Best TWAS P=2.78e-09 · Best GWAS P=3.01e-08 conditioned to NaN
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Ddr1 | alternative TSS | NM_001166022.1 | 0.03 | 1269 | 0.01 | 8.3e-03 | 5.24 | 1.62e-07 | 0.2 | FALSE |
| Adipose | Ddr1 | alternative TSS | NM_001166022.1 | 0.02 | 1269 | 0.01 | 8.9e-03 | 5.2 | 2.01e-07 | 0.19 | FALSE |
| Adipose | Gnl1 | gene expression | Gnl1 | 0.07 | 8 | 0.06 | 1.8e-07 | -5.33 | 9.95e-08 | 0.31 | FALSE |
| Adipose | LOC108353253 | isoform ratio | XR_005497429.1 | 0.61 | 2434 | 0.3 | 4.7e-34 | -5.34 | 9.25e-08 | 0.59 | TRUE |
| Adipose | Phf1 | isoform ratio | NM_001414742.1 | 0.67 | 46 | 0.09 | 5.4e-10 | -5.67 | 1.47e-08 | 0.12 | FALSE |
| Adipose | LOC120093125 | intron excision ratio | chr20_2617755_2617906 | 0.08 | 903 | 0.01 | 2.6e-02 | 5.21 | 1.94e-07 | 0.51 | FALSE |
| Adipose | LOC120093125 | intron excision ratio | chr20_2617755_2626735 | 0.08 | 903 | 0.01 | 2.7e-02 | 5.19 | 2.08e-07 | 0.51 | FALSE |
| Adipose | LOC120093125 | intron excision ratio | chr20_2624215_2624418 | 0.46 | 903 | 0.08 | 2.5e-09 | -5.41 | 6.20e-08 | 0.42 | FALSE |
| Adipose | LOC120093125 | intron excision ratio | chr20_2626584_2635694 | 0.29 | 903 | 0.05 | 5.5e-06 | -5.28 | 1.30e-07 | 0.75 | FALSE |
| Adipose | LOC120093125 | intron excision ratio | chr20_2626584_2657802 | 0.36 | 903 | 0.06 | 2.0e-07 | -5.25 | 1.51e-07 | 0.76 | FALSE |
| Adipose | LOC120093125 | intron excision ratio | chr20_2670814_2671007 | 0.36 | 903 | 0.07 | 2.7e-08 | 5.25 | 1.55e-07 | 0.75 | FALSE |
| Adipose | RT1-CE10 | intron excision ratio | chr20_3298776_3357504 | 0.56 | 2843 | 0.01 | 5.6e-02 | -5.19 | 2.13e-07 | 0.12 | FALSE |
| Adipose | RT1-CE11 | intron excision ratio | chr20_3258719_3357504 | 0.57 | 2800 | 0.01 | 3.8e-02 | -5.19 | 2.15e-07 | 0.14 | FALSE |
| Adipose | RT1-CE11 | intron excision ratio | chr20_3277094_3357504 | 0.57 | 2800 | 0.01 | 3.7e-02 | -5.18 | 2.19e-07 | 0.14 | FALSE |
| Adipose | RT1-CE11 | intron excision ratio | chr20_3298776_3357504 | 0.57 | 2800 | 0.01 | 5.8e-02 | -5.21 | 1.91e-07 | 0.13 | FALSE |
| Adipose | RT1-CE12 | intron excision ratio | chr20_3258719_3357504 | 0.58 | 2760 | 0.01 | 3.9e-02 | -5.18 | 2.18e-07 | 0.14 | FALSE |
| Adipose | RT1-CE12 | intron excision ratio | chr20_3277094_3357504 | 0.58 | 2760 | 0.01 | 3.8e-02 | -5.18 | 2.22e-07 | 0.14 | FALSE |
| Adipose | RT1-CE5 | intron excision ratio | chr20_3436430_3478842 | 0.9 | 26 | 0.1 | 2.1e-11 | 5.51 | 3.52e-08 | 0.56 | FALSE |
| Adipose | RT1-S3 | intron excision ratio | chr20_2670814_2671007 | 0.26 | 1075 | 0.07 | 5.2e-08 | 5.27 | 1.36e-07 | 0.69 | FALSE |
