Best TWAS P=1.23527e-09 · Best GWAS P=1.918992e-08 conditioned to 0.008654859
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Itga2 | mRNA stability | ENSRNOG00000058111 | 0.03 | 0.01 | blup | 2593 | 0.01 | 2.0e-02 | 5.2 | 5.8 | 6.0e-09 | 0.69 | 0.42 | 0.43 | FALSE |
| 2 | BLA | Mocs2 | intron excision ratio | chr2:46507444:46511052 | 0.23 | 0.14 | blup | 2080 | 0.21 | 2.3e-11 | 4.6 | 5.2 | 1.8e-07 | 0.86 | 0.78 | 0.22 | FALSE |
| 3 | Brain | Pelo | gene expression | ENSRNOG00000061128 | 0.05 | 0.02 | blup | 2797 | 0.04 | 2.6e-04 | 5.1 | 5.9 | 2.8e-09 | 0.78 | 0.52 | 0.44 | FALSE |
| 4 | Brain | Mocs2 | intron excision ratio | chr2:46507444:46511052 | 0.16 | 0.14 | enet | 36 | 0.16 | 6.3e-15 | 4.9 | 5.8 | 7.7e-09 | 0.83 | 0.73 | 0.27 | TRUE |
| 5 | LHb | Mocs2 | intron excision ratio | chr2:46507411:46511052 | 0.24 | 0.11 | top1 | 1 | 0.11 | 1.6e-03 | 5.2 | -5.2 | 2.1e-07 | -0.92 | 0.11 | 0.06 | TRUE |
| 6 | LHb | Mocs2 | intron excision ratio | chr2:46507444:46511052 | 0.29 | 0.06 | enet | 87 | 0.07 | 1.2e-02 | 5.0 | 6.1 | 1.2e-09 | 0.87 | 0.36 | 0.40 | TRUE |
| 7 | Liver | Mocs2 | intron excision ratio | chr2:46505866:46507267 | 0.15 | 0.13 | enet | 20 | 0.16 | 3.4e-17 | 4.8 | -5.9 | 4.5e-09 | -0.88 | 0.41 | 0.59 | FALSE |
| 8 | Liver | Mocs2 | intron excision ratio | chr2:46507411:46511052 | 0.16 | 0.14 | lasso | 8 | 0.16 | 3.6e-17 | 4.9 | -5.1 | 2.7e-07 | -0.89 | 0.57 | 0.43 | FALSE |
| 9 | Liver | Mocs2 | intron excision ratio | chr2:46507444:46511052 | 0.19 | 0.17 | lasso | 8 | 0.18 | 2.0e-19 | 4.6 | 5.1 | 3.3e-07 | 0.88 | 0.62 | 0.38 | FALSE |
| 10 | Liver | Mocs2 | mRNA stability | ENSRNOG00000056325 | 0.04 | 0.05 | top1 | 1 | 0.05 | 4.3e-06 | 5.4 | 5.4 | 7.1e-08 | 0.89 | 0.14 | 0.76 | FALSE |
| 11 | NAcc | Mocs2 | intron excision ratio | chr2:46507444:46511052 | 0.30 | 0.23 | lasso | 18 | 0.24 | 9.9e-18 | 4.8 | 5.8 | 6.3e-09 | -0.66 | 0.56 | 0.44 | TRUE |
| 12 | PL | Mocs2 | intron excision ratio | chr2:46507444:46511052 | 0.22 | 0.18 | enet | 115 | 0.22 | 1.1e-16 | 4.7 | 5.5 | 4.0e-08 | 0.83 | 0.48 | 0.52 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.