Best TWAS P=1.067488e-08 · Best GWAS P=2.163629e-07 conditioned to 0.6749135
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | Atp1b3 | gene expression | ENSRNOG00000011501 | 0.08 | 0.03 | lasso | 9 | 0.05 | 1.2e-05 | -4.9 | -5.7 | 1.1e-08 | 0.87 | 0.16 | 0.84 | TRUE |
| 2 | Brain | Trpc1 | intron excision ratio | chr8:96280099:96282351 | 0.15 | 0.14 | enet | 148 | 0.15 | 1.2e-13 | 4.8 | -5.3 | 1.4e-07 | 0.41 | 0.20 | 0.80 | FALSE |
| 3 | Liver | Pls1 | mRNA stability | ENSRNOG00000009945 | 0.02 | 0.02 | blup | 1970 | 0.02 | 4.4e-03 | 4.7 | 5.2 | 1.6e-07 | -0.45 | 0.24 | 0.43 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.