Best TWAS P = 2.28e-10 · Best GWAS P= 2.66e-10 conditioned to 0.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Cdk17 | alternative polyA | NM_001108082.2 | 0.03 | 3061 | 0.01 | 9.6e-03 | -5.41 | 6.31e-08 | 0.37 | FALSE |
| Adipose | Nr2c1 | alternative polyA | NM_145780.2 | 0.04 | 2860 | 0.03 | 2.0e-04 | -5.41 | 6.19e-08 | 0.27 | FALSE |
| Adipose | Nr2c1 | alternative polyA | XM_039078458.1 | 0.04 | 2860 | 0.03 | 2.5e-04 | 5.4 | 6.56e-08 | 0.27 | FALSE |
| Adipose | LOC134479659 | gene expression | LOC134479659 | 0.04 | 1 | 0.02 | 4.8e-03 | -5.27 | 1.40e-07 | 0.12 | TRUE |
| Adipose | Ndufa12 | gene expression | Ndufa12 | 0.4 | 158 | 0.23 | 5.0e-25 | 5.51 | 3.52e-08 | 0.17 | TRUE |
| Adipose | Vezt | gene expression | Vezt | 0.1 | 1 | 0.08 | 3.4e-09 | 5.49 | 3.97e-08 | 0.18 | FALSE |
| Adipose | Nr2c1 | isoform ratio | XM_039078459.2 | 0.02 | 2860 | 0.01 | 1.6e-02 | 6.06 | 1.34e-09 | 0.32 | FALSE |
| Adipose | Cep83 | intron excision ratio | chr7_31209896_31212408 | 0.03 | 14 | 0.03 | 3.4e-04 | -6 | 1.93e-09 | 0.57 | TRUE |
| Adipose | Nedd1 | mRNA stability | Nedd1 | 0.07 | 2923 | 0.07 | 4.1e-08 | -5.25 | 1.52e-07 | 0.53 | TRUE |
| Adipose | Vezt | mRNA stability | Vezt | 0.06 | 2707 | 0.08 | 3.9e-09 | -5.77 | 8.12e-09 | 0.62 | FALSE |
| BLA | Nr2c1 | alternative polyA | NM_145780.2 | 0.06 | 1 | 0.06 | 5.2e-04 | 5.29 | 1.21e-07 | 0.04 | FALSE |
| BLA | Nr2c1 | alternative polyA | XM_039078458.1 | 0.06 | 1 | 0.06 | 5.2e-04 | -5.29 | 1.21e-07 | 0.04 | FALSE |
| BLA | Nr2c1 | alternative TSS | XM_039078459.2 | 0.13 | 2860 | 0.02 | 1.8e-02 | -5.63 | 1.81e-08 | 0.47 | FALSE |
| BLA | Fgd6 | gene expression | Fgd6 | 0.08 | 1 | 0.09 | 1.9e-05 | 5.71 | 1.11e-08 | 0.23 | FALSE |
| BLA | Metap2 | gene expression | Metap2 | 0.1 | 9 | 0.09 | 2.5e-05 | 5.54 | 3.01e-08 | 0.21 | FALSE |
| BLA | Mir331 | gene expression | Mir331 | 0.06 | 14 | 0.07 | 1.2e-04 | 5.89 | 3.92e-09 | 0.31 | FALSE |
| BLA | Ntn4 | gene expression | Ntn4 | 0.06 | 2576 | 0.05 | 1.7e-03 | 5.76 | 8.29e-09 | 0.29 | TRUE |
| BLA | Vezt | gene expression | Vezt | 0.32 | 64 | 0.34 | 1.0e-18 | 6.27 | 3.68e-10 | 0.64 | FALSE |
| BLA | Nr2c1 | isoform ratio | NM_145780.2 | 0.04 | 2860 | 0.03 | 1.1e-02 | -5.99 | 2.12e-09 | 0.26 | FALSE |
| BLA | Vezt | mRNA stability | Vezt | 0.25 | 51 | 0.33 | 3.7e-18 | -6.12 | 9.29e-10 | 0.64 | FALSE |
