Hub : Traits : dissection: UMAP 1 of all traits : ← →

chr7:26,984,346-30,734,621

Best TWAS P=1.078642e-12 · Best GWAS P=1.534447e-12 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Elk3	gene expression	ENSRNOG00000004367	0.11	0.05	blup	2579	0.05	2.5e-06	6.20	-6.4	1.9e-10	-0.82	0.72	0.28	FALSE
2	Adipose	Hal	gene expression	ENSRNOG00000004502	0.03	0.00	blup	2432	0.01	6.9e-02	7.00	6.3	2.2e-10	0.84	0.30	0.34	FALSE
3	Adipose	Vezt	gene expression	ENSRNOG00000006514	0.11	0.08	top1	1	0.08	3.2e-09	5.86	5.9	4.5e-09	0.81	0.98	0.01	FALSE
4	Adipose	Vezt	mRNA stability	ENSRNOG00000006514	0.07	0.04	blup	2570	0.06	5.0e-07	6.13	6.6	4.2e-11	0.80	0.75	0.25	FALSE
5	BLA	Ntn4	gene expression	ENSRNOG00000005573	0.06	0.02	blup	2475	0.03	8.1e-03	-0.79	-6.2	5.9e-10	-0.85	0.44	0.37	FALSE
6	BLA	Vezt	gene expression	ENSRNOG00000006514	0.32	0.25	enet	97	0.30	1.1e-16	5.43	6.2	4.4e-10	0.81	0.87	0.13	TRUE
7	BLA	Metap2	gene expression	ENSRNOG00000021881	0.08	0.07	top1	1	0.07	1.9e-04	7.12	-7.1	1.1e-12	-0.95	0.07	0.27	TRUE
8	BLA	Mir331	gene expression	ENSRNOG00000035543	0.06	0.04	blup	2366	0.06	5.1e-04	5.09	-6.6	4.5e-11	-0.87	0.75	0.21	FALSE
9	BLA	Fgd6	gene expression	ENSRNOG00000054515	0.11	0.13	top1	1	0.13	2.7e-07	6.25	6.3	4.0e-10	0.89	0.81	0.12	FALSE
10	BLA	Lta4h	intron excision ratio	chr7:27997602:27999743	0.07	0.01	blup	2332	0.02	2.6e-02	5.62	6.1	9.3e-10	0.86	0.56	0.33	FALSE
11	BLA	Tmcc3	intron excision ratio	chr7:29133627:29159418	0.07	0.02	blup	2424	0.04	4.3e-03	5.34	5.3	1.3e-07	0.73	0.42	0.40	FALSE
12	BLA	Vezt	mRNA stability	ENSRNOG00000006514	0.40	0.42	top1	1	0.42	4.0e-24	6.50	-6.5	8.1e-11	-0.89	0.58	0.42	FALSE
13	BLA	Plxnc1	mRNA stability	ENSRNOG00000007970	0.11	0.11	top1	1	0.11	3.0e-06	5.50	-5.5	3.8e-08	-0.57	0.36	0.03	FALSE
14	Brain	Lta4h	gene expression	ENSRNOG00000004494	0.05	0.04	top1	1	0.04	9.1e-05	6.71	-6.7	1.9e-11	-0.97	0.11	0.10	TRUE
15	Brain	Vezt	gene expression	ENSRNOG00000006514	0.24	0.22	blup	2571	0.23	1.2e-20	6.65	6.4	1.5e-10	0.93	0.59	0.41	FALSE
16	Brain	Ndufa12	gene expression	ENSRNOG00000007407	0.49	0.32	blup	2574	0.34	6.1e-32	5.04	5.6	2.3e-08	0.69	1.00	0.00	FALSE
17	Brain	Socs2	gene expression	ENSRNOG00000008965	0.22	0.09	enet	118	0.11	5.0e-10	5.50	-5.1	2.9e-07	-0.17	0.95	0.05	FALSE
18	Brain	Metap2	gene expression	ENSRNOG00000021881	0.04	0.01	blup	2312	0.01	1.4e-02	6.58	-5.3	1.4e-07	-0.71	0.33	0.39	FALSE
19	Brain	Fgd6	gene expression	ENSRNOG00000054515	0.16	0.23	top1	1	0.23	8.6e-21	6.20	6.2	5.8e-10	0.88	0.90	0.10	FALSE
