Hub : Traits : Extensor digitorum longus weight : ←

chr15:46,891,340-49,413,227

Trait: Extensor digitorum longus weight

Best TWAS P=4.16e-12 · Best GWAS P=7.82e-13 conditioned to 4.55e-02

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h2	# weights	Model R2	Model R2 P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Rb1	alternative polyA	NM_017045.2	0.04	1	0.04	2.6e-05	-5.45	5.07e-08	0.31	FALSE
Adipose	Rb1	alternative polyA	XM_039092994.1	0.04	1	0.04	1.6e-05	5.45	5.07e-08	0.37	FALSE
Adipose	Rcbtb2	alternative polyA	NM_199084.1	0.07	1	0.06	1.6e-07	5.36	8.33e-08	0.52	FALSE
Adipose	Rcbtb2	alternative polyA	XM_008770847.3	0.07	1	0.06	9.3e-08	-5.36	8.33e-08	0.53	FALSE
Adipose	Fndc3a	alternative TSS	NM_001412039.1	0.03	2044	0.02	3.4e-03	-6.14	8.36e-10	0.11	FALSE
Adipose	Fndc3a	alternative TSS	NM_001412039.1	0.03	2044	0.02	2.3e-03	-6.15	7.98e-10	0.11	FALSE
Adipose	Rcbtb2	alternative TSS	NM_199084.1	0.04	1	0.03	2.7e-04	5.44	5.46e-08	0.1	FALSE
Adipose	Itm2b	gene expression	Itm2b	0.09	1978	0.09	1.7e-10	5.33	9.74e-08	0.58	FALSE
Adipose	Fndc3a	isoform ratio	NM_001412039.1	0.03	2044	0.02	1.6e-03	-6.09	1.13e-09	0.1	FALSE
Adipose	Rb1	isoform ratio	NM_017045.2	0.02	1	0.01	2.0e-02	-5.39	6.97e-08	0.04	FALSE
Adipose	Rb1	isoform ratio	XM_039092994.1	0.03	1	0.03	1.2e-04	5.36	8.33e-08	0.09	FALSE
Adipose	Rcbtb2	isoform ratio	NM_199084.1	0.08	1	0.08	4.1e-09	5.44	5.46e-08	0.64	FALSE
Adipose	Rcbtb2	isoform ratio	XM_008770853.3	0.04	1	0.03	6.5e-04	-5.23	1.66e-07	0.04	FALSE
Adipose	Rcbtb2	intron excision ratio	chr15_48333445_48336229	0.15	2080	0.14	6.3e-15	5.26	1.44e-07	0.58	FALSE
Adipose	Rb1	mRNA stability	Rb1	0.12	1	0.11	2.3e-12	-5.36	8.33e-08	0.64	FALSE
Adipose	Rcbtb2	mRNA stability	Rcbtb2	0.05	1	0.04	3.9e-05	-5.44	5.46e-08	0.27	FALSE
BLA	Fndc3a	intron excision ratio	chr15_47746789_47755535	0.2	2	0.06	3.3e-04	6.85	7.37e-12	0.76	FALSE
BLA	Rb1	mRNA stability	Rb1	0.06	1	0.03	6.4e-03	5.36	8.40e-08	0.04	FALSE
Brain	Rcbtb2	alternative polyA	NM_199084.1	0.13	2081	0.1	1.4e-09	-5.33	9.58e-08	0.61	FALSE
Brain	Rcbtb2	alternative polyA	XM_008770847.3	0.13	2081	0.1	1.7e-09	5.34	9.31e-08	0.61	FALSE
Brain	Fndc3a	gene expression	Fndc3a	0.14	43	0.14	7.6e-13	6.05	1.48e-09	0	FALSE
Brain	Itm2b	gene expression	Itm2b	0.57	1	0.33	4.4e-31	-5.24	1.64e-07	0.5	FALSE
Brain	Rcbtb2	isoform ratio	NM_199084.1	0.09	2081	0.05	2.2e-05	-5.45	4.91e-08	0.64	FALSE
Brain	Rcbtb2	isoform ratio	XM_008770853.3	0.03	1	0.04	2.2e-04	-5.31	1.12e-07	0.05	FALSE
Liver	Rcbtb2	alternative polyA	NM_199084.1	0.19	261	0.2	2.1e-21	5.37	7.85e-08	0.61	FALSE
Liver	Rcbtb2	alternative polyA	XM_008770847.3	0.19	243	0.2	1.1e-21	-5.43	5.75e-08	0.61	FALSE
Liver	LOC102554611	gene expression	LOC102554611	0.05	1896	0.01	7.9e-03	6.93	4.16e-12	0.72	TRUE
Liver	Nudt15	gene expression	Nudt15	0.05	1	0.05	5.5e-06	5.46	4.75e-08	0.72	FALSE
Liver	Rcbtb2	isoform ratio	NM_199084.1	0.16	235	0.15	2.6e-16	5.47	4.56e-08	0.59	FALSE
Liver	Rcbtb2	isoform ratio	XM_008770847.3	0.05	1	0.04	4.7e-05	-5.39	6.85e-08	0.12	FALSE
NAcc	LOC120097034	gene expression	LOC120097034	0.03	1	0.02	2.4e-03	-5.59	2.30e-08	0.03	FALSE
NAcc	Fndc3a	mRNA stability	Fndc3a	0.03	1	0.02	3.9e-03	5.36	8.40e-08	0.03	FALSE
OFC	Rcbtb2	alternative polyA	NM_199084.1	0.22	1	0.12	1.1e-03	5.31	1.12e-07	0.05	FALSE
OFC	Rcbtb2	alternative polyA	XM_008770847.3	0.21	2081	0.11	1.2e-03	5.57	2.48e-08	0.46	FALSE
OFC	Nudt15	gene expression	Nudt15	0.23	1	0.17	9.4e-05	5.35	8.60e-08	0.08	FALSE
OFC	Rb1	gene expression	Rb1	0.16	1	0.07	9.8e-03	5.49	3.97e-08	0.06	FALSE
OFC	Rcbtb2	isoform ratio	NM_199084.1	0.24	2081	0.2	1.7e-05	-5.54	2.98e-08	0.58	FALSE
PL	Rcbtb2	alternative polyA	NM_199084.1	0.08	2081	0.08	6.3e-09	-5.2	2.02e-07	0.3	FALSE
PL	Fndc3a	gene expression	Fndc3a	0.1	2045	0.08	2.9e-09	-6.14	8.00e-10	0.01	FALSE
pVTA	Rcbtb2	alternative polyA	NM_199084.1	0.08	1	0.04	9.6e-03	5.23	1.66e-07	0.04	FALSE
pVTA	Rcbtb2	alternative polyA	XM_008770847.3	0.07	1	0.03	1.3e-02	-5.23	1.66e-07	0.04	FALSE
pVTA	Rcbtb2	isoform ratio	NM_199084.1	0.09	2081	0.02	3.6e-02	-5.48	4.31e-08	0.41	FALSE
RMTg	LOC120097036	gene expression	LOC120097036	0.25	1	0.13	1.9e-04	-5.32	1.06e-07	0.06	FALSE