Hub : Traits : Liver selenium concentration : ← →

chr1:231,783,442-237,140,824

Best TWAS P=1.239946e-09 · Best GWAS P=1.001527e-08 conditioned to 0.3821021

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Lgi1	gene expression	ENSRNOG00000014758	0.03	0.01	top1	1	0.01	6.3e-02	-5.5	5.5	4.7e-08	0.60	0.07	0.04	FALSE
2	Adipose	Pde6c	gene expression	ENSRNOG00000016593	0.11	0.14	blup	2325	0.15	1.0e-16	-5.5	-5.4	6.9e-08	-0.63	0.42	0.58	FALSE
3	Adipose	Cyp26a1	gene expression	ENSRNOG00000016750	0.04	0.01	blup	2508	0.01	1.5e-02	-5.5	-5.3	8.9e-08	-0.64	0.43	0.37	FALSE
4	Adipose	Btaf1	gene expression	ENSRNOG00000017938	0.10	0.05	top1	1	0.05	3.4e-06	-5.2	-5.2	2.1e-07	-0.80	0.71	0.10	FALSE
5	Adipose	Fra10ac1	intron excision ratio	chr1:235969436:235970456	0.03	0.01	blup	2317	0.01	1.2e-02	-5.5	-5.4	6.1e-08	-0.60	0.40	0.55	FALSE
6	Adipose	Hhex	mRNA stability	ENSRNOG00000016595	0.02	0.00	blup	2105	0.01	5.7e-02	-5.4	-5.7	1.5e-08	-0.77	0.41	0.24	FALSE
7	Adipose	Marchf5	mRNA stability	ENSRNOG00000017396	0.05	0.04	top1	1	0.04	2.5e-05	-5.6	5.6	2.1e-08	0.87	0.26	0.33	FALSE
8	Adipose	Cpeb3	mRNA stability	ENSRNOG00000020689	0.07	0.04	blup	1713	0.06	3.1e-07	-5.5	5.3	9.0e-08	0.87	0.43	0.57	FALSE
9	Adipose	Hectd2	mRNA stability	ENSRNOG00000056753	0.03	0.01	blup	2247	0.02	2.8e-03	-4.0	5.4	6.9e-08	0.79	0.71	0.19	FALSE
10	BLA	Plce1	gene expression	ENSRNOG00000014276	0.12	0.04	enet	20	0.07	9.2e-05	-5.2	-5.5	4.7e-08	-0.39	0.50	0.45	FALSE
11	BLA	Myof	gene expression	ENSRNOG00000016117	0.08	0.04	blup	2288	0.06	2.3e-04	-4.1	-5.5	4.1e-08	-0.68	0.51	0.48	FALSE
12	BLA	Marchf5	gene expression	ENSRNOG00000017396	0.22	0.20	enet	41	0.20	3.9e-11	-5.4	5.5	2.9e-08	0.88	0.45	0.55	FALSE
13	BLA	Btaf1	isoform ratio	ENSRNOT00000024465	0.07	0.05	top1	1	0.05	1.3e-03	-5.3	5.3	1.1e-07	0.44	0.08	0.04	FALSE
14	BLA	Ffar4	mRNA stability	ENSRNOG00000021763	0.13	0.05	blup	2317	0.07	8.4e-05	-4.8	-5.2	2.5e-07	-0.63	0.75	0.24	FALSE
15	Brain	Cpeb3	alternative TSS	ENSRNOT00000047387	0.04	0.04	top1	1	0.04	8.9e-05	-5.6	-5.6	2.0e-08	-0.85	0.08	0.08	FALSE
16	Brain	Cpeb3	alternative TSS	ENSRNOT00000114370	0.04	0.04	top1	1	0.04	1.2e-04	-5.6	5.6	2.0e-08	0.85	0.08	0.07	FALSE
17	Brain	Myof	gene expression	ENSRNOG00000016117	0.13	0.15	blup	2288	0.17	1.3e-15	-4.7	-5.3	9.4e-08	-0.74	0.92	0.08	FALSE
18	Brain	Cyp26a1	gene expression	ENSRNOG00000016750	0.07	0.08	top1	1	0.08	7.9e-08	-5.4	-5.4	7.3e-08	-0.69	0.60	0.34	FALSE
19	Brain	Ide	gene expression	ENSRNOG00000016833	0.05	0.02	blup	1979	0.03	1.2e-03	-5.0	5.8	5.3e-09	0.80	0.49	0.49	FALSE
