Best TWAS P = 7.97e-09 · Best GWAS P= 4.05e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | LOC102546539 | alternative polyA | XR_005494104.2 | 0.03 | 1 | 0.03 | 3.0e-04 | 5.57 | 2.53e-08 | 0.23 | FALSE |
| Adipose | LOC102546539 | alternative polyA | XR_005494105.2 | 0.04 | 1 | 0.03 | 3.2e-04 | -5.57 | 2.53e-08 | 0.22 | FALSE |
| Adipose | Lrch1 | alternative polyA | XM_063274585.1 | 0.06 | 1 | 0.06 | 3.1e-07 | -5.61 | 2.02e-08 | 0.91 | FALSE |
| Adipose | Lpar6 | gene expression | Lpar6 | 0.1 | 1 | 0.08 | 3.4e-09 | -5.64 | 1.71e-08 | 0.68 | FALSE |
| Adipose | Med4 | gene expression | Med4 | 0.04 | 1 | 0.03 | 6.9e-04 | -5.55 | 2.86e-08 | 0.06 | FALSE |
| Adipose | Nudt15 | gene expression | Nudt15 | 0.07 | 7 | 0.05 | 1.7e-06 | 5.36 | 8.38e-08 | 0.52 | FALSE |
| Adipose | Rcbtb2 | gene expression | Rcbtb2 | 0.12 | 1 | 0.07 | 9.8e-09 | -5.57 | 2.52e-08 | 0.58 | FALSE |
| Adipose | LOC102546539 | isoform ratio | XR_005494105.2 | 0.02 | 1 | 0.01 | 6.7e-03 | -5.57 | 2.53e-08 | 0.06 | FALSE |
| Adipose | Lrch1 | isoform ratio | XM_063274585.1 | 0.07 | 1 | 0.07 | 1.6e-08 | -5.61 | 2.02e-08 | 0.92 | TRUE |
| Adipose | Nudt15 | intron excision ratio | chr15_55121464_55123103 | 0.02 | 1 | 0.02 | 4.5e-03 | 5.52 | 3.43e-08 | 0.03 | FALSE |
| Brain | Nudt15 | intron excision ratio | chr15_55121464_55123103 | 0.15 | 67 | 0.11 | 1.1e-10 | 5.34 | 9.24e-08 | 0.82 | FALSE |
| IC | Rcbtb2 | alternative polyA | NM_199084.1 | 0.06 | 2140 | 0.04 | 1.3e-02 | 5.49 | 4.05e-08 | 0.35 | FALSE |
| IC | Fndc3a | gene expression | Fndc3a | 0.11 | 1 | 0.11 | 2.0e-05 | -5.49 | 4.04e-08 | 0.21 | FALSE |
| IC | Nudt15 | intron excision ratio | chr15_55121464_55122799 | 0.12 | 1 | 0.1 | 4.8e-05 | -5.36 | 8.39e-08 | 0.12 | FALSE |
| IC | Nudt15 | intron excision ratio | chr15_55121464_55123103 | 0.12 | 1 | 0.1 | 4.2e-05 | 5.36 | 8.39e-08 | 0.12 | FALSE |
| IL | Rcbtb2 | alternative polyA | NM_199084.1 | 0.29 | 1 | 0.08 | 6.6e-03 | -5.46 | 4.70e-08 | 0.06 | FALSE |
| IL | Rcbtb2 | alternative polyA | XM_063274145.1 | 0.31 | 1 | 0.08 | 5.8e-03 | 5.46 | 4.70e-08 | 0.06 | FALSE |
| IL | Cysltr2 | gene expression | Cysltr2 | 0.21 | 2077 | 0.11 | 1.2e-03 | -5.6 | 2.08e-08 | 0.49 | FALSE |
| Liver | Fndc3a | alternative TSS | XM_039093358.1 | 0.04 | 1 | 0.02 | 1.3e-03 | 5.52 | 3.32e-08 | 0.05 | FALSE |
| Liver | Fndc3a | alternative TSS | XM_039093358.1 | 0.05 | 1 | 0.03 | 9.2e-05 | 5.55 | 2.86e-08 | 0.22 | FALSE |
| Liver | Fndc3a | isoform ratio | XM_039093358.1 | 0.04 | 1 | 0.03 | 7.9e-04 | 5.52 | 3.32e-08 | 0.06 | FALSE |
| Liver | Nudt15 | intron excision ratio | chr15_55121464_55123103 | 0.08 | 1 | 0.07 | 5.7e-08 | 5.36 | 8.38e-08 | 0.34 | FALSE |
