Hub : Traits : Se content in liver : ← →

chr1:231,783,442-236,943,873

Trait: Se content in liver

Best TWAS P=4.02266e-10 · Best GWAS P=1.001527e-08 conditioned to 0.4769374

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Lgi1	gene expression	ENSRNOG00000014758	0.03	0.01	top1	1	0.01	6.3e-02	-5.5	5.5	4.7e-08	0.60	0.07	0.04	FALSE
2	Adipose	Pde6c	gene expression	ENSRNOG00000016593	0.11	0.14	blup	2325	0.15	1.0e-16	-5.5	-5.4	6.9e-08	-0.63	0.42	0.58	FALSE
3	Adipose	Cyp26a1	gene expression	ENSRNOG00000016750	0.04	0.01	blup	2508	0.01	1.5e-02	-5.5	-5.3	8.9e-08	-0.64	0.43	0.37	FALSE
4	Adipose	Btaf1	gene expression	ENSRNOG00000017938	0.10	0.05	top1	1	0.05	3.4e-06	-5.2	-5.2	2.1e-07	-0.80	0.71	0.10	FALSE
5	Adipose	Exoc6	gene expression	ENSRNOG00000036601	0.13	0.08	enet	164	0.08	1.4e-09	-5.1	5.1	3.4e-07	0.78	0.79	0.21	FALSE
6	Adipose	Fra10ac1	intron excision ratio	chr1:235969436:235970456	0.03	0.01	blup	2317	0.01	1.2e-02	-5.5	-5.4	6.1e-08	-0.60	0.40	0.55	FALSE
7	Adipose	Hhex	mRNA stability	ENSRNOG00000016595	0.02	0.00	blup	2105	0.01	5.7e-02	-5.4	-5.7	1.5e-08	-0.77	0.41	0.24	FALSE
8	Adipose	Marchf5	mRNA stability	ENSRNOG00000017396	0.05	0.04	top1	1	0.04	2.5e-05	-5.6	5.6	2.1e-08	0.87	0.26	0.33	FALSE
9	Adipose	Cpeb3	mRNA stability	ENSRNOG00000020689	0.07	0.04	blup	1713	0.06	3.1e-07	-5.5	5.3	9.0e-08	0.87	0.43	0.57	FALSE
10	Adipose	Hectd2	mRNA stability	ENSRNOG00000056753	0.03	0.01	blup	2247	0.02	2.8e-03	-4.0	5.4	6.9e-08	0.79	0.71	0.19	FALSE
11	BLA	Plce1	gene expression	ENSRNOG00000014276	0.12	0.04	enet	20	0.07	9.2e-05	-5.2	-5.5	4.7e-08	-0.39	0.50	0.45	FALSE
12	BLA	Myof	gene expression	ENSRNOG00000016117	0.08	0.04	blup	2288	0.06	2.3e-04	-4.1	-5.5	4.1e-08	-0.68	0.51	0.48	FALSE
13	BLA	Marchf5	gene expression	ENSRNOG00000017396	0.22	0.20	enet	41	0.20	3.9e-11	-5.4	5.5	2.9e-08	0.88	0.45	0.55	FALSE
14	BLA	Btaf1	isoform ratio	ENSRNOT00000024465	0.07	0.05	top1	1	0.05	1.3e-03	-5.3	5.3	1.1e-07	0.44	0.08	0.04	FALSE
15	BLA	Ffar4	mRNA stability	ENSRNOG00000021763	0.13	0.05	blup	2317	0.07	8.4e-05	-4.8	-5.2	2.5e-07	-0.63	0.75	0.24	FALSE
16	Brain	Cpeb3	alternative TSS	ENSRNOT00000047387	0.04	0.04	top1	1	0.04	8.9e-05	-5.6	-5.6	2.0e-08	-0.85	0.08	0.08	FALSE
17	Brain	Cpeb3	alternative TSS	ENSRNOT00000114370	0.04	0.04	top1	1	0.04	1.2e-04	-5.6	5.6	2.0e-08	0.85	0.08	0.07	FALSE
18	Brain	Myof	gene expression	ENSRNOG00000016117	0.13	0.15	blup	2288	0.17	1.3e-15	-4.7	-5.3	9.4e-08	-0.74	0.92	0.08	FALSE
