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chr18:25,367,445-27,317,045

Trait: Body weight

Best TWAS P = 5.01e-16 · Best GWAS P= 2.28e-11 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h2	# weights	Model R2	Model R2 P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Cdc23	alternative polyA	NM_001100659.1	0.21	884	0.15	1.3e-16	-6.16	7.39e-10	0.65	FALSE
Adipose	Cdc23	alternative polyA	XM_008772028.4	0.15	884	0.12	1.5e-13	6.03	1.59e-09	0.65	FALSE
Adipose	Reep5	alternative polyA	NM_001108888.2	0.06	1156	0.06	1.3e-07	-5.46	4.86e-08	0.62	FALSE
Adipose	Reep5	alternative polyA	XM_039097000.2	0.06	1156	0.06	3.5e-07	5.35	8.94e-08	0.62	FALSE
Adipose	Brd8	gene expression	Brd8	0.03	1	0.01	4.8e-02	6.35	2.11e-10	0.03	FALSE
Adipose	Cdc23	gene expression	Cdc23	0.04	1	0.03	1.8e-04	6.16	7.31e-10	0.05	FALSE
Adipose	LOC134482927	gene expression	LOC134482927	0.09	944	0.07	5.6e-08	-6.02	1.71e-09	0.62	FALSE
Adipose	Pkd2l2	gene expression	Pkd2l2	0.03	35	0.02	9.6e-04	-5.66	1.54e-08	0.57	TRUE
Adipose	Srp19	gene expression	Srp19	0.07	1	0.03	4.7e-04	5.77	8.09e-09	0.03	FALSE
Adipose	Cdc23	isoform ratio	NM_001100659.1	0.18	884	0.14	3.6e-15	-6.16	7.36e-10	0.66	FALSE
Adipose	Cdc23	isoform ratio	XM_008772028.4	0.14	884	0.12	9.9e-13	6.11	9.92e-10	0.66	FALSE
Adipose	Fam13b	isoform ratio	XM_039096734.1	0.03	1012	0.02	2.2e-03	5.4	6.70e-08	0.48	FALSE
Adipose	Fam13b	intron excision ratio	chr18_26339258_26341471	0.03	1	0.02	9.2e-04	-5.27	1.37e-07	0.03	FALSE
Adipose	Cdc23	mRNA stability	Cdc23	0.04	1	0.03	1.2e-04	5.22	1.81e-07	0.03	FALSE
Adipose	Pkd2l2	mRNA stability	Pkd2l2	0.02	1138	0.01	2.8e-02	-5.43	5.55e-08	0.46	FALSE
BLA	Cdc23	alternative polyA	NM_001100659.1	0.15	13	0.14	4.6e-08	-6.17	6.73e-10	0.69	FALSE
BLA	Apc	intron excision ratio	chr18_26177302_26181872	0.04	1225	0.02	2.1e-02	-5.83	5.65e-09	0.5	FALSE
BLA	Reep5	intron excision ratio	chr18_26221814_26224142	0.07	1156	0.04	1.9e-03	-5.24	1.57e-07	0.66	FALSE
BLA	Reep5	intron excision ratio	chr18_26224310_26232067	0.09	1156	0.06	3.1e-04	5.43	5.60e-08	0.68	FALSE
BLA	Reep5	mRNA stability	Reep5	0.09	1156	0.04	3.7e-03	7.6	3.01e-14	0.6	TRUE
Brain	Cdc23	alternative polyA	NM_001100659.1	0.1	884	0.12	1.4e-11	-6.21	5.30e-10	0.69	FALSE
Brain	Cdc23	alternative polyA	XM_008772028.4	0.08	884	0.09	5.1e-09	6.25	4.23e-10	0.68	FALSE
Brain	Epb41l4a	alternative TSS	XM_006254583.5	0.03	1482	0.02	4.7e-03	-5.65	1.64e-08	0.54	TRUE
Brain	Fam13b	alternative TSS	XM_039096734.1	0.07	1012	0.09	9.5e-09	5.61	2.00e-08	0.67	FALSE
Brain	Brd8	gene expression	Brd8	0.03	934	0.04	3.0e-04	5.91	3.53e-09	0.43	FALSE
