Best TWAS P=9.93e-10 · Best GWAS P=4.29e-08 conditioned to 9.51e-02
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Cdc23 | alternative polyA | NM_001100659.1 | 0.17 | 868 | 0.13 | 1.3e-14 | -5.37 | 8.06e-08 | 0.66 | FALSE |
| Adipose | Cdc23 | alternative polyA | XM_008772028.3 | 0.06 | 1 | 0.04 | 6.2e-05 | -5.24 | 1.59e-07 | 0.34 | FALSE |
| Adipose | Cdc23 | alternative polyA | XM_039096724.1 | 0.11 | 868 | 0.08 | 2.1e-09 | 5.49 | 4.10e-08 | 0.66 | FALSE |
| Adipose | Cdc23 | alternative polyA | NM_001100659.1 | 0.1 | 1 | 0.08 | 7.4e-09 | -5.24 | 1.59e-07 | 0.66 | FALSE |
| Adipose | Cdc23 | alternative polyA | XM_008772028.3 | 0.1 | 1 | 0.08 | 8.3e-09 | 5.24 | 1.59e-07 | 0.66 | FALSE |
| Adipose | Brd8 | gene expression | Brd8 | 0.04 | 1 | 0.01 | 9.8e-03 | -5.44 | 5.45e-08 | 0.06 | FALSE |
| Adipose | Kif20a | gene expression | Kif20a | 0.02 | 1 | 0.02 | 3.9e-03 | -5.22 | 1.79e-07 | 0.05 | FALSE |
| Adipose | Pkd2l2 | gene expression | Pkd2l2 | 0.03 | 1 | 0.04 | 1.8e-05 | 5.22 | 1.79e-07 | 0.15 | FALSE |
| Adipose | Srp19 | gene expression | Srp19 | 0.05 | 1 | 0.03 | 3.0e-04 | -5.24 | 1.59e-07 | 0.1 | FALSE |
| Adipose | Cdc23 | isoform ratio | NM_001100659.1 | 0.14 | 868 | 0.11 | 1.6e-12 | -5.39 | 7.23e-08 | 0.66 | FALSE |
| Adipose | Cdc23 | isoform ratio | XM_008772028.3 | 0.13 | 868 | 0.1 | 5.1e-11 | 5.45 | 5.15e-08 | 0.66 | FALSE |
| Brain | Cdc23 | gene expression | Cdc23 | 0.03 | 1 | 0.02 | 3.6e-03 | -5.29 | 1.23e-07 | 0.06 | FALSE |
| Brain | Reep5 | gene expression | Reep5 | 0.05 | 1129 | 0.05 | 8.5e-06 | 5.55 | 2.89e-08 | 0.7 | FALSE |
| Brain | Cdc23 | isoform ratio | NM_001100659.1 | 0.09 | 1 | 0.09 | 4.7e-09 | 5.24 | 1.58e-07 | 0.57 | FALSE |
| Brain | Cdc23 | isoform ratio | XM_008772028.3 | 0.07 | 869 | 0.08 | 1.3e-07 | 5.43 | 5.50e-08 | 0.69 | FALSE |
| Brain | Fam13b | isoform ratio | XM_039096734.1 | 0.08 | 1 | 0.11 | 2.7e-10 | -5.24 | 1.59e-07 | 0.57 | FALSE |
| Brain | Apc | intron excision ratio | chr18_25864409_25871423 | 0.07 | 1 | 0.02 | 1.1e-02 | -5.4 | 6.73e-08 | 0.04 | FALSE |
| Brain | Kif20a | mRNA stability | Kif20a | 0.05 | 915 | 0.05 | 8.2e-06 | -5.21 | 1.90e-07 | 0.57 | FALSE |
| IL | Cdc23 | isoform ratio | NM_001100659.1 | 0.21 | 869 | 0.05 | 2.4e-02 | -5.25 | 1.54e-07 | 0.32 | FALSE |
| LHb | Cdc23 | gene expression | Cdc23 | 0.3 | 4 | 0.15 | 2.4e-04 | 5.39 | 7.20e-08 | 0.6 | FALSE |
