Best TWAS P=5.321025e-08 · Best GWAS P=2.279343e-08 conditioned to 1
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | Folr1 | gene expression | ENSRNOG00000019902 | 0.62 | 0.50 | enet | 422 | 0.51 | 1.4e-64 | 5.0 | -5.2 | 2.1e-07 | -0.77 | 0.32 | 0.68 | FALSE |
2 | Adipose | Rnf121 | gene expression | ENSRNOG00000020175 | 0.05 | 0.01 | blup | 1540 | 0.02 | 4.3e-03 | 5.0 | -5.4 | 6.0e-08 | -0.84 | 0.38 | 0.54 | FALSE |
3 | Adipose | Nup98 | gene expression | ENSRNOG00000020347 | 0.21 | 0.15 | blup | 1360 | 0.16 | 6.8e-17 | 5.2 | -5.3 | 9.9e-08 | -0.86 | 0.46 | 0.54 | FALSE |
4 | Adipose | Trim68 | isoform ratio | ENSRNOT00000095839 | 0.19 | 0.21 | lasso | 30 | 0.22 | 3.8e-24 | 4.8 | 5.4 | 5.9e-08 | 0.96 | 0.62 | 0.38 | FALSE |
5 | Adipose | NA | isoform ratio | ENSRNOT00000105061 | 0.08 | 0.03 | enet | 164 | 0.03 | 2.6e-04 | 4.7 | 5.1 | 2.7e-07 | 0.68 | 0.30 | 0.69 | FALSE |
6 | Adipose | Trim21 | mRNA stability | ENSRNOG00000018517 | 0.09 | 0.08 | blup | 2047 | 0.09 | 9.5e-10 | 4.6 | -5.3 | 1.0e-07 | -0.89 | 0.65 | 0.35 | FALSE |
7 | Adipose | Il18bp | mRNA stability | ENSRNOG00000020150 | 0.12 | 0.08 | top1 | 1 | 0.08 | 4.5e-09 | 5.2 | -5.2 | 2.4e-07 | -0.82 | 0.29 | 0.71 | FALSE |
8 | BLA | Folr2 | gene expression | ENSRNOG00000019890 | 0.12 | 0.01 | blup | 1566 | 0.04 | 4.1e-03 | -4.2 | -5.3 | 1.1e-07 | -0.79 | 0.48 | 0.40 | FALSE |
9 | BLA | Il18bp | gene expression | ENSRNOG00000020150 | 0.13 | 0.01 | blup | 1563 | 0.04 | 3.6e-03 | -4.1 | -5.3 | 1.2e-07 | -0.80 | 0.49 | 0.38 | FALSE |
10 | BLA | Pgap2 | gene expression | ENSRNOG00000020371 | 0.09 | 0.04 | blup | 1361 | 0.06 | 5.8e-04 | -4.2 | 5.1 | 3.2e-07 | 0.79 | 0.54 | 0.20 | FALSE |
11 | BLA | Trim68 | isoform ratio | ENSRNOT00000095839 | 0.19 | 0.10 | lasso | 15 | 0.14 | 4.0e-08 | 5.0 | 5.2 | 2.4e-07 | 0.96 | 0.52 | 0.48 | FALSE |
12 | BLA | Trim68 | intron excision ratio | chr1:157118269:157120638 | 0.10 | 0.02 | lasso | 16 | 0.04 | 3.5e-03 | -4.2 | -5.2 | 2.5e-07 | -0.82 | 0.61 | 0.26 | FALSE |
13 | BLA | Nup98 | mRNA stability | ENSRNOG00000020347 | 0.13 | 0.05 | lasso | 23 | 0.06 | 5.8e-04 | 5.0 | 5.1 | 3.0e-07 | 0.98 | 0.41 | 0.52 | FALSE |
14 | BLA | Hbb-bs | mRNA stability | ENSRNOG00000061299 | 0.17 | 0.09 | blup | 3262 | 0.15 | 1.2e-08 | 4.7 | -5.1 | 2.7e-07 | -0.88 | 0.69 | 0.32 | FALSE |
15 | Brain | Atg16l2 | gene expression | ENSRNOG00000019413 | 0.05 | 0.02 | enet | 10 | 0.04 | 1.5e-04 | -4.3 | -5.4 | 6.5e-08 | -0.84 | 0.49 | 0.48 | FALSE |
16 | Brain | Inppl1 | gene expression | ENSRNOG00000019730 | 0.10 | 0.06 | enet | 309 | 0.08 | 4.1e-08 | 5.1 | -5.3 | 1.3e-07 | -0.87 | 0.34 | 0.66 | FALSE |
17 | Brain | Folr2 | gene expression | ENSRNOG00000019890 | 0.04 | 0.03 | enet | 7 | 0.03 | 6.3e-04 | 5.1 | -5.2 | 2.2e-07 | -0.95 | 0.33 | 0.58 | FALSE |
18 | Brain | Lrrc51 | gene expression | ENSRNOG00000020124 | 0.04 | 0.01 | blup | 1592 | 0.02 | 3.6e-03 | -4.2 | 5.2 | 1.9e-07 | 0.80 | 0.51 | 0.29 | FALSE |
