Best TWAS P=1.073404e-07 · Best GWAS P=2.449396e-07 conditioned to 1
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | Csnk1d | alternative polyA | ENSRNOT00000106442 | 0.03 | 0.02 | blup | 1650 | 0.02 | 4.4e-03 | -4.8 | -5.1 | 3.4e-07 | 0.97 | 0.31 | 0.63 | FALSE |
2 | Adipose | Ogfod3 | gene expression | ENSRNOG00000036668 | 0.08 | 0.07 | enet | 6 | 0.08 | 6.7e-09 | -4.9 | 5.3 | 1.1e-07 | -0.91 | 0.31 | 0.69 | FALSE |
3 | BLA | Slc16a3 | gene expression | ENSRNOG00000036677 | 0.06 | 0.04 | blup | 1767 | 0.05 | 1.6e-03 | -4.7 | -5.1 | 3.0e-07 | 0.95 | 0.35 | 0.54 | FALSE |
4 | Brain | Ccdc57 | gene expression | ENSRNOG00000047531 | 0.17 | 0.16 | lasso | 2 | 0.17 | 3.5e-15 | -4.9 | -5.1 | 3.4e-07 | 0.94 | 0.36 | 0.64 | FALSE |
5 | Liver | Dus1l | gene expression | ENSRNOG00000047905 | 0.07 | 0.02 | enet | 95 | 0.04 | 1.8e-05 | -5.0 | -5.3 | 1.1e-07 | 0.98 | 0.45 | 0.55 | TRUE |
6 | Liver | Sectm1b | mRNA stability | ENSRNOG00000036673 | 0.05 | 0.01 | blup | 1573 | 0.03 | 9.8e-05 | -4.9 | -5.1 | 3.2e-07 | 0.89 | 0.37 | 0.62 | FALSE |
7 | NAcc | Ccdc57 | gene expression | ENSRNOG00000047531 | 0.06 | 0.03 | blup | 1793 | 0.05 | 1.2e-04 | -5.0 | -5.1 | 3.1e-07 | 0.96 | 0.42 | 0.57 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.