20	Brain	Marchf5	gene expression	ENSRNOG00000017396	0.27	0.27	top1	1	0.27	3.6e-25	-5.6	5.6	2.0e-08	0.87	0.41	0.59	FALSE
21	Brain	Ankrd1	gene expression	ENSRNOG00000018598	0.06	0.02	blup	2408	0.04	9.1e-05	5.3	5.4	6.5e-08	0.78	0.71	0.23	FALSE
22	Brain	NA	gene expression	ENSRNOG00000067881	0.05	0.04	top1	1	0.04	1.4e-04	5.3	5.3	1.2e-07	0.87	0.33	0.14	FALSE
23	Brain	Pank1	isoform ratio	ENSRNOT00000100218	0.21	0.17	top1	1	0.17	3.0e-15	5.2	5.2	1.8e-07	0.71	0.56	0.44	FALSE
24	Brain	Tnks2	isoform ratio	ENSRNOT00000079808	0.17	0.20	top1	1	0.20	2.4e-18	-5.3	5.3	1.1e-07	0.65	0.82	0.18	FALSE
25	Brain	Tnks2	isoform ratio	ENSRNOT00000085497	0.17	0.20	top1	1	0.20	6.9e-18	-5.3	-5.3	1.1e-07	-0.65	0.82	0.18	FALSE
26	Brain	Tnks2	intron excision ratio	chr1:234602539:234606928	0.11	0.15	top1	1	0.15	2.1e-13	-5.3	-5.3	1.1e-07	-0.70	0.82	0.18	FALSE
27	Brain	Tnks2	intron excision ratio	chr1:234603939:234606928	0.06	0.03	blup	2036	0.04	1.2e-04	-5.3	5.7	1.5e-08	0.80	0.66	0.33	FALSE
28	Brain	Hectd2	intron excision ratio	chr1:234328907:234331775	0.05	0.01	blup	2248	0.01	1.6e-02	5.6	5.9	4.7e-09	0.88	0.38	0.37	FALSE
29	Brain	Lgi1	mRNA stability	ENSRNOG00000014758	0.05	0.01	enet	77	0.01	1.5e-02	-5.5	5.2	1.7e-07	0.55	0.42	0.30	FALSE
30	Brain	Btaf1	mRNA stability	ENSRNOG00000017938	0.13	0.11	lasso	2	0.11	1.4e-10	-5.2	5.7	1.3e-08	0.81	0.72	0.28	FALSE
31	Brain	Pcgf5	mRNA stability	ENSRNOG00000018532	0.04	0.01	enet	12	0.01	1.8e-02	4.9	-5.4	6.4e-08	-0.88	0.56	0.38	FALSE
32	Eye	Cpeb3	gene expression	ENSRNOG00000020689	0.37	0.21	top1	1	0.21	4.1e-04	-5.6	5.6	2.1e-08	0.89	0.10	0.06	FALSE
33	Eye	Rpp30	intron excision ratio	chr1:233787542:233789135	0.43	0.14	top1	1	0.14	3.2e-03	5.3	5.3	1.5e-07	0.92	0.14	0.06	FALSE
34	Eye	Cpeb3	mRNA stability	ENSRNOG00000020689	0.35	0.30	top1	1	0.30	1.5e-05	-5.6	5.6	2.1e-08	0.88	0.10	0.06	FALSE
35	IL	Cyp26a1	gene expression	ENSRNOG00000016750	0.31	0.18	blup	2500	0.21	9.5e-06	-5.5	-5.7	1.0e-08	-0.77	0.57	0.42	FALSE
36	IL	Marchf5	gene expression	ENSRNOG00000017396	0.21	0.07	enet	5	0.07	7.4e-03	-5.3	6.1	1.2e-09	0.87	0.48	0.39	TRUE
37	IL	Ffar4	gene expression	ENSRNOG00000021763	0.20	0.13	blup	2310	0.18	3.9e-05	-4.8	5.5	4.7e-08	0.66	0.66	0.28	FALSE
38	IL	Cyp26c1	gene expression	ENSRNOG00000030698	0.15	0.00	blup	2493	0.08	5.2e-03	-5.0	-5.4	6.3e-08	-0.80	0.45	0.29	FALSE
39	IL	Rpp30	intron excision ratio	chr1:233797153:233804206	0.31	0.21	top1	1	0.21	7.3e-06	5.3	5.3	1.2e-07	0.92	0.16	0.06	FALSE
40	LHb	Htr7	gene expression	ENSRNOG00000018827	0.18	0.15	top1	1	0.15	2.7e-04	5.3	5.3	1.1e-07	0.92	0.14	0.06	FALSE