19 | Brain | Rnf121 | gene expression | ENSRNOG00000020175 | 0.09 | 0.05 | blup | 1540 | 0.06 | 2.0e-06 | -4.1 | -5.2 | 2.1e-07 | -0.79 | 0.87 | 0.13 | FALSE |
20 | Brain | Trpc2 | gene expression | ENSRNOG00000020188 | 0.09 | 0.04 | blup | 1523 | 0.07 | 8.5e-07 | -4.4 | 5.3 | 1.0e-07 | 0.82 | 0.66 | 0.34 | FALSE |
21 | Brain | Stim1 | gene expression | ENSRNOG00000020425 | 0.04 | 0.02 | blup | 1413 | 0.04 | 6.3e-05 | 4.9 | 5.4 | 5.6e-08 | 0.87 | 0.40 | 0.59 | FALSE |
22 | Brain | Olr61 | gene expression | ENSRNOG00000071207 | 0.09 | 0.09 | blup | 2309 | 0.12 | 6.2e-11 | 5.0 | -5.3 | 1.3e-07 | -0.98 | 0.48 | 0.52 | FALSE |
23 | Brain | Trim68 | isoform ratio | ENSRNOT00000075222 | 0.34 | 0.41 | enet | 196 | 0.43 | 7.6e-43 | 4.9 | 5.2 | 1.7e-07 | 0.85 | 0.78 | 0.22 | TRUE |
24 | Brain | Trim68 | isoform ratio | ENSRNOT00000092838 | 0.54 | 0.47 | enet | 231 | 0.48 | 1.3e-49 | 5.0 | -5.3 | 1.4e-07 | -0.81 | 0.76 | 0.24 | FALSE |
25 | Brain | Trim68 | isoform ratio | ENSRNOT00000095839 | 0.19 | 0.20 | blup | 2208 | 0.24 | 4.6e-22 | 4.8 | 5.3 | 9.6e-08 | 0.95 | 0.65 | 0.35 | FALSE |
26 | Brain | Trpc2 | intron excision ratio | chr1:156450846:156452614 | 0.12 | 0.08 | top1 | 1 | 0.08 | 8.7e-08 | 5.2 | -5.2 | 2.2e-07 | -0.83 | 0.28 | 0.72 | FALSE |
27 | Brain | Fchsd2 | mRNA stability | ENSRNOG00000019319 | 0.10 | 0.10 | enet | 23 | 0.10 | 6.9e-10 | 4.8 | -5.4 | 5.5e-08 | -0.87 | 0.36 | 0.64 | TRUE |
28 | Eye | Trim68 | isoform ratio | ENSRNOT00000075222 | 0.50 | 0.12 | top1 | 1 | 0.12 | 6.3e-03 | 5.4 | 5.4 | 8.5e-08 | 0.93 | 0.10 | 0.06 | FALSE |
29 | IL | Trim68 | isoform ratio | ENSRNOT00000092838 | 0.19 | 0.12 | lasso | 5 | 0.13 | 4.3e-04 | 5.3 | -5.3 | 9.7e-08 | -0.98 | 0.57 | 0.37 | FALSE |
30 | LHb | Hbb-b1 | isoform ratio | ENSRNOT00000089125 | 0.67 | 0.33 | enet | 14 | 0.50 | 8.4e-14 | 4.6 | 5.1 | 3.4e-07 | -0.73 | 0.69 | 0.31 | TRUE |
31 | LHb | Hbb-b1 | intron excision ratio | chr1:158218619:158219259 | 0.43 | 0.05 | blup | 3232 | 0.07 | 1.1e-02 | 4.6 | 5.1 | 3.1e-07 | 0.92 | 0.45 | 0.23 | TRUE |
32 | LHb | Hbb-b1 | intron excision ratio | chr1:158237229:158237869 | 0.25 | 0.04 | lasso | 2 | 0.07 | 8.3e-03 | 5.0 | -5.3 | 1.1e-07 | -0.89 | 0.58 | 0.35 | FALSE |
33 | Liver | Folr1 | gene expression | ENSRNOG00000019902 | 0.05 | 0.02 | top1 | 1 | 0.02 | 4.4e-03 | 5.2 | -5.2 | 2.4e-07 | -0.73 | 0.05 | 0.05 | TRUE |
34 | Liver | Il18bp | gene expression | ENSRNOG00000020150 | 0.26 | 0.14 | enet | 368 | 0.14 | 1.6e-15 | 5.0 | -5.3 | 1.4e-07 | -0.84 | 0.31 | 0.69 | FALSE |
35 | Liver | Rnf121 | gene expression | ENSRNOG00000020175 | 0.05 | 0.01 | blup | 1540 | 0.01 | 1.5e-02 | -4.2 | -5.2 | 2.4e-07 | -0.79 | 0.54 | 0.29 | FALSE |
36 | Liver | Art2b | isoform ratio | ENSRNOT00000026644 | 0.03 | 0.01 | blup | 1534 | 0.01 | 1.6e-02 | 5.0 | 5.4 | 7.7e-08 | 0.87 | 0.28 | 0.43 | FALSE |