| Brain | Nr2c1 | alternative polyA | NM_145780.2 | 0.05 | 2860 | 0.04 | 1.3e-04 | -6.22 | 4.86e-10 | 0.28 | FALSE |
| Brain | Nr2c1 | alternative polyA | XM_039078458.1 | 0.05 | 2860 | 0.04 | 2.0e-04 | 6.24 | 4.46e-10 | 0.29 | FALSE |
| Brain | Fgd6 | alternative TSS | XM_039079738.2 | 0.05 | 1 | 0.05 | 1.8e-05 | -5.84 | 5.24e-09 | 0.42 | FALSE |
| Brain | Fgd6 | alternative TSS | XM_063264098.1 | 0.05 | 1 | 0.03 | 4.2e-04 | 5.85 | 5.06e-09 | 0.16 | FALSE |
| Brain | Fgd6 | gene expression | Fgd6 | 0.16 | 23 | 0.19 | 1.4e-17 | -5.59 | 2.28e-08 | 0.18 | FALSE |
| Brain | Ndufa12 | gene expression | Ndufa12 | 0.44 | 2725 | 0.33 | 6.6e-32 | -5.7 | 1.20e-08 | 0.17 | FALSE |
| Brain | Vezt | gene expression | Vezt | 0.23 | 45 | 0.23 | 1.1e-21 | 5.76 | 8.30e-09 | 0.22 | FALSE |
| Brain | Lta4h | intron excision ratio | chr7_29884652_29886793 | 0.05 | 2416 | 0.03 | 2.1e-03 | -5.63 | 1.75e-08 | 0.71 | FALSE |
| Brain | Vezt | intron excision ratio | chr7_30423170_30425300 | 0.04 | 2707 | 0.03 | 2.1e-03 | 5.33 | 1.01e-07 | 0.17 | TRUE |
| Brain | Lta4h | mRNA stability | Lta4h | 0.12 | 2416 | 0.08 | 3.2e-08 | 5.38 | 7.53e-08 | 0.35 | FALSE |
| Brain | Vezt | mRNA stability | Vezt | 0.07 | 18 | 0.06 | 1.9e-06 | -5.81 | 6.09e-09 | 0.38 | FALSE |
| Eye | Fgd6 | gene expression | Fgd6 | 0.45 | 1 | 0.06 | 4.6e-02 | 5.64 | 1.67e-08 | 0.05 | FALSE |
| IC | Nr2c1 | alternative polyA | NM_145780.2 | 0.21 | 2832 | 0.15 | 8.5e-07 | -5.9 | 3.71e-09 | 0.19 | FALSE |
| IC | Nr2c1 | alternative polyA | XM_039078458.1 | 0.21 | 2832 | 0.16 | 4.0e-07 | 5.99 | 2.11e-09 | 0.2 | TRUE |
| IC | Fgd6 | gene expression | Fgd6 | 0.07 | 2699 | 0.04 | 7.5e-03 | -6.15 | 7.54e-10 | 0.45 | FALSE |
| IC | Ndufa12 | gene expression | Ndufa12 | 0.29 | 69 | 0.18 | 3.9e-08 | 5.57 | 2.58e-08 | 0.2 | TRUE |
| IC | Vezt | gene expression | Vezt | 0.25 | 2699 | 0.2 | 5.8e-09 | -6.1 | 1.04e-09 | 0.38 | FALSE |
| IC | Nr2c1 | isoform ratio | NM_145780.2 | 0.11 | 2832 | 0.11 | 1.7e-05 | -5.94 | 2.93e-09 | 0.21 | FALSE |
| IC | Vezt | intron excision ratio | chr7_30423170_30425300 | 0.06 | 1 | 0.02 | 5.6e-02 | -5.33 | 9.74e-08 | 0.04 | FALSE |
| IC | Vezt | mRNA stability | Vezt | 0.17 | 1 | 0.11 | 2.3e-05 | 5.52 | 3.32e-08 | 0.12 | FALSE |
| LHb | LOC120093559 | gene expression | LOC120093559 | 0.31 | 1 | 0.05 | 2.3e-02 | -5.43 | 5.50e-08 | 0.05 | FALSE |
