Best TWAS P = 5.61e-10 · Best GWAS P= 1.47e-10 conditioned to NaN
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | LOC120101678 | gene expression | LOC120101678 | 0.04 | 1 | 0.02 | 4.3e-03 | -5.54 | 3.02e-08 | 0.15 | FALSE |
| Adipose | Plcb1 | gene expression | Plcb1 | 0.1 | 1 | 0.05 | 4.4e-06 | 5.3 | 1.18e-07 | 0.05 | FALSE |
| Adipose | Plcb4 | isoform ratio | XM_063283133.1 | 0.05 | 1 | 0.06 | 9.7e-08 | 5.22 | 1.79e-07 | 0.4 | FALSE |
| Adipose | Plcb4 | isoform ratio | XM_063283135.1 | 0.03 | 4 | 0.04 | 7.8e-05 | -5.33 | 9.96e-08 | 0.36 | TRUE |
| Adipose | Plcb1 | mRNA stability | Plcb1 | 0.08 | 1 | 0.07 | 2.9e-08 | 5.26 | 1.45e-07 | 0.05 | FALSE |
| Adipose | Plcb4 | mRNA stability | Plcb4 | 0.06 | 28 | 0.05 | 1.6e-06 | -5.64 | 1.75e-08 | 0.46 | FALSE |
| BLA | Plcb4 | alternative TSS | XM_039104319.2 | 0.12 | 1407 | 0.05 | 1.0e-03 | 5.51 | 3.67e-08 | 0.2 | FALSE |
| BLA | Plcb4 | alternative TSS | XM_039104319.2 | 0.09 | 1407 | 0.05 | 1.5e-03 | 5.75 | 9.00e-09 | 0.22 | FALSE |
| BLA | Plcb1 | gene expression | Plcb1 | 0.28 | 1 | 0.24 | 4.8e-13 | 5.32 | 1.02e-07 | 0.07 | FALSE |
| BLA | Plcb4 | intron excision ratio | chr3_143493493_143559809 | 0.05 | 47 | 0.03 | 9.5e-03 | -5.93 | 3.05e-09 | 0.33 | FALSE |
| BLA | Plcb1 | mRNA stability | Plcb1 | 0.07 | 1 | 0.03 | 6.7e-03 | 5.46 | 4.66e-08 | 0.04 | FALSE |
| Brain | LOC120101919 | gene expression | LOC120101919 | 0.11 | 1199 | 0.11 | 7.8e-11 | 5.35 | 8.70e-08 | 0.44 | FALSE |
| Brain | Plcb1 | gene expression | Plcb1 | 0.6 | 1 | 0.58 | 1.8e-66 | 5.44 | 5.28e-08 | 0.13 | FALSE |
| Brain | Plcb1 | intron excision ratio | chr3_143138850_143150657 | 0.03 | 1107 | 0.03 | 1.3e-03 | 5.75 | 9.09e-09 | 0.16 | FALSE |
| Brain | Plcb1 | intron excision ratio | chr3_143138850_143222448 | 0.02 | 1107 | 0.01 | 2.3e-02 | -5.94 | 2.92e-09 | 0.31 | FALSE |
| Brain | Plcb4 | intron excision ratio | chr3_143517457_143559809 | 0.02 | 1407 | 0.02 | 3.1e-03 | -5.34 | 9.29e-08 | 0.29 | FALSE |
| IC | Plcb1 | gene expression | Plcb1 | 0.66 | 1107 | 0.48 | 1.1e-22 | 5.51 | 3.49e-08 | 0.1 | FALSE |
| IC | Plcb1 | mRNA stability | Plcb1 | 0.1 | 1 | 0.05 | 2.7e-03 | 5.39 | 7.21e-08 | 0.04 | FALSE |
| IL | Plcb1 | gene expression | Plcb1 | 0.22 | 1107 | 0.11 | 1.3e-03 | 5.73 | 9.97e-09 | 0.2 | FALSE |
| IL | Plcb4 | gene expression | Plcb4 | 0.56 | 1 | 0.3 | 6.7e-08 | -5.23 | 1.73e-07 | 0.18 | FALSE |
| IL | Plcb1 | mRNA stability | Plcb1 | 0.19 | 1 | 0.05 | 2.5e-02 | 5.3 | 1.15e-07 | 0.05 | FALSE |