| Liver | Rcbtb2 | intron excision ratio | chr15_54764575_54766821 | 0.1 | 1 | 0.08 | 4.7e-09 | -5.77 | 7.97e-09 | 0.81 | TRUE |
| Liver | Rcbtb2 | intron excision ratio | chr15_54766960_54768312 | 0.03 | 1 | 0.02 | 2.8e-03 | -5.48 | 4.18e-08 | 0.04 | FALSE |
| Liver | Rcbtb2 | intron excision ratio | chr15_54767961_54768312 | 0.22 | 1 | 0.22 | 6.1e-24 | 5.51 | 3.52e-08 | 0.5 | FALSE |
| Liver | Itm2b | mRNA stability | Itm2b | 0.1 | 2032 | 0.08 | 1.4e-09 | 5.49 | 4.09e-08 | 0.68 | TRUE |
| NAcc | Rcbtb2 | alternative polyA | NM_199084.1 | 0.05 | 1 | 0.04 | 3.9e-06 | -5.48 | 4.18e-08 | 0.4 | FALSE |
| NAcc | Rcbtb2 | alternative polyA | XM_063274145.1 | 0.05 | 81 | 0.03 | 2.0e-05 | 5.46 | 4.72e-08 | 0.49 | FALSE |
| NAcc | Cysltr2 | gene expression | Cysltr2 | 0.03 | 1 | 0.02 | 1.3e-04 | 5.51 | 3.50e-08 | 0.14 | FALSE |
| NAcc | Fndc3a | gene expression | Fndc3a | 0.12 | 25 | 0.11 | 1.9e-16 | 5.45 | 5.05e-08 | 0.76 | FALSE |
| NAcc | LOC134481988 | gene expression | LOC134481988 | 0.03 | 1999 | 0.02 | 3.2e-04 | 5.63 | 1.85e-08 | 0.77 | FALSE |
| NAcc | Med4 | gene expression | Med4 | 0.02 | 1 | 0.02 | 3.3e-04 | -5.55 | 2.87e-08 | 0.14 | FALSE |
| NAcc | Rcbtb2 | gene expression | Rcbtb2 | 0.02 | 1 | 0.01 | 5.2e-03 | 5.46 | 4.84e-08 | 0.03 | FALSE |
| NAcc | Rcbtb2 | isoform ratio | NM_199084.1 | 0.08 | 2140 | 0.05 | 1.1e-07 | 5.3 | 1.18e-07 | 0.48 | FALSE |
| NAcc | Rcbtb2 | intron excision ratio | chr15_54746357_54753289 | 0.02 | 2140 | 0.01 | 3.4e-03 | 5.43 | 5.66e-08 | 0.36 | FALSE |
| PL | Rcbtb2 | alternative polyA | NM_199084.1 | 0.09 | 17 | 0.08 | 1.8e-09 | -5.5 | 3.80e-08 | 0.53 | TRUE |
| PL | Rcbtb2 | alternative polyA | XM_063274145.1 | 0.09 | 2140 | 0.08 | 3.8e-09 | -5.41 | 6.30e-08 | 0.53 | FALSE |
| PL | Rcbtb2 | isoform ratio | NM_199084.1 | 0.08 | 2140 | 0.07 | 4.8e-08 | 5.23 | 1.65e-07 | 0.49 | FALSE |
| PL | Nudt15 | intron excision ratio | chr15_55121464_55123103 | 0.41 | 2083 | 0.17 | 3.0e-18 | -5.35 | 8.57e-08 | 0.86 | FALSE |
| PL | Itm2b | mRNA stability | Itm2b | 0.05 | 1 | 0.04 | 3.7e-05 | -5.52 | 3.45e-08 | 0.3 | FALSE |
| pVTA | Lpar6 | gene expression | Lpar6 | 0.05 | 2160 | 0.03 | 4.2e-03 | 5.55 | 2.82e-08 | 0.44 | FALSE |
| pVTA | Nudt15 | gene expression | Nudt15 | 0.38 | 2083 | 0.32 | 4.1e-26 | 5.34 | 9.07e-08 | 0.84 | TRUE |
| pVTA | Nudt15 | intron excision ratio | chr15_55121464_55122799 | 0.26 | 1 | 0.18 | 2.3e-14 | -5.58 | 2.44e-08 | 0.63 | FALSE |
| pVTA | Nudt15 | intron excision ratio | chr15_55121464_55123103 | 0.24 | 1 | 0.17 | 5.7e-14 | 5.58 | 2.44e-08 | 0.63 | FALSE |