| Liver | Nr2c1 | alternative polyA | NM_145780.2 | 0.08 | 1 | 0.08 | 1.3e-09 | 5.69 | 1.30e-08 | 0.37 | FALSE |
| Liver | Nr2c1 | alternative polyA | XM_039078458.1 | 0.08 | 1 | 0.09 | 8.5e-10 | -5.69 | 1.30e-08 | 0.37 | FALSE |
| Liver | Amdhd1 | gene expression | Amdhd1 | 0.41 | 44 | 0.37 | 8.4e-43 | -5.57 | 2.51e-08 | 0.5 | FALSE |
| Liver | Ndufa12 | gene expression | Ndufa12 | 0.4 | 2725 | 0.46 | 2.3e-56 | -5.28 | 1.27e-07 | 0.17 | FALSE |
| Liver | Nr2c1 | isoform ratio | NM_145780.2 | 0.09 | 1 | 0.1 | 2.1e-11 | 5.69 | 1.30e-08 | 0.37 | FALSE |
| Liver | Ccdc38 | mRNA stability | Ccdc38 | 0.38 | 37 | 0.35 | 5.9e-41 | 5.34 | 9.23e-08 | 0.56 | FALSE |
| Liver | Lta4h | mRNA stability | Lta4h | 0.12 | 2416 | 0.09 | 9.8e-10 | 5.6 | 2.08e-08 | 0.36 | TRUE |
| Liver | Nr2c1 | mRNA stability | Nr2c1 | 0.02 | 2860 | 0.01 | 2.8e-02 | 6.17 | 6.98e-10 | 0.33 | TRUE |
| Liver | Snrpf | mRNA stability | Snrpf | 0.03 | 2590 | 0.01 | 2.9e-02 | -5.74 | 9.31e-09 | 0.53 | FALSE |
| NAcc | Nr2c1 | alternative polyA | NM_145780.2 | 0.05 | 11 | 0.05 | 3.2e-08 | -5.55 | 2.82e-08 | 0.22 | FALSE |
| NAcc | Nr2c1 | alternative polyA | XM_039078458.1 | 0.05 | 17 | 0.05 | 5.0e-08 | 5.58 | 2.39e-08 | 0.22 | FALSE |
| NAcc | Fgd6 | gene expression | Fgd6 | 0.03 | 2699 | 0.02 | 1.6e-04 | -6.27 | 3.58e-10 | 0.4 | FALSE |
| NAcc | Lta4h | gene expression | Lta4h | 0.03 | 2416 | 0.04 | 2.8e-06 | 5.58 | 2.40e-08 | 0.29 | FALSE |
| NAcc | Vezt | gene expression | Vezt | 0.06 | 2699 | 0.11 | 5.7e-16 | -6.33 | 2.44e-10 | 0.24 | FALSE |
| NAcc | Nr2c1 | intron excision ratio | chr7_30628520_30638147 | 0.02 | 2832 | 0.01 | 1.9e-03 | 6.13 | 8.67e-10 | 0.33 | FALSE |
| NAcc | Nr2c1 | intron excision ratio | chr7_30638268_30645655 | 0.01 | 2832 | 0.01 | 1.6e-02 | -6.17 | 6.97e-10 | 0.23 | FALSE |
| NAcc | Tmcc3 | intron excision ratio | chr7_31020582_31046371 | 0.06 | 2504 | 0.06 | 3.3e-09 | -5.36 | 8.40e-08 | 0.41 | TRUE |
| NAcc | Vezt | mRNA stability | Vezt | 0.12 | 34 | 0.18 | 5.6e-26 | 5.47 | 4.56e-08 | 0.16 | FALSE |
| OFC | Ndufa12 | gene expression | Ndufa12 | 0.23 | 1 | 0.15 | 2.4e-04 | 5.67 | 1.39e-08 | 0.06 | FALSE |
| OFC | Vezt | gene expression | Vezt | 0.28 | 2707 | 0.21 | 1.1e-05 | -5.46 | 4.87e-08 | 0.25 | TRUE |
