Best TWAS P = 7.42e-11 · Best GWAS P= 2.33e-07 conditioned to NaN
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | RT1-N2 | alternative polyA | XM_063279192.1 | 0.53 | 250 | 0.3 | 2.0e-33 | 5.27 | 1.40e-07 | 0.65 | TRUE |
| Adipose | Flot1 | alternative TSS | NM_022701.2 | 0.03 | 8 | 0.02 | 5.9e-03 | -5.5 | 3.84e-08 | 0.47 | FALSE |
| Adipose | Flot1 | alternative TSS | XM_063279499.1 | 0.08 | 5 | 0.04 | 4.3e-05 | 5.72 | 1.08e-08 | 0.57 | FALSE |
| Adipose | Dhx16 | gene expression | Dhx16 | 0.19 | 1524 | 0.18 | 8.5e-20 | -5.35 | 8.87e-08 | 0.6 | FALSE |
| Adipose | Gtf2h4 | gene expression | Gtf2h4 | 0.18 | 29 | 0.14 | 8.4e-16 | 5.46 | 4.81e-08 | 0.6 | FALSE |
| Adipose | RT1-T24-3 | isoform ratio | XM_063279402.1 | 0.04 | 1390 | 0.03 | 8.2e-04 | 5.21 | 1.87e-07 | 0.45 | FALSE |
| Adipose | H2-Q7-ps1 | intron excision ratio | chr20_2629035_2629238 | 0.35 | 1164 | 0.05 | 3.8e-06 | -5.5 | 3.86e-08 | 0.57 | FALSE |
| Adipose | H2-Q7-ps1 | intron excision ratio | chr20_2631404_2640514 | 0.23 | 7 | 0.04 | 1.2e-05 | -5.38 | 7.32e-08 | 0.54 | FALSE |
| Adipose | H2-Q7-ps1 | intron excision ratio | chr20_2637860_2638063 | 0.35 | 1164 | 0.05 | 3.8e-06 | -5.5 | 3.86e-08 | 0.57 | FALSE |
| Adipose | RT1-O1l1 | intron excision ratio | chr20_2629035_2629238 | 0.35 | 1156 | 0.05 | 3.9e-06 | -5.5 | 3.85e-08 | 0.57 | FALSE |
| Adipose | RT1-O1l1 | intron excision ratio | chr20_2631404_2640514 | 0.23 | 7 | 0.04 | 1.2e-05 | -5.38 | 7.34e-08 | 0.54 | FALSE |
| Adipose | RT1-O1l1 | intron excision ratio | chr20_2637860_2638063 | 0.35 | 1156 | 0.05 | 3.9e-06 | -5.5 | 3.85e-08 | 0.57 | FALSE |
| Adipose | RT1-S3 | intron excision ratio | chr20_2629035_2629238 | 0.34 | 1303 | 0.05 | 3.9e-06 | -5.51 | 3.59e-08 | 0.54 | FALSE |
| Adipose | RT1-S3 | intron excision ratio | chr20_2637860_2638063 | 0.34 | 1303 | 0.05 | 3.9e-06 | -5.51 | 3.59e-08 | 0.54 | FALSE |
| Adipose | RT1-T24-4 | intron excision ratio | chr20_2696490_2696699 | 0.59 | 1357 | 0.15 | 1.4e-16 | 5.24 | 1.64e-07 | 0.55 | FALSE |
| Adipose | Ppp1r10 | mRNA stability | Ppp1r10 | 0.03 | 1532 | 0.01 | 7.0e-03 | 5.42 | 6.02e-08 | 0.44 | FALSE |
| BLA | RT1-M6-2 | alternative polyA | NM_001008853.1 | 0.06 | 3124 | 0.01 | 6.2e-02 | 5.36 | 8.13e-08 | 0.19 | FALSE |
| BLA | RT1-M6-2 | alternative polyA | XM_017601696.2 | 0.06 | 3124 | 0.03 | 1.7e-02 | -5.34 | 9.27e-08 | 0.18 | FALSE |