| Liver | Fam13b | gene expression | Fam13b | 0.17 | 1015 | 0.15 | 1.2e-16 | 5.47 | 4.55e-08 | 0.61 | FALSE |
| Liver | Pkd2l2 | gene expression | Pkd2l2 | 0.03 | 1 | 0.04 | 4.5e-05 | -5.24 | 1.59e-07 | 0.08 | FALSE |
| Liver | Cdc23 | isoform ratio | NM_001100659.1 | 0.08 | 868 | 0.04 | 2.0e-05 | -5.31 | 1.13e-07 | 0.66 | FALSE |
| Liver | Cdc23 | isoform ratio | XM_008772028.3 | 0.15 | 868 | 0.11 | 2.3e-12 | 5.33 | 1.01e-07 | 0.66 | FALSE |
| NAcc | Cdc23 | alternative polyA | NM_001100659.1 | 0.1 | 869 | 0.09 | 5.0e-10 | -5.58 | 2.45e-08 | 0.71 | FALSE |
| NAcc | Epb41l4a | gene expression | Epb41l4a | 0.11 | 1049 | 0.04 | 1.9e-05 | 5.9 | 3.75e-09 | 0.53 | FALSE |
| NAcc | Reep5 | gene expression | Reep5 | 0.04 | 1129 | 0.05 | 1.1e-06 | 5.25 | 1.48e-07 | 0.62 | FALSE |
| NAcc | Cdc23 | isoform ratio | NM_001100659.1 | 0.41 | 869 | 0.11 | 3.2e-13 | -5.79 | 6.87e-09 | 0.72 | FALSE |
| PL | Cdc23 | alternative polyA | NM_001100659.1 | 0.08 | 1 | 0.07 | 2.9e-08 | 5.44 | 5.21e-08 | 0.79 | FALSE |
| PL | Cdc23 | alternative polyA | NM_001100659.1 | 0.04 | 1 | 0.03 | 2.5e-04 | 5.28 | 1.31e-07 | 0.11 | FALSE |
| PL | Cdc23 | alternative polyA | XM_008772028.3 | 0.04 | 1 | 0.03 | 2.5e-04 | -5.28 | 1.31e-07 | 0.09 | FALSE |
| PL | Reep5 | gene expression | Reep5 | 0.04 | 1129 | 0.02 | 3.2e-03 | 6.11 | 9.93e-10 | 0.5 | TRUE |
| PL | Srp19 | gene expression | Srp19 | 0.02 | 1244 | 0.01 | 4.3e-02 | -5.7 | 1.21e-08 | 0.48 | FALSE |
| PL | Cdc23 | intron excision ratio | chr18_26240669_26242295 | 0.05 | 1 | 0.04 | 5.3e-05 | -5.28 | 1.29e-07 | 0.22 | FALSE |
| PL | Nme5 | intron excision ratio | chr18_26169875_26180166 | 0.07 | 1 | 0.04 | 1.3e-05 | -5.46 | 4.79e-08 | 0.6 | FALSE |
| pVTA | Cdc23 | alternative polyA | XM_039096724.1 | 0.11 | 1 | 0.03 | 2.3e-02 | -5.17 | 2.29e-07 | 0.05 | FALSE |
| pVTA | Brd8 | gene expression | Brd8 | 0.11 | 1 | 0.09 | 1.6e-04 | -5.36 | 8.13e-08 | 0.08 | FALSE |
| pVTA | Nme5 | gene expression | Nme5 | 0.08 | 923 | 0.03 | 1.6e-02 | -5.68 | 1.33e-08 | 0.48 | FALSE |
| pVTA | Cdc23 | isoform ratio | XM_008772028.3 | 0.3 | 869 | 0.29 | 4.7e-13 | 5.59 | 2.30e-08 | 0.71 | FALSE |
| RMTg | Nme5 | intron excision ratio | chr18_26164061_26169757 | 0.09 | 1 | 0.07 | 7.4e-03 | -5.44 | 5.39e-08 | 0.06 | FALSE |
| RMTg | Nme5 | intron excision ratio | chr18_26169875_26180166 | 0.12 | 923 | 0.12 | 4.0e-04 | 5.47 | 4.60e-08 | 0.59 | FALSE |