Hub : Traits : dissection: UMAP 1 of all traits : →

chr1:149,857,704-153,371,149

Best TWAS P=6.972149e-09 · Best GWAS P=9.8153e-09 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Aqp11	alternative polyA	ENSRNOT00000018091	0.21	0.12	blup	1746	0.14	8.4e-15	4.7	-5.3	1.4e-07	-0.83	0.73	0.27	FALSE
2	Adipose	Aqp11	alternative polyA	ENSRNOT00000117732	0.22	0.12	blup	1746	0.14	6.0e-15	4.7	5.3	1.3e-07	0.83	0.73	0.27	FALSE
3	Adipose	Aqp11	gene expression	ENSRNOG00000013358	0.49	0.21	blup	1746	0.31	5.7e-35	4.6	-5.4	5.7e-08	-0.80	0.72	0.27	FALSE
4	Adipose	Rsf1	gene expression	ENSRNOG00000024194	0.04	0.00	blup	1605	0.00	8.3e-02	4.6	-5.4	5.8e-08	-0.82	0.32	0.21	FALSE
5	Adipose	Aqp11	isoform ratio	ENSRNOT00000018091	0.17	0.04	blup	1746	0.06	5.8e-07	4.6	-5.3	1.2e-07	-0.85	0.72	0.28	FALSE
6	Adipose	Aqp11	isoform ratio	ENSRNOT00000117732	0.16	0.03	blup	1746	0.06	8.2e-07	4.6	5.3	1.2e-07	0.85	0.72	0.28	FALSE
7	BLA	Aamdc	alternative TSS	ENSRNOT00000099902	0.31	0.23	lasso	15	0.26	4.4e-14	-4.9	-5.4	7.1e-08	0.23	0.43	0.57	FALSE
8	BLA	Aamdc	alternative TSS	ENSRNOT00000099902	0.32	0.25	lasso	12	0.27	7.4e-15	-4.9	-5.3	1.4e-07	0.38	0.43	0.57	TRUE
9	BLA	Alg8	gene expression	ENSRNOG00000012292	0.45	0.34	blup	1736	0.35	2.5e-19	4.9	5.3	1.3e-07	0.88	0.50	0.49	FALSE
10	BLA	Kctd21	gene expression	ENSRNOG00000024793	0.22	0.14	blup	1829	0.15	1.4e-08	-4.0	5.1	2.8e-07	0.66	0.53	0.47	FALSE
11	BLA	NA	gene expression	ENSRNOG00000071115	0.07	0.03	enet	6	0.04	3.5e-03	5.3	5.4	5.6e-08	0.92	0.38	0.43	TRUE
12	BLA	Aamdc	isoform ratio	ENSRNOT00000016783	0.24	0.06	blup	1605	0.13	3.2e-07	4.3	5.1	3.3e-07	0.77	0.60	0.40	TRUE
13	BLA	Aamdc	intron excision ratio	chr1:151869894:151876144	0.22	0.09	blup	1605	0.11	1.3e-06	-4.9	5.5	4.4e-08	0.68	0.45	0.54	FALSE
14	Brain	Aamdc	alternative TSS	ENSRNOT00000105468	0.25	0.21	blup	1605	0.24	2.1e-22	-5.1	5.1	2.8e-07	0.66	0.46	0.54	FALSE
15	Brain	Nars2	gene expression	ENSRNOG00000011476	0.04	0.02	lasso	20	0.02	2.9e-03	-5.1	5.2	2.1e-07	0.51	0.61	0.19	FALSE
16	Brain	Alg8	gene expression	ENSRNOG00000012292	0.16	0.12	enet	15	0.14	1.4e-12	5.0	5.6	2.5e-08	0.84	0.50	0.50	FALSE
17	Brain	Gab2	mRNA stability	ENSRNOG00000011882	0.05	0.04	blup	2045	0.05	3.9e-05	4.9	-5.4	6.8e-08	-0.87	0.46	0.53	FALSE
18	Brain	Clns1a	mRNA stability	ENSRNOG00000012788	0.38	0.38	top1	1	0.38	6.3e-37	5.1	-5.1	2.9e-07	-0.86	0.26	0.74	TRUE
19	Brain	Rsf1	mRNA stability	ENSRNOG00000024194	0.11	0.11	top1	1	0.11	1.4e-10	-5.1	-5.1	2.7e-07	-0.36	0.23	0.77	FALSE
20	IL	Alg8	gene expression	ENSRNOG00000012292	0.20	0.02	enet	15	0.07	1.1e-02	4.7	5.5	4.9e-08	0.85	0.31	0.29	FALSE
21	IL	Kctd21	gene expression	ENSRNOG00000024793	0.27	0.07	blup	1824	0.09	4.4e-03	-4.8	5.6	2.5e-08	0.80	0.34	0.31	FALSE
22	LHb	Aamdc	isoform ratio	ENSRNOT00000099902	0.22	0.05	blup	1602	0.09	3.3e-03	-4.7	-5.7	1.3e-08	-0.79	0.35	0.31	FALSE
