Best TWAS P = 1.43e-16 · Best GWAS P= 2.06e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Cdc23 | alternative polyA | NM_001100659.1 | 0.21 | 884 | 0.15 | 1.3e-16 | -5.54 | 3.11e-08 | 0.66 | FALSE |
| Adipose | Cdc23 | alternative polyA | XM_008772028.4 | 0.15 | 884 | 0.12 | 1.5e-13 | 5.55 | 2.85e-08 | 0.66 | FALSE |
| Adipose | Brd8 | gene expression | Brd8 | 0.03 | 1 | 0.01 | 4.8e-02 | 5.37 | 7.79e-08 | 0.03 | FALSE |
| Adipose | Cdc23 | gene expression | Cdc23 | 0.04 | 1 | 0.03 | 1.8e-04 | 5.36 | 8.34e-08 | 0.05 | FALSE |
| Adipose | LOC134482927 | gene expression | LOC134482927 | 0.09 | 944 | 0.07 | 5.6e-08 | -5.35 | 8.83e-08 | 0.62 | FALSE |
| Adipose | Srp19 | gene expression | Srp19 | 0.07 | 1 | 0.03 | 4.7e-04 | 5.46 | 4.80e-08 | 0.05 | FALSE |
| Adipose | Cdc23 | isoform ratio | NM_001100659.1 | 0.18 | 884 | 0.14 | 3.6e-15 | -5.53 | 3.19e-08 | 0.66 | FALSE |
| Adipose | Cdc23 | isoform ratio | XM_008772028.4 | 0.14 | 884 | 0.12 | 9.9e-13 | 5.57 | 2.58e-08 | 0.67 | FALSE |
| BLA | Cdc23 | alternative polyA | NM_001100659.1 | 0.15 | 13 | 0.14 | 4.6e-08 | -5.34 | 9.15e-08 | 0.69 | FALSE |
| BLA | Apc | intron excision ratio | chr18_26177302_26181872 | 0.04 | 1225 | 0.02 | 2.1e-02 | -5.34 | 9.20e-08 | 0.5 | FALSE |
| BLA | Reep5 | mRNA stability | Reep5 | 0.09 | 1156 | 0.04 | 3.7e-03 | 7.44 | 9.80e-14 | 0.6 | TRUE |
| Brain | Cdc23 | alternative polyA | NM_001100659.1 | 0.1 | 884 | 0.12 | 1.4e-11 | -5.57 | 2.50e-08 | 0.69 | FALSE |
| Brain | Cdc23 | alternative polyA | XM_008772028.4 | 0.08 | 884 | 0.09 | 5.1e-09 | 5.6 | 2.14e-08 | 0.68 | FALSE |
| Brain | Epb41l4a | alternative TSS | XM_006254583.5 | 0.03 | 1482 | 0.02 | 4.7e-03 | -5.69 | 1.30e-08 | 0.54 | FALSE |
| Brain | Brd8 | gene expression | Brd8 | 0.03 | 934 | 0.04 | 3.0e-04 | 5.37 | 7.80e-08 | 0.43 | FALSE |
| Brain | Reep5 | gene expression | Reep5 | 0.04 | 1156 | 0.05 | 1.4e-05 | 5.48 | 4.16e-08 | 0.69 | FALSE |
| Brain | Cdc23 | isoform ratio | NM_001100659.1 | 0.1 | 884 | 0.13 | 4.8e-12 | -5.61 | 2.04e-08 | 0.71 | FALSE |
| Brain | Cdc23 | isoform ratio | XM_008772028.4 | 0.06 | 884 | 0.07 | 7.3e-07 | 5.63 | 1.82e-08 | 0.69 | FALSE |
| Eye | Cdc25c | alternative TSS | XM_063277372.1 | 0.25 | 793 | 0.09 | 1.7e-02 | 5.68 | 1.33e-08 | 0.4 | FALSE |
| Eye | Srp19 | intron excision ratio | chr18_26210140_26210233 | 0.22 | 1271 | 0.07 | 3.4e-02 | 6.56 | 5.47e-11 | 0.33 | FALSE |
| Eye | Srp19 | intron excision ratio | chr18_26210344_26211679 | 0.22 | 1271 | 0.06 | 4.6e-02 | -6.79 | 1.14e-11 | 0.3 | FALSE |
| IC | Cdc23 | alternative polyA | NM_001100659.1 | 0.21 | 884 | 0.17 | 1.4e-07 | -5.5 | 3.85e-08 | 0.75 | FALSE |
