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chr1:140,510,980-142,727,457

Best TWAS P=4.539153e-17 · Best GWAS P=1.187198e-17 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Ctsc	alternative polyA	ENSRNOT00000022342	0.16	0.14	blup	2515	0.17	2.8e-18	5.4	6.8	1.2e-11	-0.84	1.00	0.00	FALSE
2	Adipose	Ctsc	alternative polyA	ENSRNOT00000097085	0.17	0.13	blup	2515	0.19	1.5e-20	5.2	-6.9	3.8e-12	0.86	0.98	0.02	FALSE
3	Adipose	Ctsc	isoform ratio	ENSRNOT00000022342	0.16	0.10	blup	2515	0.16	4.3e-17	5.4	7.0	2.3e-12	-0.87	0.82	0.18	FALSE
4	Adipose	Ctsc	isoform ratio	ENSRNOT00000097085	0.18	0.11	blup	2515	0.18	1.3e-19	-7.7	-7.1	9.1e-13	0.88	0.62	0.38	FALSE
5	Adipose	Ctsc	intron excision ratio	chr1:142031177:142036233	0.05	0.03	blup	2515	0.04	6.5e-05	-8.0	-7.3	2.4e-13	0.90	0.39	0.60	FALSE
6	Adipose	Ctsc	intron excision ratio	chr1:142031177:142045569	0.04	0.01	blup	2515	0.02	4.7e-03	-8.0	7.1	1.7e-12	-0.87	0.47	0.50	FALSE
7	BLA	Ctsc	alternative polyA	ENSRNOT00000022342	0.07	0.00	blup	2518	0.01	5.1e-02	-6.4	6.0	2.3e-09	-0.72	0.46	0.19	FALSE
8	BLA	Ctsc	alternative polyA	ENSRNOT00000097085	0.07	0.00	blup	2518	0.02	3.2e-02	2.2	-5.7	1.4e-08	0.68	0.46	0.16	FALSE
9	BLA	Tyr	gene expression	ENSRNOG00000016421	0.15	0.09	top1	1	0.09	2.4e-05	5.8	5.8	5.4e-09	-0.76	0.44	0.02	FALSE
10	BLA	Ctsc	gene expression	ENSRNOG00000016496	0.12	0.10	top1	1	0.10	5.0e-06	-6.9	-6.9	4.9e-12	0.93	0.35	0.03	FALSE
11	BLA	Ctsc	mRNA stability	ENSRNOG00000016496	0.05	0.03	top1	1	0.03	1.5e-02	-8.3	8.3	1.5e-16	-0.88	0.09	0.08	FALSE
12	Brain	Grm5	gene expression	ENSRNOG00000016429	0.16	0.10	lasso	6	0.15	5.3e-14	-7.7	6.9	6.6e-12	-0.84	0.38	0.62	FALSE
13	Brain	Ctsc	gene expression	ENSRNOG00000016496	0.23	0.27	blup	2518	0.31	4.5e-29	5.2	-6.7	2.4e-11	0.83	1.00	0.00	FALSE
14	Brain	Ctsc	isoform ratio	ENSRNOT00000022342	0.03	0.04	top1	1	0.04	1.7e-04	-8.4	8.4	4.5e-17	-0.88	0.04	0.71	TRUE
15	Eye	Ctsc	gene expression	ENSRNOG00000016496	0.29	0.15	top1	1	0.15	2.9e-03	-7.5	-7.5	7.4e-14	0.91	0.14	0.06	FALSE
16	IL	Ctsc	gene expression	ENSRNOG00000016496	0.30	0.16	top1	1	0.16	1.0e-04	-7.8	-7.8	8.8e-15	0.91	0.13	0.05	FALSE
17	LHb	Ctsc	gene expression	ENSRNOG00000016496	0.17	0.08	top1	1	0.08	6.2e-03	5.2	-5.2	1.6e-07	0.79	0.13	0.05	FALSE
18	LHb	Ctsc	mRNA stability	ENSRNOG00000016496	0.17	0.09	top1	1	0.09	3.4e-03	5.2	5.2	1.9e-07	-0.57	0.13	0.05	TRUE
19	Liver	Ctsc	mRNA stability	ENSRNOG00000016496	0.05	0.04	blup	2515	0.04	1.8e-05	5.3	6.4	1.2e-10	-0.80	0.99	0.01	FALSE
20	NAcc	Ctsc	gene expression	ENSRNOG00000016496	0.15	0.09	blup	2509	0.12	1.3e-03	-7.8	-7.5	6.7e-14	0.92	0.43	0.44	FALSE
21	NAcc	Grm5	mRNA stability	ENSRNOG00000016429	0.33	0.21	blup	2627	0.26	1.4e-06	-7.8	-7.7	9.4e-15	0.93	0.37	0.62	TRUE
22	NAcc2	Grm5	gene expression	ENSRNOG00000016429	0.09	0.08	top1	1	0.08	2.9e-05	5.6	5.6	2.4e-08	-0.92	0.15	0.04	FALSE
23	NAcc2	Ctsc	gene expression	ENSRNOG00000016496	0.12	0.07	top1	1	0.07	9.0e-05	-7.9	-7.9	2.9e-15	0.92	0.16	0.10	FALSE
24	OFC	Ctsc	gene expression	ENSRNOG00000016496	0.14	0.05	top1	1	0.05	2.4e-02	5.2	-5.2	1.8e-07	0.71	0.12	0.05	FALSE
25	OFC	Grm5	mRNA stability	ENSRNOG00000016429	0.17	0.05	blup	2628	0.08	6.5e-03	5.4	-6.0	1.9e-09	0.71	0.47	0.21	TRUE
26	PL	Ctsc	gene expression	ENSRNOG00000016496	0.22	0.10	enet	13	0.18	3.8e-05	5.4	-7.2	4.2e-13	0.95	0.64	0.34	FALSE
27	PL	Grm5	mRNA stability	ENSRNOG00000016429	0.18	0.05	blup	2628	0.07	1.1e-02	-7.7	-7.2	7.4e-13	0.85	0.41	0.35	FALSE
28	PL2	Ctsc	gene expression	ENSRNOG00000016496	0.13	0.06	blup	2518	0.08	4.8e-05	-7.0	-7.3	3.6e-13	0.88	0.47	0.52	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.