Best TWAS P=1.91e-08 · Best GWAS P=1.22e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Ehd2 | alternative TSS | NM_001024897.1 | 0.06 | 4 | 0.01 | 1.3e-02 | 5.18 | 2.26e-07 | 0.5 | FALSE |
| Adipose | Ehd2 | alternative TSS | XM_039081636.1 | 0.06 | 3 | 0.01 | 8.7e-03 | -5.29 | 1.22e-07 | 0.5 | FALSE |
| Adipose | Zswim9 | gene expression | Zswim9 | 0.06 | 1 | 0.05 | 1.9e-06 | -5.61 | 2.02e-08 | 0.75 | FALSE |
| BLA | Lig1 | gene expression | Lig1 | 0.29 | 1402 | 0.16 | 7.0e-09 | 5.59 | 2.22e-08 | 0.66 | FALSE |
| BLA | Lig1 | mRNA stability | Lig1 | 0.12 | 1 | 0.05 | 9.6e-04 | -5.57 | 2.55e-08 | 0.17 | FALSE |
| Brain | LOC120098270 | gene expression | LOC120098270 | 0.37 | 1 | 0.14 | 3.5e-13 | 5.18 | 2.20e-07 | 0.97 | FALSE |
| Brain | Lig1 | intron excision ratio | chr1_74202463_74203983 | 0.18 | 5 | 0.17 | 1.3e-15 | 5.47 | 4.52e-08 | 0.68 | FALSE |
| Brain | Lig1 | intron excision ratio | chr1_74203426_74203983 | 0.09 | 1 | 0.1 | 2.2e-09 | 5.41 | 6.21e-08 | 0.59 | FALSE |
| Brain | Lig1 | mRNA stability | Lig1 | 0.17 | 19 | 0.17 | 3.4e-15 | -5.57 | 2.56e-08 | 0.7 | FALSE |
| Brain | Zswim9 | mRNA stability | Zswim9 | 0.05 | 1 | 0.04 | 1.5e-04 | -5.62 | 1.91e-08 | 0.23 | TRUE |
| LHb | Lig1 | gene expression | Lig1 | 0.17 | 25 | 0.09 | 3.4e-03 | -5.6 | 2.17e-08 | 0.57 | FALSE |
| Liver | Sult2a6 | alternative TSS | NM_012695.3 | 0.09 | 1 | 0.06 | 9.1e-08 | -5.45 | 5.13e-08 | 0.73 | FALSE |
| Liver | Sult2a6 | alternative TSS | XM_039101066.1 | 0.1 | 1 | 0.08 | 7.2e-09 | 5.45 | 5.13e-08 | 0.74 | FALSE |
| Liver | Sult2a6 | alternative TSS | NM_012695.3 | 0.03 | 1 | 0.01 | 1.5e-02 | 5.53 | 3.17e-08 | 0.04 | FALSE |
| Liver | LOC120099768 | gene expression | LOC120099768 | 0.27 | 114 | 0.25 | 1.3e-27 | -5.19 | 2.13e-07 | 0.8 | FALSE |
| Liver | Selenow | gene expression | Selenow | 0.64 | 883 | 0.24 | 8.5e-27 | 5.58 | 2.40e-08 | 0.86 | FALSE |
| Liver | Sult2a1 | gene expression | Sult2a1 | 0.29 | 1 | 0.18 | 6.9e-20 | -5.45 | 5.13e-08 | 0.99 | FALSE |
| Liver | Nop53 | isoform ratio | NM_207591.2 | 0.04 | 881 | 0.02 | 1.7e-03 | 5.34 | 9.23e-08 | 0.68 | FALSE |
| Liver | LOC120099768 | intron excision ratio | chr1_76058779_76072421 | 0.44 | 40 | 0.42 | 7.0e-50 | 5.62 | 1.95e-08 | 0.86 | FALSE |
| Liver | LOC120099768 | intron excision ratio | chr1_76072598_76076963 | 0.46 | 44 | 0.46 | 1.3e-56 | -5.57 | 2.57e-08 | 0.86 | FALSE |
| Liver | Sult2a1 | mRNA stability | Sult2a1 | 0.51 | 4 | 0.34 | 2.2e-38 | -5.55 | 2.92e-08 | 0.99 | FALSE |
| NAcc | Lig1 | gene expression | Lig1 | 0.04 | 1 | 0.03 | 4.5e-04 | -5.52 | 3.38e-08 | 0.1 | FALSE |
| NAcc | Zbtb45 | intron excision ratio | chr1_73638091_73639378 | 0.17 | 1 | 0.04 | 5.1e-05 | -5.44 | 5.30e-08 | 0.94 | TRUE |
| NAcc | Zbtb45 | intron excision ratio | chr1_73638091_73639508 | 0.13 | 1 | 0.04 | 5.5e-05 | 5.42 | 5.93e-08 | 0.9 | FALSE |
| OFC | Lig1 | gene expression | Lig1 | 0.16 | 1 | 0.1 | 2.0e-03 | -5.41 | 6.21e-08 | 0.05 | TRUE |
| PL | Lig1 | gene expression | Lig1 | 0.17 | 13 | 0.16 | 3.5e-17 | 5.28 | 1.31e-07 | 0.65 | FALSE |
| PL | Slc8a2 | isoform ratio | XM_039080711.1 | 0.03 | 5 | 0.02 | 3.4e-03 | 5.45 | 4.91e-08 | 0.67 | FALSE |
| PL | Lig1 | intron excision ratio | chr1_74202463_74203983 | 0.07 | 1 | 0.05 | 4.4e-06 | -5.52 | 3.38e-08 | 0.71 | FALSE |
| PL | Lig1 | intron excision ratio | chr1_74203426_74203983 | 0.05 | 1 | 0.04 | 6.5e-05 | 5.56 | 2.63e-08 | 0.54 | FALSE |
| PL | Lig1 | mRNA stability | Lig1 | 0.1 | 1 | 0.08 | 3.3e-09 | -5.43 | 5.74e-08 | 0.61 | FALSE |
| pVTA | Lig1 | gene expression | Lig1 | 0.2 | 36 | 0.12 | 7.7e-06 | -5.38 | 7.40e-08 | 0.68 | FALSE |