| Adipose | RT1-T24-4 | intron excision ratio | chr20_2691672_2691881 | 0.49 | 1129 | 0.07 | 3.2e-08 | 5.4 | 6.67e-08 | 0.32 | FALSE |
| Adipose | Taf11 | intron excision ratio | chr20_5956380_5957018 | 0.12 | 1 | 0.01 | 4.2e-02 | 5.25 | 1.48e-07 | 0.06 | FALSE |
| BLA | Lst1 | alternative TSS | NM_022634.2 | 0.1 | 15 | 0.04 | 5.4e-03 | 5.2 | 2.02e-07 | 0.1 | TRUE |
| BLA | Lst1 | alternative TSS | XM_006256080.4 | 0.1 | 15 | 0.04 | 5.3e-03 | -5.2 | 1.96e-07 | 0.1 | FALSE |
| BLA | RT1-N3 | alternative TSS | NM_001008855.2 | 0.46 | 34 | 0.18 | 9.7e-10 | -5.18 | 2.24e-07 | 0.56 | FALSE |
| BLA | Dhx16 | gene expression | Dhx16 | 0.12 | 1315 | 0.06 | 3.1e-04 | -5.46 | 4.85e-08 | 0.29 | FALSE |
| BLA | RT1-T24-2 | gene expression | RT1-T24-2 | 0.23 | 1239 | 0.17 | 1.6e-09 | -5.35 | 8.94e-08 | 0.31 | FALSE |
| BLA | Cchcr1 | isoform ratio | XM_039098942.1 | 0.09 | 2249 | 0.02 | 3.2e-02 | 5.34 | 9.30e-08 | 0.23 | FALSE |
| BLA | RT1-M6-2 | isoform ratio | XM_017601696.2 | 0.08 | 2861 | 0.04 | 5.7e-03 | -5.19 | 2.09e-07 | 0.34 | FALSE |
| BLA | RT1-N3 | isoform ratio | XM_006255908.4 | 0.51 | 27 | 0.27 | 7.9e-15 | 5.26 | 1.47e-07 | 0.44 | FALSE |
| Brain | Dhx16 | alternative polyA | XM_039098481.1 | 0.22 | 1315 | 0.13 | 5.7e-12 | 5.54 | 3.10e-08 | 0.3 | TRUE |
| Brain | LOC120093125 | alternative polyA | XM_039099257.1 | 0.17 | 948 | 0.14 | 5.8e-13 | -5.32 | 1.04e-07 | 0.41 | FALSE |
| Brain | LOC120093125 | alternative polyA | XM_039099257.1 | 0.17 | 948 | 0.14 | 1.3e-12 | -5.33 | 1.00e-07 | 0.4 | FALSE |
| Brain | Neu1 | alternative TSS | NM_031522.3 | 0.12 | 32 | 0.06 | 1.8e-06 | 5.2 | 1.94e-07 | 0.44 | FALSE |
| Brain | Neu1 | alternative TSS | XM_039098415.1 | 0.12 | 33 | 0.06 | 1.3e-06 | -5.22 | 1.79e-07 | 0.45 | FALSE |
| Brain | RT1-N3 | alternative TSS | XM_039098420.1 | 0.72 | 12 | 0.15 | 3.3e-14 | 5.22 | 1.80e-07 | 0.68 | FALSE |
| Brain | RT1-CE13 | gene expression | RT1-CE13 | 0.16 | 2580 | 0.1 | 2.3e-09 | -5.39 | 7.24e-08 | 0.48 | FALSE |
| Brain | LOC120093125 | isoform ratio | XM_039099258.1 | 0.26 | 7 | 0.15 | 1.9e-13 | 5.37 | 7.97e-08 | 0.54 | FALSE |
| Brain | RT1-N2 | isoform ratio | XM_039098783.1 | 0.28 | 17 | 0.36 | 2.8e-34 | -5.2 | 2.03e-07 | 0.4 | FALSE |
| Brain | RT1-S3 | isoform ratio | NM_001008886.2 | 0.05 | 1120 | 0.04 | 1.7e-04 | -5.43 | 5.69e-08 | 0.39 | FALSE |
| Brain | RT1-S3 | isoform ratio | XM_006255917.4 | 0.05 | 1120 | 0.04 | 1.4e-04 | 5.43 | 5.69e-08 | 0.4 | FALSE |
| Brain | Prr3 | intron excision ratio | chr20_2793415_2793683 | 0.05 | 1262 | 0.02 | 7.9e-03 | -5.25 | 1.51e-07 | 0.33 | FALSE |
| Brain | RT1-CE10 | intron excision ratio | chr20_3276101_3276342 | 0.25 | 28 | 0.14 | 1.5e-12 | -5.91 | 3.52e-09 | 0.25 | FALSE |