19	Brain	Cyp26a1	gene expression	ENSRNOG00000016750	0.07	0.08	top1	1	0.08	7.9e-08	-5.4	-5.4	7.3e-08	-0.69	0.60	0.34	FALSE
20	Brain	Ide	gene expression	ENSRNOG00000016833	0.05	0.02	blup	1979	0.03	1.2e-03	-5.0	5.8	5.3e-09	0.80	0.49	0.49	FALSE
21	Brain	Marchf5	gene expression	ENSRNOG00000017396	0.27	0.27	top1	1	0.27	3.6e-25	-5.6	5.6	2.0e-08	0.87	0.41	0.59	FALSE
22	Brain	Ankrd1	gene expression	ENSRNOG00000018598	0.06	0.02	blup	2408	0.04	9.1e-05	5.3	5.4	6.5e-08	0.78	0.71	0.23	FALSE
23	Brain	NA	gene expression	ENSRNOG00000067881	0.05	0.04	top1	1	0.04	1.4e-04	5.3	5.3	1.2e-07	0.87	0.33	0.14	FALSE
24	Brain	Pank1	isoform ratio	ENSRNOT00000100218	0.21	0.17	top1	1	0.17	3.0e-15	5.2	5.2	1.8e-07	0.71	0.56	0.44	FALSE
25	Brain	Tnks2	isoform ratio	ENSRNOT00000079808	0.17	0.20	top1	1	0.20	2.4e-18	-5.3	5.3	1.1e-07	0.65	0.82	0.18	FALSE
26	Brain	Tnks2	isoform ratio	ENSRNOT00000085497	0.17	0.20	top1	1	0.20	6.9e-18	-5.3	-5.3	1.1e-07	-0.65	0.82	0.18	FALSE
27	Brain	Tnks2	intron excision ratio	chr1:234602539:234606928	0.11	0.15	top1	1	0.15	2.1e-13	-5.3	-5.3	1.1e-07	-0.70	0.82	0.18	FALSE
28	Brain	Tnks2	intron excision ratio	chr1:234603939:234606928	0.06	0.03	blup	2036	0.04	1.2e-04	-5.3	5.7	1.5e-08	0.80	0.66	0.33	FALSE
29	Brain	Hectd2	intron excision ratio	chr1:234328907:234331775	0.05	0.01	blup	2248	0.01	1.6e-02	5.6	5.9	4.7e-09	0.88	0.38	0.37	FALSE
30	Brain	Lgi1	mRNA stability	ENSRNOG00000014758	0.05	0.01	enet	77	0.01	1.5e-02	-5.5	5.2	1.7e-07	0.55	0.42	0.30	FALSE
31	Brain	Btaf1	mRNA stability	ENSRNOG00000017938	0.13	0.11	lasso	2	0.11	1.4e-10	-5.2	5.7	1.3e-08	0.81	0.72	0.28	FALSE
32	Brain	Pcgf5	mRNA stability	ENSRNOG00000018532	0.04	0.01	enet	12	0.01	1.8e-02	4.9	-5.4	6.4e-08	-0.88	0.56	0.38	FALSE
33	Eye	Cpeb3	gene expression	ENSRNOG00000020689	0.37	0.21	top1	1	0.21	4.1e-04	-5.6	5.6	2.1e-08	0.89	0.10	0.06	FALSE
34	Eye	Rpp30	intron excision ratio	chr1:233787542:233789135	0.43	0.14	top1	1	0.14	3.2e-03	5.3	5.3	1.5e-07	0.92	0.14	0.06	FALSE
35	Eye	Cpeb3	mRNA stability	ENSRNOG00000020689	0.35	0.30	top1	1	0.30	1.5e-05	-5.6	5.6	2.1e-08	0.88	0.10	0.06	FALSE
36	IL	Cyp26a1	gene expression	ENSRNOG00000016750	0.31	0.18	blup	2500	0.21	9.5e-06	-5.5	-5.7	1.0e-08	-0.77	0.57	0.42	FALSE
37	IL	Marchf5	gene expression	ENSRNOG00000017396	0.21	0.07	enet	5	0.07	7.4e-03	-5.3	6.1	1.2e-09	0.87	0.48	0.39	FALSE
38	IL	Ffar4	gene expression	ENSRNOG00000021763	0.20	0.13	blup	2310	0.18	3.9e-05	-4.8	5.5	4.7e-08	0.66	0.66	0.28	FALSE