| BLA | RT1-N2 | alternative polyA | XM_039098782.2 | 0.22 | 1195 | 0.13 | 2.9e-07 | 5.3 | 1.18e-07 | 0.63 | FALSE |
| BLA | RT1-T18 | alternative TSS | XM_063279363.1 | 0.49 | 9 | 0.09 | 1.4e-05 | -5.67 | 1.42e-08 | 0.64 | FALSE |
| BLA | Ddr1 | gene expression | Ddr1 | 0.34 | 5 | 0.26 | 3.4e-14 | 5.25 | 1.55e-07 | 0.56 | FALSE |
| BLA | Gtf2h4 | gene expression | Gtf2h4 | 0.19 | 14 | 0.15 | 3.5e-08 | 5.25 | 1.55e-07 | 0.59 | FALSE |
| BLA | LOC134483846 | gene expression | LOC134483846 | 0.79 | 43 | 0.71 | 4.3e-52 | 5.22 | 1.79e-07 | 0.62 | FALSE |
| BLA | RT1-M6-2 | isoform ratio | XM_017601696.2 | 0.1 | 3124 | 0.07 | 9.5e-05 | -5.26 | 1.43e-07 | 0.23 | FALSE |
| BLA | Abcf1 | intron excision ratio | chr20_2807464_2811704 | 0.08 | 1500 | 0.03 | 6.9e-03 | 5.22 | 1.78e-07 | 0.28 | FALSE |
| BLA | Dhx16 | intron excision ratio | chr20_2868362_2869501 | 0.1 | 8 | 0.02 | 2.5e-02 | -5.44 | 5.27e-08 | 0.27 | FALSE |
| BLA | RT1-CE10 | intron excision ratio | chr20_3280797_3281038 | 0.27 | 3056 | 0.04 | 3.7e-03 | 5.6 | 2.17e-08 | 0.42 | TRUE |
| BLA | RT1-CE11 | intron excision ratio | chr20_3280797_3281038 | 0.27 | 3055 | 0.04 | 3.7e-03 | 5.6 | 2.17e-08 | 0.42 | FALSE |
| BLA | RT1-CE14 | intron excision ratio | chr20_3280797_3281038 | 0.25 | 2648 | 0.04 | 4.0e-03 | 5.69 | 1.30e-08 | 0.4 | FALSE |
| BLA | RT1-CE15 | intron excision ratio | chr20_3280797_3281038 | 0.25 | 154 | 0.04 | 2.7e-03 | 6.34 | 2.27e-10 | 0.4 | FALSE |
| BLA | RT1-CE16 | intron excision ratio | chr20_3280797_3281038 | 0.26 | 2619 | 0.04 | 4.7e-03 | 5.75 | 9.16e-09 | 0.4 | FALSE |
| Brain | Dhx16 | alternative polyA | XM_039098481.2 | 0.23 | 1524 | 0.15 | 6.3e-14 | 5.67 | 1.42e-08 | 0.58 | FALSE |
| Brain | RT1-N2 | alternative polyA | XM_039098782.2 | 0.36 | 30 | 0.32 | 7.5e-31 | 5.86 | 4.51e-09 | 0.66 | FALSE |
| Brain | RT1-N2 | alternative polyA | XM_039098782.2 | 0.36 | 29 | 0.33 | 8.7e-32 | 5.77 | 7.93e-09 | 0.66 | TRUE |
| Brain | Dhx16 | alternative TSS | XM_039098484.2 | 0.06 | 1524 | 0.03 | 6.8e-04 | 5.27 | 1.35e-07 | 0.46 | FALSE |
| Brain | Gabbr1 | isoform ratio | NM_031028.3 | 0.05 | 3649 | 0.04 | 1.3e-04 | -5.28 | 1.32e-07 | 0.35 | FALSE |
| Brain | RT1-M6-2 | isoform ratio | XM_017601696.2 | 0.23 | 19 | 0.24 | 3.7e-22 | -5.21 | 1.88e-07 | 0.11 | FALSE |
| Brain | RT1-M6-2 | isoform ratio | XM_063279325.1 | 0.15 | 170 | 0.16 | 7.2e-15 | 5.33 | 9.96e-08 | 0.12 | FALSE |
| Brain | Zfp57 | isoform ratio | XM_039098787.2 | 0.07 | 3517 | 0.04 | 1.2e-04 | -5.21 | 1.87e-07 | 0.41 | FALSE |
