Hub : Traits : Left kidney weight : →

chr1:72,902,361-77,357,366

Trait: Left kidney weight

Best TWAS P=4.304831e-09 · Best GWAS P=1.22378e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Lig1	gene expression	ENSRNOG00000014193	0.11	0.07	lasso	13	0.08	4.0e-09	5.5	5.4	5.2e-08	0.91	0.40	0.60	FALSE
2	Adipose	Lig1	isoform ratio	ENSRNOT00000019799	0.08	0.04	blup	1398	0.04	4.2e-05	5.5	5.5	4.6e-08	1.00	0.38	0.62	FALSE
3	Adipose	Ehd2	intron excision ratio	chr1:76656052:76656522	0.07	0.06	top1	1	0.06	4.2e-07	5.7	5.7	1.5e-08	0.92	0.06	0.93	FALSE
4	BLA	Lig1	gene expression	ENSRNOG00000014193	0.34	0.19	top1	1	0.19	2.0e-10	5.5	5.5	4.7e-08	1.00	0.36	0.64	FALSE
5	BLA	Lig1	isoform ratio	ENSRNOT00000019799	0.17	0.09	top1	1	0.09	2.4e-05	5.5	5.5	4.8e-08	0.95	0.17	0.26	FALSE
6	BLA	Lig1	isoform ratio	ENSRNOT00000109652	0.19	0.06	lasso	34	0.09	1.3e-05	5.5	-5.5	4.8e-08	-0.93	0.34	0.66	TRUE
7	BLA	Lig1	intron excision ratio	chr1:74202463:74203983	0.07	0.02	top1	1	0.02	3.3e-02	5.5	5.5	3.6e-08	0.98	0.06	0.04	FALSE
8	BLA	Lig1	intron excision ratio	chr1:74203426:74203983	0.07	0.02	top1	1	0.02	4.5e-02	5.5	-5.5	3.6e-08	-0.99	0.06	0.04	FALSE
9	BLA	Lig1	mRNA stability	ENSRNOG00000014193	0.07	0.03	blup	1400	0.03	1.1e-02	5.6	5.6	1.9e-08	0.96	0.26	0.46	FALSE
10	Brain	Lig1	isoform ratio	ENSRNOT00000019799	0.35	0.32	lasso	33	0.33	3.0e-31	5.5	5.8	5.9e-09	0.96	0.34	0.66	FALSE
11	Brain	Lig1	isoform ratio	ENSRNOT00000109652	0.34	0.31	enet	104	0.33	6.1e-31	5.5	-5.9	4.3e-09	-0.97	0.33	0.67	TRUE
12	Brain	Lig1	intron excision ratio	chr1:74202463:74203983	0.16	0.16	lasso	9	0.16	1.2e-14	5.6	5.7	1.0e-08	0.98	0.32	0.68	FALSE
13	Brain	Lig1	intron excision ratio	chr1:74203426:74203983	0.09	0.09	lasso	7	0.09	7.6e-09	5.6	-5.7	1.4e-08	-0.96	0.31	0.69	FALSE
14	Brain	Zswim9	mRNA stability	ENSRNOG00000014186	0.04	0.04	lasso	2	0.04	9.3e-05	5.5	5.1	3.0e-07	0.88	0.33	0.64	FALSE
15	Eye	Lig1	gene expression	ENSRNOG00000014193	0.47	0.13	blup	1400	0.18	9.2e-04	5.5	5.6	2.0e-08	0.99	0.30	0.45	FALSE
16	IL	Lig1	isoform ratio	ENSRNOT00000109652	0.29	0.20	enet	5	0.28	2.3e-07	2.5	-5.5	4.3e-08	-0.01	0.51	0.41	TRUE
17	LHb	Lig1	gene expression	ENSRNOG00000014193	0.18	0.16	top1	1	0.16	1.5e-04	5.5	5.5	3.5e-08	1.00	0.09	0.09	FALSE
18	LHb	Lig1	isoform ratio	ENSRNOT00000019799	0.30	0.09	lasso	3	0.13	5.9e-04	5.5	5.6	2.2e-08	1.00	0.30	0.64	FALSE
19	LHb	Lig1	isoform ratio	ENSRNOT00000109652	0.45	0.31	top1	1	0.31	5.0e-08	5.5	-5.5	3.4e-08	-0.90	0.17	0.34	FALSE
20	LHb	Lig1	mRNA stability	ENSRNOG00000014193	0.32	0.04	blup	1376	0.18	3.9e-05	5.5	5.1	3.4e-07	0.83	0.34	0.57	TRUE
21	Liver	Cabp5	alternative polyA	ENSRNOT00000096394	0.03	0.02	top1	1	0.02	3.4e-03	5.5	-5.5	3.3e-08	-0.97	0.06	0.05	FALSE
22	Liver	Sult2a2	alternative polyA	ENSRNOT00000052129	0.16	0.10	top1	1	0.10	6.1e-11	5.5	-5.5	3.2e-08	-0.99	0.01	0.99	FALSE