Brain	LOC134482927	gene expression	LOC134482927	0.04	1	0.04	8.2e-05	-5.4	6.75e-08	0.03	FALSE
Brain	Reep5	gene expression	Reep5	0.04	1156	0.05	1.4e-05	6.07	1.24e-09	0.7	FALSE
Brain	Cdc23	isoform ratio	NM_001100659.1	0.1	884	0.13	4.8e-12	-6.21	5.25e-10	0.7	FALSE
Brain	Cdc23	isoform ratio	XM_008772028.4	0.06	884	0.07	7.3e-07	6.22	4.91e-10	0.69	FALSE
Brain	Fam13b	isoform ratio	XM_039096734.1	0.09	1012	0.09	8.1e-09	5.47	4.60e-08	0.68	FALSE
Brain	Reep5	intron excision ratio	chr18_26224310_26232067	0.04	1156	0.04	2.6e-04	5.28	1.33e-07	0.66	FALSE
Eye	Cdc25c	alternative TSS	XM_063277372.1	0.25	793	0.09	1.7e-02	6.33	2.46e-10	0.4	FALSE
Eye	Fam13b	gene expression	Fam13b	0.26	1	0.06	4.6e-02	5.39	7.13e-08	0.06	FALSE
Eye	Srp19	intron excision ratio	chr18_26210140_26210233	0.22	1271	0.07	3.4e-02	6.96	3.29e-12	0.33	FALSE
Eye	Srp19	intron excision ratio	chr18_26210344_26211679	0.22	1271	0.06	4.6e-02	-7.09	1.35e-12	0.3	FALSE
IC	Cdc23	alternative polyA	NM_001100659.1	0.21	884	0.17	1.4e-07	-6.31	2.84e-10	0.75	FALSE
IC	Cdc23	alternative polyA	XM_008772028.4	0.23	1	0.13	4.6e-06	5.25	1.49e-07	0.03	FALSE
IC	Reep5	alternative polyA	NM_001108888.2	0.19	1	0.15	5.7e-07	-6.31	2.79e-10	0.47	FALSE
IC	Reep5	alternative polyA	XM_039097000.2	0.16	1	0.14	1.8e-06	6.31	2.79e-10	0.43	FALSE
IC	Fam13b	alternative TSS	XM_039096734.1	0.06	4	0.07	8.8e-04	6.22	5.02e-10	0.46	FALSE
IC	LOC103694952	gene expression	LOC103694952	0.05	1201	0.04	7.9e-03	5.58	2.46e-08	0.46	FALSE
IC	LOC134482981	gene expression	LOC134482981	0.08	1	0.07	5.1e-04	5.28	1.26e-07	0.04	FALSE
IC	Cdc23	isoform ratio	NM_001100659.1	0.18	23	0.16	4.0e-07	-5.77	8.14e-09	0.74	FALSE
IC	Cdc23	isoform ratio	XM_008772028.4	0.12	884	0.1	4.6e-05	6.22	4.91e-10	0.71	FALSE
IL	Cdc23	alternative polyA	NM_001100659.1	0.25	884	0.11	1.6e-03	-6.17	6.80e-10	0.53	FALSE
IL	Cdc23	alternative polyA	XM_008772028.4	0.19	884	0.09	4.1e-03	5.97	2.40e-09	0.44	FALSE
IL	LOC134482927	gene expression	LOC134482927	0.24	131	0.13	4.9e-04	-6.2	5.74e-10	0.64	FALSE
IL	Cdc23	isoform ratio	NM_001100659.1	0.29	16	0.09	3.1e-03	-6.61	3.96e-11	0.45	TRUE
LHb	Reep5	alternative polyA	NM_001108888.2	0.14	861	0.04	3.1e-02	-5.87	4.43e-09	0.34	FALSE
LHb	Reep5	alternative polyA	XM_039097000.2	0.12	861	0.04	4.4e-02	5.94	2.87e-09	0.32	FALSE
LHb	Cdc23	gene expression	Cdc23	0.3	1	0.18	5.6e-05	6.56	5.38e-11	0.08	FALSE
LHb	Epb41l4a	gene expression	Epb41l4a	0.9	12	0.17	8.3e-05	-8.11	5.01e-16	0.17	TRUE
LHb	Kdm3b	gene expression	Kdm3b	0.23	1	0.08	5.5e-03	-5.77	8.15e-09	0.05	FALSE