| Liver | LOC103691897 | gene expression | LOC103691897 | 0.12 | 23 | 0.12 | 2.3e-13 | -5.53 | 3.16e-08 | 0.15 | TRUE |
| Liver | Plcb1 | gene expression | Plcb1 | 0.05 | 33 | 0.04 | 6.2e-05 | -5.56 | 2.65e-08 | 0.11 | FALSE |
| Liver | Plcb1 | isoform ratio | NM_001077641.2 | 0.02 | 1 | 0.01 | 4.7e-02 | -5.26 | 1.45e-07 | 0.03 | FALSE |
| Liver | Hao1 | mRNA stability | Hao1 | 0.39 | 47 | 0.27 | 9.0e-30 | 5.87 | 4.31e-09 | 0.08 | FALSE |
| NAcc | Plcb4 | gene expression | Plcb4 | 0.11 | 24 | 0.14 | 1.0e-20 | -5.32 | 1.03e-07 | 0.25 | FALSE |
| NAcc | Plcb1 | intron excision ratio | chr3_143138850_143222448 | 0.04 | 1 | 0.03 | 6.2e-05 | -6.2 | 5.61e-10 | 0.88 | TRUE |
| NAcc | Plcb1 | mRNA stability | Plcb1 | 0.06 | 1 | 0.03 | 6.7e-05 | 5.34 | 9.14e-08 | 0.07 | FALSE |
| OFC | Plcb1 | gene expression | Plcb1 | 0.33 | 1 | 0.37 | 9.0e-10 | 5.24 | 1.56e-07 | 0.05 | FALSE |
| OFC | Plcb4 | gene expression | Plcb4 | 0.52 | 238 | 0.46 | 1.6e-12 | -5.32 | 1.02e-07 | 0.26 | FALSE |
| OFC | Plcb1 | mRNA stability | Plcb1 | 0.29 | 1 | 0.23 | 4.4e-06 | 5.33 | 1.01e-07 | 0.05 | FALSE |
| PL | Plcb4 | alternative TSS | XM_039104317.2 | 0.03 | 1 | 0.03 | 1.4e-04 | -5.23 | 1.71e-07 | 0.04 | TRUE |
| PL | Plcb4 | alternative TSS | XM_039104319.2 | 0.16 | 8 | 0.12 | 1.7e-13 | 5.43 | 5.62e-08 | 0.21 | TRUE |
| PL | Plcb1 | gene expression | Plcb1 | 0.27 | 77 | 0.24 | 1.7e-26 | 5.33 | 9.85e-08 | 0.09 | FALSE |
| PL | Plcb1 | isoform ratio | XM_017591467.3 | 0.02 | 1 | 0.01 | 3.8e-02 | 5.33 | 1.00e-07 | 0.03 | FALSE |
| PL | Plcb1 | intron excision ratio | chr3_143138850_143150657 | 0.02 | 1107 | 0.01 | 9.9e-03 | 5.83 | 5.63e-09 | 0.21 | FALSE |
| PL | Plcb4 | intron excision ratio | chr3_143493493_143559809 | 0.16 | 1407 | 0.09 | 3.3e-10 | -5.43 | 5.78e-08 | 0.19 | TRUE |
| PL | Plcb1 | mRNA stability | Plcb1 | 0.08 | 1 | 0.06 | 5.5e-07 | 5.34 | 9.08e-08 | 0.09 | FALSE |
| pVTA | Plcb4 | alternative TSS | XM_039104325.2 | 0.1 | 14 | 0.13 | 1.7e-10 | -5.27 | 1.38e-07 | 0.22 | FALSE |
| pVTA | Plcb4 | isoform ratio | XM_063283134.1 | 0.08 | 1407 | 0.08 | 2.8e-07 | 5.86 | 4.52e-09 | 0.25 | FALSE |
| pVTA | Plcb4 | intron excision ratio | chr3_143517457_143559809 | 0.02 | 1 | 0.02 | 1.1e-02 | -5.2 | 1.95e-07 | 0.04 | FALSE |
| pVTA | Plcb1 | mRNA stability | Plcb1 | 0.17 | 1107 | 0.26 | 1.3e-20 | 5.54 | 2.95e-08 | 0.1 | FALSE |
| RMTg | Plcb1 | alternative TSS | NM_001077641.2 | 0.14 | 22 | 0.06 | 9.9e-03 | -5.4 | 6.51e-08 | 0.13 | FALSE |
| RMTg | Plcb1 | alternative TSS | XM_017591467.3 | 0.13 | 17 | 0.06 | 8.4e-03 | 5.4 | 6.51e-08 | 0.13 | FALSE |