| Brain | Znrd1as1 | intron excision ratio | chr20_1592067_1595158 | 0.03 | 2915 | 0.01 | 1.7e-02 | 5.32 | 1.01e-07 | 0.25 | FALSE |
| Brain | RT1-M6-2 | mRNA stability | RT1-M6-2 | 0.76 | 51 | 0.54 | 5.4e-60 | -5.21 | 1.89e-07 | 0.13 | FALSE |
| Brain | Trim15 | mRNA stability | Trim15 | 0.06 | 32 | 0.04 | 1.2e-04 | 5.26 | 1.43e-07 | 0.34 | FALSE |
| Eye | Mrps18b | alternative polyA | NM_212534.2 | 0.43 | 1532 | 0.05 | 5.8e-02 | 5.29 | 1.21e-07 | 0.18 | FALSE |
| Eye | Mrps18b | alternative polyA | XM_039098476.2 | 0.44 | 1532 | 0.06 | 5.1e-02 | -5.31 | 1.12e-07 | 0.18 | FALSE |
| Eye | H2-Q7-ps1 | intron excision ratio | chr20_2631404_2662623 | 0.76 | 1164 | 0.19 | 7.7e-04 | -5.52 | 3.47e-08 | 0.28 | FALSE |
| Eye | RT1-O1l1 | intron excision ratio | chr20_2631404_2662623 | 0.76 | 1156 | 0.19 | 7.7e-04 | -5.52 | 3.48e-08 | 0.28 | FALSE |
| Eye | RT1-S2 | intron excision ratio | chr20_2631404_2662623 | 0.77 | 1208 | 0.19 | 7.6e-04 | -5.51 | 3.55e-08 | 0.28 | FALSE |
| Eye | RT1-CE4 | mRNA stability | RT1-CE4 | 0.39 | 3147 | 0.07 | 3.2e-02 | 5.23 | 1.72e-07 | 0.12 | FALSE |
| IC | Znrd1as1 | gene expression | Znrd1as1 | 0.22 | 80 | 0.13 | 3.0e-06 | 5.31 | 1.10e-07 | 0.4 | FALSE |
| IC | Dhx16 | intron excision ratio | chr20_2868393_2869501 | 0.14 | 1524 | 0.01 | 1.4e-01 | 5.78 | 7.53e-09 | 0.22 | FALSE |
| IL | RT1-CE15 | alternative polyA | NM_001008838.2 | 0.22 | 2609 | 0.05 | 2.9e-02 | -5.69 | 1.24e-08 | 0.24 | FALSE |
| IL | RT1-N2 | alternative polyA | XM_039098782.2 | 0.32 | 1195 | 0.17 | 8.5e-05 | 5.46 | 4.88e-08 | 0.58 | FALSE |
| IL | RT1-N2 | alternative polyA | XM_039098782.2 | 0.41 | 1195 | 0.2 | 1.2e-05 | 5.65 | 1.61e-08 | 0.61 | FALSE |
| IL | RT1-O1l1 | alternative polyA | XM_039099255.2 | 0.26 | 1156 | 0.13 | 5.4e-04 | 5.56 | 2.64e-08 | 0.52 | FALSE |
| IL | RT1-O1l1 | gene expression | RT1-O1l1 | 0.78 | 1156 | 0.46 | 1.1e-12 | -5.34 | 9.30e-08 | 0.66 | FALSE |
| IL | Abcf1 | isoform ratio | NM_001109883.2 | 0.23 | 1500 | 0.14 | 3.8e-04 | 5.51 | 3.65e-08 | 0.4 | FALSE |
| IL | Abcf1 | isoform ratio | XM_017601783.3 | 0.22 | 1500 | 0.13 | 5.6e-04 | -5.5 | 3.75e-08 | 0.38 | FALSE |
| IL | RT1-T24-4 | isoform ratio | NM_001008826.3 | 0.31 | 1357 | 0.15 | 1.7e-04 | 5.55 | 2.91e-08 | 0.44 | FALSE |
| IL | Abcf1 | intron excision ratio | chr20_2807464_2812594 | 0.27 | 1500 | 0.12 | 9.7e-04 | -5.47 | 4.55e-08 | 0.42 | FALSE |
