Best TWAS P=1.29e-08 · Best GWAS P=9.17e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Esd | gene expression | ENSRNOG00000009512 | 0.17 | 1 | 0.11 | 1.1e-12 | 5.41 | 6.28e-08 | 0.93 | FALSE |
| Adipose | Rcbtb2 | gene expression | ENSRNOG00000015054 | 0.11 | 1 | 0.06 | 2.5e-07 | 5.43 | 5.61e-08 | 0.51 | FALSE |
| Adipose | Lpar6 | gene expression | ENSRNOG00000015577 | 0.07 | 148 | 0.05 | 1.3e-06 | 5.47 | 4.60e-08 | 0.73 | FALSE |
| Adipose | Med4 | gene expression | ENSRNOG00000017170 | 0.03 | 1 | 0.02 | 1.5e-03 | 5.36 | 8.32e-08 | 0.04 | FALSE |
| Adipose | Nudt15 | intron excision ratio | chr15:48711928:48713567 | 0.03 | 1 | 0.02 | 6.5e-03 | -5.36 | 8.36e-08 | 0.03 | FALSE |
| Adipose | Itm2b | mRNA stability | ENSRNOG00000016271 | 0.04 | 1 | 0.04 | 1.5e-05 | -5.5 | 3.71e-08 | 0.34 | FALSE |
| BLA | Fndc3a | gene expression | ENSRNOG00000014478 | 0.1 | 1 | 0.05 | 1.6e-03 | 5.21 | 1.89e-07 | 0.05 | FALSE |
| Brain | Nudt15 | intron excision ratio | chr15:48711928:48713567 | 0.14 | 2021 | 0.09 | 4.5e-09 | -5.4 | 6.59e-08 | 0.82 | FALSE |
| Liver | Rcbtb2 | intron excision ratio | chr15:48355011:48357257 | 0.1 | 1 | 0.08 | 2.2e-09 | 5.68 | 1.32e-08 | 0.82 | FALSE |
| Liver | Rcbtb2 | intron excision ratio | chr15:48357396:48358748 | 0.03 | 1 | 0.02 | 1.9e-03 | 5.36 | 8.12e-08 | 0.04 | FALSE |
| Liver | Rcbtb2 | intron excision ratio | chr15:48358397:48358748 | 0.2 | 1 | 0.21 | 1.1e-22 | -5.36 | 8.32e-08 | 0.43 | FALSE |
| Liver | Nudt15 | intron excision ratio | chr15:48711928:48713567 | 0.07 | 2019 | 0.06 | 3.7e-07 | -5.54 | 3.06e-08 | 0.67 | FALSE |
| PL | Nudt15 | intron excision ratio | chr15:48711928:48713567 | 0.24 | 1 | 0.14 | 1.3e-10 | -5.69 | 1.29e-08 | 0.84 | TRUE |