Best TWAS P=2.194133e-07 · Best GWAS P=2.194133e-07 conditioned to 1
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | P2ry2 | alternative polyA | ENSRNOT00000026115 | 0.03 | 0.02 | top1 | 1 | 0.02 | 0.00470 | -5.2 | -5.2 | 2.2e-07 | 0.99 | 0.04 | 0.12 | TRUE |
2 | Adipose | P2ry2 | alternative polyA | ENSRNOT00000114931 | 0.03 | 0.02 | top1 | 1 | 0.02 | 0.00440 | -5.2 | 5.2 | 2.2e-07 | -0.99 | 0.04 | 0.13 | FALSE |
3 | Adipose | Arap1 | mRNA stability | ENSRNOG00000019555 | 0.06 | 0.03 | top1 | 1 | 0.03 | 0.00044 | -5.1 | -5.1 | 2.8e-07 | 0.95 | 0.04 | 0.66 | FALSE |
4 | Liver | Mrpl48 | alternative polyA | ENSRNOT00000024290 | 0.03 | 0.02 | top1 | 1 | 0.02 | 0.00230 | -5.1 | 5.1 | 2.8e-07 | -0.97 | 0.06 | 0.16 | FALSE |
5 | Liver | Mrpl48 | alternative polyA | ENSRNOT00000110624 | 0.04 | 0.02 | top1 | 1 | 0.02 | 0.00170 | -5.1 | -5.1 | 2.8e-07 | 0.98 | 0.06 | 0.20 | FALSE |
6 | Liver | Mrpl48 | alternative polyA | ENSRNOT00000024290 | 0.05 | 0.02 | top1 | 1 | 0.03 | 0.00078 | -5.1 | 5.1 | 2.8e-07 | -0.99 | 0.05 | 0.30 | FALSE |
7 | Liver | Mrpl48 | alternative polyA | ENSRNOT00000110624 | 0.06 | 0.03 | top1 | 1 | 0.03 | 0.00056 | -5.1 | -5.1 | 2.8e-07 | 0.98 | 0.05 | 0.38 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.