Best TWAS P = 2.23e-10 · Best GWAS P= 5.37e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLA | Cryga | gene expression | Cryga | 0.08 | 1846 | 0.06 | 2.4e-04 | -5.5 | 3.71e-08 | 0.48 | FALSE |
| BLA | Mettl21a | gene expression | Mettl21a | 0.12 | 1 | 0.08 | 3.1e-05 | 5.77 | 7.92e-09 | 0.12 | FALSE |
| BLA | Plekhm3 | gene expression | Plekhm3 | 0.05 | 1 | 0.04 | 3.8e-03 | 5.42 | 5.99e-08 | 0.04 | FALSE |
| Brain | Cryga | alternative polyA | XM_063267734.1 | 0.07 | 1 | 0.03 | 3.9e-04 | 5.66 | 1.50e-08 | 0.18 | FALSE |
| Brain | Cryga | alternative polyA | XM_063267738.1 | 0.07 | 1 | 0.03 | 4.0e-04 | -5.59 | 2.21e-08 | 0.12 | FALSE |
| Brain | Plekhm3 | alternative polyA | XM_017596816.3 | 0.06 | 14 | 0.08 | 1.5e-07 | 5.59 | 2.29e-08 | 0.46 | FALSE |
| Brain | Plekhm3 | alternative polyA | XM_063267901.1 | 0.06 | 1 | 0.09 | 1.7e-08 | -5.43 | 5.73e-08 | 0.21 | FALSE |
| Brain | Plekhm3 | alternative polyA | XM_017596816.3 | 0.06 | 14 | 0.08 | 8.9e-08 | 5.53 | 3.20e-08 | 0.43 | FALSE |
| Brain | Plekhm3 | alternative polyA | XM_063267901.1 | 0.06 | 1 | 0.09 | 9.6e-09 | -5.43 | 5.73e-08 | 0.21 | FALSE |
| Brain | LOC134480377 | gene expression | LOC134480377 | 0.03 | 590 | 0.02 | 7.2e-03 | -5.81 | 6.17e-09 | 0.38 | FALSE |
| Brain | Mettl21a | gene expression | Mettl21a | 0.06 | 1 | 0.06 | 7.0e-06 | 5.77 | 7.97e-09 | 0.46 | FALSE |
| Brain | Plekhm3 | gene expression | Plekhm3 | 0.03 | 14 | 0.04 | 1.5e-04 | 5.52 | 3.37e-08 | 0.4 | FALSE |
| Brain | Cryga | isoform ratio | XR_010054633.1 | 0.1 | 1846 | 0.15 | 1.7e-13 | 5.69 | 1.24e-08 | 0.45 | FALSE |
| Brain | Cryga | intron excision ratio | chr9_73978240_73984047 | 0.08 | 1846 | 0.06 | 1.5e-06 | 5.36 | 8.47e-08 | 0.61 | FALSE |
| Brain | Cryga | intron excision ratio | chr9_73980494_73984047 | 0.14 | 32 | 0.17 | 1.3e-15 | -5.46 | 4.86e-08 | 0.58 | FALSE |
| Brain | Creb1 | mRNA stability | Creb1 | 0.03 | 1224 | 0.01 | 2.4e-02 | -5.25 | 1.56e-07 | 0.35 | FALSE |
| IC | Cryga | alternative polyA | XM_063267734.1 | 0.08 | 1846 | 0.04 | 1.1e-02 | 5.29 | 1.21e-07 | 0.45 | FALSE |
| IC | Cryga | alternative polyA | XM_063267738.1 | 0.07 | 1846 | 0.04 | 1.2e-02 | -5.33 | 9.96e-08 | 0.45 | FALSE |
| IC | Cryga | gene expression | Cryga | 0.06 | 1846 | 0.03 | 1.5e-02 | -5.36 | 8.27e-08 | 0.45 | FALSE |
