Hub : Traits : dissection: UMAP 1 of all traits : ← →

chr1:169,577,644-171,490,581

Best TWAS P=6.483634e-09 · Best GWAS P=6.215272e-09 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Nucb2	alternative TSS	ENSRNOT00000027752	0.04	0.03	lasso	2	0.03	2.0e-04	5.7	-5.7	1.3e-08	-0.96	0.52	0.44	FALSE
2	Adipose	Nucb2	alternative TSS	ENSRNOT00000107803	0.04	0.03	lasso	2	0.03	2.8e-04	5.7	5.7	1.3e-08	0.97	0.51	0.43	FALSE
3	Adipose	Sox6	gene expression	ENSRNOG00000020514	0.03	0.01	top1	1	0.01	1.4e-02	5.7	5.7	1.2e-08	1.00	0.03	0.03	FALSE
4	Adipose	Pik3c2a	mRNA stability	ENSRNOG00000020479	0.10	0.06	top1	1	0.06	6.4e-07	5.8	-5.8	6.5e-09	-0.99	0.21	0.73	TRUE
5	Adipose	RGD1311703	mRNA stability	ENSRNOG00000053659	0.07	0.04	blup	758	0.04	2.5e-05	5.7	-5.7	1.3e-08	-1.00	0.42	0.57	FALSE
6	BLA	Plekha7	gene expression	ENSRNOG00000024602	0.42	0.15	enet	26	0.17	3.5e-09	5.6	5.6	1.8e-08	0.99	0.42	0.58	FALSE
7	BLA	Rps13	isoform ratio	ENSRNOT00000118821	0.05	0.03	enet	24	0.04	4.0e-03	5.7	5.8	7.5e-09	0.98	0.34	0.40	FALSE
8	Brain	Plekha7	alternative TSS	ENSRNOT00000110407	0.03	0.02	top1	1	0.02	5.5e-03	5.7	5.7	9.0e-09	1.00	0.03	0.04	FALSE
9	Brain	Plekha7	gene expression	ENSRNOG00000024602	0.23	0.19	lasso	2	0.20	7.4e-18	5.6	5.7	1.3e-08	0.99	0.41	0.59	FALSE
10	Brain	RGD1311703	gene expression	ENSRNOG00000053659	0.08	0.05	blup	758	0.05	1.3e-05	5.7	-5.7	1.4e-08	-1.00	0.43	0.57	FALSE
11	Brain	Rps13	gene expression	ENSRNOG00000068955	0.06	0.04	blup	923	0.05	1.0e-05	5.7	5.6	1.9e-08	0.99	0.47	0.53	FALSE
12	Brain	Plekha7	isoform ratio	ENSRNOT00000097576	0.06	0.03	top1	1	0.03	9.7e-04	5.2	-5.2	2.5e-07	-0.99	0.06	0.03	FALSE
13	Brain	Plekha7	isoform ratio	ENSRNOT00000103236	0.03	0.02	blup	907	0.02	9.3e-03	5.7	5.6	1.8e-08	1.00	0.34	0.40	FALSE
14	Liver	Pik3c2a	gene expression	ENSRNOG00000020479	0.02	0.01	blup	1024	0.01	2.5e-02	5.3	-5.6	2.8e-08	-0.98	0.23	0.20	FALSE
15	Liver	Nucb2	isoform ratio	ENSRNOT00000027752	0.03	0.02	top1	1	0.02	6.1e-03	5.7	-5.7	1.2e-08	-0.98	0.04	0.04	FALSE
16	Liver	Nucb2	isoform ratio	ENSRNOT00000107803	0.03	0.01	top1	1	0.01	1.5e-02	5.7	5.7	1.2e-08	0.98	0.03	0.03	FALSE
17	Liver	Nucb2	intron excision ratio	chr1:170750971:170769341	0.03	0.00	blup	1025	0.01	1.3e-02	5.7	5.5	4.2e-08	0.97	0.34	0.28	FALSE
18	Liver	Nucb2	intron excision ratio	chr1:170756101:170769341	0.04	0.02	top1	1	0.02	4.7e-03	5.7	-5.7	1.3e-08	-0.98	0.03	0.04	FALSE
19	Liver	Sox6	intron excision ratio	chr1:169943000:170010640	0.20	0.01	top1	1	0.01	2.2e-02	5.7	-5.7	1.2e-08	-1.00	0.02	0.03	FALSE
20	NAcc	Sox6	mRNA stability	ENSRNOG00000020514	0.19	0.08	top1	1	0.08	7.8e-03	5.7	5.7	1.2e-08	1.00	0.04	0.06	FALSE
21	NAcc2	RGD1311703	alternative polyA	ENSRNOT00000090773	0.07	0.02	blup	758	0.03	6.9e-03	5.7	-5.7	1.3e-08	-1.00	0.36	0.47	FALSE
22	NAcc2	RGD1311703	alternative polyA	ENSRNOT00000099493	0.07	0.02	blup	758	0.03	6.9e-03	5.7	5.7	1.3e-08	1.00	0.35	0.46	FALSE
23	NAcc2	RGD1311703	gene expression	ENSRNOG00000053659	0.09	0.09	top1	1	0.09	1.0e-05	5.7	-5.7	9.0e-09	-1.00	0.14	0.27	FALSE
24	NAcc2	NA	gene expression	ENSRNOG00000063596	0.05	0.03	top1	1	0.03	1.3e-02	5.2	-5.2	2.0e-07	-0.98	0.04	0.04	FALSE
25	NAcc2	Pik3c2a	mRNA stability	ENSRNOG00000020479	0.17	0.04	blup	1024	0.07	1.2e-04	5.7	-5.6	2.1e-08	-0.98	0.40	0.58	FALSE
26	OFC	Rps13	alternative polyA	ENSRNOT00000114376	0.17	0.08	top1	1	0.08	7.5e-03	5.6	5.6	1.8e-08	0.99	0.05	0.06	FALSE
27	OFC	Rps13	alternative polyA	ENSRNOT00000118821	0.17	0.08	top1	1	0.08	6.0e-03	5.6	-5.6	1.8e-08	-0.99	0.05	0.06	FALSE
28	OFC	Plekha7	gene expression	ENSRNOG00000024602	0.37	0.13	blup	904	0.15	1.7e-04	5.7	5.6	1.7e-08	1.00	0.44	0.49	FALSE
29	PL2	Plekha7	gene expression	ENSRNOG00000024602	0.08	0.02	blup	907	0.04	4.4e-03	5.2	5.7	1.4e-08	1.00	0.34	0.42	FALSE
30	PL2	Pik3c2a	intron excision ratio	chr1:170632278:170641697	0.04	0.03	blup	1024	0.04	3.5e-03	5.8	5.6	2.2e-08	0.98	0.37	0.37	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.