Best TWAS P = 9.62e-12 · Best GWAS P= 5.98e-12 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Epb41l5 | alternative polyA | NM_001401160.1 | 0.05 | 1378 | 0 | 1.8e-01 | 5.4 | 6.67e-08 | 0.21 | FALSE |
| Adipose | Dbi | gene expression | Dbi | 0.46 | 5 | 0.17 | 5.9e-19 | -6.5 | 8.05e-11 | 0.96 | FALSE |
| Adipose | Inhbb | gene expression | Inhbb | 0.19 | 21 | 0.1 | 1.4e-11 | -6.26 | 3.79e-10 | 0.64 | FALSE |
| Adipose | Dbi | mRNA stability | Dbi | 0.08 | 1 | 0.02 | 2.1e-03 | 6.6 | 4.02e-11 | 0.09 | FALSE |
| Adipose | En1 | mRNA stability | En1 | 0.03 | 29 | 0.01 | 5.4e-02 | -5.23 | 1.72e-07 | 0.15 | FALSE |
| BLA | Dbi | gene expression | Dbi | 0.25 | 1390 | 0.08 | 3.5e-05 | -5.27 | 1.39e-07 | 0.88 | FALSE |
| BLA | LOC134481483 | gene expression | LOC134481483 | 0.42 | 2599 | 0.28 | 4.8e-15 | -6.58 | 4.82e-11 | 0.5 | FALSE |
| BLA | Dbi | mRNA stability | Dbi | 0.49 | 77 | 0.36 | 1.0e-19 | 6.69 | 2.24e-11 | 0.92 | FALSE |
| Brain | Dbi | gene expression | Dbi | 0.47 | 21 | 0.32 | 1.3e-30 | -6.07 | 1.26e-09 | 0.87 | FALSE |
| Brain | Epb41l5 | gene expression | Epb41l5 | 0.27 | 1378 | 0.01 | 2.0e-02 | -6.06 | 1.35e-09 | 0.42 | FALSE |
| Brain | LOC134481483 | gene expression | LOC134481483 | 0.13 | 1 | 0.13 | 8.9e-12 | -6.1 | 1.07e-09 | 0.11 | FALSE |
| Brain | Tsn | isoform ratio | XM_063272570.1 | 0.12 | 4 | -0 | 4.5e-01 | 5.76 | 8.42e-09 | 0.14 | FALSE |
| Brain | LOC120096233 | intron excision ratio | chr13_34804337_34840383 | 0.05 | 2707 | 0.03 | 5.8e-04 | -5.73 | 1.03e-08 | 0.31 | FALSE |
| Brain | Dbi | mRNA stability | Dbi | 0.58 | 33 | 0.42 | 9.2e-42 | 6.18 | 6.43e-10 | 0.86 | FALSE |
| IC | Dbi | gene expression | Dbi | 0.26 | 14 | 0.08 | 3.0e-04 | -5.73 | 1.02e-08 | 0.82 | FALSE |
| IC | LOC120096233 | gene expression | LOC120096233 | 0.21 | 1 | 0.08 | 2.3e-04 | -6.59 | 4.40e-11 | 0.1 | FALSE |
| IC | Dbi | mRNA stability | Dbi | 0.79 | 28 | 0.4 | 7.0e-18 | 5.88 | 4.18e-09 | 0.92 | FALSE |
| IL | Dbi | gene expression | Dbi | 0.58 | 22 | 0.13 | 5.5e-04 | -6.54 | 5.97e-11 | 0.78 | FALSE |
| LHb | Clasp1 | intron excision ratio | chr13_32226523_32237646 | 0.21 | 1 | 0.04 | 3.8e-02 | 6.08 | 1.20e-09 | 0.07 | FALSE |
| Liver | Epb41l5 | alternative polyA | XM_039090680.2 | 0.23 | 116 | 0.08 | 3.5e-09 | 6.63 | 3.39e-11 | 0.81 | FALSE |
| Liver | Epb41l5 | alternative polyA | NM_001401160.1 | 0.09 | 1378 | 0.02 | 1.6e-03 | -6.25 | 3.99e-10 | 0.71 | FALSE |
