Best TWAS P=1.35e-08 · Best GWAS P=2.28e-08 conditioned to 1.41e-01
Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
---|---|---|---|---|---|---|---|---|---|---|---|
Adipose | Folr1 | alternative polyA | XM_039085665.1 | 0.08 | 22 | 0.06 | 9.2e-07 | 5.22 | 1.83e-07 | 0.64 | FALSE |
Adipose | Folr1 | alternative TSS | NM_133527.2 | 0.06 | 1561 | 0.03 | 2.7e-04 | -5.32 | 1.06e-07 | 0.45 | FALSE |
Adipose | Folr1 | alternative TSS | XM_006229842.4 | 0.1 | 1561 | 0.06 | 1.9e-07 | 5.43 | 5.60e-08 | 0.65 | FALSE |
Adipose | Folr1 | alternative TSS | XM_017588710.2 | 0.09 | 1561 | 0.04 | 2.6e-05 | 5.25 | 1.50e-07 | 0.33 | FALSE |
Adipose | Folr2 | alternative TSS | XM_006229858.4 | 0.06 | 1557 | 0.03 | 5.5e-04 | -5.25 | 1.51e-07 | 0.39 | FALSE |
Adipose | Nup98 | gene expression | Nup98 | 0.25 | 29 | 0.17 | 2.4e-18 | -5.68 | 1.35e-08 | 0.52 | TRUE |
Adipose | Rnf121 | gene expression | Rnf121 | 0.05 | 1524 | 0.02 | 1.4e-03 | -5.44 | 5.44e-08 | 0.62 | FALSE |
Adipose | Trim21 | gene expression | Trim21 | 0.05 | 21 | 0.04 | 9.2e-06 | 5.3 | 1.14e-07 | 0.32 | FALSE |
Adipose | Pgap2 | isoform ratio | XM_039111474.1 | 0.02 | 1361 | 0.01 | 7.8e-03 | 5.4 | 6.72e-08 | 0.33 | FALSE |
Adipose | Anapc15 | mRNA stability | Anapc15 | 0.03 | 1 | 0.01 | 1.4e-02 | -5.29 | 1.19e-07 | 0.04 | FALSE |
Adipose | Trim21 | mRNA stability | Trim21 | 0.09 | 2049 | 0.1 | 7.2e-11 | -5.24 | 1.57e-07 | 0.32 | FALSE |
BLA | Atg16l2 | gene expression | Atg16l2 | 0.35 | 1 | 0.17 | 1.6e-09 | 5.25 | 1.53e-07 | 0.9 | FALSE |
BLA | Folr2 | gene expression | Folr2 | 0.15 | 6 | 0.06 | 4.1e-04 | -5.21 | 1.93e-07 | 0.41 | FALSE |
BLA | Numa1 | gene expression | Numa1 | 0.07 | 1594 | 0.02 | 1.8e-02 | -5.34 | 9.24e-08 | 0.3 | FALSE |
BLA | Trim68 | isoform ratio | XM_039101114.1 | 0.12 | 1 | 0.02 | 3.2e-02 | -5.4 | 6.66e-08 | 0.05 | FALSE |
BLA | Nup98 | mRNA stability | Nup98 | 0.18 | 96 | 0.14 | 9.9e-08 | -5.52 | 3.37e-08 | 0.66 | FALSE |
BLA | Trim68 | mRNA stability | Trim68 | 0.24 | 2206 | 0.27 | 7.6e-15 | -5.25 | 1.50e-07 | 0.2 | FALSE |
Brain | Atg16l2 | gene expression | Atg16l2 | 0.04 | 1653 | 0.03 | 8.3e-04 | -5.38 | 7.25e-08 | 0.63 | FALSE |
Brain | Folr2 | gene expression | Folr2 | 0.04 | 1 | 0.03 | 4.1e-04 | 5.18 | 2.22e-07 | 0.07 | FALSE |
Brain | Inppl1 | gene expression | Inppl1 | 0.1 | 1572 | 0.06 | 1.3e-06 | -5.42 | 6.00e-08 | 0.67 | FALSE |
Brain | Fam168a | isoform ratio | XM_006229773.4 | 0.1 | 5 | 0.07 | 1.7e-07 | -5.21 | 1.91e-07 | 0.67 | FALSE |
