Best TWAS P=1.06e-08 · Best GWAS P=9.17e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Lpar6 | gene expression | Lpar6 | 0.08 | 1 | 0.07 | 5.5e-08 | -5.68 | 1.32e-08 | 0.81 | FALSE |
| Adipose | Med4 | gene expression | Med4 | 0.04 | 1 | 0.03 | 5.6e-04 | -5.36 | 8.32e-08 | 0.05 | FALSE |
| Adipose | Rcbtb2 | gene expression | Rcbtb2 | 0.12 | 1 | 0.07 | 6.8e-08 | -5.43 | 5.61e-08 | 0.53 | FALSE |
| Adipose | Nudt15 | intron excision ratio | chr15_48711928_48713567 | 0.02 | 1 | 0.02 | 5.4e-03 | 5.43 | 5.61e-08 | 0.03 | FALSE |
| Brain | Nudt15 | intron excision ratio | chr15_48711928_48713567 | 0.16 | 1 | 0.12 | 1.6e-11 | 5.72 | 1.06e-08 | 0.86 | TRUE |
| IL | Rcbtb2 | alternative polyA | NM_199084.1 | 0.26 | 1 | 0.12 | 9.1e-04 | -5.32 | 1.04e-07 | 0.05 | FALSE |
| IL | Rcbtb2 | alternative polyA | XM_008770847.3 | 0.26 | 1 | 0.12 | 8.6e-04 | 5.32 | 1.04e-07 | 0.05 | FALSE |
| LHb | Rcbtb2 | intron excision ratio | chr15_48333445_48336229 | 0.21 | 2081 | 0.1 | 2.5e-03 | -5.46 | 4.75e-08 | 0.39 | FALSE |
| Liver | Fndc3a | alternative TSS | XM_006252298.4 | 0.02 | 1 | 0.01 | 1.6e-02 | -5.3 | 1.16e-07 | 0.03 | FALSE |
| Liver | Fndc3a | alternative TSS | XM_006252298.4 | 0.02 | 1 | 0.02 | 6.2e-03 | -5.3 | 1.16e-07 | 0.04 | FALSE |
| Liver | Rcbtb2 | isoform ratio | XM_008770853.3 | 0.04 | 1 | 0.04 | 4.5e-05 | 5.6 | 2.16e-08 | 0.45 | FALSE |
| Liver | Nudt15 | intron excision ratio | chr15_48711928_48713567 | 0.08 | 34 | 0.07 | 5.5e-08 | 5.51 | 3.49e-08 | 0.65 | FALSE |
| Liver | Rcbtb2 | intron excision ratio | chr15_48355011_48357257 | 0.1 | 1 | 0.07 | 1.4e-08 | -5.68 | 1.32e-08 | 0.82 | FALSE |
| Liver | Rcbtb2 | intron excision ratio | chr15_48357396_48358748 | 0.03 | 1 | 0.02 | 1.2e-03 | -5.36 | 8.12e-08 | 0.04 | FALSE |
| Liver | Rcbtb2 | intron excision ratio | chr15_48358397_48358748 | 0.22 | 1 | 0.21 | 3.6e-23 | 5.32 | 1.03e-07 | 0.38 | FALSE |
| Liver | Itm2b | mRNA stability | Itm2b | 0.1 | 1978 | 0.08 | 4.8e-09 | 5.38 | 7.40e-08 | 0.68 | FALSE |
| NAcc | Rcbtb2 | alternative polyA | XM_008770847.3 | 0.05 | 17 | 0.02 | 2.6e-03 | -5.27 | 1.33e-07 | 0.38 | FALSE |
| PL | Rcbtb2 | isoform ratio | NM_199084.1 | 0.09 | 2081 | 0.06 | 6.5e-07 | 5.19 | 2.14e-07 | 0.46 | FALSE |
| PL | Nudt15 | intron excision ratio | chr15_48711928_48713263 | 0.46 | 2038 | 0.16 | 2.2e-17 | 5.18 | 2.24e-07 | 0.85 | FALSE |
| PL | Nudt15 | intron excision ratio | chr15_48711928_48713567 | 0.43 | 2038 | 0.17 | 5.6e-18 | -5.24 | 1.61e-07 | 0.85 | FALSE |
| PL | Itm2b | mRNA stability | Itm2b | 0.06 | 9 | 0.05 | 2.3e-06 | 5.42 | 6.11e-08 | 0.57 | FALSE |
| pVTA | Nudt15 | intron excision ratio | chr15_48711928_48713567 | 0.33 | 1 | 0.24 | 1.0e-10 | 5.49 | 3.95e-08 | 0.64 | FALSE |
| pVTA | Itm2b | mRNA stability | Itm2b | 0.14 | 1 | 0.09 | 1.4e-04 | -5.46 | 4.72e-08 | 0.17 | FALSE |
| RMTg | Nudt15 | intron excision ratio | chr15_48711928_48713567 | 0.16 | 2038 | 0.03 | 5.5e-02 | -5.25 | 1.55e-07 | 0.39 | FALSE |