| OFC | Plxnc1 | mRNA stability | Plxnc1 | 0.19 | 3252 | 0.08 | 5.7e-03 | 6.03 | 1.66e-09 | 0.24 | FALSE |
| OFC | Vezt | mRNA stability | Vezt | 0.53 | 1 | 0.36 | 2.6e-09 | 5.34 | 9.17e-08 | 0.06 | FALSE |
| PL | LOC108351432 | alternative polyA | XR_010053677.1 | 0.03 | 1 | 0.03 | 8.4e-04 | -5.69 | 1.30e-08 | 0.13 | FALSE |
| PL | Nr2c1 | alternative polyA | NM_145780.2 | 0.04 | 18 | 0.04 | 9.4e-06 | -5.53 | 3.14e-08 | 0.22 | FALSE |
| PL | Nr2c1 | alternative polyA | XM_039078458.1 | 0.04 | 14 | 0.04 | 1.6e-05 | 5.52 | 3.34e-08 | 0.22 | FALSE |
| PL | Fgd6 | gene expression | Fgd6 | 0.05 | 1 | 0.07 | 1.3e-08 | 5.38 | 7.51e-08 | 0.1 | FALSE |
| PL | Lta4h | gene expression | Lta4h | 0.03 | 2416 | 0.02 | 3.4e-03 | 5.68 | 1.34e-08 | 0.44 | FALSE |
| PL | Mir331 | gene expression | Mir331 | 0.03 | 13 | 0.03 | 5.4e-04 | -5.93 | 3.04e-09 | 0.5 | FALSE |
| PL | Ndufa12 | gene expression | Ndufa12 | 0.06 | 31 | 0.08 | 3.1e-09 | 5.88 | 3.99e-09 | 0.27 | FALSE |
| PL | Vezt | gene expression | Vezt | 0.29 | 44 | 0.38 | 3.7e-43 | 6.17 | 6.72e-10 | 0.86 | TRUE |
| PL | Cep83 | isoform ratio | XM_063264041.1 | 0.02 | 2840 | 0.01 | 1.7e-02 | -5.81 | 6.13e-09 | 0.31 | FALSE |
| PL | Cfap54 | mRNA stability | Cfap54 | 0.02 | 1 | 0.02 | 3.0e-03 | 5.36 | 8.17e-08 | 0.06 | TRUE |
| PL | LOC134479863 | mRNA stability | LOC134479863 | 0.04 | 3521 | 0.02 | 1.3e-03 | 5.84 | 5.34e-09 | 0.37 | TRUE |
| PL | Lta4h | mRNA stability | Lta4h | 0.05 | 2416 | 0.05 | 1.4e-06 | 5.71 | 1.13e-08 | 0.32 | FALSE |
| PL | Vezt | mRNA stability | Vezt | 0.12 | 23 | 0.17 | 4.7e-18 | -5.67 | 1.39e-08 | 0.21 | FALSE |
| pVTA | LOC108351432 | alternative polyA | XR_010053676.1 | 0.06 | 2923 | 0.02 | 1.6e-02 | -5.44 | 5.43e-08 | 0.37 | TRUE |
| pVTA | Fgd6 | gene expression | Fgd6 | 0.05 | 2699 | 0.05 | 5.4e-05 | -6.34 | 2.28e-10 | 0.29 | TRUE |
| pVTA | Lta4h | gene expression | Lta4h | 0.05 | 22 | 0.03 | 3.2e-03 | 6.06 | 1.33e-09 | 0.4 | FALSE |
| pVTA | Ndufa12 | gene expression | Ndufa12 | 0.03 | 1 | 0.05 | 9.7e-05 | 5.72 | 1.06e-08 | 0.08 | FALSE |
| pVTA | Vezt | gene expression | Vezt | 0.15 | 22 | 0.17 | 2.6e-13 | -5.8 | 6.61e-09 | 0.21 | TRUE |
| pVTA | Cdk17 | mRNA stability | Cdk17 | 0.04 | 24 | 0.03 | 3.6e-03 | 5.71 | 1.10e-08 | 0.12 | FALSE |
| pVTA | Lta4h | mRNA stability | Lta4h | 0.07 | 2416 | 0.06 | 6.7e-06 | 5.97 | 2.37e-09 | 0.38 | FALSE |