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chr4:17,825,992-20,728,817

Best TWAS P=8.127602e-12 · Best GWAS P=7.395848e-12 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Brain	Pclo	alternative polyA	ENSRNOT00000007608	0.08	0.03	lasso	6	0.04	2.3e-04	-6.1	-5.9	3.4e-09	0.88	0.32	0.62	FALSE
2	Brain	Pclo	alternative polyA	ENSRNOT00000008637	0.08	0.03	lasso	6	0.04	1.9e-04	-6.1	5.9	4.2e-09	-0.88	0.33	0.61	FALSE
3	Brain	Cacna2d1	gene expression	ENSRNOG00000033531	0.05	0.06	top1	1	0.06	5.7e-06	-6.8	-6.8	8.1e-12	0.99	0.40	0.47	TRUE
4	Brain	Pclo	isoform ratio	ENSRNOT00000007608	0.05	0.01	enet	29	0.03	1.0e-03	-5.6	-5.9	3.6e-09	0.73	0.39	0.48	FALSE
5	Brain	Pclo	isoform ratio	ENSRNOT00000008637	0.05	0.01	enet	30	0.03	5.5e-04	-5.6	5.8	5.8e-09	-0.70	0.40	0.50	FALSE
6	Brain	Pclo	mRNA stability	ENSRNOG00000005726	0.28	0.19	enet	64	0.24	4.1e-22	-5.0	5.6	1.9e-08	-0.92	0.81	0.19	FALSE
7	IL	Hgf	gene expression	ENSRNOG00000007027	0.45	0.31	enet	18	0.34	6.6e-09	4.4	-5.2	2.4e-07	0.71	1.00	0.00	FALSE
8	LHb	Pclo	intron excision ratio	chr4:19838555:19842972	0.18	0.05	enet	6	0.05	2.9e-02	-4.8	-5.5	4.9e-08	0.89	0.38	0.22	FALSE
9	NAcc	Cacna2d1	gene expression	ENSRNOG00000033531	0.21	0.07	top1	1	0.07	1.2e-02	-6.8	-6.8	1.5e-11	0.99	0.13	0.05	FALSE
10	PL2	NA	gene expression	ENSRNOG00000070617	0.35	0.42	blup	2612	0.42	8.1e-25	4.5	5.3	1.1e-07	-0.77	1.00	0.00	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.