| IC | Plekhm3 | gene expression | Plekhm3 | 0.07 | 1 | 0.02 | 7.0e-02 | 5.82 | 5.91e-09 | 0.05 | FALSE |
| IC | Cryga | intron excision ratio | chr9_73980494_73984047 | 0.11 | 225 | 0.09 | 1.4e-04 | -5.64 | 1.68e-08 | 0.45 | FALSE |
| IC | Plekhm3 | intron excision ratio | chr9_73799503_73814060 | 0.06 | 1383 | 0.03 | 1.5e-02 | -5.6 | 2.12e-08 | 0.25 | FALSE |
| IL | Fzd5 | gene expression | Fzd5 | 0.18 | 1290 | 0.06 | 1.4e-02 | -5.55 | 2.92e-08 | 0.31 | FALSE |
| Liver | Mettl21a | gene expression | Mettl21a | 0.05 | 1342 | 0.03 | 1.2e-04 | 5.37 | 8.05e-08 | 0.42 | FALSE |
| NAcc | Cryga | alternative polyA | XM_063267734.1 | 0.03 | 1 | 0.04 | 1.8e-06 | 5.28 | 1.33e-07 | 0.1 | FALSE |
| NAcc | Cryga | alternative polyA | XM_063267738.1 | 0.03 | 1 | 0.04 | 2.4e-06 | -5.28 | 1.33e-07 | 0.09 | FALSE |
| NAcc | Plekhm3 | alternative polyA | XM_017596816.3 | 0.02 | 1383 | 0.01 | 2.3e-03 | 5.27 | 1.38e-07 | 0.31 | FALSE |
| NAcc | Plekhm3 | alternative polyA | XM_017596816.3 | 0.02 | 1383 | 0.01 | 2.1e-03 | 5.31 | 1.11e-07 | 0.33 | FALSE |
| NAcc | Plekhm3 | alternative polyA | XM_063267901.1 | 0.02 | 1383 | 0.01 | 4.4e-03 | -5.37 | 8.08e-08 | 0.32 | FALSE |
| NAcc | Creb1 | alternative TSS | NM_031017.2 | 0.31 | 1224 | 0.01 | 1.2e-02 | 6.34 | 2.23e-10 | 0.4 | TRUE |
| NAcc | Plekhm3 | alternative TSS | XM_039084592.2 | 0.02 | 1383 | 0.02 | 3.8e-04 | -5.59 | 2.24e-08 | 0.44 | FALSE |
| NAcc | Plekhm3 | alternative TSS | XM_006245080.5 | 0.03 | 1 | 0.01 | 3.5e-03 | -5.38 | 7.43e-08 | 0.03 | FALSE |
| NAcc | Plekhm3 | alternative TSS | XM_017596820.3 | 0.01 | 50 | 0.01 | 1.3e-02 | 5.44 | 5.26e-08 | 0.29 | FALSE |
| NAcc | Cryga | gene expression | Cryga | 0.02 | 1 | 0.02 | 1.6e-03 | -5.37 | 8.03e-08 | 0.03 | FALSE |
| NAcc | Plekhm3 | gene expression | Plekhm3 | 0.06 | 1383 | 0.07 | 1.8e-10 | 5.44 | 5.29e-08 | 0.52 | FALSE |
| NAcc | Cryga | isoform ratio | XM_063267738.1 | 0.03 | 1846 | 0.01 | 2.5e-03 | -5.4 | 6.49e-08 | 0.31 | FALSE |
| NAcc | Cryga | isoform ratio | XR_010054633.1 | 0.04 | 1846 | 0.04 | 9.1e-07 | 5.7 | 1.20e-08 | 0.5 | FALSE |
| NAcc | Cryga | intron excision ratio | chr9_73980494_73984047 | 0.04 | 1846 | 0.02 | 1.1e-04 | -5.43 | 5.76e-08 | 0.51 | FALSE |
| OFC | Cryga | isoform ratio | XM_063267738.1 | 0.24 | 1846 | 0.08 | 5.3e-03 | -5.28 | 1.29e-07 | 0.33 | FALSE |