| Liver | Epb41l5 | alternative polyA | XM_039090680.2 | 0.1 | 1 | 0.02 | 9.6e-04 | 6.25 | 4.19e-10 | 0.04 | FALSE |
| Liver | Sctr | gene expression | Sctr | 0.05 | 916 | 0 | 1.4e-01 | 6.3 | 3.05e-10 | 0.51 | FALSE |
| Liver | Dbi | mRNA stability | Dbi | 0.28 | 17 | 0.05 | 3.0e-06 | 6.69 | 2.21e-11 | 0.91 | FALSE |
| NAcc | Dbi | gene expression | Dbi | 0.21 | 4 | 0.1 | 7.4e-15 | -6.42 | 1.36e-10 | 0.93 | FALSE |
| NAcc | LOC120096233 | gene expression | LOC120096233 | 0.15 | 1 | 0.09 | 2.9e-13 | -6.81 | 9.62e-12 | 0.9 | TRUE |
| NAcc | Dbi | mRNA stability | Dbi | 0.43 | 1 | 0.23 | 6.1e-35 | 6.55 | 5.66e-11 | 0.86 | FALSE |
| OFC | Dbi | gene expression | Dbi | 0.54 | 1 | 0.18 | 4.0e-05 | -5.67 | 1.42e-08 | 0.05 | FALSE |
| OFC | LOC120096233 | gene expression | LOC120096233 | 0.21 | 2707 | 0.1 | 2.9e-03 | -6.14 | 8.39e-10 | 0.48 | FALSE |
| PL | LOC120096233 | gene expression | LOC120096233 | 0.11 | 1 | 0.08 | 4.4e-09 | -6.12 | 9.19e-10 | 0.09 | FALSE |
| PL | Ralb | gene expression | Ralb | 0.05 | 1595 | 0.01 | 1.0e-02 | -5.47 | 4.46e-08 | 0.57 | FALSE |
| pVTA | Ccdc93 | alternative TSS | XM_039090684.2 | 0.05 | 17 | 0.02 | 1.0e-02 | 5.61 | 2.03e-08 | 0.32 | FALSE |
| pVTA | Dbi | gene expression | Dbi | 0.18 | 1 | 0.05 | 4.2e-05 | -6.6 | 4.02e-11 | 0.68 | FALSE |
| pVTA | Inhbb | gene expression | Inhbb | 0.11 | 1767 | 0.04 | 3.3e-04 | 5.74 | 9.55e-09 | 0.71 | FALSE |
| pVTA | LOC134481483 | gene expression | LOC134481483 | 0.63 | 2599 | 0.38 | 9.8e-32 | -6.04 | 1.54e-09 | 0.45 | FALSE |
| pVTA | LOC134481621 | gene expression | LOC134481621 | 0.16 | 1 | 0.12 | 1.4e-09 | -5.97 | 2.35e-09 | 0.06 | FALSE |
| pVTA | Tmem177 | gene expression | Tmem177 | 0.13 | 1007 | 0.04 | 4.6e-04 | 5.38 | 7.45e-08 | 0.61 | FALSE |
| pVTA | Epb41l5 | intron excision ratio | chr13_33254185_33272115 | 0.08 | 45 | 0 | 2.4e-01 | -6.65 | 2.87e-11 | 0.03 | FALSE |
| pVTA | LOC134481483 | intron excision ratio | chr13_35111875_35113956 | 0.14 | 2599 | 0.1 | 3.3e-08 | 5.98 | 2.26e-09 | 0.08 | FALSE |
| pVTA | LOC134481483 | intron excision ratio | chr13_35128262_35130575 | 0.05 | 2599 | 0.01 | 3.0e-02 | -5.92 | 3.19e-09 | 0.58 | FALSE |
| pVTA | Dbi | mRNA stability | Dbi | 0.39 | 15 | 0.42 | 5.6e-36 | 6.38 | 1.78e-10 | 0.9 | FALSE |
| RMTg | Epb41l5 | alternative polyA | XM_039090680.2 | 0.26 | 174 | 0.04 | 3.5e-02 | 5.88 | 4.22e-09 | 0.2 | FALSE |