| IL | LOC134483846 | intron excision ratio | chr20_2630996_2650951 | 0.41 | 1390 | 0.19 | 2.5e-05 | -5.58 | 2.45e-08 | 0.5 | FALSE |
| IL | LOC134483846 | intron excision ratio | chr20_2639816_2650951 | 0.41 | 1390 | 0.19 | 2.5e-05 | -5.58 | 2.45e-08 | 0.5 | FALSE |
| IL | RT1-A2 | intron excision ratio | chr20_4909750_4909928 | 0.57 | 874 | 0.35 | 3.1e-09 | -5.32 | 1.02e-07 | 0.29 | FALSE |
| LHb | Znrd1as1 | gene expression | Znrd1as1 | 0.24 | 2915 | 0.03 | 7.9e-02 | 5.35 | 8.68e-08 | 0.21 | FALSE |
| LHb | RT1-T24-4 | isoform ratio | NM_001008826.3 | 0.42 | 21 | 0.21 | 1.0e-05 | 5.25 | 1.51e-07 | 0.55 | FALSE |
| Liver | RT1-N2 | alternative polyA | XM_039098782.2 | 0.34 | 15 | 0.34 | 3.7e-39 | 5.34 | 9.51e-08 | 0.68 | FALSE |
| Liver | RT1-N2 | alternative polyA | XM_039098782.2 | 0.36 | 15 | 0.35 | 7.9e-40 | 5.53 | 3.21e-08 | 0.68 | FALSE |
| Liver | RT1-O1l1 | alternative polyA | XM_039099255.2 | 0.28 | 4 | 0.19 | 1.6e-20 | 5.79 | 7.12e-09 | 0.68 | FALSE |
| Liver | RT1-S2 | alternative polyA | NM_001008857.1 | 0.27 | 1208 | 0.24 | 1.2e-26 | -5.25 | 1.53e-07 | 0.64 | FALSE |
| Liver | Abcf1 | gene expression | Abcf1 | 0.14 | 1500 | 0.12 | 1.0e-12 | 5.45 | 5.04e-08 | 0.58 | FALSE |
| Liver | Dhx16 | gene expression | Dhx16 | 0.16 | 1524 | 0.13 | 1.4e-14 | -5.47 | 4.49e-08 | 0.59 | FALSE |
| Liver | Gtf2h4 | gene expression | Gtf2h4 | 0.3 | 224 | 0.29 | 4.9e-33 | 5.29 | 1.22e-07 | 0.6 | FALSE |
| Liver | Abcf1 | isoform ratio | NM_001109883.2 | 0.05 | 1500 | 0.04 | 3.2e-05 | 5.41 | 6.30e-08 | 0.54 | FALSE |
| Liver | Abcf1 | isoform ratio | XM_017601783.3 | 0.06 | 1500 | 0.04 | 1.1e-05 | -5.38 | 7.51e-08 | 0.54 | FALSE |
| Liver | RT1-N2 | isoform ratio | XM_039098783.2 | 0.41 | 19 | 0.4 | 1.4e-47 | 5.27 | 1.38e-07 | 0.66 | FALSE |
| Liver | RT1-O1l1 | isoform ratio | XM_039099255.2 | 0.29 | 7 | 0.29 | 2.1e-32 | 5.55 | 2.78e-08 | 0.68 | FALSE |
| Liver | RT1-O1l1 | isoform ratio | XM_039099257.2 | 0.42 | 13 | 0.39 | 3.0e-46 | -5.25 | 1.49e-07 | 0.67 | FALSE |
| Liver | LOC134483846 | intron excision ratio | chr20_2727582_2729544 | 0.46 | 4 | 0.09 | 2.7e-10 | -5.42 | 6.09e-08 | 0.59 | FALSE |
| Liver | RT1-CE10 | intron excision ratio | chr20_3362457_3384434 | 0.58 | 447 | 0.19 | 1.4e-20 | -5.23 | 1.69e-07 | 0 | FALSE |
| Liver | RT1-CE10 | intron excision ratio | chr20_3384252_3384434 | 0.56 | 426 | 0.19 | 5.1e-21 | 5.22 | 1.80e-07 | 0 | TRUE |
