Best TWAS P=1.50e-08 · Best GWAS P=1.24e-07 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | LOC120096689 | gene expression | LOC120096689 | 0.42 | 2551 | 0.41 | 1.1e-48 | -5.18 | 2.20e-07 | 0.81 | FALSE |
| Adipose | LOC120096689 | isoform ratio | XR_005493474.1 | 0.16 | 2551 | 0.13 | 7.6e-14 | 5.2 | 2.00e-07 | 0.85 | FALSE |
| Adipose | B3gnt2 | mRNA stability | B3gnt2 | 0.07 | 1414 | 0.06 | 6.4e-07 | -5.58 | 2.43e-08 | 0.54 | FALSE |
| BLA | Tmem17 | intron excision ratio | chr14_96522291_96523082 | 0.09 | 1329 | 0.03 | 7.5e-03 | 5.42 | 5.99e-08 | 0.48 | FALSE |
| Brain | Commd1 | isoform ratio | XM_017599130.2 | 0.2 | 1 | 0.31 | 7.1e-29 | 5.27 | 1.36e-07 | 0.81 | FALSE |
| Brain | Tmem17 | isoform ratio | XM_039092230.1 | 0.1 | 1329 | 0.06 | 3.3e-06 | -5.56 | 2.66e-08 | 0.65 | TRUE |
| Brain | B3gnt2 | mRNA stability | B3gnt2 | 0.06 | 1416 | 0.08 | 9.6e-08 | 5.21 | 1.86e-07 | 0.53 | FALSE |
| IL | Commd1 | isoform ratio | XM_017599130.2 | 0.26 | 29 | 0.16 | 9.5e-05 | -5.28 | 1.32e-07 | 0.56 | FALSE |
| IL | LOC102552091 | isoform ratio | XR_005493490.1 | 0.17 | 1462 | 0.09 | 4.2e-03 | 5.23 | 1.66e-07 | 0.48 | FALSE |
| LHb | Tmem17 | gene expression | Tmem17 | 0.22 | 313 | -0 | 3.8e-01 | 5.66 | 1.50e-08 | 0.13 | TRUE |
| Liver | B3gnt2 | gene expression | B3gnt2 | 0.05 | 1 | 0.09 | 1.4e-10 | -5.22 | 1.82e-07 | 0.76 | FALSE |
| PL | LOC102552091 | alternative polyA | XR_005493486.1 | 0.02 | 1462 | 0.01 | 1.0e-02 | 5.19 | 2.13e-07 | 0.49 | FALSE |
| PL | LOC102552091 | isoform ratio | XR_005493490.1 | 0.04 | 1 | 0.04 | 5.9e-05 | -5.29 | 1.24e-07 | 0.56 | FALSE |
| PL | Tmem17 | isoform ratio | XM_039092230.1 | 0.07 | 1 | 0.05 | 1.8e-06 | 5.21 | 1.93e-07 | 0.77 | TRUE |
| pVTA | Commd1 | alternative TSS | XM_017599129.2 | 0.22 | 1 | 0.22 | 5.8e-10 | 5.23 | 1.72e-07 | 0.77 | FALSE |
| pVTA | Commd1 | alternative TSS | NM_001115022.1 | 0.23 | 1 | 0.24 | 7.4e-11 | -5.23 | 1.72e-07 | 0.77 | FALSE |
| pVTA | Commd1 | alternative TSS | XM_017599129.2 | 0.25 | 1 | 0.25 | 3.3e-11 | 5.23 | 1.72e-07 | 0.77 | FALSE |
| pVTA | Commd1 | isoform ratio | XM_017599130.2 | 0.24 | 8 | 0.27 | 5.2e-12 | -5.19 | 2.12e-07 | 0.53 | FALSE |