| Brain | RT1-CE14 | intron excision ratio | chr20_3276101_3276342 | 0.23 | 31 | 0.14 | 1.1e-12 | -5.93 | 3.11e-09 | 0.32 | FALSE |
| Brain | RT1-CE15 | intron excision ratio | chr20_3276101_3276342 | 0.23 | 21 | 0.14 | 1.2e-12 | -5.84 | 5.33e-09 | 0.36 | FALSE |
| Brain | RT1-CE16 | intron excision ratio | chr20_3276101_3276342 | 0.23 | 20 | 0.14 | 1.4e-12 | -5.78 | 7.69e-09 | 0.37 | FALSE |
| Eye | LOC120093125 | isoform ratio | XM_039099255.1 | 0.42 | 33 | 0.13 | 5.6e-03 | -5.43 | 5.66e-08 | 0.18 | TRUE |
| IL | LOC120093125 | alternative polyA | XM_039099255.1 | 0.4 | 948 | 0.17 | 6.9e-05 | 5.36 | 8.32e-08 | 0.38 | FALSE |
| IL | LOC120093125 | isoform ratio | XM_039099257.1 | 0.31 | 948 | 0.21 | 7.1e-06 | -5.36 | 8.35e-08 | 0.38 | FALSE |
| IL | RT1-N2 | isoform ratio | XM_039098786.1 | 0.64 | 10 | 0.36 | 1.2e-09 | 5.31 | 1.10e-07 | 0.4 | FALSE |
| IL | Abcf1 | intron excision ratio | chr20_2802656_2807786 | 0.25 | 1268 | 0.12 | 8.4e-04 | -5.34 | 9.10e-08 | 0.28 | FALSE |
| LHb | RT1-N3 | alternative TSS | XM_039098420.1 | 0.37 | 1052 | 0.17 | 9.0e-05 | -5.42 | 6.04e-08 | 0.36 | FALSE |
| LHb | Ilrun | gene expression | Ilrun | 0.81 | 1 | 0.27 | 3.3e-07 | 5.23 | 1.69e-07 | 0.58 | FALSE |
| LHb | RT1-CE4 | mRNA stability | RT1-CE4 | 0.49 | 280 | 0.19 | 2.7e-05 | -5.94 | 2.78e-09 | 0.14 | TRUE |
| Liver | LOC120093125 | alternative polyA | XM_039099255.1 | 0.38 | 17 | 0.15 | 3.0e-16 | 5.24 | 1.62e-07 | 0.42 | FALSE |
| Liver | LOC120093125 | alternative polyA | XM_039099257.1 | 0.47 | 26 | 0.22 | 4.3e-24 | -5.2 | 2.02e-07 | 0.41 | FALSE |
| Liver | LOC120093125 | alternative polyA | XM_039099255.1 | 0.35 | 19 | 0.18 | 4.6e-19 | 5.24 | 1.56e-07 | 0.41 | FALSE |
| Liver | LOC120093125 | alternative polyA | XM_039099257.1 | 0.41 | 160 | 0.19 | 6.2e-21 | 5.42 | 5.80e-08 | 0.41 | FALSE |
| Liver | LOC120098967 | alternative polyA | XR_005497790.1 | 0.09 | 1213 | 0.05 | 1.1e-06 | -5.27 | 1.33e-07 | 0.57 | FALSE |
| Liver | LOC120098967 | alternative polyA | XR_005497791.1 | 0.1 | 1213 | 0.06 | 9.0e-07 | 5.28 | 1.32e-07 | 0.56 | FALSE |
| Liver | RT1-N2 | alternative polyA | XM_017601671.2 | 0.83 | 22 | 0.22 | 5.7e-24 | 5.2 | 1.98e-07 | 0.41 | FALSE |
| Liver | Abcf1 | gene expression | Abcf1 | 0.14 | 1223 | 0.11 | 3.3e-12 | 5.28 | 1.29e-07 | 0.3 | FALSE |
| Liver | Abcf1 | isoform ratio | XM_017601783.2 | 0.06 | 1223 | 0.05 | 3.4e-06 | -5.21 | 1.91e-07 | 0.3 | FALSE |
| Liver | LOC120093125 | isoform ratio | XM_039099255.1 | 0.84 | 145 | 0.3 | 3.6e-33 | -5.21 | 1.92e-07 | 0.4 | FALSE |
| Liver | RT1-N2 | isoform ratio | XM_039098783.1 | 0.3 | 34 | 0.29 | 2.4e-32 | 5.23 | 1.66e-07 | 0.41 | FALSE |