LHb	Cdc23	isoform ratio	XM_008772028.4	0.42	884	0.16	1.1e-04	6.01	1.86e-09	0.64	FALSE
Liver	Cdc23	alternative polyA	NM_001100659.1	0.09	1	0.07	7.2e-08	-6.38	1.78e-10	0.6	FALSE
Liver	Cdc23	alternative polyA	XM_008772028.4	0.18	884	0.12	7.8e-13	6.17	7.01e-10	0.66	FALSE
Liver	Reep5	alternative polyA	NM_001108888.2	0.09	1	0.09	1.2e-09	-5.3	1.15e-07	0	FALSE
Liver	Reep5	alternative polyA	XM_039097000.2	0.08	23	0.07	1.3e-08	6.07	1.26e-09	0.58	FALSE
Liver	Fam13b	alternative TSS	XM_039096734.1	0.03	1	0.02	8.9e-04	6.61	3.93e-11	0.23	FALSE
Liver	Brd8	gene expression	Brd8	0.08	1	0.06	6.9e-07	6.35	2.11e-10	0.53	FALSE
Liver	Cdc23	gene expression	Cdc23	0.17	28	0.12	1.2e-13	5.68	1.31e-08	0.64	FALSE
Liver	Fam13b	gene expression	Fam13b	0.16	1012	0.14	3.3e-15	6.6	4.07e-11	0.61	FALSE
Liver	Reep5	gene expression	Reep5	0.16	1156	0.14	1.1e-15	6.29	3.26e-10	0.61	FALSE
Liver	Srp19	gene expression	Srp19	0.05	1271	0.01	6.8e-03	7.02	2.20e-12	0.55	FALSE
Liver	Cdc23	isoform ratio	NM_001100659.1	0.09	1	0.06	1.3e-07	-6.38	1.78e-10	0.6	FALSE
Liver	Cdc23	isoform ratio	XM_008772028.4	0.16	884	0.12	8.9e-13	6.17	7.04e-10	0.66	FALSE
Liver	Reep5	isoform ratio	NM_001108888.2	0.04	1156	0.04	4.5e-05	-5.49	3.91e-08	0.58	FALSE
Liver	Reep5	isoform ratio	XM_039097000.2	0.05	1156	0.04	1.9e-05	5.6	2.18e-08	0.57	FALSE
Liver	Reep5	mRNA stability	Reep5	0.02	1156	-0	3.9e-01	5.45	5.01e-08	0.41	FALSE
NAcc	Cdc23	alternative polyA	NM_001100659.1	0.11	884	0.12	1.6e-17	-6.25	4.21e-10	0.56	FALSE
NAcc	Cdc23	alternative polyA	XM_008772028.4	0.11	884	0.12	1.6e-17	6.36	1.98e-10	0.71	FALSE
NAcc	Pkd2l2	alternative polyA	NM_001106156.1	0.03	1	0.02	4.8e-04	6.5	8.18e-11	0.14	FALSE
NAcc	Pkd2l2	alternative polyA	XM_063277220.1	0.03	1	0.02	4.9e-04	-6.5	8.18e-11	0.14	FALSE
NAcc	Reep5	alternative polyA	NM_001108888.2	0.08	1	0.12	1.7e-17	-6.5	8.18e-11	0.76	FALSE
NAcc	Reep5	alternative polyA	XM_039097000.2	0.08	1	0.1	4.9e-15	6.5	8.18e-11	0.76	FALSE
NAcc	LOC134482927	gene expression	LOC134482927	0.05	1	0.05	1.0e-07	-6.28	3.29e-10	0.45	FALSE
NAcc	Cdc23	isoform ratio	NM_001100659.1	0.14	884	0.13	1.0e-18	-6.32	2.66e-10	0.57	FALSE
NAcc	Cdc23	isoform ratio	XM_008772028.4	0.12	884	0.1	3.4e-14	6.36	2.05e-10	0.66	FALSE
NAcc	Nme5	isoform ratio	NM_001427396.1	0.02	1	0.01	3.5e-03	6.35	2.13e-10	0.04	FALSE
NAcc	Apc	intron excision ratio	chr18_26138569_26143339	0.02	1	0.02	4.9e-04	-6.26	3.92e-10	0.04	FALSE
NAcc	Nme5	intron excision ratio	chr18_26444014_26454298	0.02	1	0.02	1.6e-03	5.31	1.07e-07	0.03	FALSE
NAcc	Reep5	intron excision ratio	chr18_26224310_26232067	0.02	1	0.02	8.5e-04	6.21	5.17e-10	0.04	FALSE
