Hub : Traits : Extensor digitorum longus weight : ←

chr15:53,151,915-56,059,088

Trait: Extensor digitorum longus weight

Best TWAS P = 1.11e-12 · Best GWAS P= 6.16e-13 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h2	# weights	Model R2	Model R2 P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Rb1	alternative polyA	NM_017045.2	0.13	1	0.12	1.3e-13	-5.5	3.82e-08	0.61	FALSE
Adipose	Rb1	alternative polyA	XM_039092994.2	0.13	1	0.13	9.6e-14	5.5	3.82e-08	0.61	FALSE
Adipose	Rcbtb2	alternative polyA	NM_199084.1	0.07	1	0.07	5.6e-08	5.5	3.82e-08	0.53	FALSE
Adipose	Rcbtb2	alternative polyA	XM_063274145.1	0.07	1	0.07	6.3e-08	-5.5	3.82e-08	0.53	FALSE
Adipose	Fndc3a	alternative TSS	NM_001412039.1	0.03	2094	0.02	4.9e-03	-5.82	5.96e-09	0.09	FALSE
Adipose	Fndc3a	alternative TSS	NM_001412039.1	0.03	2094	0.02	4.1e-03	-5.81	6.13e-09	0.08	FALSE
Adipose	Itm2b	gene expression	Itm2b	0.1	2032	0.1	3.2e-11	5.43	5.73e-08	0.6	FALSE
Adipose	LOC120097036	gene expression	LOC120097036	0.07	100	0.05	2.9e-06	5.41	6.39e-08	0.5	FALSE
Adipose	LOC134482148	gene expression	LOC134482148	0.16	10	0.09	8.1e-10	-5.55	2.83e-08	0	FALSE
Adipose	Fndc3a	isoform ratio	NM_001412039.1	0.03	2094	0.02	5.2e-03	-5.92	3.20e-09	0.09	FALSE
Adipose	Rb1	isoform ratio	NM_017045.2	0.11	1	0.12	8.7e-13	-5.5	3.82e-08	0.61	FALSE
Adipose	Rb1	isoform ratio	XM_039092994.2	0.11	1	0.1	1.2e-11	5.5	3.82e-08	0.61	FALSE
Adipose	Rcbtb2	isoform ratio	NM_199084.1	0.09	1	0.08	3.3e-09	5.48	4.30e-08	0.51	FALSE
Adipose	Rcbtb2	isoform ratio	XM_039093165.2	0.17	1	0.12	2.1e-13	-5.48	4.30e-08	0.51	FALSE
Adipose	Rcbtb2	intron excision ratio	chr15_54743011_54745795	0.15	1	0.14	5.5e-15	-5.34	9.31e-08	0.33	FALSE
Adipose	Rcbtb2	mRNA stability	Rcbtb2	0.05	1	0.04	1.1e-05	-5.5	3.82e-08	0.29	FALSE
BLA	Fndc3a	intron excision ratio	chr15_54156388_54165134	0.23	6	0.06	2.3e-04	7	2.57e-12	0.79	FALSE
Brain	Rcbtb2	alternative polyA	NM_199084.1	0.12	2140	0.07	2.4e-07	-5.48	4.16e-08	0.59	FALSE
Brain	Rcbtb2	alternative polyA	XM_063274145.1	0.13	2140	0.07	2.0e-07	5.49	3.97e-08	0.6	FALSE
Brain	Fndc3a	gene expression	Fndc3a	0.15	35	0.14	3.0e-13	5.74	9.19e-09	0	TRUE
Brain	Itm2b	gene expression	Itm2b	0.58	1	0.35	2.8e-33	-5.51	3.62e-08	0.64	FALSE
Brain	Med4	gene expression	Med4	0.08	1	0.1	1.7e-09	5.65	1.60e-08	0.84	FALSE
Brain	Nudt15	gene expression	Nudt15	0.51	20	0.39	1.8e-38	-5.48	4.30e-08	0.66	FALSE
Brain	Rcbtb2	isoform ratio	NM_199084.1	0.09	2140	0.05	1.2e-05	-5.37	7.70e-08	0.54	FALSE
Brain	Itm2b	mRNA stability	Itm2b	0.21	28	0.18	3.0e-16	-5.69	1.30e-08	0.25	FALSE
IC	Itm2b	gene expression	Itm2b	0.46	1	0.17	1.3e-07	-5.51	3.54e-08	0.5	FALSE