Brain | Trim68 | intron excision ratio | chr1_157118269_157120638 | 0.06 | 2206 | 0.06 | 4.1e-06 | -5.2 | 2.01e-07 | 0.27 | FALSE |
Brain | Xndc1 | intron excision ratio | chr1_156450846_156452614 | 0.12 | 1 | 0.08 | 4.0e-08 | 5.18 | 2.24e-07 | 0.72 | FALSE |
Brain | Fchsd2 | mRNA stability | Fchsd2 | 0.09 | 9 | 0.07 | 5.1e-07 | 5.38 | 7.45e-08 | 0.67 | FALSE |
Brain | Rnf121 | mRNA stability | Rnf121 | 0.32 | 1526 | 0.23 | 1.4e-21 | 5.34 | 9.37e-08 | 0.7 | FALSE |
Eye | Hbb | gene expression | Hbb | 0.45 | 1 | 0.01 | 1.9e-01 | -5.32 | 1.04e-07 | 0.06 | FALSE |
Eye | Hbb-b2 | intron excision ratio | chr1_158237229_158237869 | 0.42 | 1 | 0.12 | 6.2e-03 | 5.22 | 1.82e-07 | 0.06 | FALSE |
Eye | Hbb-b2 | intron excision ratio | chr1_158243955_158244595 | 0.49 | 1 | 0.15 | 2.5e-03 | 5.22 | 1.82e-07 | 0.06 | FALSE |
Eye | Hbb-bs | intron excision ratio | chr1_158237229_158237869 | 0.42 | 1 | 0.12 | 6.2e-03 | 5.22 | 1.82e-07 | 0.06 | FALSE |
Eye | Hbb-bs | intron excision ratio | chr1_158243955_158244595 | 0.5 | 1 | 0.15 | 2.5e-03 | 5.22 | 1.82e-07 | 0.06 | FALSE |
Eye | LOC100134871 | intron excision ratio | chr1_158237229_158237869 | 0.42 | 1 | 0.12 | 6.2e-03 | 5.22 | 1.82e-07 | 0.06 | FALSE |
Eye | LOC100134871 | intron excision ratio | chr1_158243955_158244595 | 0.5 | 1 | 0.15 | 2.5e-03 | 5.22 | 1.82e-07 | 0.06 | FALSE |
Eye | Trim68 | mRNA stability | Trim68 | 0.53 | 98 | 0.06 | 3.9e-02 | 5.38 | 7.30e-08 | 0.22 | FALSE |
IL | Rnf121 | gene expression | Rnf121 | 0.23 | 1526 | 0.11 | 1.2e-03 | -5.36 | 8.50e-08 | 0.49 | FALSE |
LHb | Hbb-b1 | gene expression | Hbb-b1 | 0.42 | 1 | 0.25 | 1.5e-06 | 5.21 | 1.87e-07 | 0.39 | FALSE |
LHb | LOC100134871 | gene expression | LOC100134871 | 0.6 | 30 | 0.39 | 3.9e-10 | -5.3 | 1.15e-07 | 0.32 | FALSE |
LHb | Xndc1 | gene expression | Xndc1 | 0.28 | 1525 | 0.04 | 3.3e-02 | 5.44 | 5.40e-08 | 0.32 | FALSE |
LHb | Hbb-b1 | intron excision ratio | chr1_158218619_158219259 | 0.61 | 1 | 0.39 | 2.2e-10 | 5.21 | 1.87e-07 | 0.68 | FALSE |
LHb | Hbb-bs | intron excision ratio | chr1_158218619_158219259 | 0.61 | 1 | 0.39 | 2.2e-10 | 5.21 | 1.88e-07 | 0.68 | FALSE |
LHb | Hbb | intron excision ratio | chr1_158218619_158219259 | 0.61 | 1 | 0.39 | 2.2e-10 | 5.21 | 1.91e-07 | 0.69 | FALSE |
LHb | LOC100134871 | intron excision ratio | chr1_158218619_158219259 | 0.61 | 1 | 0.39 | 2.2e-10 | 5.21 | 1.89e-07 | 0.69 | FALSE |
Liver | Folr2 | gene expression | Folr2 | 0.39 | 1557 | 0.22 | 1.7e-24 | -5.32 | 1.03e-07 | 0.45 | FALSE |
Liver | Il18bp | gene expression | Il18bp | 0.28 | 1563 | 0.16 | 1.0e-17 | -5.34 | 9.45e-08 | 0.68 | FALSE |