20	Brain	Lta4h	intron excision ratio	chr7:27997602:27999743	0.04	0.02	top1	1	0.02	4.8e-03	5.76	5.8	8.4e-09	0.86	0.10	0.03	FALSE
21	Brain	Lta4h	mRNA stability	ENSRNOG00000004494	0.05	0.02	blup	2332	0.03	9.8e-04	6.71	-6.6	3.8e-11	-0.94	0.36	0.59	FALSE
22	Brain	Vezt	mRNA stability	ENSRNOG00000006514	0.20	0.20	lasso	28	0.20	1.6e-18	6.18	-6.3	2.3e-10	-0.91	0.68	0.32	FALSE
23	Eye	Lta4h	gene expression	ENSRNOG00000004494	0.41	0.04	lasso	24	0.07	3.0e-02	6.49	-6.2	5.2e-10	-0.95	0.26	0.41	FALSE
24	Eye	Fgd6	gene expression	ENSRNOG00000054515	0.52	0.13	blup	2560	0.15	2.3e-03	5.10	5.8	5.8e-09	0.79	0.43	0.16	FALSE
25	Eye	Elk3	isoform ratio	ENSRNOT00000005911	0.36	0.01	blup	2579	0.10	1.2e-02	6.60	6.9	5.8e-12	0.95	0.26	0.45	FALSE
26	IL	Vezt	gene expression	ENSRNOG00000006514	0.29	0.20	lasso	4	0.26	7.2e-07	5.03	5.2	2.4e-07	0.81	0.61	0.38	FALSE
27	IL	Vezt	mRNA stability	ENSRNOG00000006514	0.23	0.06	blup	2568	0.10	2.4e-03	5.17	-6.4	1.3e-10	-0.80	0.60	0.25	FALSE
28	LHb	Nr2c1	alternative polyA	ENSRNOT00000009578	0.20	0.19	top1	1	0.19	2.6e-05	5.52	-5.5	3.5e-08	-0.72	0.14	0.05	FALSE
29	LHb	Nr2c1	alternative polyA	ENSRNOT00000089228	0.32	0.21	top1	1	0.21	8.9e-06	5.52	5.5	3.5e-08	0.71	0.15	0.05	FALSE
30	LHb	Ntn4	gene expression	ENSRNOG00000005573	0.21	0.04	blup	2473	0.06	1.6e-02	6.88	5.9	4.1e-09	0.86	0.33	0.47	FALSE
31	LHb	Cdk17	isoform ratio	ENSRNOT00000109496	0.18	0.05	blup	2984	0.11	1.4e-03	4.54	-5.9	3.9e-09	-0.75	0.50	0.26	FALSE
32	LHb	Vezt	mRNA stability	ENSRNOG00000006514	0.40	0.20	enet	84	0.21	1.1e-05	6.19	-6.7	2.1e-11	-0.91	0.60	0.40	FALSE
33	Liver	Amdhd1	gene expression	ENSRNOG00000005266	0.37	0.31	lasso	40	0.34	1.7e-39	5.56	6.5	1.0e-10	0.88	0.99	0.01	FALSE
34	Liver	Ntn4	gene expression	ENSRNOG00000005573	0.10	0.05	blup	2475	0.06	4.3e-07	6.11	6.9	4.4e-12	0.90	0.47	0.53	FALSE
35	Liver	Ccdc38	gene expression	ENSRNOG00000021892	0.32	0.35	top1	1	0.35	1.8e-40	5.56	-5.6	2.7e-08	-0.85	1.00	0.00	FALSE
36	Liver	Lta4h	mRNA stability	ENSRNOG00000004494	0.11	0.11	top1	1	0.11	6.2e-12	6.71	-6.7	1.9e-11	-0.93	0.38	0.62	FALSE
37	Liver	Amdhd1	mRNA stability	ENSRNOG00000005266	0.24	0.22	top1	1	0.22	6.1e-24	5.56	5.6	2.7e-08	0.87	1.00	0.00	FALSE
38	Liver	Snrpf	mRNA stability	ENSRNOG00000005556	0.03	0.02	top1	1	0.02	1.4e-03	5.59	5.6	2.3e-08	0.86	0.08	0.03	FALSE
39	Liver	Tmcc3	mRNA stability	ENSRNOG00000007713	0.17	0.05	lasso	13	0.05	1.3e-06	-4.67	5.1	3.0e-07	0.36	0.98	0.01	FALSE
