chr18:25,502,820-27,317,045

Trait: BMI without tail

Best TWAS P = 2.57e-12 · Best GWAS P= 2.22e-08 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h²	# weights	Model R²	Model R² P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Brd8	gene expression	Brd8	0.03	1	0.01	4.8e-02	-5.26	1.44e-07	0.03	FALSE
Adipose	Cdc23	gene expression	Cdc23	0.04	1	0.03	1.8e-04	-5.26	1.43e-07	0.09	FALSE
BLA	Cdc23	alternative polyA	NM_001100659.1	0.15	13	0.14	4.7e-08	-5.26	1.41e-07	0.69	FALSE
BLA	Reep5	mRNA stability	Reep5	0.09	1156	0.04	3.7e-03	5.9	3.69e-09	0.6	TRUE
Eye	Cdc25c	alternative TSS	XM_063277372.1	0.25	793	0.09	1.7e-02	5.29	1.22e-07	0.4	FALSE
Eye	Srp19	intron excision ratio	chr18_26210140_26210233	0.22	1271	0.07	3.4e-02	5.41	6.43e-08	0.33	FALSE
Eye	Srp19	intron excision ratio	chr18_26210344_26211679	0.22	1271	0.06	4.6e-02	-5.43	5.76e-08	0.3	FALSE
IC	Cdc23	alternative polyA	NM_001100659.1	0.21	884	0.17	1.4e-07	-5.25	1.50e-07	0.75	FALSE
IC	Reep5	alternative polyA	NM_001108888.2	0.19	1	0.15	5.7e-07	5.34	9.44e-08	0.66	FALSE
IC	Reep5	alternative polyA	XM_039097000.2	0.16	1	0.14	1.8e-06	-5.34	9.44e-08	0.63	FALSE
IC	Fam13b	alternative TSS	XM_039096734.1	0.06	4	0.07	7.8e-04	5.24	1.62e-07	0.5	FALSE
IC	Cdc23	isoform ratio	XM_008772028.4	0.12	884	0.1	4.6e-05	5.22	1.83e-07	0.7	FALSE
IL	Cdc23	isoform ratio	NM_001100659.1	0.29	10	0.09	3.2e-03	-5.34	9.51e-08	0.45	TRUE
LHb	Cdc23	gene expression	Cdc23	0.3	1	0.18	5.6e-05	-5.51	3.51e-08	0.09	FALSE
LHb	Epb41l4a	gene expression	Epb41l4a	0.9	12	0.17	8.3e-05	-7	2.57e-12	0.17	TRUE
Liver	Cdc23	alternative polyA	NM_001100659.1	0.09	1	0.07	7.2e-08	5.29	1.24e-07	0.62	FALSE
Liver	Fam13b	alternative TSS	XM_039096734.1	0.03	1	0.02	8.9e-04	-5.46	4.77e-08	0.17	FALSE
Liver	Brd8	gene expression	Brd8	0.08	1	0.06	6.9e-07	-5.26	1.44e-07	0.56	FALSE
Liver	Fam13b	gene expression	Fam13b	0.16	1012	0.14	3.3e-15	5.26	1.43e-07	0.61	FALSE
Liver	Srp19	gene expression	Srp19	0.05	1271	0.01	6.8e-03	5.34	9.55e-08	0.55	TRUE
Liver	Cdc23	isoform ratio	NM_001100659.1	0.09	1	0.06	1.3e-07	5.29	1.24e-07	0.62	FALSE
NAcc	Cdc23	alternative polyA	NM_001100659.1	0.11	884	0.12	1.6e-17	-5.29	1.23e-07	0.62	FALSE
NAcc	Cdc23	alternative polyA	XM_008772028.4	0.11	884	0.12	1.6e-17	5.37	8.03e-08	0.72	FALSE
NAcc	Pkd2l2	alternative polyA	NM_001106156.1	0.03	1	0.02	4.8e-04	-5.36	8.37e-08	0.12	FALSE
NAcc	Pkd2l2	alternative polyA	XM_063277220.1	0.03	1	0.02	4.9e-04	5.36	8.37e-08	0.11	FALSE
NAcc	Reep5	alternative polyA	NM_001108888.2	0.08	1	0.12	1.7e-17	5.36	8.37e-08	0.71	FALSE
NAcc	Reep5	alternative polyA	XM_039097000.2	0.08	1	0.1	4.9e-15	-5.36	8.37e-08	0.71	FALSE
NAcc	LOC134482927	gene expression	LOC134482927	0.05	1	0.05	1.0e-07	5.24	1.58e-07	0.57	FALSE
NAcc	Cdc23	isoform ratio	NM_001100659.1	0.14	884	0.13	1.0e-18	-5.38	7.29e-08	0.64	FALSE
NAcc	Cdc23	isoform ratio	XM_008772028.4	0.12	884	0.1	3.4e-14	5.39	7.10e-08	0.69	FALSE
NAcc	Nme5	isoform ratio	NM_001427396.1	0.02	1	0.01	3.5e-03	-5.36	8.52e-08	0.05	FALSE
NAcc	Reep5	intron excision ratio	chr18_26224310_26232067	0.02	1	0.02	8.5e-04	-5.31	1.11e-07	0.09	FALSE
NAcc	Apc	mRNA stability	Apc	0.02	1	0.02	1.6e-03	-5.36	8.37e-08	0.06	FALSE
PL	Reep5	gene expression	Reep5	0.08	1156	0.07	1.4e-08	5.83	5.44e-09	0.71	FALSE
PL	Cdc23	isoform ratio	XM_008772028.4	0.08	1	0.06	2.1e-07	-5.51	3.51e-08	0.85	FALSE
PL	Reep5	mRNA stability	Reep5	0.04	1	0.01	6.2e-02	-5.42	5.88e-08	0.04	FALSE
pVTA	Reep5	alternative polyA	NM_001108888.2	0.06	1	0.05	7.7e-05	5.34	9.15e-08	0.21	FALSE
pVTA	Reep5	alternative polyA	XM_039097000.2	0.06	1	0.04	1.7e-04	-5.34	9.15e-08	0.14	FALSE
pVTA	Brd8	gene expression	Brd8	0.05	1	0.05	9.0e-05	-5.29	1.25e-07	0.31	FALSE
RMTg	Nme5	intron excision ratio	chr18_26444014_26454298	0.16	88	0.16	3.9e-05	-5.29	1.23e-07	0.65	FALSE