39	IL	Cyp26c1	gene expression	ENSRNOG00000030698	0.15	0.00	blup	2493	0.08	5.2e-03	-5.0	-5.4	6.3e-08	-0.80	0.45	0.29	FALSE
40	IL	Rpp30	intron excision ratio	chr1:233797153:233804206	0.31	0.21	top1	1	0.21	7.3e-06	5.3	5.3	1.2e-07	0.92	0.16	0.06	FALSE
41	LHb	Htr7	gene expression	ENSRNOG00000018827	0.18	0.15	top1	1	0.15	2.7e-04	5.3	5.3	1.1e-07	0.92	0.14	0.06	FALSE
42	LHb	Slc35g1	gene expression	ENSRNOG00000029740	0.17	0.05	lasso	12	0.06	1.5e-02	-4.4	-5.2	1.9e-07	-0.67	0.45	0.32	FALSE
43	LHb	Exoc6	gene expression	ENSRNOG00000036601	0.14	0.00	blup	2289	0.06	1.8e-02	-5.6	-5.6	1.7e-08	-0.82	0.46	0.39	FALSE
44	LHb	Tnks2	gene expression	ENSRNOG00000052664	0.25	0.21	blup	2029	0.23	3.7e-06	5.7	5.4	8.7e-08	0.95	0.43	0.54	FALSE
45	LHb	Hectd2	gene expression	ENSRNOG00000056753	0.25	0.08	lasso	3	0.09	4.7e-03	-5.1	5.3	1.1e-07	0.74	0.59	0.26	FALSE
46	LHb	Slc35g1	mRNA stability	ENSRNOG00000029740	0.20	0.15	top1	1	0.15	2.5e-04	-5.5	-5.5	4.8e-08	-0.63	0.10	0.06	FALSE
47	Liver	Ppp1r3c	alternative polyA	ENSRNOT00000024941	0.06	0.07	top1	1	0.07	5.5e-08	5.7	-5.7	1.4e-08	-0.97	0.41	0.58	FALSE
48	Liver	Ppp1r3c	alternative polyA	ENSRNOT00000107925	0.08	0.08	top1	1	0.08	4.2e-09	5.7	5.7	1.4e-08	0.98	0.41	0.59	FALSE
49	Liver	Myof	gene expression	ENSRNOG00000016117	0.03	0.01	top1	1	0.01	3.1e-02	-5.6	-5.6	2.3e-08	-0.65	0.07	0.04	FALSE
50	Liver	Ppp1r3c	gene expression	ENSRNOG00000018494	0.03	0.02	top1	1	0.02	2.7e-03	-5.2	-5.2	2.2e-07	-0.74	0.06	0.03	FALSE
51	Liver	Exoc6	gene expression	ENSRNOG00000036601	0.06	0.05	top1	1	0.05	2.6e-06	-5.5	5.5	3.4e-08	0.83	0.51	0.44	FALSE
52	Liver	Ppp1r3c	isoform ratio	ENSRNOT00000024941	0.03	0.02	enet	21	0.03	8.3e-04	5.7	-5.7	1.4e-08	-0.85	0.45	0.48	FALSE
53	Liver	Tnks2	isoform ratio	ENSRNOT00000079808	0.02	0.01	top1	1	0.01	7.6e-03	-5.2	5.2	2.1e-07	0.69	0.06	0.03	FALSE
54	Liver	Marchf5	mRNA stability	ENSRNOG00000017396	0.05	0.02	top1	1	0.02	1.7e-03	-5.6	-5.6	2.1e-08	-0.88	0.08	0.07	FALSE
55	Liver	Slc16a12	mRNA stability	ENSRNOG00000021916	0.11	0.12	top1	1	0.12	1.1e-13	5.2	-5.2	1.9e-07	-0.62	0.38	0.62	FALSE
56	NAcc	Pank1	alternative TSS	ENSRNOT00000100218	0.05	0.03	top1	1	0.03	1.3e-03	5.3	5.3	1.2e-07	0.75	0.08	0.04	FALSE
57	NAcc	Cyp26a1	gene expression	ENSRNOG00000016750	0.06	0.05	blup	2509	0.06	3.8e-05	-5.5	-6.3	4.0e-10	-0.86	0.44	0.55	TRUE
58	NAcc	Tnks2	gene expression	ENSRNOG00000052664	0.08	0.06	blup	2036	0.06	1.4e-05	-5.7	6.0	2.2e-09	0.94	0.48	0.52	FALSE
59	NAcc	NA	gene expression	ENSRNOG00000067881	0.04	0.04	top1	1	0.04	3.7e-04	5.3	5.3	1.2e-07	0.87	0.09	0.04	FALSE