| IC | Reep5 | alternative polyA | NM_001108888.2 | 0.19 | 1 | 0.15 | 5.7e-07 | -5.41 | 6.33e-08 | 0.3 | FALSE |
| IC | Reep5 | alternative polyA | XM_039097000.2 | 0.16 | 1 | 0.14 | 1.8e-06 | 5.41 | 6.33e-08 | 0.28 | FALSE |
| IC | Fam13b | alternative TSS | XM_039096734.1 | 0.06 | 4 | 0.07 | 8.8e-04 | 5.36 | 8.19e-08 | 0.44 | FALSE |
| IC | Cdc23 | isoform ratio | XM_008772028.4 | 0.12 | 884 | 0.1 | 4.6e-05 | 5.68 | 1.34e-08 | 0.71 | FALSE |
| IL | Cdc23 | alternative polyA | NM_001100659.1 | 0.25 | 884 | 0.11 | 1.6e-03 | -5.69 | 1.30e-08 | 0.53 | FALSE |
| IL | Cdc23 | alternative polyA | XM_008772028.4 | 0.19 | 884 | 0.09 | 4.1e-03 | 5.58 | 2.45e-08 | 0.43 | FALSE |
| IL | LOC134482927 | gene expression | LOC134482927 | 0.24 | 131 | 0.13 | 4.9e-04 | -5.8 | 6.69e-09 | 0.62 | FALSE |
| IL | Cdc23 | isoform ratio | NM_001100659.1 | 0.29 | 16 | 0.09 | 3.1e-03 | -5.72 | 1.08e-08 | 0.44 | TRUE |
| LHb | Reep5 | alternative polyA | NM_001108888.2 | 0.14 | 861 | 0.04 | 3.1e-02 | -5.35 | 8.83e-08 | 0.34 | FALSE |
| LHb | Reep5 | alternative polyA | XM_039097000.2 | 0.12 | 861 | 0.04 | 4.4e-02 | 5.39 | 7.09e-08 | 0.32 | FALSE |
| LHb | Cdc23 | gene expression | Cdc23 | 0.3 | 1 | 0.18 | 5.6e-05 | 5.98 | 2.18e-09 | 0.13 | FALSE |
| LHb | Epb41l4a | gene expression | Epb41l4a | 0.9 | 12 | 0.17 | 8.3e-05 | -8.26 | 1.43e-16 | 0.17 | TRUE |
| Liver | Cdc23 | alternative polyA | NM_001100659.1 | 0.09 | 1 | 0.07 | 7.2e-08 | -5.4 | 6.52e-08 | 0.31 | FALSE |
| Liver | Cdc23 | alternative polyA | XM_008772028.4 | 0.18 | 884 | 0.12 | 7.8e-13 | 5.56 | 2.68e-08 | 0.67 | FALSE |
| Liver | Reep5 | alternative polyA | XM_039097000.2 | 0.08 | 23 | 0.07 | 1.3e-08 | 5.39 | 6.91e-08 | 0.6 | FALSE |
| Liver | Fam13b | alternative TSS | XM_039096734.1 | 0.03 | 1 | 0.02 | 8.9e-04 | 5.66 | 1.53e-08 | 0.1 | FALSE |
| Liver | Brd8 | gene expression | Brd8 | 0.08 | 1 | 0.06 | 6.9e-07 | 5.37 | 7.79e-08 | 0.26 | FALSE |
| Liver | Fam13b | gene expression | Fam13b | 0.16 | 1012 | 0.14 | 3.3e-15 | 6.12 | 9.35e-10 | 0.62 | FALSE |
| Liver | Reep5 | gene expression | Reep5 | 0.16 | 1156 | 0.14 | 1.1e-15 | 5.88 | 4.19e-09 | 0.62 | FALSE |
| Liver | Srp19 | gene expression | Srp19 | 0.05 | 1271 | 0.01 | 6.8e-03 | 6.62 | 3.65e-11 | 0.55 | FALSE |
| Liver | Cdc23 | isoform ratio | NM_001100659.1 | 0.09 | 1 | 0.06 | 1.3e-07 | -5.4 | 6.52e-08 | 0.31 | FALSE |
| Liver | Cdc23 | isoform ratio | XM_008772028.4 | 0.16 | 884 | 0.12 | 8.9e-13 | 5.53 | 3.18e-08 | 0.67 | FALSE |
| NAcc | Cdc23 | alternative polyA | NM_001100659.1 | 0.11 | 884 | 0.12 | 1.6e-17 | -5.6 | 2.14e-08 | 0.56 | FALSE |
| NAcc | Cdc23 | alternative polyA | XM_008772028.4 | 0.11 | 884 | 0.12 | 1.6e-17 | 5.67 | 1.43e-08 | 0.71 | FALSE |