| Liver | RT1-CE11 | intron excision ratio | chr20_3362457_3384434 | 0.58 | 435 | 0.19 | 1.4e-20 | -5.26 | 1.45e-07 | 0 | FALSE |
| Liver | RT1-CE11 | intron excision ratio | chr20_3384252_3384434 | 0.56 | 388 | 0.19 | 4.9e-21 | 5.33 | 1.00e-07 | 0 | FALSE |
| Liver | Znrd1as1 | intron excision ratio | chr20_1592067_1595158 | 0.16 | 2915 | 0.05 | 1.7e-06 | 5.31 | 1.11e-07 | 0.09 | FALSE |
| NAcc | Dhx16 | alternative polyA | XM_039098481.2 | 0.08 | 9 | 0.08 | 1.6e-12 | 5.62 | 1.90e-08 | 0.58 | FALSE |
| NAcc | Prr3 | alternative TSS | XM_063279198.1 | 0.04 | 1496 | 0.03 | 8.7e-06 | -5.56 | 2.74e-08 | 0.57 | FALSE |
| NAcc | Prr3 | alternative TSS | XM_063279199.1 | 0.03 | 1496 | 0.02 | 4.4e-04 | 5.22 | 1.80e-07 | 0.55 | FALSE |
| NAcc | Prr3 | alternative TSS | XM_063279198.1 | 0.04 | 1496 | 0.03 | 1.7e-05 | -5.58 | 2.41e-08 | 0.58 | FALSE |
| NAcc | Prr3 | alternative TSS | XM_063279199.1 | 0.04 | 1496 | 0.03 | 9.5e-06 | 5.56 | 2.64e-08 | 0.57 | FALSE |
| NAcc | RT1-M6-2 | alternative TSS | XM_017601696.2 | 0.03 | 3124 | 0.04 | 4.2e-06 | 5.38 | 7.38e-08 | 0.13 | FALSE |
| NAcc | RT1-M6-2 | alternative TSS | XM_017601696.2 | 0.04 | 3124 | 0.04 | 6.1e-07 | 5.35 | 8.75e-08 | 0.09 | FALSE |
| NAcc | Dhx16 | gene expression | Dhx16 | 0.08 | 1524 | 0.06 | 4.8e-10 | -5.51 | 3.69e-08 | 0.58 | FALSE |
| NAcc | RT1-T24-2 | gene expression | RT1-T24-2 | 0.04 | 1416 | 0.03 | 7.6e-05 | 5.52 | 3.36e-08 | 0.55 | FALSE |
| NAcc | Dhx16 | isoform ratio | NM_212496.2 | 0.06 | 1524 | 0.05 | 2.0e-08 | 5.47 | 4.61e-08 | 0.52 | FALSE |
| NAcc | Prr3 | isoform ratio | NM_212544.2 | 0.03 | 1496 | 0.02 | 3.0e-04 | 5.49 | 4.12e-08 | 0.5 | FALSE |
| NAcc | RT1-T24-4 | isoform ratio | NM_001008826.3 | 0.35 | 90 | 0.15 | 1.5e-22 | 6.14 | 8.51e-10 | 0.48 | FALSE |
| NAcc | Prr3 | intron excision ratio | chr20_2798224_2798492 | 0.02 | 1496 | 0.02 | 1.5e-03 | -5.28 | 1.28e-07 | 0.43 | FALSE |
| NAcc | RT1-T24-4 | intron excision ratio | chr20_2746170_2746348 | 0.04 | 1357 | 0.02 | 1.1e-04 | 5.64 | 1.72e-08 | 0.59 | FALSE |
| NAcc | Nudt3 | mRNA stability | Nudt3 | 0.07 | 2415 | 0.03 | 6.5e-05 | 5.38 | 7.53e-08 | 0.8 | FALSE |
| OFC | RT1-N2 | alternative polyA | XM_039098782.2 | 0.43 | 1195 | 0.32 | 2.6e-08 | 5.57 | 2.62e-08 | 0.64 | FALSE |
| OFC | RT1-CE13 | isoform ratio | XM_063279407.1 | 0.14 | 2740 | 0.1 | 3.0e-03 | 5.23 | 1.71e-07 | 0.21 | FALSE |
| OFC | RT1-O1l1 | isoform ratio | XM_039099255.2 | 0.43 | 1156 | 0.35 | 3.6e-09 | 5.41 | 6.14e-08 | 0.65 | FALSE |