23	Liver	Sult2a2	alternative polyA	ENSRNOT00000089371	0.15	0.09	top1	1	0.10	1.1e-10	5.5	5.5	3.2e-08	0.99	0.01	0.99	FALSE
24	Liver	AC107531.3	alternative polyA	ENSRNOT00000015108	0.10	0.05	top1	1	0.05	2.4e-06	5.4	-5.4	5.2e-08	-1.00	0.30	0.70	FALSE
25	Liver	AC107531.3	alternative polyA	ENSRNOT00000107542	0.09	0.05	top1	1	0.05	6.4e-06	5.4	5.4	5.2e-08	0.99	0.30	0.70	FALSE
26	Liver	Sult2a2	alternative TSS	ENSRNOT00000041367	0.17	0.10	lasso	4	0.12	2.3e-13	5.4	-5.5	4.9e-08	-0.92	0.01	0.99	FALSE
27	Liver	Sult2a2	alternative TSS	ENSRNOT00000052129	0.16	0.10	lasso	4	0.12	3.4e-13	5.4	5.4	6.0e-08	0.91	0.01	0.99	FALSE
28	Liver	AC107531.3	alternative TSS	ENSRNOT00000107542	0.16	0.12	blup	1222	0.13	1.2e-14	5.5	5.1	3.1e-07	0.97	0.38	0.62	FALSE
29	Liver	AC107531.3	alternative TSS	ENSRNOT00000117195	0.16	0.13	blup	1222	0.13	1.3e-14	5.5	-5.2	2.3e-07	-0.98	0.35	0.65	FALSE
30	Liver	Cabp5	gene expression	ENSRNOG00000014787	0.69	0.34	lasso	70	0.39	1.8e-45	4.3	5.3	1.1e-07	0.91	0.93	0.07	FALSE
31	Liver	Selenow	gene expression	ENSRNOG00000067799	0.66	0.23	blup	885	0.24	2.1e-26	5.5	5.5	2.9e-08	1.00	0.14	0.86	FALSE
32	Liver	Lig1	isoform ratio	ENSRNOT00000109652	0.08	0.05	enet	9	0.06	2.3e-07	5.6	-5.6	2.1e-08	-0.93	0.30	0.70	FALSE
33	Liver	Sult2a2	isoform ratio	ENSRNOT00000052129	0.22	0.13	lasso	3	0.13	2.3e-14	5.5	-5.5	3.9e-08	-1.00	0.01	0.99	FALSE
34	Liver	Sult2a2	isoform ratio	ENSRNOT00000089371	0.21	0.13	top1	1	0.13	3.4e-14	5.5	5.5	3.9e-08	0.87	0.01	0.99	FALSE
35	Liver	Sult2a2	isoform ratio	ENSRNOT00000112779	0.20	0.12	lasso	3	0.12	2.9e-13	5.5	-5.5	3.9e-08	-1.00	0.01	0.99	FALSE
36	Liver	NA	isoform ratio	ENSRNOT00000104720	0.03	0.01	blup	269	0.01	1.0e-02	5.7	-5.8	8.8e-09	-0.97	0.07	0.76	FALSE
37	NAcc	AABR07002065.2	alternative polyA	ENSRNOT00000094704	0.29	0.07	lasso	4	0.07	6.0e-06	2.5	5.5	3.6e-08	-0.21	0.96	0.03	TRUE
38	NAcc	Lig1	gene expression	ENSRNOG00000014193	0.05	0.02	blup	1399	0.02	7.1e-03	4.5	5.2	2.2e-07	0.98	0.32	0.35	FALSE
39	NAcc	Lig1	isoform ratio	ENSRNOT00000109652	0.08	0.04	blup	1399	0.04	6.7e-04	5.5	-5.6	2.0e-08	-0.97	0.34	0.63	FALSE
40	OFC	Lig1	gene expression	ENSRNOG00000014193	0.22	0.07	lasso	2	0.11	1.4e-03	5.5	5.5	4.9e-08	0.77	0.29	0.40	FALSE
41	OFC	Lig1	isoform ratio	ENSRNOT00000109652	0.17	0.07	top1	1	0.07	1.0e-02	5.5	-5.5	4.4e-08	-0.94	0.07	0.06	FALSE
42	PL	Lig1	gene expression	ENSRNOG00000014193	0.28	0.11	blup	1399	0.16	3.7e-12	5.4	5.4	8.7e-08	0.99	0.39	0.61	FALSE
43	PL	Lig1	isoform ratio	ENSRNOT00000019799	0.25	0.17	top1	1	0.17	9.6e-13	5.5	5.5	3.6e-08	0.99	0.30	0.70	FALSE
44	PL	Lig1	isoform ratio	ENSRNOT00000109652	0.30	0.22	top1	1	0.22	9.2e-17	5.5	-5.5	3.6e-08	-0.96	0.30	0.70	FALSE
45	PL	Lig1	intron excision ratio	chr1:74202463:74203983	0.10	0.06	blup	1399	0.07	6.1e-06	5.6	5.3	1.4e-07	0.86	0.32	0.68	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.