Best TWAS P=5.733758e-09 · Best GWAS P=6.125104e-08 conditioned to 0.3024685
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Mtus2 | gene expression | ENSRNOG00000032410 | 0.04 | 0.04 | top1 | 1 | 0.04 | 7.3e-05 | 5.1 | 5.1 | 3.3e-07 | 0.85 | 0.12 | 0.21 | FALSE |
| 2 | Adipose | Slc7a1 | mRNA stability | ENSRNOG00000000924 | 0.08 | 0.06 | top1 | 1 | 0.06 | 4.2e-07 | 5.3 | 5.3 | 1.1e-07 | 0.82 | 0.11 | 0.88 | FALSE |
| 3 | Brain | Slc7a1 | mRNA stability | ENSRNOG00000000924 | 0.21 | 0.16 | enet | 174 | 0.16 | 4.3e-15 | 5.2 | 5.8 | 5.7e-09 | 0.83 | 0.26 | 0.74 | TRUE |
| 4 | NAcc | Slc7a1 | mRNA stability | ENSRNOG00000000924 | 0.11 | 0.12 | top1 | 1 | 0.12 | 4.2e-09 | 5.1 | 5.1 | 2.8e-07 | 0.83 | 0.24 | 0.76 | FALSE |
| 5 | PL | Slc7a1 | mRNA stability | ENSRNOG00000000924 | 0.13 | 0.12 | top1 | 1 | 0.12 | 4.3e-09 | 5.1 | 5.1 | 3.3e-07 | 0.84 | 0.27 | 0.73 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.