Abnormal impulse behavior control / Impulsivity assay, delay discounting using an adjusting amount procedure, subject’s calculated value for AUC-traditional in 11-16 week old NIH heterogeneous stock rats for males and females (MEDPC V equipment, where immediate lever with 0s delay provides choice dependent adjusting amounts starting at 75µl of sucrose solution and delayed lever provides 150µl of sucrose solution).
Project: u01_suzanne_mitchell
2 significantly associated models · 2 unique genes
| # | chr | p0 | p1 | # assoc genes | # joint models | best TWAS P | best SNP P | cond SNP P | % var exp | joint genes |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 10 | 44859582 | 46252667 | 1 | 1 | 2.8e-07 | 0.051 | 4.9e-03 | -109 | Tmem11 |
| 2 | 10 | 62271668 | 63667097 | 1 | 1 | 2.9e-12 | 0.040 | 5.7e-19 | -1776 | Eral1 |
p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.
| Trait | chisq ratio | # genes+ | # genes++ | % genes++ | corr | corr P | genes |
|---|---|---|---|---|---|---|---|
| heart_g | 3.6 | 1 | 0 | 0 | 0 | 1 | Eral1 |
| Average time between licks in bursts | 5.5 | 1 | 0 | 0 | 0 | 1 | Eral1 |
| Std. dev. time between licks in bursts | 13.9 | 1 | 0 | 0 | 0 | 1 | Eral1 |
| Food consumed during 24 hour testing period | 14.7 | 1 | 0 | 0 | 0 | 1 | Eral1 |
| Times rat made contact with spout | 19.7 | 1 | 0 | 0 | 0 | 1 | Eral1 |
| Average drop size | 10.0 | 2 | 0 | 0 | 0 | 1 | Tmem11 Eral1 |
| Ambulatory time at time1 of open field | 49.0 | 1 | 1 | 50 | 0 | 1 | Eral1 |
| dd_expon_k | 32.2 | 2 | 2 | 100 | 0 | 1 | Tmem11 Eral1 |
| Area under the delay curve | 35.0 | 2 | 2 | 100 | 0 | 1 | Tmem11 Eral1 |
| punishment | 14.0 | 1 | 0 | 0 | 0 | 1 | Eral1 |
| runstartmale1 | 38.3 | 1 | 1 | 50 | 0 | 1 | Eral1 |
| locomotor2 | 13.5 | 1 | 0 | 0 | 0 | 1 | Eral1 |
chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.
| tissue | modality | # hits | % hits/tests | avg chisq |
|---|---|---|---|---|
| Adipose | alternative polyA | 0 | 0.000 | 1.05 |
| Adipose | alternative TSS | 0 | 0.000 | 1.02 |
| Adipose | gene expression | 1 | 0.012 | 1.08 |
| Adipose | isoform ratio | 0 | 0.000 | 1.03 |
| Adipose | intron excision ratio | 0 | 0.000 | 1.04 |
| Adipose | mRNA stability | 0 | 0.000 | 1.05 |
| BLA | alternative polyA | 0 | 0.000 | 1.11 |
| BLA | alternative TSS | 0 | 0.000 | 0.98 |
| BLA | gene expression | 0 | 0.000 | 1.11 |
| BLA | isoform ratio | 0 | 0.000 | 1.01 |
| BLA | intron excision ratio | 0 | 0.000 | 1.05 |
| BLA | mRNA stability | 0 | 0.000 | 1.12 |
| Brain | alternative polyA | 0 | 0.000 | 1.08 |
| Brain | alternative TSS | 0 | 0.000 | 1.03 |
| Brain | gene expression | 0 | 0.000 | 1.11 |