60	NAcc	Tnks2	isoform ratio	ENSRNOT00000079808	0.11	0.09	top1	1	0.09	2.2e-07	-5.1	5.1	2.9e-07	0.73	0.85	0.08	FALSE
61	NAcc	Tnks2	isoform ratio	ENSRNOT00000085497	0.12	0.09	top1	1	0.10	1.5e-07	-5.1	-5.1	2.9e-07	-0.74	0.86	0.08	FALSE
62	NAcc	Cpeb3	mRNA stability	ENSRNOG00000020689	0.06	0.03	enet	55	0.04	5.3e-04	-5.4	5.1	3.2e-07	0.76	0.45	0.54	FALSE
63	OFC	Marchf5	gene expression	ENSRNOG00000017396	0.12	0.09	top1	1	0.09	3.9e-03	-5.6	5.6	2.0e-08	0.89	0.09	0.05	FALSE
64	OFC	Ffar4	gene expression	ENSRNOG00000021763	0.18	0.04	blup	2310	0.09	3.8e-03	-5.1	5.8	5.7e-09	0.62	0.48	0.33	FALSE
65	OFC	Exoc6	gene expression	ENSRNOG00000036601	0.29	0.12	blup	2290	0.23	4.2e-06	-5.4	-5.5	4.9e-08	-0.83	0.50	0.49	FALSE
66	OFC	Tnks2	gene expression	ENSRNOG00000052664	0.35	0.23	top1	1	0.23	4.0e-06	-5.6	-5.6	2.1e-08	-0.96	0.14	0.09	FALSE
67	PL	Ankrd1	alternative TSS	ENSRNOT00000108356	0.04	0.02	top1	1	0.02	8.9e-03	5.7	-5.7	1.4e-08	-0.93	0.09	0.06	FALSE
68	PL	Ankrd1	alternative TSS	ENSRNOT00000117221	0.03	0.01	top1	1	0.01	2.4e-02	5.6	5.6	1.8e-08	0.93	0.09	0.05	FALSE
69	PL	Ankrd1	alternative TSS	ENSRNOT00000117221	0.03	0.02	top1	1	0.02	2.1e-02	5.6	5.6	1.8e-08	0.93	0.09	0.05	FALSE
70	PL	Pank1	alternative TSS	ENSRNOT00000100218	0.04	0.03	lasso	17	0.03	3.5e-03	5.7	5.7	1.6e-08	0.85	0.29	0.64	FALSE
71	PL	Cyp26a1	gene expression	ENSRNOG00000016750	0.19	0.12	enet	23	0.20	2.0e-15	-5.3	-5.9	3.9e-09	-0.77	0.66	0.34	FALSE
72	PL	Ide	gene expression	ENSRNOG00000016833	0.04	0.01	blup	1979	0.02	1.7e-02	-5.6	5.4	6.3e-08	0.86	0.38	0.47	FALSE
73	PL	Marchf5	gene expression	ENSRNOG00000017396	0.21	0.16	lasso	46	0.16	5.2e-12	-5.6	5.6	2.1e-08	0.87	0.42	0.58	FALSE
74	PL	Pcgf5	gene expression	ENSRNOG00000018532	0.08	0.09	top1	1	0.09	3.7e-07	5.3	5.3	9.8e-08	0.96	0.69	0.25	FALSE
75	PL	Cpeb3	gene expression	ENSRNOG00000020689	0.04	0.03	top1	1	0.03	3.6e-03	-5.2	-5.2	2.5e-07	-0.53	0.06	0.03	FALSE
76	PL	Cyp26c1	gene expression	ENSRNOG00000030698	0.05	0.01	blup	2502	0.02	6.8e-03	-5.1	-5.7	1.4e-08	-0.71	0.69	0.25	FALSE
77	PL	Exoc6	gene expression	ENSRNOG00000036601	0.20	0.28	lasso	18	0.28	3.1e-21	-5.2	-5.5	4.6e-08	-0.82	0.50	0.50	FALSE
78	PL	Pank1	isoform ratio	ENSRNOT00000100218	0.06	0.04	top1	1	0.04	4.1e-04	5.2	5.2	1.9e-07	0.69	0.11	0.06	FALSE
79	PL	Marchf5	mRNA stability	ENSRNOG00000017396	0.06	0.04	top1	1	0.04	2.6e-04	5.7	-5.7	1.4e-08	-0.89	0.14	0.20	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.