41	LHb	Slc35g1	gene expression	ENSRNOG00000029740	0.17	0.05	lasso	12	0.06	1.5e-02	-4.4	-5.2	1.9e-07	-0.67	0.45	0.32	FALSE
42	LHb	Exoc6	gene expression	ENSRNOG00000036601	0.14	0.00	blup	2289	0.06	1.8e-02	-5.6	-5.6	1.7e-08	-0.82	0.46	0.39	FALSE
43	LHb	Tnks2	gene expression	ENSRNOG00000052664	0.25	0.21	blup	2029	0.23	3.7e-06	5.7	5.4	8.7e-08	0.95	0.43	0.54	FALSE
44	LHb	Hectd2	gene expression	ENSRNOG00000056753	0.25	0.08	lasso	3	0.09	4.7e-03	-5.1	5.3	1.1e-07	0.74	0.59	0.26	FALSE
45	LHb	Slc35g1	mRNA stability	ENSRNOG00000029740	0.20	0.15	top1	1	0.15	2.5e-04	-5.5	-5.5	4.8e-08	-0.63	0.10	0.06	FALSE
46	Liver	Ppp1r3c	alternative polyA	ENSRNOT00000024941	0.06	0.07	top1	1	0.07	5.5e-08	5.7	-5.7	1.4e-08	-0.97	0.41	0.58	FALSE
47	Liver	Ppp1r3c	alternative polyA	ENSRNOT00000107925	0.08	0.08	top1	1	0.08	4.2e-09	5.7	5.7	1.4e-08	0.98	0.41	0.59	FALSE
48	Liver	Myof	gene expression	ENSRNOG00000016117	0.03	0.01	top1	1	0.01	3.1e-02	-5.6	-5.6	2.3e-08	-0.65	0.07	0.04	FALSE
49	Liver	Ppp1r3c	gene expression	ENSRNOG00000018494	0.03	0.02	top1	1	0.02	2.7e-03	-5.2	-5.2	2.2e-07	-0.74	0.06	0.03	FALSE
50	Liver	Exoc6	gene expression	ENSRNOG00000036601	0.06	0.05	top1	1	0.05	2.6e-06	-5.5	5.5	3.4e-08	0.83	0.51	0.44	FALSE
51	Liver	Ppp1r3c	isoform ratio	ENSRNOT00000024941	0.03	0.02	enet	21	0.03	8.3e-04	5.7	-5.7	1.4e-08	-0.85	0.45	0.48	FALSE
52	Liver	Tnks2	isoform ratio	ENSRNOT00000079808	0.02	0.01	top1	1	0.01	7.6e-03	-5.2	5.2	2.1e-07	0.69	0.06	0.03	FALSE
53	Liver	Marchf5	mRNA stability	ENSRNOG00000017396	0.05	0.02	top1	1	0.02	1.7e-03	-5.6	-5.6	2.1e-08	-0.88	0.08	0.07	FALSE
54	Liver	Slc16a12	mRNA stability	ENSRNOG00000021916	0.11	0.12	top1	1	0.12	1.1e-13	5.2	-5.2	1.9e-07	-0.62	0.38	0.62	FALSE
55	NAcc	Pank1	alternative TSS	ENSRNOT00000100218	0.17	0.07	blup	2246	0.07	1.0e-02	5.2	5.3	1.1e-07	0.78	0.32	0.39	FALSE
56	NAcc	Rbp4	gene expression	ENSRNOG00000015518	0.21	0.02	blup	2315	0.04	3.6e-02	-4.7	-5.2	2.5e-07	-0.59	0.39	0.17	FALSE
57	NAcc	Ppp1r3c	gene expression	ENSRNOG00000018494	0.32	0.26	top1	1	0.26	1.6e-06	5.7	5.7	1.4e-08	0.98	0.20	0.22	FALSE
58	NAcc	Pank1	gene expression	ENSRNOG00000018944	0.50	0.27	lasso	4	0.28	4.1e-07	5.2	-5.2	2.0e-07	-0.57	0.59	0.41	FALSE
59	NAcc	Tnks2	gene expression	ENSRNOG00000052664	0.14	0.06	enet	5	0.09	4.3e-03	-5.5	6.1	1.4e-09	0.90	0.40	0.36	FALSE
60	NAcc	Pank1	isoform ratio	ENSRNOT00000100218	0.17	0.07	blup	2246	0.09	4.2e-03	-4.1	5.2	2.5e-07	0.76	0.34	0.35	FALSE
61	NAcc2	Marchf5	gene expression	ENSRNOG00000017396	0.13	0.10	blup	1719	0.12	8.6e-07	-5.6	5.5	5.0e-08	0.85	0.43	0.57	FALSE
