Best TWAS P = 1.58e-08 · Best GWAS P= 3.38e-08 conditioned to 3.53e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Zrsr2-ps1 | intron excision ratio | chr14_101174724_101174845 | 0.18 | 1412 | 0.08 | 2.5e-09 | -5.22 | 1.77e-07 | 0.58 | FALSE |
| Adipose | B3gnt2 | mRNA stability | B3gnt2 | 0.06 | 1441 | 0.06 | 7.8e-07 | -5.65 | 1.64e-08 | 0.58 | FALSE |
| Brain | Tmem17 | intron excision ratio | chr14_100723524_100724315 | 0.06 | 30 | 0.07 | 5.5e-07 | 5.38 | 7.39e-08 | 0.6 | FALSE |
| NAcc | Commd1 | alternative TSS | XM_017599129.3 | 0.02 | 1 | 0.02 | 7.1e-04 | 5.45 | 5.13e-08 | 0.13 | FALSE |
| NAcc | Commd1 | alternative TSS | XM_017599129.3 | 0.02 | 1 | 0.02 | 3.8e-04 | 5.45 | 5.13e-08 | 0.19 | FALSE |
| NAcc | Commd1 | isoform ratio | NM_001115022.1 | 0.14 | 1 | 0.21 | 7.4e-31 | -5.45 | 5.13e-08 | 0.9 | FALSE |
| NAcc | Commd1 | isoform ratio | XM_017599129.3 | 0.08 | 1 | 0.08 | 6.0e-12 | 5.45 | 5.13e-08 | 0.9 | FALSE |
| NAcc | Tmem17 | intron excision ratio | chr14_100723524_100724315 | 0.07 | 1359 | 0.03 | 1.1e-05 | 5.46 | 4.71e-08 | 0.59 | FALSE |
| PL | LOC102552414 | gene expression | LOC102552414 | 0.05 | 1434 | 0.03 | 2.7e-04 | 5.65 | 1.58e-08 | 0.49 | TRUE |
| pVTA | Commd1 | alternative TSS | NM_001115022.1 | 0.15 | 1 | 0.22 | 1.4e-17 | -5.25 | 1.56e-07 | 0.75 | FALSE |
| pVTA | Rpl28l3 | gene expression | Rpl28l3 | 0.16 | 1332 | 0.04 | 2.4e-04 | -5.54 | 3.03e-08 | 0.25 | FALSE |
| pVTA | Commd1 | isoform ratio | NM_001115022.1 | 0.14 | 1 | 0.25 | 1.0e-19 | -5.25 | 1.56e-07 | 0.75 | FALSE |
| pVTA | Commd1 | isoform ratio | XM_017599129.3 | 0.1 | 1 | 0.11 | 8.4e-09 | 5.45 | 5.13e-08 | 0.9 | FALSE |
| pVTA | Tmem17 | intron excision ratio | chr14_100723524_100724315 | 0.06 | 1359 | 0.04 | 5.1e-04 | 5.29 | 1.23e-07 | 0.59 | FALSE |