Hub : Traits : Liver selenium concentration : ← →

chr1:238,391,248-240,123,287

Best TWAS P=9.139454e-08 · Best GWAS P=1.03346e-07 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Tctn3	gene expression	ENSRNOG00000062728	0.11	0.07	top1	1	0.07	2.7e-08	-5.2	5.2	2.5e-07	-0.96	0.49	0.51	FALSE
2	Adipose	Sorbs1	intron excision ratio	chr1:239171438:239176063	0.15	0.11	lasso	20	0.12	2.8e-13	-5.1	-5.1	3.2e-07	0.96	0.55	0.44	FALSE
3	Adipose	Sorbs1	intron excision ratio	chr1:239171438:239182421	0.16	0.14	lasso	20	0.16	4.9e-17	-5.1	5.1	3.2e-07	-0.96	0.56	0.44	FALSE
4	Adipose	Sorbs1	intron excision ratio	chr1:239184817:239189712	0.08	0.05	top1	1	0.05	3.4e-06	-5.2	5.2	2.4e-07	-0.96	0.37	0.31	FALSE
5	Adipose	Sorbs1	intron excision ratio	chr1:239189741:239193373	0.03	0.02	top1	1	0.02	2.8e-03	-5.2	-5.2	2.4e-07	0.96	0.07	0.03	FALSE
6	Adipose	Sorbs1	intron excision ratio	chr1:239193514:239203110	0.13	0.12	top1	1	0.12	2.8e-13	-5.1	-5.1	3.2e-07	0.96	0.60	0.40	FALSE
7	Adipose	Sorbs1	intron excision ratio	chr1:239197213:239197853	0.18	0.11	lasso	26	0.13	2.0e-14	-5.1	5.1	3.2e-07	-0.96	0.55	0.45	FALSE
8	Adipose	Sorbs1	intron excision ratio	chr1:239197213:239203110	0.07	0.04	top1	1	0.04	5.9e-05	-5.1	-5.1	3.2e-07	0.96	0.41	0.27	FALSE
9	BLA	Tctn3	gene expression	ENSRNOG00000062728	0.26	0.23	lasso	31	0.25	9.4e-14	-5.2	5.2	1.9e-07	-0.97	0.52	0.48	FALSE
10	Brain	Entpd1	alternative TSS	ENSRNOT00000019751	0.03	0.02	top1	1	0.02	4.2e-03	-5.3	-5.3	1.5e-07	0.94	0.07	0.04	FALSE
11	Brain	Entpd1	alternative TSS	ENSRNOT00000115487	0.03	0.02	top1	1	0.02	5.6e-03	-5.3	5.3	1.5e-07	-0.95	0.07	0.04	FALSE
12	Brain	Pdlim1	gene expression	ENSRNOG00000016166	0.12	0.13	top1	1	0.13	2.3e-12	-5.3	5.3	1.0e-07	-0.96	0.38	0.62	FALSE
13	Brain	Aldh18a1	gene expression	ENSRNOG00000067262	0.05	0.08	top1	1	0.08	1.0e-07	-5.2	-5.2	2.1e-07	0.96	0.43	0.50	FALSE
14	Brain	Sorbs1	intron excision ratio	chr1:239184817:239189712	0.07	0.11	lasso	5	0.11	2.7e-10	-5.2	5.3	1.2e-07	0.88	0.58	0.42	TRUE
15	Brain	Sorbs1	intron excision ratio	chr1:239184817:239193373	0.08	0.10	enet	74	0.11	3.0e-10	-5.2	-5.3	1.2e-07	0.95	0.61	0.39	FALSE
16	Brain	Sorbs1	intron excision ratio	chr1:239189741:239193373	0.02	0.01	top1	1	0.01	2.8e-02	-5.2	5.2	2.4e-07	-0.96	0.08	0.04	FALSE
17	Brain	Sorbs1	intron excision ratio	chr1:239193514:239196842	0.07	0.02	blup	2347	0.05	2.8e-05	-5.2	5.2	2.0e-07	-0.85	0.58	0.40	TRUE