40	NAcc	Vezt	gene expression	ENSRNOG00000006514	0.23	0.14	blup	2568	0.19	5.5e-05	6.46	6.7	2.1e-11	0.87	0.52	0.45	FALSE
41	NAcc2	Plxnc1	gene expression	ENSRNOG00000007970	0.10	0.09	top1	1	0.09	1.5e-05	5.19	5.2	2.1e-07	0.58	0.63	0.02	FALSE
42	NAcc2	Mir331	gene expression	ENSRNOG00000035543	0.04	0.03	enet	75	0.04	2.6e-03	6.89	-6.8	1.1e-11	-0.99	0.34	0.59	FALSE
43	NAcc2	Tmcc3	isoform ratio	ENSRNOT00000102476	0.04	0.03	top1	1	0.03	7.9e-03	5.30	5.3	1.2e-07	0.77	0.10	0.04	FALSE
44	NAcc2	Tmcc3	intron excision ratio	chr7:29133627:29159418	0.06	0.07	top1	1	0.07	8.3e-05	5.23	5.2	1.7e-07	0.77	0.12	0.04	FALSE
45	NAcc2	Lta4h	mRNA stability	ENSRNOG00000004494	0.08	0.09	top1	1	0.09	1.0e-05	7.02	-7.0	2.2e-12	-0.94	0.08	0.62	FALSE
46	NAcc2	Vezt	mRNA stability	ENSRNOG00000006514	0.09	0.04	blup	2571	0.06	4.2e-04	5.75	-6.7	1.9e-11	-0.85	0.80	0.20	FALSE
47	OFC	Vezt	gene expression	ENSRNOG00000006514	0.38	0.25	enet	117	0.28	3.0e-07	6.58	6.5	6.0e-11	0.96	0.40	0.60	FALSE
48	OFC	Ndufa12	gene expression	ENSRNOG00000007407	0.19	0.16	top1	1	0.16	1.1e-04	6.70	6.7	2.1e-11	0.82	0.11	0.27	FALSE
49	OFC	Vezt	mRNA stability	ENSRNOG00000006514	0.24	0.12	blup	2568	0.14	3.2e-04	6.19	-6.9	5.9e-12	-0.89	0.60	0.36	FALSE
50	PL	Tmcc3	gene expression	ENSRNOG00000007713	0.58	0.20	lasso	19	0.24	1.8e-06	-4.74	-5.6	1.6e-08	-0.29	0.80	0.03	TRUE
51	PL	Vezt	mRNA stability	ENSRNOG00000006514	0.21	0.09	top1	1	0.09	3.2e-03	6.85	-6.9	7.3e-12	-0.89	0.12	0.11	FALSE
52	PL2	Vezt	gene expression	ENSRNOG00000006514	0.57	0.40	blup	2571	0.45	1.0e-26	5.76	6.0	1.9e-09	0.85	0.88	0.12	FALSE
53	PL2	Ndufa12	gene expression	ENSRNOG00000007407	0.09	0.06	blup	2574	0.07	7.5e-05	6.76	6.2	4.3e-10	0.80	0.42	0.57	FALSE
54	PL2	Socs2	gene expression	ENSRNOG00000008965	0.09	0.04	top1	1	0.04	3.6e-03	6.22	-6.2	5.0e-10	-0.50	0.13	0.04	TRUE
55	PL2	Fgd6	gene expression	ENSRNOG00000054515	0.08	0.05	blup	2571	0.05	9.5e-04	4.91	6.4	1.7e-10	0.84	0.62	0.38	FALSE
56	PL2	Socs2	intron excision ratio	chr7:30015321:30041048	0.06	0.00	blup	3386	0.03	8.8e-03	2.23	5.9	2.7e-09	0.51	0.45	0.29	FALSE
57	PL2	Vezt	mRNA stability	ENSRNOG00000006514	0.30	0.40	lasso	7	0.42	2.2e-24	6.36	-6.6	4.8e-11	-0.87	0.88	0.12	FALSE
58	PL2	Plxnc1	mRNA stability	ENSRNOG00000007970	0.05	0.03	blup	3125	0.04	3.0e-03	5.68	-6.1	8.5e-10	-0.57	0.55	0.37	FALSE
59	PL2	Cradd	mRNA stability	ENSRNOG00000008507	0.08	0.01	blup	3492	0.04	1.9e-03	6.28	-6.7	2.2e-11	-0.54	0.35	0.57	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.