62	NAcc2	Hells	gene expression	ENSRNOG00000047692	0.08	0.04	blup	1386	0.05	1.1e-03	-4.9	-5.1	2.8e-07	-0.46	0.36	0.60	FALSE
63	NAcc2	Tnks2	gene expression	ENSRNOG00000052664	0.07	0.05	blup	2036	0.05	1.2e-03	-5.6	5.9	3.2e-09	0.95	0.45	0.48	FALSE
64	NAcc2	NA	gene expression	ENSRNOG00000067881	0.05	0.03	lasso	27	0.03	6.1e-03	5.3	5.3	1.1e-07	0.84	0.55	0.25	FALSE
65	NAcc2	Myof	mRNA stability	ENSRNOG00000016117	0.09	0.03	blup	2288	0.04	2.7e-03	-4.7	-5.4	5.8e-08	-0.72	0.76	0.20	FALSE
66	NAcc2	Cpeb3	mRNA stability	ENSRNOG00000020689	0.08	0.05	top1	1	0.05	1.2e-03	-5.4	5.4	6.9e-08	0.89	0.08	0.05	FALSE
67	NAcc2	Tnks2	mRNA stability	ENSRNOG00000052664	0.09	0.06	top1	1	0.06	5.9e-04	-5.5	5.5	4.0e-08	0.92	0.09	0.04	FALSE
68	OFC	Marchf5	gene expression	ENSRNOG00000017396	0.12	0.09	top1	1	0.09	3.9e-03	-5.6	5.6	2.0e-08	0.89	0.09	0.05	FALSE
69	OFC	Ffar4	gene expression	ENSRNOG00000021763	0.18	0.04	blup	2310	0.09	3.8e-03	-5.1	5.8	5.7e-09	0.62	0.48	0.33	FALSE
70	OFC	Exoc6	gene expression	ENSRNOG00000036601	0.29	0.12	blup	2290	0.23	4.2e-06	-5.4	-5.5	4.9e-08	-0.83	0.50	0.49	FALSE
71	OFC	Tnks2	gene expression	ENSRNOG00000052664	0.35	0.23	top1	1	0.23	4.0e-06	-5.6	-5.6	2.1e-08	-0.96	0.14	0.09	FALSE
72	PL	Cyp26a1	gene expression	ENSRNOG00000016750	0.32	0.30	top1	1	0.30	5.5e-08	-5.4	-5.4	7.0e-08	-0.80	0.36	0.20	FALSE
73	PL	Marchf5	gene expression	ENSRNOG00000017396	0.14	0.07	blup	1713	0.11	1.7e-03	-5.6	5.6	1.8e-08	0.86	0.38	0.43	FALSE
74	PL	Exoc6	gene expression	ENSRNOG00000036601	0.30	0.08	blup	2290	0.23	3.3e-06	-5.4	-5.5	4.7e-08	-0.79	0.48	0.51	FALSE
75	PL	Tnks2	gene expression	ENSRNOG00000052664	0.52	0.17	enet	9	0.20	2.1e-05	-5.6	-5.1	3.0e-07	-0.83	0.46	0.43	FALSE
76	PL2	Pank1	alternative TSS	ENSRNOT00000100218	0.08	0.03	blup	2255	0.04	2.1e-03	-3.8	5.1	3.0e-07	0.77	0.47	0.36	FALSE
77	PL2	Cyp26a1	gene expression	ENSRNOG00000016750	0.21	0.05	enet	57	0.14	5.4e-08	-4.4	-5.7	1.3e-08	-0.72	0.67	0.33	FALSE
78	PL2	Cyp26c1	gene expression	ENSRNOG00000030698	0.06	0.03	lasso	2	0.03	9.0e-03	-5.1	-5.6	2.8e-08	-0.74	0.54	0.23	FALSE
79	PL2	Exoc6	gene expression	ENSRNOG00000036601	0.22	0.23	blup	2296	0.28	1.8e-15	-5.4	-5.2	2.1e-07	-0.80	0.49	0.51	FALSE
80	PL2	Pank1	isoform ratio	ENSRNOT00000100218	0.09	0.03	blup	2255	0.05	1.3e-03	5.2	5.2	1.8e-07	0.77	0.48	0.43	FALSE
81	PL2	Marchf5	mRNA stability	ENSRNOG00000017396	0.06	0.04	top1	1	0.04	2.0e-03	5.7	-5.7	1.4e-08	-0.88	0.07	0.05	FALSE
82	PL2	Ffar4	mRNA stability	ENSRNOG00000021763	0.16	0.11	enet	15	0.14	5.9e-08	-4.8	-5.5	2.9e-08	-0.63	0.92	0.07	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.