18	Brain	Sorbs1	intron excision ratio	chr1:239193514:239203110	0.14	0.18	top1	1	0.18	2.5e-16	-5.1	-5.1	2.7e-07	0.96	0.57	0.43	FALSE
19	Brain	Sorbs1	intron excision ratio	chr1:239197213:239203110	0.10	0.08	blup	2347	0.09	5.1e-09	-5.0	5.3	1.0e-07	-0.91	0.63	0.37	FALSE
20	LHb	Tctn3	gene expression	ENSRNOG00000062728	0.24	0.19	lasso	2	0.21	8.9e-06	-5.2	5.2	2.6e-07	-0.98	0.54	0.44	FALSE
21	LHb	Sorbs1	intron excision ratio	chr1:239171438:239182421	0.23	-0.01	blup	2337	0.00	2.9e-01	-5.2	5.1	3.1e-07	-0.83	0.42	0.24	FALSE
22	Liver	Tctn3	gene expression	ENSRNOG00000062728	0.03	0.01	top1	1	0.01	3.3e-02	-5.1	5.1	2.8e-07	-0.97	0.06	0.03	FALSE
23	Liver	Sorbs1	intron excision ratio	chr1:239171438:239176063	0.05	0.04	top1	1	0.04	1.6e-05	-5.1	-5.1	3.2e-07	0.96	0.39	0.26	FALSE
24	NAcc	Entpd1	alternative TSS	ENSRNOT00000115487	0.42	0.20	blup	2186	0.22	1.3e-05	-5.0	5.2	2.5e-07	-0.96	0.53	0.46	FALSE
25	NAcc	Entpd1	alternative TSS	ENSRNOT00000019751	0.38	0.03	blup	2186	0.15	2.6e-04	-5.1	-5.3	1.1e-07	0.95	0.52	0.45	FALSE
26	NAcc	Entpd1	alternative TSS	ENSRNOT00000115487	0.38	0.05	blup	2186	0.16	2.2e-04	-5.1	5.3	1.1e-07	-0.95	0.53	0.45	FALSE
27	NAcc2	Entpd1	alternative TSS	ENSRNOT00000115487	0.06	0.03	top1	1	0.03	8.1e-03	-5.2	5.2	2.1e-07	-0.96	0.09	0.04	FALSE
28	NAcc2	Tctn3	gene expression	ENSRNOG00000062728	0.15	0.12	top1	1	0.12	6.4e-07	-5.2	5.2	2.4e-07	-0.95	0.40	0.40	FALSE
29	NAcc2	Sorbs1	intron excision ratio	chr1:239116238:239130234	0.05	0.03	top1	1	0.03	9.2e-03	-5.3	5.3	9.1e-08	-0.96	0.09	0.05	TRUE
30	NAcc2	Sorbs1	intron excision ratio	chr1:239128876:239130234	0.08	0.10	lasso	4	0.10	4.7e-06	-5.2	-5.3	1.5e-07	0.96	0.59	0.40	FALSE
31	NAcc2	Sorbs1	intron excision ratio	chr1:239184817:239193373	0.11	0.04	blup	2347	0.06	2.0e-04	-3.9	-5.1	2.7e-07	0.93	0.63	0.36	FALSE
32	OFC	Entpd1	gene expression	ENSRNOG00000014574	0.23	0.15	lasso	4	0.19	3.0e-05	-5.2	-5.2	2.5e-07	0.96	0.53	0.45	FALSE
33	PL	Pdlim1	gene expression	ENSRNOG00000016166	0.29	0.26	blup	2525	0.27	4.2e-07	-5.0	5.1	3.3e-07	-0.96	0.65	0.34	FALSE
34	PL2	Tctn3	gene expression	ENSRNOG00000062728	0.09	0.08	enet	20	0.08	5.5e-05	-5.2	5.2	2.2e-07	-0.96	0.54	0.45	FALSE
35	PL2	Aldh18a1	gene expression	ENSRNOG00000067262	0.07	0.05	top1	1	0.05	1.1e-03	-5.2	-5.2	2.4e-07	0.95	0.10	0.06	FALSE
36	PL2	Sorbs1	intron excision ratio	chr1:239184817:239189712	0.05	0.03	top1	1	0.03	1.1e-02	-5.3	5.3	1.0e-07	-0.95	0.09	0.04	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.