Hub : Traits : Bone: periosteal estimation : ← →

chr16:558,324-2,117,247

Trait: Bone: periosteal estimation

Best TWAS P=1.650755e-07 · Best GWAS P=1.900658e-07 conditioned to 1.163803e-133

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	BLA	Zcchc24	gene expression	ENSRNOG00000040205	0.15	0.05	top1	1	0.05	1.2e-03	-5.1	-5.1	2.8e-07	0.92	0.11	0.19	FALSE
2	Brain	Zcchc24	gene expression	ENSRNOG00000040205	0.34	0.36	lasso	86	0.38	9.0e-37	-5.2	-5.2	1.8e-07	0.99	0.28	0.72	FALSE
3	Brain	Ppif	mRNA stability	ENSRNOG00000010558	0.16	0.13	lasso	29	0.14	1.3e-12	-5.2	-5.2	1.9e-07	0.99	0.27	0.73	FALSE
4	IL	Tmem254	alternative TSS	ENSRNOT00000108510	0.17	0.11	top1	1	0.11	1.5e-03	-5.2	-5.2	2.6e-07	0.95	0.07	0.06	FALSE
5	IL	Ppif	gene expression	ENSRNOG00000010558	0.51	0.27	blup	1694	0.28	1.6e-07	-5.1	-5.1	2.7e-07	0.98	0.29	0.71	FALSE
6	LHb	Tmem254	alternative TSS	ENSRNOT00000015011	0.29	0.09	top1	1	0.10	3.0e-03	-5.1	5.1	3.1e-07	-0.92	0.08	0.07	FALSE
7	LHb	Tmem254	alternative TSS	ENSRNOT00000108510	0.47	0.17	top1	1	0.17	6.4e-05	-5.1	-5.1	3.1e-07	0.95	0.09	0.15	FALSE
8	LHb	Zcchc24	gene expression	ENSRNOG00000040205	0.35	0.27	top1	1	0.27	3.4e-07	-5.1	-5.1	3.5e-07	0.97	0.17	0.30	FALSE
9	Liver	Ppif	gene expression	ENSRNOG00000010558	0.71	0.61	lasso	37	0.62	1.4e-87	-5.2	5.2	2.4e-07	-0.99	0.27	0.73	FALSE
10	NAcc	Zcchc24	gene expression	ENSRNOG00000040205	0.10	0.08	top1	1	0.08	7.9e-07	-5.1	-5.1	2.8e-07	0.94	0.26	0.71	FALSE
11	PL	Zcchc24	gene expression	ENSRNOG00000040205	0.16	0.04	lasso	33	0.04	2.3e-04	-5.2	-5.1	2.7e-07	1.00	0.30	0.67	FALSE
12	PL	Ppif	mRNA stability	ENSRNOG00000010558	0.29	0.18	enet	302	0.22	9.7e-17	-5.1	-5.2	1.7e-07	0.91	0.28	0.72	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.