.02 | 4.4e-03 | -5.56 | 2.75e-08 | 0.62 | FALSE |
| Brain | Arhgef18 | gene expression | ENSRNOG00000028090 | 0.12 | 11 | 0.08 | 1.2e-07 | -5.68 | 1.31e-08 | 0.73 | FALSE |
| Brain | Trappc5 | intron excision ratio | chr12:1737769:1740114 | 0.05 | 18 | 0.03 | 5.1e-04 | -6.2 | 5.75e-10 | 0.56 | TRUE |
| Brain | ENSRNOG00000068541 | intron excision ratio | chr12:3870992:3873703 | 0.13 | 14 | 0.1 | 1.0e-09 | -5.23 | 1.72e-07 | 0.74 | FALSE |
| Brain | Elavl1 | mRNA stability | ENSRNOG00000001069 | 0.19 | 22 | 0.07 | 2.6e-07 | 5.37 | 7.98e-08 | 0.73 | FALSE |
| Eye | Elavl1 | intron excision ratio | chr12:2667464:2684652 | 0.69 | 30 | 0.31 | 1.3e-05 | 5.74 | 9.28e-09 | 0.61 | FALSE |
| IL | Zfp958l1 | alternative TSS | ENSRNOT00000035992 | 0.2 | 1 | 0 | 2.5e-01 | 5.1 | 3.42e-07 | 0.05 | FALSE |
| IL | Zfp958l1 | alternative TSS | ENSRNOT00000119165 | 0.19 | 1 | 0.02 | 1.3e-01 | -5.1 | 3.42e-07 | 0.05 | FALSE |
| IL | Insr | intron excision ratio | chr12:1257822:1307450 | 0.73 | 1 | 0.5 | 6.5e-14 | 5.3 | 1.14e-07 | 0.82 | FALSE |
| IL | N4bp2l2 | mRNA stability | ENSRNOG00000001108 | 0.16 | 1 | 0.08 | 4.7e-03 | 5.16 | 2.49e-07 | 0.28 | FALSE |
| Liver | N4bp2l2 | alternative polyA | ENSRNOT00000111844 | 0.1 | 681 | 0.07 | 2.3e-08 | 5.55 | 2.79e-08 | 0.81 | FALSE |
| Liver | N4bp2l2 | alternative polyA | ENSRNOT00000118063 | 0.1 | 681 | 0.07 | 1.5e-08 | -5.58 | 2.34e-08 | 0.81 | FALSE |
| Liver | Mcoln1 | gene expression | ENSRNOG00000000975 | 0.09 | 39 | 0.04 | 1.7e-05 | 5.19 | 2.06e-07 | 0.78 | FALSE |
| Liver | Stxbp2 | isoform ratio | ENSRNOT00000107607 | 0.15 | 10 | 0.09 | 5.9e-10 | -5.56 | 2.75e-08 | 0.68 | FALSE |
| Liver | Stxbp2 | isoform ratio | ENSRNOT00000115749 | 0.1 | 1 | 0.05 | 6.9e-06 | 5.25 | 1.55e-07 | 0.7 | FALSE |
| Liver | N4bp2l1 | isoform ratio | ENSRNOT00000110394 | 0.06 | 587 | 0.04 | 6.9e-05 | 5.58 | 2.37e-08 | 0.8 | FALSE |
| Liver | Pet100 | intron excision ratio | chr12:1680794:1680963 | 0.21 | 1823 | 0.09 | 1.9e-10 | -5.71 | 1.13e-08 | 0.66 | FALSE |
| Liver | Zfp958 | intron excision ratio | chr12:3971128:3971331 | 0.07 | 1 | 0.03 | 7.0e-04 | 5.13 | 2.84e-07 | 0.09 | FALSE |
| Liver | ENSRNOG00000068541 | intron excision ratio | chr12:3870992:3871195 | 0.09 | 1 | 0.04 | 1.0e-05 | 5.22 | 1.75e-07 | 0.39 | TRUE |
| Liver | ENSRNOG00000068541 | intron excision ratio | chr12:3870992:3873703 | 0.18 | 1 | 0.1 | 7.7e-11 | -5.15 | 2.65e-07 | 0.69 | FALSE |
