Best TWAS P=2.403618e-07 · Best GWAS P=1.549822e-07 conditioned to 1
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Pik3c2a | mRNA stability | ENSRNOG00000020479 | 0.10 | 0.06 | top1 | 1 | 0.06 | 6.4e-07 | -5.2 | 5.2 | 2.4e-07 | -0.99 | 0.29 | 0.63 | FALSE |
| 2 | Adipose | RGD1311703 | mRNA stability | ENSRNOG00000053659 | 0.07 | 0.04 | blup | 758 | 0.04 | 2.5e-05 | -5.1 | 5.1 | 2.8e-07 | -1.00 | 0.42 | 0.58 | FALSE |
| 3 | BLA | Rps13 | isoform ratio | ENSRNOT00000118821 | 0.05 | 0.03 | enet | 24 | 0.04 | 4.0e-03 | -5.1 | -5.2 | 2.6e-07 | 0.98 | 0.35 | 0.40 | FALSE |
| 4 | Brain | Plekha7 | alternative TSS | ENSRNOT00000110407 | 0.03 | 0.02 | top1 | 1 | 0.02 | 5.5e-03 | -5.1 | -5.1 | 3.2e-07 | 1.00 | 0.03 | 0.04 | FALSE |
| 5 | Brain | RGD1311703 | gene expression | ENSRNOG00000053659 | 0.08 | 0.05 | blup | 758 | 0.05 | 1.3e-05 | -5.1 | 5.1 | 3.2e-07 | -1.00 | 0.43 | 0.57 | FALSE |
| 6 | Liver | Nucb2 | isoform ratio | ENSRNOT00000027752 | 0.03 | 0.02 | top1 | 1 | 0.02 | 6.1e-03 | -5.2 | 5.2 | 2.5e-07 | -0.98 | 0.04 | 0.04 | FALSE |
| 7 | Liver | Nucb2 | isoform ratio | ENSRNOT00000107803 | 0.03 | 0.01 | top1 | 1 | 0.01 | 1.5e-02 | -5.2 | -5.2 | 2.5e-07 | 0.98 | 0.03 | 0.03 | FALSE |
| 8 | Liver | Nucb2 | intron excision ratio | chr1:170756101:170769341 | 0.04 | 0.02 | top1 | 1 | 0.02 | 4.7e-03 | -5.2 | 5.2 | 2.5e-07 | -0.98 | 0.03 | 0.04 | FALSE |
| 9 | Liver | Sox6 | intron excision ratio | chr1:169943000:170010640 | 0.20 | 0.01 | top1 | 1 | 0.01 | 2.2e-02 | -5.2 | 5.2 | 2.4e-07 | -1.00 | 0.02 | 0.03 | TRUE |
| 10 | NAcc | Sox6 | mRNA stability | ENSRNOG00000020514 | 0.19 | 0.08 | top1 | 1 | 0.08 | 7.8e-03 | -5.2 | -5.2 | 2.5e-07 | 1.00 | 0.04 | 0.06 | FALSE |
| 11 | NAcc2 | RGD1311703 | alternative polyA | ENSRNOT00000090773 | 0.07 | 0.02 | blup | 758 | 0.03 | 6.9e-03 | -5.2 | 5.1 | 3.1e-07 | -1.00 | 0.35 | 0.47 | FALSE |
| 12 | NAcc2 | RGD1311703 | alternative polyA | ENSRNOT00000099493 | 0.07 | 0.02 | blup | 758 | 0.03 | 6.9e-03 | -5.2 | -5.1 | 3.1e-07 | 1.00 | 0.35 | 0.46 | FALSE |
| 13 | NAcc2 | RGD1311703 | gene expression | ENSRNOG00000053659 | 0.09 | 0.09 | top1 | 1 | 0.09 | 1.0e-05 | -5.1 | 5.1 | 3.2e-07 | -1.00 | 0.16 | 0.21 | FALSE |
| 14 | PL2 | Plekha7 | gene expression | ENSRNOG00000024602 | 0.08 | 0.02 | blup | 907 | 0.04 | 4.4e-03 | -4.7 | -5.1 | 3.3e-07 | 1.00 | 0.33 | 0.42 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.