37 | Liver | Trpc2 | intron excision ratio | chr1:156450846:156452614 | 0.05 | 0.03 | enet | 212 | 0.03 | 4.5e-04 | 5.0 | -5.1 | 3.4e-07 | -0.81 | 0.34 | 0.63 | FALSE |
38 | Liver | Nup98 | intron excision ratio | chr1:156575961:156590985 | 0.02 | 0.02 | top1 | 1 | 0.02 | 5.4e-03 | 5.2 | 5.2 | 2.6e-07 | 0.82 | 0.04 | 0.03 | FALSE |
39 | Liver | Nup98 | intron excision ratio | chr1:156575961:156591264 | 0.02 | 0.01 | blup | 1360 | 0.01 | 1.3e-02 | 5.2 | -5.4 | 7.2e-08 | -0.85 | 0.27 | 0.30 | FALSE |
40 | Liver | Pde2a | mRNA stability | ENSRNOG00000019560 | 0.05 | 0.01 | blup | 1630 | 0.02 | 1.2e-03 | -4.0 | -5.2 | 2.0e-07 | -0.83 | 0.46 | 0.49 | FALSE |
41 | NAcc | Il18bp | gene expression | ENSRNOG00000020150 | 0.05 | 0.03 | top1 | 1 | 0.03 | 2.1e-03 | 5.2 | -5.2 | 2.2e-07 | -0.81 | 0.06 | 0.05 | FALSE |
42 | NAcc | Trpc2 | gene expression | ENSRNOG00000020188 | 0.07 | 0.04 | top1 | 1 | 0.04 | 4.1e-04 | 5.2 | 5.2 | 2.2e-07 | 0.84 | 0.07 | 0.08 | FALSE |
43 | NAcc | Hbb-b1 | gene expression | ENSRNOG00000047098 | 0.06 | 0.04 | blup | 3252 | 0.04 | 3.5e-04 | 4.9 | 5.1 | 2.6e-07 | 0.90 | 0.64 | 0.35 | FALSE |
44 | NAcc | Trim68 | isoform ratio | ENSRNOT00000095839 | 0.21 | 0.16 | blup | 2201 | 0.20 | 1.1e-14 | 5.0 | 5.2 | 1.8e-07 | 0.97 | 0.49 | 0.51 | FALSE |
45 | NAcc | Trim68 | intron excision ratio | chr1:157115748:157116120 | 0.03 | 0.01 | blup | 2201 | 0.02 | 1.0e-02 | -4.5 | -5.4 | 5.3e-08 | -0.95 | 0.44 | 0.33 | TRUE |
46 | NAcc | Trim68 | intron excision ratio | chr1:157116858:157118174 | 0.06 | 0.06 | top1 | 1 | 0.06 | 3.5e-05 | 5.2 | -5.2 | 2.1e-07 | -0.82 | 0.23 | 0.26 | FALSE |
47 | NAcc | Trim68 | intron excision ratio | chr1:157118269:157120638 | 0.08 | 0.06 | blup | 2201 | 0.07 | 8.2e-06 | 5.1 | -5.2 | 1.6e-07 | -0.97 | 0.52 | 0.48 | FALSE |
48 | NAcc | Hbb-bs | mRNA stability | ENSRNOG00000061299 | 0.34 | 0.25 | enet | 35 | 0.29 | 1.6e-21 | 4.5 | -5.2 | 1.6e-07 | -0.76 | 0.76 | 0.24 | TRUE |
49 | OFC | Numa1 | gene expression | ENSRNOG00000000417 | 0.33 | 0.01 | blup | 1569 | 0.03 | 6.1e-02 | -4.2 | -5.1 | 3.1e-07 | -0.78 | 0.28 | 0.17 | FALSE |
50 | OFC | Olr61 | gene expression | ENSRNOG00000071207 | 0.13 | 0.13 | top1 | 1 | 0.13 | 4.5e-04 | 5.3 | -5.3 | 1.3e-07 | -0.98 | 0.12 | 0.05 | FALSE |
51 | OFC | Trim68 | isoform ratio | ENSRNOT00000095839 | 0.28 | 0.02 | blup | 2197 | 0.06 | 1.8e-02 | 5.2 | 5.4 | 8.6e-08 | 0.96 | 0.42 | 0.47 | FALSE |
52 | PL | Atg16l2 | gene expression | ENSRNOG00000019413 | 0.21 | 0.16 | top1 | 1 | 0.16 | 2.7e-12 | 5.2 | -5.2 | 1.5e-07 | -0.93 | 0.10 | 0.90 | FALSE |
53 | PL | Trim68 | isoform ratio | ENSRNOT00000095839 | 0.18 | 0.22 | blup | 2201 | 0.25 | 4.2e-19 | 4.9 | 5.3 | 1.3e-07 | 0.92 | 0.75 | 0.25 | FALSE |
54 | PL | Trim68 | intron excision ratio | chr1:157115748:157116120 | 0.05 | 0.04 | top1 | 1 | 0.04 | 2.4e-04 | 5.2 | -5.2 | 2.3e-07 | -0.81 | 0.12 | 0.10 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.