| Liver | ENSRNOG00000068541 | intron excision ratio | chr12:3871255:3873703 | 0.14 | 1 | 0.09 | 6.4e-10 | 5.13 | 2.84e-07 | 0.67 | FALSE |
| Liver | Elavl1 | mRNA stability | ENSRNOG00000001069 | 0.16 | 4 | 0.05 | 3.3e-06 | 5.41 | 6.21e-08 | 0.75 | FALSE |
| NAcc | Pet100 | alternative TSS | ENSRNOT00000071928 | 0.08 | 1 | 0.03 | 1.4e-03 | 5.16 | 2.51e-07 | 0.13 | FALSE |
| NAcc | Stxbp2 | gene expression | ENSRNOG00000000994 | 0.1 | 1 | 0.07 | 9.6e-06 | -5.16 | 2.51e-07 | 0.28 | FALSE |
| NAcc | Arhgef18 | gene expression | ENSRNOG00000028090 | 0.13 | 1531 | 0.08 | 1.3e-06 | -5.65 | 1.59e-08 | 0.51 | FALSE |
| NAcc | Lrrc8e | gene expression | ENSRNOG00000028460 | 0.31 | 12 | 0.07 | 1.2e-05 | -5.53 | 3.13e-08 | 0.77 | FALSE |
| NAcc | Trappc5 | isoform ratio | ENSRNOT00000001327 | 0.11 | 38 | 0.04 | 2.9e-04 | -5.58 | 2.45e-08 | 0.78 | FALSE |
| NAcc | Trappc5 | isoform ratio | ENSRNOT00000111016 | 0.09 | 29 | 0.03 | 5.1e-03 | 5.49 | 4.02e-08 | 0.75 | FALSE |
| NAcc | ENSRNOG00000068541 | intron excision ratio | chr12:3871255:3873703 | 0.06 | 1 | 0.05 | 1.7e-04 | 5.19 | 2.07e-07 | 0.12 | FALSE |
| NAcc | Snapc2 | mRNA stability | ENSRNOG00000001056 | 0.13 | 1 | 0.06 | 1.3e-05 | -5.36 | 8.30e-08 | 0.57 | FALSE |
| NAcc | Brca2 | mRNA stability | ENSRNOG00000001111 | 0.14 | 42 | 0.09 | 4.2e-07 | 5.17 | 2.30e-07 | 0.88 | FALSE |
| OFC | Stxbp2 | gene expression | ENSRNOG00000000994 | 0.43 | 1 | 0.14 | 2.8e-04 | -5.21 | 1.84e-07 | 0.07 | FALSE |
| OFC | Snapc2 | gene expression | ENSRNOG00000001056 | 0.54 | 2272 | 0.12 | 1.0e-03 | -5.1 | 3.42e-07 | 0.08 | FALSE |
| OFC | Insr | intron excision ratio | chr12:1257822:1307450 | 0.64 | 1 | 0.28 | 2.2e-07 | 5.3 | 1.14e-07 | 0.61 | FALSE |
| PL | Stxbp2 | gene expression | ENSRNOG00000000994 | 0.13 | 1819 | 0.06 | 2.6e-05 | -5.1 | 3.47e-07 | 0.62 | FALSE |
| PL | Pet100 | intron excision ratio | chr12:1679962:1680708 | 0.08 | 1 | 0.03 | 3.6e-03 | -5.17 | 2.34e-07 | 0.1 | FALSE |
| PL | Pet100 | intron excision ratio | chr12:1680171:1680708 | 0.09 | 1 | 0.03 | 1.3e-03 | 5.15 | 2.61e-07 | 0.1 | FALSE |
| PL | Pet100 | intron excision ratio | chr12:1680794:1680963 | 0.49 | 1822 | 0.18 | 2.5e-13 | -5.74 | 9.70e-09 | 0.76 | TRUE |
| PL | Pet100 | intron excision ratio | chr12:1680995:1681508 | 0.38 | 17 | 0.16 | 1.8e-12 | 5.12 | 3.00e-07 | 0.76 | TRUE |
| PL | N4bp2l2 | mRNA stability | ENSRNOG00000001108 | 0.05 | 1 | 0.04 | 2.7e-04 | -5.6 | 2.16e-08 | 0.28 | FALSE |