Best TWAS P=1.214433e-07 · Best GWAS P=8.111532e-08 conditioned to 1
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | Bpnt2 | alternative TSS | ENSRNOT00000033151 | 0.04 | 0.02 | blup | 2397 | 0.03 | 3.7e-04 | 4.9 | -5.1 | 2.9e-07 | -0.72 | 0.54 | 0.44 | FALSE |
| 2 | Brain | Bpnt2 | alternative TSS | ENSRNOT00000072803 | 0.04 | 0.03 | blup | 2397 | 0.04 | 2.6e-04 | 4.9 | 5.1 | 2.7e-07 | 0.73 | 0.54 | 0.45 | FALSE |
| 3 | Brain | Penk | gene expression | ENSRNOG00000008943 | 0.30 | 0.12 | lasso | 5 | 0.14 | 1.7e-12 | 5.3 | 5.3 | 1.2e-07 | 0.95 | 0.09 | 0.91 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.