IC	Med4	gene expression	Med4	0.09	1	0.06	1.3e-03	5.55	2.79e-08	0.06	FALSE
IC	Nudt15	gene expression	Nudt15	0.4	1	0.35	1.8e-15	5.51	3.62e-08	0.71	FALSE
IL	Itm2b	gene expression	Itm2b	0.37	16	0.22	4.4e-06	5.51	3.61e-08	0.6	FALSE
IL	Rcbtb2	isoform ratio	NM_199084.1	0.35	2140	0.19	2.7e-05	-5.3	1.18e-07	0.44	FALSE
LHb	Nudt15	gene expression	Nudt15	0.49	24	0.38	5.3e-10	-5.44	5.39e-08	0.65	FALSE
Liver	Rcbtb2	alternative polyA	NM_199084.1	0.18	214	0.19	1.2e-20	5.55	2.78e-08	0.62	FALSE
Liver	Rcbtb2	alternative polyA	XM_063274145.1	0.19	272	0.2	2.4e-21	-5.57	2.57e-08	0.62	FALSE
Liver	LOC120097033	gene expression	LOC120097033	0.03	2082	0.01	1.2e-02	-5.84	5.11e-09	0.05	FALSE
Liver	LOC134482148	gene expression	LOC134482148	0.05	1	0.03	4.3e-04	5.5	3.82e-08	0.03	FALSE
Liver	LOC134482150	gene expression	LOC134482150	0.14	23	0.12	7.3e-13	5.38	7.33e-08	0.64	FALSE
Liver	Nudt15	gene expression	Nudt15	0.05	1	0.05	2.4e-06	5.48	4.30e-08	0.6	TRUE
Liver	Rb1	gene expression	Rb1	0.06	2146	0.05	1.8e-06	5.27	1.35e-07	0.64	FALSE
Liver	Rcbtb2	gene expression	Rcbtb2	0.15	31	0.1	3.1e-11	-5.27	1.35e-07	0.65	TRUE
Liver	Rb1	isoform ratio	XM_063273967.1	0.04	2146	0.03	3.7e-04	5.35	8.96e-08	0.56	FALSE
Liver	Rcbtb2	isoform ratio	NM_199084.1	0.15	2140	0.14	1.8e-15	-5.69	1.28e-08	0.61	FALSE
Liver	Rcbtb2	isoform ratio	XM_063274147.1	0.02	1	0.02	6.2e-03	5.5	3.79e-08	0.03	FALSE
Liver	Rcbtb2	intron excision ratio	chr15_54743011_54745795	0.18	2140	0.08	1.9e-09	5.53	3.26e-08	0.47	FALSE
NAcc	Fndc3a	mRNA stability	Fndc3a	0.03	2094	0.02	1.6e-03	-6.18	6.25e-10	0.32	FALSE
OFC	Rcbtb2	alternative polyA	NM_199084.1	0.25	2140	0.18	5.3e-05	-5.69	1.30e-08	0.58	FALSE
OFC	Rcbtb2	alternative polyA	XM_063274145.1	0.22	2140	0.17	9.7e-05	5.69	1.27e-08	0.56	FALSE
OFC	Nudt15	gene expression	Nudt15	0.25	1	0.21	8.7e-06	5.41	6.27e-08	0.09	FALSE
OFC	Rb1	gene expression	Rb1	0.15	1	0.1	2.2e-03	5.41	6.27e-08	0.05	FALSE
OFC	Rcbtb2	isoform ratio	NM_199084.1	0.29	1	0.22	6.6e-06	5.41	6.27e-08	0.08	FALSE
PL	Fndc3a	gene expression	Fndc3a	0.1	21	0.08	3.7e-09	5.82	5.93e-09	0.01	FALSE
PL	LOC134481988	gene expression	LOC134481988	0.03	1	0.03	2.2e-04	-5.26	1.42e-07	0.13	FALSE
pVTA	Rcbtb2	alternative polyA	NM_199084.1	0.09	2140	0.08	6.3e-07	-5.5	3.89e-08	0.63	FALSE
pVTA	Rcbtb2	alternative polyA	XM_063274145.1	0.09	2140	0.08	2.7e-07	5.47	4.44e-08	0.63	FALSE
pVTA	LOC134481986	gene expression	LOC134481986	0.21	1	0.09	1.9e-07	-7.12	1.11e-12	0.83	TRUE
pVTA	Rcbtb2	isoform ratio	NM_199084.1	0.07	1	0.06	2.4e-05	5.65	1.60e-08	0.64	FALSE
pVTA	Itm2b	mRNA stability	Itm2b	0.08	7	0.08	6.9e-07	-5.54	2.95e-08	0.1	TRUE