23	LHb	Aamdc	intron excision ratio	chr1:151869894:151876144	0.24	0.04	blup	1602	0.11	1.3e-03	-4.8	5.6	2.1e-08	0.79	0.42	0.38	FALSE
24	LHb	Aamdc	intron excision ratio	chr1:151869894:151890505	0.46	0.28	blup	1602	0.29	1.5e-07	-4.7	-5.2	1.8e-07	-0.60	0.47	0.52	FALSE
25	LHb	Aamdc	intron excision ratio	chr1:151890553:151891907	0.68	0.33	lasso	7	0.38	5.5e-10	-4.7	-5.3	8.9e-08	-0.81	0.48	0.52	FALSE
26	Liver	Aamdc	alternative TSS	ENSRNOT00000099902	0.52	0.44	enet	348	0.45	6.3e-55	-4.8	-5.4	6.2e-08	-0.45	0.47	0.53	FALSE
27	Liver	Aamdc	alternative TSS	ENSRNOT00000105468	0.50	0.44	enet	249	0.45	1.5e-55	-3.7	5.4	6.8e-08	0.27	0.48	0.52	FALSE
28	Liver	Aamdc	alternative TSS	ENSRNOT00000099902	0.52	0.45	enet	335	0.47	9.9e-58	-4.8	-5.3	1.0e-07	-0.45	0.47	0.53	FALSE
29	Liver	Aamdc	alternative TSS	ENSRNOT00000105468	0.51	0.45	enet	373	0.47	2.4e-58	-4.8	5.4	6.1e-08	0.38	0.48	0.52	FALSE
30	Liver	Tsku	gene expression	ENSRNOG00000027784	0.15	0.02	enet	23	0.03	1.3e-04	-5.0	5.2	2.2e-07	0.64	0.38	0.51	FALSE
31	Liver	Aamdc	isoform ratio	ENSRNOT00000016783	0.39	0.26	enet	224	0.32	2.7e-36	4.7	5.4	5.7e-08	0.73	0.70	0.30	TRUE
32	Liver	Aamdc	intron excision ratio	chr1:151862389:151869799	0.48	0.39	enet	226	0.41	4.2e-49	-4.9	5.7	1.5e-08	0.57	0.45	0.55	FALSE
33	NAcc	Aamdc	intron excision ratio	chr1:151876293:151891907	0.37	0.06	blup	1602	0.07	1.1e-02	-5.1	5.4	5.5e-08	0.67	0.37	0.39	FALSE
34	NAcc2	Tenm4	intron excision ratio	chr1:151047589:151058146	0.17	0.08	top1	1	0.09	2.4e-05	-5.1	5.1	3.0e-07	0.68	0.17	0.08	TRUE
35	OFC	Acer3	alternative TSS	ENSRNOT00000019987	0.18	0.01	blup	1479	0.08	7.4e-03	-4.3	-5.4	7.7e-08	-0.66	0.27	0.36	FALSE
36	OFC	Acer3	alternative TSS	ENSRNOT00000102980	0.17	0.01	blup	1479	0.07	8.4e-03	-4.3	5.3	9.0e-08	0.65	0.27	0.35	FALSE
37	OFC	Alg8	gene expression	ENSRNOG00000012292	0.27	0.05	enet	7	0.11	1.6e-03	5.0	5.1	3.1e-07	0.88	0.49	0.41	FALSE
38	OFC	Pak1	gene expression	ENSRNOG00000029784	0.35	0.22	blup	1733	0.23	4.5e-06	-4.9	5.6	2.6e-08	0.70	0.46	0.52	FALSE
39	OFC	Tenm4	mRNA stability	ENSRNOG00000011151	0.24	0.20	top1	1	0.20	1.7e-05	5.6	-5.6	1.6e-08	-0.88	0.15	0.07	FALSE
40	PL	Aamdc	intron excision ratio	chr1:151869894:151890505	0.49	0.34	blup	1602	0.37	8.5e-10	-4.8	-5.3	1.1e-07	-0.65	0.50	0.50	FALSE
41	PL	Aamdc	intron excision ratio	chr1:151876293:151891907	0.17	0.04	blup	1602	0.10	2.5e-03	-5.0	5.5	3.3e-08	0.70	0.37	0.41	FALSE
42	PL	Aamdc	intron excision ratio	chr1:151890553:151891907	0.61	0.36	blup	1602	0.38	5.6e-10	-4.8	-5.2	2.4e-07	-0.54	0.47	0.53	FALSE
43	PL	Tenm4	mRNA stability	ENSRNOG00000011151	0.31	0.07	blup	3096	0.11	1.6e-03	4.9	-5.4	8.6e-08	-0.85	0.39	0.40	TRUE
44	PL2	Aamdc	alternative TSS	ENSRNOT00000099902	0.36	0.14	enet	27	0.17	1.9e-09	-4.9	-5.3	1.1e-07	0.42	0.44	0.56	TRUE
45	PL2	Aamdc	intron excision ratio	chr1:151869894:151876144	0.21	0.01	blup	1605	0.01	4.7e-02	-4.9	5.8	7.0e-09	0.70	0.29	0.32	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.