chr18:25,427,994-26,946,372

Trait: BMI with tail

Best TWAS P=9.93e-10 · Best GWAS P=4.29e-08 conditioned to 9.51e-02

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
Adipose Cdc23 alternative polyA NM_001100659.1 0.17 868 0.13 1.3e-14 -5.37 8.06e-08 0.66 FALSE
Adipose Cdc23 alternative polyA XM_008772028.3 0.06 1 0.04 6.2e-05 -5.24 1.59e-07 0.34 FALSE
Adipose Cdc23 alternative polyA XM_039096724.1 0.11 868 0.08 2.1e-09 5.49 4.10e-08 0.66 FALSE
Adipose Cdc23 alternative polyA NM_001100659.1 0.1 1 0.08 7.4e-09 -5.24 1.59e-07 0.66 FALSE
Adipose Cdc23 alternative polyA XM_008772028.3 0.1 1 0.08 8.3e-09 5.24 1.59e-07 0.66 FALSE
Adipose Brd8 gene expression Brd8 0.04 1 0.01 9.8e-03 -5.44 5.45e-08 0.06 FALSE
Adipose Kif20a gene expression Kif20a 0.02 1 0.02 3.9e-03 -5.22 1.79e-07 0.05 FALSE
Adipose Pkd2l2 gene expression Pkd2l2 0.03 1 0.04 1.8e-05 5.22 1.79e-07 0.15 FALSE
Adipose Srp19 gene expression Srp19 0.05 1 0.03 3.0e-04 -5.24 1.59e-07 0.1 FALSE
Adipose Cdc23 isoform ratio NM_001100659.1 0.14 868 0.11 1.6e-12 -5.39 7.23e-08 0.66 FALSE
Adipose Cdc23 isoform ratio XM_008772028.3 0.13 868 0.1 5.1e-11 5.45 5.15e-08 0.66 FALSE
Brain Cdc23 gene expression Cdc23 0.03 1 0.02 3.6e-03 -5.29 1.23e-07 0.06 FALSE
Brain Reep5 gene expression Reep5 0.05 1129 0.05 8.5e-06 5.55 2.89e-08 0.7 FALSE
Brain Cdc23 isoform ratio NM_001100659.1 0.09 1 0.09 4.7e-09 5.24 1.58e-07 0.57 FALSE
Brain Cdc23 isoform ratio XM_008772028.3 0.07 869 0.08 1.3e-07 5.43 5.50e-08 0.69 FALSE
Brain Fam13b isoform ratio XM_039096734.1 0.08 1 0.11 2.7e-10 -5.24 1.59e-07 0.57 FALSE
Brain Apc intron excision ratio chr18_25864409_25871423 0.07 1 0.02 1.1e-02 -5.4 6.73e-08 0.04 FALSE
Brain Kif20a mRNA stability Kif20a 0.05 915 0.05 8.2e-06 -5.21 1.90e-07 0.57 FALSE
IL Cdc23 isoform ratio NM_001100659.1 0.21 869 0.05 2.4e-02 -5.25 1.54e-07 0.32 FALSE
LHb Cdc23 gene expression Cdc23 0.3 4 0.15 2.4e-04 5.39 7.20e-08 0.6 FALSE
Liver Fam13b gene expression Fam13b 0.17 1015 0.15 1.2e-16 5.47 4.55e-08 0.61 FALSE
Liver Pkd2l2 gene expression Pkd2l2 0.03 1 0.04 4.5e-05 -5.24 1.59e-07 0.08 FALSE
Liver Cdc23 isoform ratio NM_001100659.1 0.08 868 0.04 2.0e-05 -5.31 1.13e-07 0.66 FALSE
Liver Cdc23 isoform ratio XM_008772028.3 0.15 868 0.11 2.3e-12 5.33 1.01e-07 0.66 FALSE
NAcc Cdc23 alternative polyA NM_001100659.1 0.1 869 0.09 5.0e-10 -5.58 2.45e-08 0.71 FALSE
NAcc Epb41l4a gene expression Epb41l4a 0.11 1049 0.04 1.9e-05 5.9 3.75e-09 0.53 FALSE
NAcc Reep5 gene expression Reep5 0.04 1129 0.05 1.1e-06 5.25 1.48e-07 0.62 FALSE
NAcc Cdc23 isoform ratio NM_001100659.1 0.41 869 0.11 3.2e-13 -5.79 6.87e-09 0.72 FALSE
PL Cdc23 alternative polyA NM_001100659.1 0.08 1 0.07 2.9e-08 5.44 5.21e-08 0.79 FALSE
PL Cdc23 alternative polyA NM_001100659.1 0.04 1 0.03 2.5e-04 5.28 1.31e-07 0.11 FALSE
PL Cdc23 alternative polyA XM_008772028.3 0.04 1 0.03 2.5e-04 -5.28 1.31e-07 0.09 FALSE
PL Reep5 gene expression Reep5 0.04 1129 0.02 3.2e-03 6.11 9.93e-10 0.5 TRUE
PL Srp19 gene expression Srp19 0.02 1244 0.01 4.3e-02 -5.7 1.21e-08 0.48 FALSE
PL Cdc23 intron excision ratio chr18_26240669_26242295 0.05 1 0.04 5.3e-05 -5.28 1.29e-07 0.22 FALSE
PL Nme5 intron excision ratio chr18_26169875_26180166 0.07 1 0.04 1.3e-05 -5.46 4.79e-08 0.6 FALSE
pVTA Cdc23 alternative polyA XM_039096724.1 0.11 1 0.03 2.3e-02 -5.17 2.29e-07 0.05 FALSE
pVTA Brd8 gene expression Brd8 0.11 1 0.09 1.6e-04 -5.36 8.13e-08 0.08 FALSE
pVTA Nme5 gene expression Nme5 0.08 923 0.03 1.6e-02 -5.68 1.33e-08 0.48 FALSE
pVTA Cdc23 isoform ratio XM_008772028.3 0.3 869 0.29 4.7e-13 5.59 2.30e-08 0.71 FALSE
RMTg Nme5 intron excision ratio chr18_26164061_26169757 0.09 1 0.07 7.4e-03 -5.44 5.39e-08 0.06 FALSE
RMTg Nme5 intron excision ratio chr18_26169875_26180166 0.12 923 0.12 4.0e-04 5.47 4.60e-08 0.59 FALSE