| NAcc | Pkd2l2 | alternative polyA | NM_001106156.1 | 0.03 | 1 | 0.02 | 4.8e-04 | 5.73 | 1.02e-08 | 0.13 | FALSE |
| NAcc | Pkd2l2 | alternative polyA | XM_063277220.1 | 0.03 | 1 | 0.02 | 4.9e-04 | -5.73 | 1.02e-08 | 0.13 | FALSE |
| NAcc | Reep5 | alternative polyA | NM_001108888.2 | 0.08 | 1 | 0.12 | 1.7e-17 | -5.73 | 1.02e-08 | 0.73 | FALSE |
| NAcc | Reep5 | alternative polyA | XM_039097000.2 | 0.08 | 1 | 0.1 | 4.9e-15 | 5.73 | 1.02e-08 | 0.73 | FALSE |
| NAcc | Epb41l4a | gene expression | Epb41l4a | 0.1 | 1068 | 0.05 | 1.5e-07 | 5.28 | 1.26e-07 | 0.03 | TRUE |
| NAcc | LOC134482927 | gene expression | LOC134482927 | 0.05 | 1 | 0.05 | 1.0e-07 | -5.7 | 1.17e-08 | 0.71 | FALSE |
| NAcc | Cdc23 | isoform ratio | NM_001100659.1 | 0.14 | 884 | 0.13 | 1.0e-18 | -5.67 | 1.41e-08 | 0.57 | FALSE |
| NAcc | Cdc23 | isoform ratio | XM_008772028.4 | 0.12 | 884 | 0.1 | 3.4e-14 | 5.57 | 2.48e-08 | 0.68 | FALSE |
| NAcc | Nme5 | isoform ratio | NM_001427396.1 | 0.02 | 1 | 0.01 | 3.5e-03 | 5.44 | 5.39e-08 | 0.03 | FALSE |
| NAcc | Apc | intron excision ratio | chr18_26138569_26143339 | 0.02 | 1 | 0.02 | 4.9e-04 | -5.46 | 4.71e-08 | 0.04 | FALSE |
| NAcc | Reep5 | intron excision ratio | chr18_26224310_26232067 | 0.02 | 1 | 0.02 | 8.5e-04 | 5.4 | 6.75e-08 | 0.04 | FALSE |
| NAcc | Apc | mRNA stability | Apc | 0.02 | 1 | 0.02 | 1.6e-03 | 5.73 | 1.02e-08 | 0.06 | FALSE |
| PL | LOC134482927 | gene expression | LOC134482927 | 0.05 | 944 | 0.05 | 2.6e-06 | -5.32 | 1.01e-07 | 0.65 | FALSE |
| PL | Reep5 | gene expression | Reep5 | 0.08 | 1156 | 0.07 | 1.4e-08 | 7.34 | 2.13e-13 | 0.71 | FALSE |
| PL | Cdc23 | isoform ratio | XM_008772028.4 | 0.08 | 1 | 0.06 | 2.1e-07 | 5.98 | 2.18e-09 | 0.92 | FALSE |
| PL | Nme5 | intron excision ratio | chr18_26444014_26454298 | 0.06 | 947 | 0.05 | 7.1e-06 | 5.68 | 1.37e-08 | 0.69 | FALSE |
| PL | Reep5 | mRNA stability | Reep5 | 0.04 | 1 | 0.01 | 6.2e-02 | 5.85 | 4.93e-09 | 0.05 | FALSE |
| pVTA | Cdc23 | alternative polyA | XM_008772028.4 | 0.26 | 884 | 0.26 | 4.2e-21 | 5.45 | 5.15e-08 | 0.55 | FALSE |
| pVTA | Reep5 | alternative polyA | NM_001108888.2 | 0.06 | 1 | 0.05 | 7.7e-05 | -5.58 | 2.46e-08 | 0.14 | FALSE |
| pVTA | Reep5 | alternative polyA | XM_039097000.2 | 0.06 | 1 | 0.04 | 1.7e-04 | 5.58 | 2.46e-08 | 0.1 | FALSE |
| pVTA | Brd8 | gene expression | Brd8 | 0.05 | 1 | 0.05 | 9.0e-05 | 5.47 | 4.39e-08 | 0.17 | FALSE |
| pVTA | Cdc23 | gene expression | Cdc23 | 0.15 | 884 | 0.18 | 1.1e-14 | 5.51 | 3.53e-08 | 0.73 | FALSE |
| RMTg | Nme5 | intron excision ratio | chr18_26444014_26454298 | 0.16 | 88 | 0.16 | 3.9e-05 | 5.79 | 7.00e-09 | 0.64 | FALSE |