Liver | LOC102546541 | gene expression | LOC102546541 | 0.7 | 32 | 0.41 | 1.2e-48 | -5.41 | 6.34e-08 | 0.74 | FALSE |
Liver | Rnf121 | gene expression | Rnf121 | 0.05 | 1524 | 0.02 | 2.1e-03 | -5.34 | 9.05e-08 | 0.42 | FALSE |
Liver | Atg16l2 | intron excision ratio | chr1_155708732_155710770 | 0.41 | 1653 | 0.15 | 6.3e-16 | -5.23 | 1.70e-07 | 0.7 | FALSE |
Liver | LOC102546541 | intron excision ratio | chr1_155708732_155710770 | 0.41 | 1641 | 0.15 | 6.0e-16 | -5.23 | 1.74e-07 | 0.7 | FALSE |
Liver | Pgap2 | mRNA stability | Pgap2 | 0.06 | 1361 | 0.04 | 7.2e-05 | 5.32 | 1.02e-07 | 0.43 | FALSE |
NAcc | Folr2 | gene expression | Folr2 | 0.03 | 14 | 0.01 | 2.1e-02 | 5.21 | 1.90e-07 | 0.32 | FALSE |
NAcc | Pgap2 | gene expression | Pgap2 | 0.07 | 1363 | 0.07 | 9.5e-09 | 5.37 | 7.81e-08 | 0.54 | FALSE |
NAcc | Rnf121 | gene expression | Rnf121 | 0.04 | 1526 | 0 | 8.3e-02 | -5.42 | 6.02e-08 | 0.54 | FALSE |
NAcc | Xndc1 | gene expression | Xndc1 | 0.09 | 1525 | 0.07 | 8.1e-09 | 5.41 | 6.22e-08 | 0.7 | FALSE |
NAcc | Trim68 | isoform ratio | XM_039101109.1 | 0.08 | 21 | 0.1 | 1.3e-11 | -5.48 | 4.36e-08 | 0.24 | FALSE |
NAcc | Trim68 | intron excision ratio | chr1_157115599_157116120 | 0.04 | 2206 | 0.02 | 2.0e-03 | 5.23 | 1.73e-07 | 0.23 | FALSE |
NAcc | Trim68 | intron excision ratio | chr1_157115748_157116120 | 0.04 | 2206 | 0.02 | 1.8e-03 | -5.25 | 1.49e-07 | 0.24 | FALSE |
OFC | LOC120097890 | gene expression | LOC120097890 | 0.23 | 1 | 0.16 | 1.2e-04 | 5.39 | 7.19e-08 | 0.07 | FALSE |
PL | Stard10 | alternative polyA | NM_001013069.1 | 0.05 | 1638 | 0.03 | 2.9e-04 | 5.31 | 1.09e-07 | 0.58 | FALSE |
PL | Stard10 | alternative polyA | XM_039106105.1 | 0.05 | 27 | 0.04 | 8.2e-05 | 5.22 | 1.81e-07 | 0.61 | FALSE |
PL | Atg16l2 | gene expression | Atg16l2 | 0.16 | 1 | 0.13 | 1.3e-14 | 5.25 | 1.53e-07 | 0.9 | FALSE |
PL | Pgap2 | gene expression | Pgap2 | 0.04 | 85 | 0.03 | 4.5e-04 | -5.48 | 4.35e-08 | 0.51 | FALSE |
PL | Olr59 | intron excision ratio | chr1_157195372_157198411 | 0.02 | 2508 | 0.02 | 5.6e-03 | 5.4 | 6.49e-08 | 0.41 | FALSE |
PL | Olr59 | intron excision ratio | chr1_157198543_157211031 | 0.02 | 2508 | 0.01 | 1.2e-02 | -5.33 | 1.01e-07 | 0.36 | FALSE |
PL | Nup98 | mRNA stability | Nup98 | 0.04 | 1365 | 0.02 | 2.3e-03 | 5.36 | 8.18e-08 | 0.6 | FALSE |
PL | Trim21 | mRNA stability | Trim21 | 0.06 | 1 | 0.1 | 4.0e-11 | 5.2 | 1.95e-07 | 0.54 | FALSE |
pVTA | Pgap2 | gene expression | Pgap2 | 0.22 | 1363 | 0.12 | 5.7e-06 | 5.36 | 8.24e-08 | 0.43 | FALSE |