| Brain | isoform ratio | 0 | 0.000 | 1.02 |
| Brain | intron excision ratio | 0 | 0.000 | 1.08 |
| Brain | mRNA stability | 0 | 0.000 | 1.06 |
| Eye | alternative polyA | 0 | 0.000 | 0.86 |
| Eye | alternative TSS | 0 | 0.000 | 1.08 |
| Eye | gene expression | 0 | 0.000 | 1.07 |
| Eye | isoform ratio | 0 | 0.000 | 1.28 |
| Eye | intron excision ratio | 0 | 0.000 | 1.06 |
| Eye | mRNA stability | 0 | 0.000 | 1.06 |
| IL | alternative polyA | 0 | 0.000 | 1.10 |
| IL | alternative TSS | 0 | 0.000 | 1.11 |
| IL | gene expression | 0 | 0.000 | 1.09 |
| IL | isoform ratio | 0 | 0.000 | 0.96 |
| IL | intron excision ratio | 0 | 0.000 | 0.96 |
| IL | mRNA stability | 0 | 0.000 | 1.03 |
| LHb | alternative polyA | 0 | 0.000 | 1.06 |
| LHb | alternative TSS | 0 | 0.000 | 1.12 |
| LHb | gene expression | 0 | 0.000 | 1.08 |
| LHb | isoform ratio | 0 | 0.000 | 1.08 |
| LHb | intron excision ratio | 0 | 0.000 | 1.00 |
| LHb | mRNA stability | 0 | 0.000 | 1.04 |
| Liver | alternative polyA | 0 | 0.000 | 1.07 |
| Liver | alternative TSS | 0 | 0.000 | 1.05 |
| Liver | gene expression | 0 | 0.000 | 1.10 |
| Liver | isoform ratio | 0 | 0.000 | 1.06 |
| Liver | intron excision ratio | 0 | 0.000 | 1.08 |
| Liver | mRNA stability | 0 | 0.000 | 1.06 |
| NAcc | alternative polyA | 0 | 0.000 | 0.98 |
| NAcc | alternative TSS | 0 | 0.000 | 1.03 |
| NAcc | gene expression | 0 | 0.000 | 1.13 |
| NAcc | isoform ratio | 0 | 0.000 | 1.00 |
| NAcc | intron excision ratio | 0 | 0.000 | 1.13 |
| NAcc | mRNA stability | 0 | 0.000 | 1.03 |
| NAcc2 | alternative polyA | 0 | 0.000 | 1.12 |
| NAcc2 | alternative TSS | 0 | 0.000 | 0.98 |
| NAcc2 | gene expression | 0 | 0.000 | 1.10 |
| NAcc2 | isoform ratio | 0 | 0.000 | 0.98 |
| NAcc2 | intron excision ratio | 0 | 0.000 | 1.02 |
| NAcc2 | mRNA stability | 0 | 0.000 | 1.02 |
| OFC | alternative polyA | 0 | 0.000 | 1.08 |
| OFC | alternative TSS | 0 | 0.000 | 1.39 |
| OFC | gene expression | 0 | 0.000 | 1.09 |
| OFC | isoform ratio | 0 | 0.000 | 1.07 |
| OFC | intron excision ratio | 0 | 0.000 | 0.99 |
| OFC | mRNA stability | 0 | 0.000 | 0.95 |
| PL | alternative polyA | 0 | 0.000 | 1.14 |
| PL | alternative TSS | 0 | 0.000 | 1.10 |
| PL | gene expression | 1 | 0.027 | 1.14 |
| PL | isoform ratio | 0 | 0.000 | 1.06 |
| PL | intron excision ratio | 0 | 0.000 | 1.07 |
| PL | mRNA stability | 0 | 0.000 | 1.02 |
| PL2 | alternative polyA | 0 | 0.000 | 1.03 |
| PL2 | alternative TSS | 0 | 0.000 | 1.08 |
| PL2 | gene expression | 0 | 0.000 | 1.11 |
| PL2 | isoform ratio | 0 | 0.000 | 1.02 |
| PL2 | intron excision ratio | 0 | 0.000 | 1.03 |
| PL2 | mRNA stability | 0 | 0.000 | 1.05 |
avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.