| Liver | RT1-T24-4 | intron excision ratio | chr20_2741803_2741939 | 0.19 | 1129 | 0.03 | 7.2e-04 | -5.35 | 8.66e-08 | 0.28 | FALSE |
| NAcc | Dhx16 | alternative polyA | XM_039098481.1 | 0.14 | 1315 | 0.06 | 5.3e-08 | 5.78 | 7.42e-09 | 0.3 | FALSE |
| NAcc | RT1-N3 | alternative TSS | NM_001008855.2 | 0.06 | 1052 | 0.04 | 3.5e-05 | 5.2 | 1.95e-07 | 0.7 | FALSE |
| NAcc | RT1-N3 | alternative TSS | XM_039098420.1 | 0.19 | 32 | 0.17 | 1.4e-19 | -5.21 | 1.94e-07 | 0.34 | FALSE |
| NAcc | Nudt3 | gene expression | Nudt3 | 0.2 | 74 | 0.11 | 2.2e-12 | -5.31 | 1.09e-07 | 0.85 | FALSE |
| NAcc | RT1-N3 | isoform ratio | XM_039098420.1 | 0.27 | 17 | 0.24 | 2.7e-27 | -5.35 | 8.85e-08 | 0.34 | FALSE |
| NAcc | RT1-S3 | isoform ratio | NM_001008886.2 | 0.08 | 1120 | 0.05 | 3.4e-06 | -5.21 | 1.91e-07 | 0.68 | FALSE |
| NAcc | RT1-S3 | isoform ratio | XM_006255917.4 | 0.09 | 1120 | 0.05 | 2.6e-06 | 5.22 | 1.78e-07 | 0.68 | FALSE |
| NAcc | RT1-CE4 | mRNA stability | RT1-CE4 | 0.15 | 2968 | 0.07 | 3.4e-08 | 5.27 | 1.33e-07 | 0.06 | FALSE |
| OFC | RT1-N2 | alternative polyA | XM_017601671.2 | 0.43 | 999 | 0.3 | 6.7e-08 | 5.24 | 1.62e-07 | 0.39 | FALSE |
| OFC | RT1-CE13 | gene expression | RT1-CE13 | 0.23 | 2580 | 0.15 | 2.6e-04 | -5.25 | 1.51e-07 | 0.14 | FALSE |
| OFC | RT1-N2 | isoform ratio | XM_039098783.1 | 0.49 | 27 | 0.43 | 2.4e-11 | 5.19 | 2.12e-07 | 0.39 | FALSE |
| OFC | RT1-N3 | isoform ratio | XM_006255908.4 | 0.23 | 1052 | 0.09 | 4.4e-03 | 5.43 | 5.63e-08 | 0.35 | FALSE |
| OFC | RT1-N3 | isoform ratio | XM_039098420.1 | 0.24 | 1052 | 0.18 | 5.0e-05 | -5.36 | 8.32e-08 | 0.44 | FALSE |
| OFC | RT1-CE7 | intron excision ratio | chr20_3503725_3503935 | 0.36 | 31 | 0.19 | 3.6e-05 | -5.22 | 1.79e-07 | 0.08 | FALSE |
| PL | RT1-N3 | alternative TSS | XM_039098420.1 | 0.23 | 20 | 0.27 | 3.7e-29 | -5.41 | 6.22e-08 | 0.33 | TRUE |
| PL | RT1-N3 | alternative TSS | NM_001008855.2 | 0.12 | 1052 | 0.11 | 4.7e-12 | 5.43 | 5.70e-08 | 0.36 | FALSE |
| PL | RT1-N3 | alternative TSS | XM_039098421.1 | 0.05 | 1052 | 0.03 | 2.2e-04 | -5.43 | 5.64e-08 | 0.45 | FALSE |
| PL | Dhx16 | gene expression | Dhx16 | 0.11 | 1315 | 0.09 | 6.3e-10 | -5.43 | 5.60e-08 | 0.3 | FALSE |
| pVTA | RT1-N3 | alternative TSS | NM_001008855.2 | 0.16 | 1052 | 0.1 | 4.6e-05 | 5.24 | 1.57e-07 | 0.64 | FALSE |
| pVTA | LOC108349027 | gene expression | LOC108349027 | 0.25 | 10 | 0.11 | 1.6e-05 | -5.27 | 1.39e-07 | 0.54 | FALSE |
| pVTA | Abcf1 | isoform ratio | NM_001109883.2 | 0.15 | 1268 | 0.06 | 1.4e-03 | 5.18 | 2.25e-07 | 0.25 | TRUE |
| RMTg | Cchcr1 | gene expression | Cchcr1 | 0.44 | 32 | 0.28 | 2.8e-08 | 5.57 | 2.59e-08 | 0.7 | FALSE |