| OFC | RT1-T24-4 | isoform ratio | NM_001008826.3 | 0.49 | 1357 | 0.34 | 5.2e-09 | 5.65 | 1.61e-08 | 0.59 | FALSE |
| OFC | LOC134483846 | intron excision ratio | chr20_2630996_2650951 | 0.38 | 22 | 0.17 | 7.2e-05 | -5.43 | 5.50e-08 | 0.49 | TRUE |
| OFC | LOC134483846 | intron excision ratio | chr20_2639816_2650951 | 0.38 | 22 | 0.17 | 8.7e-05 | -5.43 | 5.52e-08 | 0.49 | FALSE |
| PL | Dhx16 | gene expression | Dhx16 | 0.09 | 1524 | 0.09 | 6.3e-10 | -5.52 | 3.40e-08 | 0.6 | FALSE |
| PL | Gtf2h4 | gene expression | Gtf2h4 | 0.11 | 1495 | 0.13 | 1.0e-13 | 5.45 | 5.02e-08 | 0.6 | FALSE |
| PL | RT1-T24-2 | gene expression | RT1-T24-2 | 0.77 | 1416 | 0.1 | 5.5e-11 | 6.51 | 7.42e-11 | 0.6 | TRUE |
| PL | Ddr1 | isoform ratio | XM_063278984.1 | 0.04 | 21 | 0.03 | 2.8e-04 | 5.38 | 7.55e-08 | 0.45 | FALSE |
| PL | Dhx16 | isoform ratio | NM_212496.2 | 0.04 | 1524 | 0.03 | 2.4e-04 | 5.26 | 1.46e-07 | 0.51 | FALSE |
| PL | RT1-S2 | isoform ratio | XM_063278970.1 | 0.34 | 8 | 0.17 | 5.3e-18 | -5.23 | 1.70e-07 | 0.62 | FALSE |
| PL | Zfp57 | isoform ratio | NM_213565.4 | 0.04 | 3517 | 0.03 | 1.6e-04 | 5.35 | 8.76e-08 | 0.25 | FALSE |
| PL | Zfp57 | isoform ratio | XM_039098787.2 | 0.03 | 3517 | 0.03 | 2.8e-04 | -5.31 | 1.10e-07 | 0.32 | FALSE |
| PL | RT1-A2 | intron excision ratio | chr20_4852635_4852768 | 0.38 | 95 | 0.29 | 2.4e-32 | -5.46 | 4.76e-08 | 0.34 | TRUE |
| PL | RT1-CE10 | intron excision ratio | chr20_3280797_3281038 | 0.14 | 3056 | 0.12 | 4.8e-13 | 5.22 | 1.83e-07 | 0.19 | FALSE |
| PL | RT1-CE11 | intron excision ratio | chr20_3280797_3281038 | 0.14 | 3055 | 0.12 | 4.8e-13 | 5.22 | 1.83e-07 | 0.19 | FALSE |
| PL | RT1-CE14 | intron excision ratio | chr20_3280797_3281038 | 0.13 | 2648 | 0.12 | 4.8e-13 | 5.22 | 1.81e-07 | 0.18 | FALSE |
| PL | RT1-CE15 | intron excision ratio | chr20_3280797_3281038 | 0.13 | 2609 | 0.12 | 4.7e-13 | 5.22 | 1.77e-07 | 0.19 | FALSE |
| PL | RT1-CE16 | intron excision ratio | chr20_3280797_3281038 | 0.13 | 2619 | 0.12 | 5.2e-13 | 5.22 | 1.76e-07 | 0.2 | FALSE |
| PL | Trim15 | mRNA stability | Trim15 | 0.03 | 2465 | 0.03 | 8.1e-04 | 5.38 | 7.61e-08 | 0.19 | FALSE |
| pVTA | Trim15 | alternative polyA | NM_001291382.2 | 0.17 | 44 | 0.15 | 2.4e-12 | -5.23 | 1.73e-07 | 0.13 | FALSE |
| pVTA | Tubb5 | gene expression | Tubb5 | 0.08 | 8 | 0.07 | 4.2e-06 | 5.58 | 2.38e-08 | 0.6 | FALSE |