NAcc	Apc	mRNA stability	Apc	0.02	1	0.02	1.6e-03	6.5	8.18e-11	0.07	FALSE
NAcc	Nme5	mRNA stability	Nme5	0.02	947	0.01	9.2e-03	5.27	1.40e-07	0.47	FALSE
PL	Reep5	alternative polyA	NM_001108888.2	0.07	1	0.12	8.3e-13	-5.24	1.57e-07	0	FALSE
PL	Reep5	alternative polyA	XM_039097000.2	0.08	1	0.12	3.5e-13	5.24	1.57e-07	0	FALSE
PL	Fam13b	alternative TSS	XM_039096734.1	0.03	1012	0.03	6.3e-04	5.52	3.31e-08	0.67	FALSE
PL	Apc	gene expression	Apc	0.02	1225	0.02	1.7e-03	-5.22	1.81e-07	0.54	FALSE
PL	LOC134482927	gene expression	LOC134482927	0.05	944	0.05	2.6e-06	-6	1.95e-09	0.65	FALSE
PL	Nme5	gene expression	Nme5	0.04	1	0.03	2.5e-04	-5.77	8.15e-09	0.03	FALSE
PL	Reep5	gene expression	Reep5	0.08	1156	0.07	1.4e-08	7.45	9.58e-14	0.71	FALSE
PL	Cdc23	isoform ratio	NM_001100659.1	0.13	884	0.12	1.2e-12	-5.97	2.42e-09	0.71	FALSE
PL	Cdc23	isoform ratio	XM_008772028.4	0.08	1	0.06	2.1e-07	6.56	5.38e-11	0.83	FALSE
PL	Nme5	isoform ratio	NM_001427396.1	0.04	1	0.04	9.6e-05	5.35	8.57e-08	0.58	FALSE
PL	Reep5	isoform ratio	NM_001108888.2	0.04	1	0.06	3.2e-07	-5.27	1.33e-07	0	FALSE
PL	Reep5	isoform ratio	XM_039097000.2	0.04	1	0.05	1.3e-06	5.27	1.33e-07	0.01	FALSE
PL	Apc	intron excision ratio	chr18_26138569_26145583	0.03	1	0.01	3.7e-02	5.26	1.45e-07	0.03	FALSE
PL	Cdc23	intron excision ratio	chr18_26514797_26516423	0.05	884	0.03	3.0e-04	5.8	6.78e-09	0.66	FALSE
PL	Nme5	intron excision ratio	chr18_26444014_26454298	0.06	947	0.05	7.1e-06	6.18	6.60e-10	0.69	FALSE
PL	Reep5	mRNA stability	Reep5	0.04	1	0.01	6.2e-02	6.49	8.51e-11	0.04	FALSE
pVTA	Cdc23	alternative polyA	NM_001100659.1	0.22	1	0.12	5.5e-10	-5.23	1.70e-07	0	FALSE
pVTA	Cdc23	alternative polyA	XM_008772028.4	0.26	884	0.26	4.2e-21	6.05	1.44e-09	0.57	FALSE
pVTA	Reep5	alternative polyA	NM_001108888.2	0.06	1	0.05	7.7e-05	-6.51	7.54e-11	0.28	FALSE
pVTA	Reep5	alternative polyA	XM_039097000.2	0.06	1	0.04	1.7e-04	6.51	7.54e-11	0.2	FALSE
pVTA	Brd8	gene expression	Brd8	0.05	1	0.05	9.0e-05	6.36	1.98e-10	0.27	FALSE
pVTA	Cdc23	gene expression	Cdc23	0.15	884	0.18	1.1e-14	6.18	6.36e-10	0.72	FALSE
pVTA	Nme5	gene expression	Nme5	0.06	5	0.03	8.6e-04	-5.43	5.72e-08	0.64	FALSE
pVTA	Cdc23	isoform ratio	NM_001100659.1	0.11	1	0.09	6.4e-08	-5.58	2.35e-08	0.01	FALSE
pVTA	Cdc23	isoform ratio	XM_008772028.4	0.27	9	0.28	1.2e-22	5.29	1.21e-07	0.53	FALSE
pVTA	Cdc23	intron excision ratio	chr18_26514293_26514524	0.03	1	0.03	2.1e-03	-5.32	1.02e-07	0.03	FALSE
RMTg	Nme5	intron excision ratio	chr18_26444014_26454298	0.16	88	0.16	3.9e-05	6.42	1.33e-10	0.66	FALSE