| PL | Cryga | alternative polyA | XM_063267734.1 | 0.09 | 1 | 0.09 | 1.2e-09 | 5.44 | 5.35e-08 | 0.23 | FALSE |
| PL | Cryga | alternative polyA | XM_063267738.1 | 0.1 | 1 | 0.09 | 1.4e-09 | -5.44 | 5.35e-08 | 0.23 | FALSE |
| PL | Cryga | alternative TSS | XM_063267736.1 | 0.03 | 1 | 0.03 | 4.1e-04 | -5.33 | 9.89e-08 | 0.03 | FALSE |
| PL | Fzd5 | gene expression | Fzd5 | 0.05 | 1290 | 0.05 | 7.0e-06 | -5.43 | 5.77e-08 | 0.43 | FALSE |
| PL | Plekhm3 | gene expression | Plekhm3 | 0.03 | 1383 | 0.02 | 2.8e-03 | 5.54 | 2.97e-08 | 0.34 | FALSE |
| PL | Cryga | isoform ratio | XM_063267738.1 | 0.09 | 11 | 0.1 | 1.5e-10 | -5.66 | 1.53e-08 | 0.55 | FALSE |
| PL | Cryga | isoform ratio | XR_010054633.1 | 0.13 | 1846 | 0.14 | 5.6e-15 | 5.44 | 5.44e-08 | 0.55 | FALSE |
| PL | Cryga | intron excision ratio | chr9_73980494_73984047 | 0.16 | 1846 | 0.14 | 2.4e-15 | -5.36 | 8.55e-08 | 0.54 | FALSE |
| PL | Idh1 | mRNA stability | Idh1 | 0.02 | 32 | 0.01 | 1.4e-02 | -5.29 | 1.22e-07 | 0.38 | FALSE |
| pVTA | Cryga | alternative polyA | XM_063267734.1 | 0.04 | 1846 | 0.02 | 6.8e-03 | 5.42 | 6.12e-08 | 0.36 | FALSE |
| pVTA | Cryga | alternative polyA | XM_063267738.1 | 0.04 | 1846 | 0.02 | 7.3e-03 | -5.43 | 5.63e-08 | 0.36 | FALSE |
| pVTA | Cryga | alternative polyA | XM_063267734.1 | 0.12 | 1846 | 0.18 | 4.4e-14 | 5.58 | 2.42e-08 | 0.52 | FALSE |
| pVTA | Cryga | alternative polyA | XM_063267738.1 | 0.12 | 1846 | 0.17 | 8.6e-14 | -5.59 | 2.29e-08 | 0.52 | FALSE |
| pVTA | Mettl21a | alternative TSS | NM_001399451.1 | 0.03 | 1 | 0.04 | 1.8e-04 | -5.61 | 2.07e-08 | 0.05 | FALSE |
| pVTA | Pikfyve | alternative TSS | XM_039084597.2 | 0.04 | 155 | 0.03 | 8.4e-04 | 5.4 | 6.65e-08 | 0.44 | FALSE |
| pVTA | Cryga | gene expression | Cryga | 0.05 | 1 | 0.07 | 3.5e-06 | -5.68 | 1.38e-08 | 0.31 | FALSE |
| pVTA | Pikfyve | gene expression | Pikfyve | 0.09 | 2039 | 0.11 | 5.1e-09 | -5.65 | 1.57e-08 | 0.5 | FALSE |
| pVTA | Cryga | isoform ratio | XM_063267738.1 | 0.1 | 1846 | 0.1 | 4.8e-08 | -5.33 | 9.59e-08 | 0.52 | FALSE |
| pVTA | Pikfyve | isoform ratio | XM_039084597.2 | 0.04 | 1 | 0.03 | 2.3e-03 | 5.33 | 9.72e-08 | 0.03 | FALSE |
| pVTA | Cryga | intron excision ratio | chr9_73980494_73984047 | 0.11 | 35 | 0.19 | 2.0e-15 | -5.65 | 1.57e-08 | 0.57 | FALSE |